Personality Disorder, Borderline


Article Author:
Jennifer Chapman


Article Editor:
Carl Fleisher



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Mark Pellegrini
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Phillip Hynes


Updated:
10/27/2018 12:31:47 PM

Introduction

A personality disorder is a mental disorder involving a rigid and unhealthy pattern of thinking. Personality disorders are prevalent in the general population and more so in clinical populations. In the pediatric population, all personality disorders can be diagnosed, except anti-social personality disorder, as long as the pathologic behavior has been present for a year or more. The Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) lists 10 personality disorders divided into the 3 clusters (A, B, and C). Borderline personality disorder (BPD) is 1 of 4 cluster-B disorders that includes borderline, antisocial, narcissistic, and histrionic. Borderline personality disorder (BPD) is characterized by hypersensitivity to rejection and resulting instability of interpersonal relationships, self-image, affect and behavior. Borderline personality disorder causes significant impairment and distress and is associated with multiple medical and psychiatric co-morbidities. Surveys have estimated the prevalence of borderline personality disorder to be 1.6% in the general population and 20% of the psychiatric, inpatient population. In contrast, obsessive-compulsive personality disorder (OCPD) appears to be the most prevalent personality disorder with rates around 5% of the general population in some studies. Patients with borderline personality disorder have been shown to utilize extensive treatment resources and are at increased morbidity and mortality compared with the general populations. It is perhaps the reason why borderline personality disorder has been studied more extensively than other personality disorders.

Features of borderline personality disorder include:

  • Poor emotional regulation with an inability to self-soothe in times of emotional distress
  • Excessive emotional reactions to social stressors which may result in self-injurious behavior, suicide threats 
  • Inability to maintain appropriate boundaries in relationships

Etiology

Borderline personality disorder is multifactorial in etiology. There is a genetic predisposition. Twin studies show over 50% heritability (greater than that for major depression). Twin studies performed in 2000 and 2008 both demonstrated higher concordance of the rate of borderline personality disorder for monozygotic versus dizygotic twins. Environmental factors that have been identified as contributing to the development of borderline personality disorder include childhood abuse (physical, sexual, or neglect), maternal separation, poor maternal attachment, faulty family boundaries, parental substance abuse, and serious parental psychopathology.

There are many theories about the development of borderline personality disorder. In the mentalizing model of Peter Fonagy and Anthony Bateman, borderline personality disorder is the manifestation of a lack of resilience against psychological stressors, mediated primarily by difficulty in generating adaptive re-appraisal of negative events or stressors. In the biosocial model popularized by Dr. Marsha Linehan, genetic vulnerability interacts with a "chronically invalidating environment" to produce the constellation of borderline personality disorder symptoms. In another theory, borderline personality disorder arises from the inability to regulate affect and the lack of formation of appropriate coping mechanisms in response to stress. Otto Kernberg theorized that lack of integration in the early material relationship led to borderline personality disorder. Kernberg hypothesized that the infant experiences the maternal figure in a dichotomous framework, the loving and nurturing mother who provides for the child and the punishing, hateful mother who deprives the child. This contradiction causes intense anxiety and, if not integrated into a more moderate unitary concept, ultimately leads to the development of splitting. The term "splitting" refers to the defense mechanism in which the patient cannot form a realistic view of another person. At any given time the other person is viewed as entirely good or entirely bad. This inability to view others as having both positive and negative attributes impairs personal relationships.

Neuroimaging studies have identified differences in the amygdala, hippocampus, and medial temporal lobes in patients with borderline personality disorder. Such studies also suggest that patients with borderline personality disorder misattribute negative emotions (fear, anger, disgust) to neutral faces more so than controls or other patients, despite having the perception of happy and upset faces equivalent to those groups. Neurobiological studies have suggested that impaired neuropeptide function, specifically serotonin, may be present in patients with borderline personality disorder. On neuropsychological testing, a meta-analysis published in 2005 showed that patient with borderline personality disorder had lower performance on neurocognitive testing in the following domains: attention, cognitive flexibility, learning and memory, planning, speed processing, and visuospatial abilities.

Epidemiology

Large, nation-wide, epidemiologic studies published in 2007 and 2008, estimated the point prevalence of borderline personality disorder in the general population at 1.6% with a lifetime prevalence of 5.9%. No significant difference in rates of borderline personality disorder was found between females and males in the general population. In the clinical setting, however, the ratio of female to male has been reported as 3:1. These studies challenged previous reports that borderline personality disorder was more prevalent in women. The prevalence of borderline personality disorder in the psychiatric, outpatient population has been estimated at 11% and in the psychiatric, inpatient population as high as 20%. Multiple studies examining the relationship between ethnicity and borderline personality disorder have not produced similar results.

