Mixed Urinary Incontinence


Article Author:
Shauna Harris


Article Editor:
John Riggs


Editors In Chief:
Stephen Leslie
Karim Hamawy


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Steve Bhimji
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Nazia Sadiq
Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
1/16/2019 10:03:44 AM

Introduction

Urinary incontinence is the involuntary leakage of urine causing symptoms of wide-ranging severity and affecting patients' quality of life. Symptoms may force significant lifestyle changes including changes in physical and psychosocial well-being. Due to embarrassment, many women with urinary incontinence fail to report symptoms unless the symptoms are severe. There are many behavioral, medical, and surgical techniques available to improve lifestyle due to incontinence.[1][2]

Etiology

There are 3 major types of urinary incontinence:

  • Stress urinary incontinence
  • Urgency urinary incontinence
  • Mixed urinary incontinence[1]

There are also a variety of subtypes including genitourinary (fistula, infectious, congenital) and non-genitourinary (functional, environmental, pharmacological, metabolic). Classification is endorsed by the International Urogynecological Association (IUGA)/International Incontinence Society (ICS).

Stress incontinence is the involuntary loss of urine with increased intraabdominal pressure or physical exertion (coughing, sneezing, jumping, lifting, exercise). The pathophysiology is due to pelvic floor weakness/prolapse and/or loss of the normal urethra vesical angle.

Urge incontinence is the involuntary loss of urine preceded by a sudden and severe desire to pass urine. Bladder contractions may be stimulated by a change in body position (from supine to upright) or with sensory stimulation (running water, hand washing, cold weather). The pathophysiology is uninhibited bladder contractions caused by irritation or loss of neurologic control of bladder contractions.

Mixed urinary incontinence is a combination of stress and urge incontinence. This type may take on the pathophysiology of both.[3]

Epidemiology

Urinary incontinence affects nearly 40% of all adult American women. More than 25% of teenage and college-aged female athletes experience incontinence with more than 90% withholding incontinence information to their primary care providers. In nursing homes, approximately 6% of admissions are due to urinary incontinence. The cost to treat urinary incontinence either medically or surgically is well over $10 billion per year. Urinary incontinence, particularly mixed type, is an issue across all age groups.[4]

Pathophysiology

The pathophysiology of stress incontinence is due to pelvic floor weakness or prolapse and/or loss of the normal urethra vesical angle. The pathophysiology of urge incontinence is uninhibited bladder contractions caused by irritation or loss of neurologic control of bladder contractions.

History and Physical

A thorough history needs to be obtained to help diagnose urinary incontinence. The clinician should ask for this information directly since the patient may be too embarrassed to talk about symptoms of increased frequency, urgency, or dysuria. Signs may include hesitancy, slow stream, straining to void, incomplete emptying, or wetting pads or clothes. Details about the nature of incontinence are invaluable. These can include duration, precipitating events, voiding frequency, and fluid intake. Many validating questionnaires can assess symptomatic effects on daily living. Comorbidities and confounding factors should also be explored. Medications that affect urinary incontinence should be reviewed, particularly cholinergic drugs and diuretics. Lack of estrogen during perimenopause or postmenopause should also be discussed. Bladder diaries may be used by both patient and physician for objective means of quantifying incontinence.[5]

The focus on the physical exam on patients with mixed incontinence should focus on abdominal and pelvic areas. A large panniculus, prior surgical incisions, and suprapubic muscle tone should be noted. The patient should be examined with both a full and empty bladder in standing and supine positions. The grade of uterine, vaginal prolapse should be assessed along with obvious stress urinary incontinence with coughing.[1]

Evaluation

Simple office incontinence testing should be utilized to help differentiate the 3 types of urinary incontinence. A positive cough stress test in both the sitting and supine positions is highly diagnostic for stress incontinence. Vaginal prolapse may mask or decrease incontinence symptoms; therefore, it is important to elevate the areas of prolapse surrounding the urethra and check for incontinence with stress (Marshall Test). A Q-tip test is performed with a cotton-tipped swab to check for urethral mobility. A displacement of the urethral angle of at least 30 degrees with Valsalva is suggestive of urethral hypermobility. A urinalysis and culture should be sent for any infectious process such as cystitis. A post-void residual urine volume is measured to check for overflow incontinence. Indications for multi-channel urodynamics include:

  • Abnormal office cystometry tests
  • Continuous, unpredictable leakage
  • Pelvic radiation
  • History of radical pelvic surgery
  • Previous incontinence surgery[6]

Treatment / Management

The primary care provider including the general obstetrics and gynecology physician can treat most cases of urinary incontinence with behavioral techniques or pharmacologic agents. However, referral to a urogynecologist and or urologist may be necessary particularly when surgical intervention is necessary with mixed incontinence. Indications for referral may include:

  • Uncertain diagnosis
  • Unsuccessful medical therapy
  • Patients with “heavy” stress urinary incontinence (multiple pads per day)
  • Symptomatic pelvic organ prolapse
  • Voiding dysfunction (elevated post-void residual)
  • Underlying neurologic condition
  • Prior failed surgery
  • Hematuria without infection
  • Recurrent urinary tract infections
  • Surgical intervention considered when a patient is not satisfied even when the urge component of mixed incontinence cured[7]

The treatment of mixed urinary incontinence should always begin with the least invasive management to see if symptoms are tolerable or minimized by the patient. Behavioral methods include:

  • Dietary changes (no coffee, tea, soda, chocolates, or methylxanthines)
  • Bladder retraining (timed voiding)
  • Kegel exercises
  • Biofeedback
  • Electrostimulation
  • Collagen injections
  • Pessaries (multiple types and sizes  to fit the patient properly so the pessary does not fall out or cause difficulty with voiding)[8]

Pharmacologic agents may help improve voiding dysfunction with urge incontinence. Medications include:

  • Oxybutynin
  • Ca channel blockers
  • Tricyclic antidepressants
  • Alpha-adrenergics
  • Estrogen[9]

When mixed urinary incontinence includes significant prolapse with stress urinary incontinence and pelvic pressure symptoms, surgical treatment provides the best overall cure. The current goals of surgery include:

  • Restore and/or reinforce the pubourethral ligaments at the mid-urethra level
  • Restore and/or reinforce the suburethral vaginal hammock at the mid-urethra
  • Reinforce the paraurethral connective tissue

Surgical treatment includes both abdominal and vaginal procedures with similar cure rates:

  • Abdominal: Marshall Marchetti Krantz (MMK), Burch, paravaginal repair, laparoscopic procedures
  • Vaginal: Modified Pereyra procedure (MPP), Stamey, RAZ, sling procedures (TVT) (TVT-O)[10]

Always attempt conservative treatment first with behavioral techniques or medications even if surgery is planned for mixed incontinence. The patient may be satisfied with improved incontinence if it avoids any surgical procedure, particularly if the patient is high risk.

Prognosis

If the stress urinary incontinence cure is desired (no leakage), proper informed consent for surgical treatment should be discussed and explained to the patient. Counseling regarding surgical success rates. Abdominally or vaginally the rates are approximately 86% for a cure, 7% improvement rate, and 7% failure rate.[10]

A clinical cure, meaning no further incontinence, means the patient does not need postoperative urodynamic testing. Clinical improvement (occasional intermittent incontinence) or failed procedures require urodynamic testing to differentiate stress versus urge or any other subtypes. Behavioral or medical therapy may be necessary in refractory cases with the possibility of another reoperation as a last resort.

