Carbon Dioxide Embolism


Article Author:
Vwaire Orhurhu
Catherine Gao


Article Editor:
Cindy Ku


Editors In Chief:
Heather Murphy-Lavoie
Jeffrey Cooper
Stephen Hendriksen


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Frank Smeeks
Kristina Soman-Faulkner
Trevor Nezwek
Radia Jamil
Patrick Le
Sobhan Daneshfar
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Pritesh Sheth
Hassam Zulfiqar
Navid Mahabadi
Steve Bhimji
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Nazia Sadiq
Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
3/31/2019 1:41:05 PM

Introduction

Laparoscopic surgery has gained increasing popularity in clinical practice. As part of laparoscopic surgeries, gas insufflation is usually adopted to increase operative space and visualization for surgeons. The abdomen is the most common location for these laparoscopic interventions, particularly in areas such as general and gynecologic surgeries. Carbon dioxide (CO2) is the most commonly used gas for insufflation during laparoscopic surgery because it is colorless, inexpensive, nonflammable, and has higher blood solubility than air, which reduces the risk of complications if venous embolism occurs.[1]

The use of CO2 gas for insufflation presents some risk. Among the most common complications associated with CO2 insufflation is CO2 embolism.  Although CO2 microembolism commonly occurs during laparoscopy, clinically significant emboli are rare and potentially fatal. The clinical sign of CO2 embolism depends on the volume of embolized gas and ranges from asymptomatic to cardiovascular collapse or even death. This article reviews the epidemiology, pathophysiology, clinical presentation, treatment, and prevention of CO2 embolisms.  

Etiology

CO2 embolism may occur during insufflation of the abdomen for laparoscopic surgeries. This usually occurs due to the accidental placement of the Veress needle into an organ or large vessel.[2] The insertion of the Veress needle and subsequent CO2 insufflation after negative aspiration are both techniques performed without visual guidance.  Later onset embolism may be associated with injured vessels that allow CO2 to enter the circulation.[3]

Epidemiology

The incidence of CO2 embolism is very rare. A recent meta-analysis reported an occurrence of 7 in 489335 laparoscopic surgeries (0.001%).[4]  However, when transesophageal echocardiography (TEE) was used during laparoscopic surgery to monitor for CO2 embolism, the incidence of any grade of gas embolism during laparoscopic surgeries varied widely. The incidence of CO2 embolism varied between 6.25% and 100%.[5][6] Despite these variations in incidence, clinically significant CO2 embolism remains fatal with mortality as high as 28%.[7]

Pathophysiology

Two possible mechanisms can explain the pathophysiology of CO2 embolism:

1) CO2 embolism can occur from accidental intravascular injection of CO2, which may arise from the inappropriate placement of the Veress needle within the intravascular space.  A similar mechanism is possible with trocar insertion.

2) CO2 embolism can also result from gas entering injured vessels, abdominal wall, or operative sites. This proposed mechanism results in less profound clinical change and may explain late onset CO2 embolism.

The volume of gas entrained affects clinical presentation. In a study on cardiopulmonary responses to experimental venous CO2 embolism in pigs, researchers found a mortality of 60% at a continuous intravenous CO2 infusion rate of 1.2 mL/kg/min.[8] When converted for a 60 kg person, this equates to a rate of 72 mL/min and represents approximately 5% of the volume of CO2 that could be infused into a vein by a Veress needle in one minute at a low-flow rate.[8]

Gas in the venous circulation may obstruct pulmonary circulation and subsequently cause cardiac symptoms including cardiovascular collapse and neurological sequelae.[2] It is associated with hypotension, increased central venous pressure (CVP), increased pulmonary arterial pressure (PAP), and hypoxemia.[9] In patients with patent foramen ovale, paradoxical arterial embolism may be possible and can result in transient or permanent neurological deficits.

History and Physical

CO2 embolism may be small, asymptomatic, transient and self-resolving. Signs of gas embolism include systemic hypotension, tachypnea, dyspnea, cyanosis, tachycardia or bradycardia, arrhythmia, asystole, or “mill-wheel” splashing auscultatory murmur.[6] Paradoxical embolism may be associated with altered mental status, focal neurological deficits, or loss of consciousness.