Pathophysiology

The pathophysiology of borderline personality disorder is likely a combination of genetic predisposition combined with early childhood environmental factors and neurobiological dysfunction. A greater understanding of the neurobiology and specifically neurotransmitter dysfunction may lead to improved therapeutic options for treating borderline personality disorder. A recent study published in 2015 examined the role of oxytocin in the regulation of social reward and empathy networks as a contributing cause of borderline personality disorder and other personality disorders. Specifically, serotonin dysregulation reduced the sensitivity of the 5HT-1A receptor may contribute to borderline personality disorder. Increased rates of learning disorders, attention-deficit/hyperactivity disorder, and neurocognitive deficits, as well as abnormal electroencephalographic findings, have also been reported in patients with borderline personality disorder.

History and Physical

A careful history and physical exam should be performed before performing a comprehensive psychiatric assessment. There are structured diagnostic screening tools used to assess for personality disorders and specifically borderline personality disorder, for example, as the Zanarini Rating Scale for Borderline Personality Disorder.

The DSM-5 diagnostic criteria for borderline personality disorder

A pervasive pattern of instability of interpersonal relationships, self-image, and affects as well as marked impulsivity beginning by early adulthood and present in a variety of contexts as indicated by 5 or more of the following:

  1. Frantic efforts to avoid real or imagined abandonment. Note: Do not include suicidal or self-mutilating behavior covered in criterion 5.
  2. A pattern of unstable and intense interpersonal relationships characterized by alternating between extremes of idealization and devaluation
  3. Identity disturbance: Markedly and persistently unstable self-image or sense of self
  4. Impulsivity in at least 2 areas that are potentially self-damaging, for example, spending, sex, substance abuse, reckless driving, binge eating. Note: Do not include suicidal or self-mutilating behavior covered in criterion 5.
  5. Affective instability due to a marked reactivity of mood, for example, intense episodic dysphoria, irritability, or anxiety usually lasting a few hours and only rarely more than a few days
  6. Chronic feelings of emptiness
  7. Inappropriate, intense anger or difficulty controlling anger, for example, frequent displays of temper, constant anger, recurrent physical fights
  8. Transient, stress-related paranoid ideation or severe dissociative symptoms

Evaluation

Several diagnostic instruments are available to aid in diagnosis. These include the McClean Screening Instrument for Borderline Personality Disorder, Personality Diagnostic Questionnaire, Structured Clinical Interview for DSM-5 Personality Disorders, the Minnesota Borderline Personality Disorder Scale, and the Personality Assessment Inventory-Borderline Features Scale. Diagnostic tools may be separated into the general categories of the self-report and structured interview.

Patients with borderline personality disorder have been shown to have high rates of co-morbid disorders:

  • Mood disorders 80% to 96%
  • Anxiety disorders 88%
  • Substance abuse disorders 64%
  • Eating disorders 53%
  • Attention deficit hyperactivity disorder (ADHD) 30%
  • Bipolar disorder 15%
  • Somatoform disorders 10%

Treatment / Management

Treatment of borderline personality disorder relies on psychotherapy. Three evidence-based therapies are effective for patients with borderline personality disorder. First, mentalizing-based therapy (MBT) helps patients manage emotion dysregulation by feeling understood, allowing them to be more curious and make fewer assumptions about the intentions of the people around them. A second therapy, dialectical behavior therapy (DBT) combines mindfulness practices with concrete interpersonal and emotion regulation skills. Third, transference-focused psychotherapy (TFP) focuses on using the patient-therapist relationship to develop the patient's awareness of problematic interpersonal dynamics. MBT and DBT each incorporate individual and group treatment over 12 to 18 months. For adolescents, family therapy may be an appropriate substitute for group therapy, though not always.

No medications are FDA-approved for the treatment of borderline personality disorder. Medications such as SSRIs, mood stabilizers, and antipsychotics have shown limited effectiveness in trials aiming at control of symptoms such as anxiety, sleep disturbance, depression, or psychotic symptoms. Anxiety can be challenging to treat because patients may label their internal experiences with the word anxiety even when they are not truly based on fear. Thus, "anxiety" may need to be accurately re-labeled, with treatment recommendations stemming from the patient's specific internal experience. The exception to the misleading use of the word anxiety is that patients with borderline personality disorder often have a fear of being alone, in other words, they have attachment-related anxiety. However, attachment-related anxiety is not necessarily similar in etiology or treatment to recognized anxiety disorders.

Self-injurious behavior, boundary issues, and frequent suicidal threats present therapeutic challenges specific to the treatment of patients with borderline personality disorder. High rates of co-morbid substance abuse may also confound treatment of borderline personality disorder patients. Patients with borderline personality disorder do not typically require hospitalization; however, inpatient care may be required in certain situations such as:

  • Imminent risk of high lethality behaviors due to overt suicidal ideation or impulsivity
  • Severe social stressors causing intense negative thoughts or transient psychosis
  • The rapid escalation in the severity of self-injurious behavior
  • Decompensation of co-morbid psychiatric diagnoses or severe substance abuse

The traditional belief that prolonged (longer than 1 week) inpatient hospitalization is counterproductive or even deleterious for patients with borderline personality disorder was not supported in a recent study. The data showed equal improvement among inpatients with and without borderline personality disorder over several weeks of hospitalization.