Complications

The risk of surgical treatment pertinent to stress urinary incontinence should also be documented and explained to the patient. Risks include:

  • Infection
  • Bleeding with transfusion
  • Injury to the genitourinary or gastrointestinal tract
  • Postop dyspareunia[10]
  • Persistent or recurrent urinary incontinence or prolapse

Postoperative and Rehabilitation Care

Postoperative patients may require prolonged catheterization either with an urethral or suprapubic catheter. Postvoid residual urine should be at most be less than 100 mL. Any voiding dysfunction after catheter removal usually resolves spontaneously within a few days or weeks. Coital activity should be avoided at least 6 weeks postop to avoid disruption of the surgical site till healing is complete. The patient should be told no heavy lifting greater than 25 lbs to avoid increasing intraabdominal pressure that may give rise to recurrent prolapse and incontinence.

Deterrence and Patient Education

Education involving the patient and public in general, as well as the health care providers is necessary to provide the best patient outcomes according to evidence-based medicine. These resources should include:

  1. UpToDate Patient Education: Urinary Incontinence in Women (Beyond the Basics)
  2. The American College of Obstetrics and Gynecology website
  3. Educational handouts that may be obtained online from the International Urogynecological Association regarding urinary incontinence

Enhancing Healthcare Team Outcomes

Urinary incontinence is a salient issue in any primary care physician practice. It is imperative that a thorough history and workup be done to establish a differential diagnosis that is accurate before discussing treatment strategies. The physician should inform the patient all treatment options available before deciding on further management. Not all treatment is intended to cure the patient of all symptoms completely. Even if the incontinence is reduced in severity to a level where the patient is satisfied with the quality of life, this should still be considered a success. A clear understanding of patient expectations is paramount during collaboration. All possible reasons for failing to meet expectations should also be explained to the patient. It is the ethical responsibility of the physician to offer the least invasive treatment (behavioral modification or medications) options before proceeding to surgical plans. An interprofessional approach with excellent communication is essential when urogynecologists, urologists, or other health care providers become involved in management to improve outcomes. (Level III)


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Mixed Urinary Incontinence - Questions

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A patient has mixed urinary incontinence. The pelvic floor has been strengthened but the patient continues to get the urge to urinate every 30 minutes. What is the next step in therapy?



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Mixed Urinary Incontinence - References

References

ACOG Practice Bulletin No. 155: Urinary Incontinence in Women. Obstetrics and gynecology. 2015 Nov     [PubMed]
Brown HW,Guan W,Schmuhl NB,Smith PD,Whitehead WE,Rogers RG, If We Don't Ask, They Won't Tell: Screening for Urinary and Fecal Incontinence by Primary Care Providers. Journal of the American Board of Family Medicine : JABFM. 2018 Sep-Oct     [PubMed]
Irwin DE,Milsom I,Chancellor MB,Kopp Z,Guan Z, Dynamic progression of overactive bladder and urinary incontinence symptoms: a systematic review. European urology. 2010 Oct     [PubMed]
Carls C, The prevalence of stress urinary incontinence in high school and college-age female athletes in the midwest: implications for education and prevention. Urologic nursing. 2007 Feb     [PubMed]
Committee Opinion No. 603: Evaluation of uncomplicated stress urinary incontinence in women before surgical treatment. Obstetrics and gynecology. 2014 Jun     [PubMed]
Rosier PF,Gajewski JB,Sand PK,Szab� L,Capewell A,Hosker GL, Executive summary: The International Consultation on Incontinence 2008--Committee on:     [PubMed]
Lovatsis D,Easton W,Wilkie D, No. 248-Guidelines for the Evaluation and Treatment of Recurrent Urinary Incontinence Following Pelvic Floor Surgery. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC. 2017 Sep     [PubMed]
Subak LL,Quesenberry CP,Posner SF,Cattolica E,Soghikian K, The effect of behavioral therapy on urinary incontinence: a randomized controlled trial. Obstetrics and gynecology. 2002 Jul     [PubMed]
Shamliyan T,Wyman JF,Ramakrishnan R,Sainfort F,Kane RL, Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review. Annals of internal medicine. 2012 Jun 19     [PubMed]
Riggs JA, Retropubic cystourethropexy: a review of two operative procedures with long-term follow-up. Obstetrics and gynecology. 1986 Jul     [PubMed]

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