Hyponatremia


Article Author:
Helbert Rondon


Article Editor:
Madhu Badireddy


Editors In Chief:
Dustin Constant
Donald Kushner


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
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Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
12/13/2018 1:57:46 PM

Introduction

Hyponatremia is defined as a serum sodium concentration of less than 135 mEq/L but can vary to a small extent in different laboratories. Hyponatremia is a common electrolyte abnormality caused by an excess of total body water when compared to total body sodium content. Edelman discovered that serum sodium concentration does not depend on total body sodium but on the ratio of total body solutes (e.g., total body sodium and total body potassium) to total body water. Hyponatremia represents an imbalance in this ratio where total body water is more than total body solutes. Total body water (TBW) has two main compartments, extracellular fluid (ECF) accounting for one-third and intracellular fluid (ICF) accounting for the remaining two-thirds. Sodium is the major solute of ECF and potassium for ICF. 

Etiology

Etiology of hyponatremia can be classified based on volume status, the extracellular fluid. As mentioned earlier sodium is the major solute of extracellular fluid (ECF). Based on volume of ECF, a patient can be hypovolemic, euvolemic or hypervolemic.

Physiologic stimuli that cause vasopressin release combined with fluid intake can cause hyponatremia. Hypothyroidism and adrenal insufficiency may contribute to an increased release of vasopressin. Physiologic stimuli for vasopressin release include loss of intravascular volume (hypovolemic hyponatremia) and the loss of effective intravascular volume (hypervolemic hyponatremia).

Causes of Hypovolemic Hyponatremia (TBW decreases more than a decrease in total body sodium)[0]

  • Gastrointestinal fluid loss (diarrhea or vomiting)
  • Third spacing of fluids (pancreatitis, hypoalbuminemia, small bowel obstruction)
  • Diuretics
  • Osmotic diuresis (glucose, mannitol)
  • Salt-wasting nephropathies
  • Cerebral salt-wasting syndrome (urinary salt wasting, possibly caused by increased brain natriuretic peptide)
  • Mineralocorticoid deficiency

Causes of Hypervolemic Hyponatremia (TBW increases greater than an increase in total body sodium)[0]

  • Renal causes (Acute renal failure, chronic renal failure, Nephrotic syndrome)
  • Extrarenal causes (Congestive heart failure, Cirrhosis)
  • Iatrogenic

Causes of Euvolemic Hyponatremia (TBW increase with stable total body sodium)

Nonosmotic, pathologic vasopressin release may occur in the setting of normal volume status, as with euvolemic hyponatremia.

Causes of euvolemic hyponatremia include:

  • Drugs as mentioned below.
  • Syndrome of inappropriate antidiuretic hormone (SIADH)
  • Addison's disease
  • Hypothyroidism
  • High fluid intake in conditions like primary polydipsia; or potomania (caused by a low intake of solutes with relatively high fluid intake)
  • Medical testing related to excessive fluids such as a colonoscopy or cardiac catheterization
  • Iatrogenic

Many drugs cause hyponatremia and the most common include:

  • Vasopressin analogs such as desmopressin and oxytocin
  • Medications that stimulate vasopressin release or potentiate the effects of vasopressin such as selective serotonin-reuptake inhibitors and other antidepressants morphine and other opioids
  • Medications that impair urinary dilution such as thiazide diuretics
  • Medications that cause hyponatremia such as carbamazepine or its analogs, vincristine, nicotine, antipsychotics, chlorpropamide, cyclophosphamide, nonsteroidal anti-inflammatory drugs
  • Illicit drugs such as methylenedioxymethamphetamine (MDMA or ecstasy).

Epidemiology

Hyponatremia is the most common electrolyte disorder with a prevalence of 20% to 35% in hospitalized patients. Incidence of hyponatremia is more in critically ill patients in ICU and also postoperative patients. This is more common in elderly patients due to multiple comorbidities, multiple medications and lack of access to food and drinks. 

Pathophysiology

Thirst stimulation, ADH secretion and handling of filtered sodium by Kidneys maintains serum sodium and osmolality. Normal plasma osmolality is around 275-290 mosm/kg. To maintain normal osmolality, water intake should be equal to water excretion. Imbalance of water intake and excretion causes hyponatremia or hypernatremia. Water intake is regulated by thirst mechanism where osmoreceptors in the hypothalamus trigger thirst when body osmolality reaches 295 mosm/kg. Water excretion is tightly regulated by antidiuretic hormone (ADH), synthesized in the hypothalamus and stored in the posterior pituitary gland. Changes in tonicity leads to either enhancement or suppression of ADH secretion. Increased ADH secretion causes reabsorption of water in the kidney and suppression causes the opposite effect. Baroreceptors in carotid sinus can also stimulate ADH secretion but it is less sensitive than the osmoreceptors. Baroreceptors trigger ADH secretion due to decreased due to effective circulating volume, nausea, pain, stress and drugs. [0]

Hypertonic hyponatremia (Serum osmolality of greater than 290 mOsm/kg)

  • Hyperglycemia
  • Mannitol

Isotonic hyponatremia (Serum osmolality between 275 and 290 mOsm/kg)

  • Pseudo-hyponatremia: a laboratory artifact. Usually caused by hypertriglyceridemia, cholestasis (lipoprotein X), and hyperproteinemia (monoclonal gammopathy, IVIG). Two-thirds of clinical labs in use still use indirect ion-selective electrode technology and therefore this problem is still present.
  • Nonconductive irrigant solutions: these solutions contain mannitol, glycine or sorbitol, and are used in urological and gynecological procedures such as TURP.