Given high co-morbidity with ADHD, all patients with borderline personality disorder should be screened for this condition. When dealing with adolescents, parents and teachers should be asked to fill out a standardized questionnaire (Conners, SNAP, Vanderbilt). For adults, no standard of care is established for self-report or observer-report of inattentive or hyperactive symptoms. A combination of 2 self-reports to guide clinical decision-making, the ADHD Symptom Rating Scale (World Health Organization) and the Wender-Utah ADHD Rating Scale (WURS-25) provide more than 80% sensitivity and specificity.

Differential Diagnosis

When considering a diagnosis of borderline personality disorder, the differential diagnosis should always include other personality disorders, since overlap is common, especially within cluster B. Other diagnostic considerations include:

  • Substance use disorder
  • Non-suicidal self-injury disorder (a time-limited phenomenon in many patients)
  • Bipolar disorder (5-times less prevalent, but co-morbidity approaches 15%)
  • Autism spectrum disorder (patients with congenital deficits in theory of mind may also show severe mood dysregulation)

Prognosis

There is a hopeful prognosis for patients with borderline personality disorder. A longitudinal study of 290 inpatients diagnosed with borderline personality disorder and reassessed at 2-year intervals over 16 years yielded the following rates of remission:

  • 35% remission after 2 years
  • 91% remission after 10 years
  • 99% remission after 16 years

Unfortunately, the authors of this study noted that remission was associated with an impoverished social landscape, leading them to suggest that patients may appear to remit because they avoid interpersonal relationships, rather than gradually developing better interpersonal skills. Once achieved, remission was nonetheless sustained for over eight years in 75% of patients. Several factors were associated with the faster onset of remission including lack of co-morbid, axis-1 disorders, no history of childhood sexual abuse, no history of family substance abuse, high baseline functioning (demonstrated at school or in the workplace), and age less than 25 years. Sustained remission from borderline personality disorder has been demonstrated in several other studies as well.


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Personality Disorder, Borderline - Questions

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Which is FALSE about borderline personality disorder?



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Assessment of a patient with borderline personality disorder should focus less on which of the following?



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A 17-year-old female with borderline personality disorder is in an inpatient psychiatric unit secondary to a recent heroin overdose. Upon a routine physical exam, she is found to have superficial skin scratches on her forearm bilaterally. What is the appropriate management?



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Which of the following is considered a personality disorder that is most likely to include erratic, emotional behaviors?



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A patient with borderline personality disorder tells the provider that she or he is the only person he can trust but the next day he says the provider lied to him. Which of the following would be the best response?



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A patient with borderline personality disorder makes a sexual comment about you during group. What is the best strategy?



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A patient has a steady job but has unstable relationships, episodes of rage, and frequent, daily mood shifts but no other overt psychopathology. What is the most likely diagnosis?



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A 16-year-old female comes to the office for an intake. She reports fluctuating mood that has been lower than usual for the last few months, along with hopelessness and passive suicidal ideation. She has an increased appetite and disrupted sleep. She tells you of breaking up and getting back together with her boyfriend several times in the last few months, each break-up was initiated by her boyfriend in response to her frequent text messages when he is out of contact. During periods of being broken up, the patient has at times used alcohol or marijuana to feel less despair. She tells you that when her relationship with her boyfriend was stable, she felt numb rather than happy. In addition, her mother describes noticing horizontal cuts on her daughter's arms and changes in mood lasting for 20 to 30 minutes. What two diagnoses should be most strongly considered?



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Personality Disorder, Borderline - References

References

The DSM-5: Classification and criteria changes., Regier DA,Kuhl EA,Kupfer DJ,, World psychiatry : official journal of the World Psychiatric Association (WPA), 2013 Jun     [PubMed]
Gunderson JG,Stout RL,McGlashan TH,Shea MT,Morey LC,Grilo CM,Zanarini MC,Yen S,Markowitz JC,Sanislow C,Ansell E,Pinto A,Skodol AE, Ten-year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders study. Archives of general psychiatry. 2011 Aug;     [PubMed]
Foxhall M,Hamilton-Giachritsis C,Button K, The link between rejection sensitivity and borderline personality disorder: A systematic review and meta-analysis. The British journal of clinical psychology. 2019 Mar 21;     [PubMed]
Ellison WD,Rosenstein LK,Morgan TA,Zimmerman M, Community and Clinical Epidemiology of Borderline Personality Disorder. The Psychiatric clinics of North America. 2018 Dec;     [PubMed]
Grant JE,Mooney ME,Kushner MG, Prevalence, correlates, and comorbidity of DSM-IV obsessive-compulsive personality disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of psychiatric research. 2012 Apr;     [PubMed]

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