Evaluation

Transesophageal (TEE) is the most sensitive method for detecting subclinical intravenous CO2 as small as 0.1mL/kg.[10] The TEE transgastric view has been shown to optimally identify CO2 embolism.[11][12][13]

The transesophageal Doppler is a highly sensitive but less expensive alternative to TEEs.[13] The precordial Doppler may also be used but has a high false negative rate associated with the positioning of the probe.[6] Standard intraoperative noninvasive monitors can aid in detecting CO2 embolism, albeit with less sensitivity. Five-lead ECG may show right ventricular strain as indicated by widened QRS complex, right bundle branch block, right axis deviation. Sudden decrease or loss of end-tidal CO2 suggests a drastic decrease in cardiac output due to gas embolism. Continuous pulmonary arterial pressure can be used to evaluate for gas embolism.[6]

Treatment / Management

Management of a suspected CO2 embolism begins with desufflation of the abdomen.[14] Surgeons should be informed immediately and stop insufflation when there is clinical suspicion for CO2 embolism. Note that hemorrhage is possible when the intraabdominal pressure is reduced since the embolism may have been due to a vascular injury. The Durant or Trendelenburg position is used to direct the gas bubble into the right ventricle apex and away from the pulmonary artery.[2][15]

Ventilation with 100% oxygen could be used to wash out CO2, reduce ventilation-perfusion mismatch, and improve hypoxemia.[16] Hyperventilation is also used to help eliminate CO2. While the placement of multi-orifice central venous catheter may be a consideration in surgeries with high-risk of air embolism (e.g., specific neurosurgical cases) to perform aspiration, placement of a central venous catheter in an unanticipated case of CO2 embolism would be more beneficial for potential vasopressor administration, although aspiration could be attempted.[2]

Also, hyperbaric oxygen may be used to reduce bubble size in patients experiencing neurologic deficits. Supportive treatment with fluid, vasopressors, and cardiopulmonary bypass may be necessary for patients with severe cardiovascular collapse.[6]

Differential Diagnosis

  • Air embolism
  • Pulmonary embolism
  • Pneumothorax
  • Bronchospasm
  • Pulmonary edema
  • Hypovolemia
  • Cardiogenic shock
  • Myocardial infarction
  • Septic shock
  • Electromechanical dissociation
  • Cerebral hypoperfusion
  • Stroke
  • Other embolisms (e.g., amniotic fluid, fat)

Prognosis

Prognosis varies depending on the size of the embolism and severity of clinical presentation.

Complications

  • Cardiac arrest
  • Neurological sequelae (e.g. motor deficits, cognitive deficits, seizures)
  • Death

Deterrence and Patient Education

Prevention of CO2 embolism targets potential methods of gas entry into circulation during laparoscopic surgery. Correct positioning of the Veress needle should be verified with a negative aspiration of blood before insufflation with low flow rate and low-pressure setting, or alternative modes of entry and pneumoperitoneum creation should be utilized.[14] Low insufflation pressure during laparoscopic surgery may diminish the pathophysiological changes. After proper placement of the trocars, patients should be placed in Trendelenburg position.[2] Positive end-expiratory pressure (PEEP) of 5 cm H2O may be used intraoperatively to decrease atelectasis caused by pneumoperitoneum.[17]

Enhancing Healthcare Team Outcomes

Minimally invasive laparoscopic procedures have increased in popularity and in many cases have superseded traditionally open surgical procedures. Patients should be assessed via pre-operative medical evaluation to determine cardiopulmonary risks and anticipate possible complications.14  (Level V) Additionally, it is important to foster a “speak up” culture where all members of the care team feel comfortable communicating potential concerns related to patient safety.[18] (Level V)

An alternative to using the Veress needle technique is to apply the Hasson technique for establishing pneumoperitoneum.[4] In a systematic review, gas embolism was 0.001% (7/489000 cases) with the Veress needle while no embolisms were reported in 12444 cases using the Hasson technique.[4] (Level I)

Further, reducing the insufflation pressure can reduce the risk of CO2 embolism. In a randomized trial of 498 patients undergoing endoscopic saphenous vein harvesting, the incidence of CO2 embolisms was significantly higher in the high insufflation pressure group (15 mg Hg CO2) compared to that of the low insufflation group (12 mg Hg CO2).[11] (Level II)

The healthcare team, including clinicians and nurses, must work together to prevent CO2 embolism by preventing gas entry into circulation during laparoscopic surgery. Correct positioning of the Veress needle should be verified with a negative aspiration of blood before insufflation with low flow rate and low-pressure setting, or alternative modes of entry and pneumoperitoneum creation should be utilized.


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Carbon Dioxide Embolism - Questions

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A 34-year-old female with bowel perforation and sepsis was immediately taken to the operating room for emergent laparotomy. After anesthesia induction, a right internal jugular triple lumen catheter was inserted and connected to an inappropriately primed rapid fluid infuser. Three minutes after the use of the rapid fluid infuser at a rate of 10 milliliters per minute to treat severe hypotension, the patient’s vitals show a blood pressure of 62/35 mmHg, heart rate 123 beats/min, CVP 22 mm H2O and SaO2 84%. Which of the following is the most sensitive test to diagnose the patient's current complication?



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Carbon Dioxide Embolism - References

References

Naude GP,Bongard FS, Helium insufflation in laparoscopic surgery. Endoscopic surgery and allied technologies. 1995 Aug;     [PubMed]
Gutt CN,Oniu T,Mehrabi A,Schemmer P,Kashfi A,Kraus T,B�chler MW, Circulatory and respiratory complications of carbon dioxide insufflation. Digestive surgery. 2004;     [PubMed]
McDonald NJ,Lavelle P,Gallacher WN,Harpin RP, Use of the oxygen cost of breathing as an index of weaning ability from mechanical ventilation. Intensive care medicine. 1988;     [PubMed]
Bonjer HJ,Hazebroek EJ,Kazemier G,Giuffrida MC,Meijer WS,Lange JF, Open versus closed establishment of pneumoperitoneum in laparoscopic surgery. The British journal of surgery. 1997 May;     [PubMed]
Fahy BG,Hasnain JU,Flowers JL,Plotkin JS,Odonkor P,Ferguson MK, Transesophageal echocardiographic detection of gas embolism and cardiac valvular dysfunction during laparoscopic nephrectomy. Anesthesia and analgesia. 1999 Mar;     [PubMed]
Kim CS,Kim JY,Kwon JY,Choi SH,Na S,An J,Kim KJ, Venous air embolism during total laparoscopic hysterectomy: comparison to total abdominal hysterectomy. Anesthesiology. 2009 Jul;     [PubMed]
Cottin V,Delafosse B,Viale JP, Gas embolism during laparoscopy: a report of seven cases in patients with previous abdominal surgical history. Surgical endoscopy. 1996 Feb;     [PubMed]
Mayer KL,Ho HS,Mathiesen KA,Wolfe BM, Cardiopulmonary responses to experimental venous carbon dioxide embolism. Surgical endoscopy. 1998 Aug;     [PubMed]
Yau P,Watson DI,Lafullarde T,Jamieson GG, Experimental study of effect of embolism of different laparoscopy insufflation gases. Journal of laparoendoscopic     [PubMed]
Couture P,Boudreault D,Derouin M,Allard M,Lepage Y,Girard D,Blaise G, Venous carbon dioxide embolism in pigs: an evaluation of end-tidal carbon dioxide, transesophageal echocardiography, pulmonary artery pressure, and precordial auscultation as monitoring modalities. Anesthesia and analgesia. 1994 Nov;     [PubMed]
Chiu KM,Lin TY,Wang MJ,Chu SH, Reduction of carbon dioxide embolism for endoscopic saphenous vein harvesting. The Annals of thoracic surgery. 2006 May;     [PubMed]
Lin TY,Chiu KM,Wang MJ,Chu SH, Carbon dioxide embolism during endoscopic saphenous vein harvesting in coronary artery bypass surgery. The Journal of thoracic and cardiovascular surgery. 2003 Dec;     [PubMed]
Mann C,Boccara G,Fabre JM,Grevy V,Colson P, The detection of carbon dioxide embolism during laparoscopy in pigs: a comparison of transesophageal Doppler and end-tidal carbon dioxide monitoring. Acta anaesthesiologica Scandinavica. 1997 Feb;     [PubMed]
Daugherty A,Woodward B, Carbachol and dibutyryl cyclic GMP on the vulnerability to ventricular fibrillation in rat isolated hearts. British journal of pharmacology. 1985 Jul;     [PubMed]
Fong J,Gadalla F,Druzin M, Venous emboli occurring caesarean section: the effect of patient position. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1991 Mar;     [PubMed]
Nichols SL,Tompkins BM,Henderson PA, Probable carbon dioxide embolism during laparoscopy; case report. Wisconsin medical journal. 1981 Mar;     [PubMed]
Kim JY,Shin CS,Kim HS,Jung WS,Kwak HJ, Positive end-expiratory pressure in pressure-controlled ventilation improves ventilatory and oxygenation parameters during laparoscopic cholecystectomy. Surgical endoscopy. 2010 May;     [PubMed]
Schwappach D,Sendlhofer G, Speaking Up about Patient Safety in Perioperative Care: Differences between Academic and Nonacademic Hospitals in Austria and Switzerland. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2019 Jan 15;     [PubMed]

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