Hypotonic hyponatremia (Serum osmolality of less than 275 mOsm/kg)

Hypotonic hyponatremia represents an excess of free water. This excess free water can be caused by two mechanisms:

  • Increased free water intake: Patient drinks a large volume of free water (greater than 18L/day or greater than 750 mL/h) that overwhelms kidney capacity to excrete free water. Examples of this are psychogenic polydipsia, marathon runners, water drinking competitions, and ecstasy.
  • Decreased free water excretion: Patients drink a normal volume of free water, but the kidneys cannot excrete the water for some reason.

There are three mechanisms involved in the inability of kidneys to excrete water:

1. High ADH activity: High ADH can be caused by three different mechanisms:

  • Decreased effective arterial blood volume (EABV): antidiuretic hormone (ADH) is released when there is a reduction of 15% or more of the EABV. This occurs with hypovolemia (e.g., vomiting, diarrhea), decreased cardiac output (e.g. heart failure), or vasodilation (e.g., cirrhosis).
  • SIADH: ADH is secreted autonomously. Four general causes of this are brain disorders, lung disorders, drugs (e.g., SSRI), and miscellanea (e.g., nausea and pain).
  • Cortisol deficiency: Cortisol exerts an inhibitory effect on ADH release. When cortisol is decreased, ADH is released in large amounts. Adrenal insufficiency is the cause of this mechanism.

2. Low glomerular filtration rate (GFR): a low glomerular filtration rate would impair kidney's ability to get rid of water. Typical examples are Acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD).

3. Low solute intake: Patients on a regular diet consume 600 to 900 mOsm of solute per day. Solutes are defined as substances that are freely filtered by the glomeruli but have a relative or absolute difficulty in being reabsorbed by the tubules in relationship to water. The main solutes are urea (which comes from the metabolism of proteins) and electrolytes (e.g., salt). Carbohydrates do not contribute to solute load. In steady-state conditions, solute intake is equal to urine solute load. Therefore, it is expected that these patients also excrete 600 to 900 mOsm of solute in the urine. Urine volume, and hence water excretion, is dependent on the urine solute load. The more solute one needs to excrete, the larger the urine volume one needs to produce. The less solute one needs to excrete, the smaller the urine volume one needs to produce. Patients who eat a low amount of solute per day (e.g., 200 mOsm/day), on steady-state conditions, will also excrete a low amount of solute in the urine and therefore they will do it in a smaller volume of urine. This decreased urine volume will limit the capacity of the kidneys to excrete water. Typical examples of this are beer potomania and tea-and-toast diet.

SIADH (Syndrome of inappropriate antidiuretic hormone secretion). [4]

This is a condition where inappropriate secretion of ADH despite normal or increases plasma volume causes impaired water excretion by kidney leading to hyponatremia. SIADH is a diagnosis of exclusion as there is no single test to confirm the diagnosis. Patients are hyponatremic and euvolemic.

Causes of SIADH include

  • Any CNS disorder,
  • Ectopic production of ADH (most common small cell carcinoma of lung),
  • Drugs (Carbamazepine, Oxcarbazepine, chlropropamide and multiple other drugs),
  • HIV,
  • Pulmonary diseases (pneumonia, TB),
  • Postoperative patients (pain medicated)

Treatment include fluid restriction and use of Vasopressin 2 receptor inhibitors.

History and Physical

Symptoms depends upon degree and chronicity of hyponatremia. Patients with mild-to-moderate hyponatremia (>120 mEq/L) or gradual decrease in sodium (>48 hours) have minimal symptoms. Patients with severe hyponatremia (<120 mEq/L) or rapid decrease in sodium levels have multiple symptoms.

Symptoms can range from anorexia, nausea and vomiting, fatigue, headache and muscle cramps to altered mental status, agitation, seizures and even coma.

Apart from symptoms, a detailed history taking to include history of pulmonary and CNS disorders, all home medications and social history (increased beer intake or use of MDM or ecstasy) is very important.

Important physical examination includes assessing volume status and neurological status. 

Patients with neurological symptoms and signs needs to be treated promptly to prevent permanent neurological damage.

Evaluation

Step 1: Plasma osmolality (275-290 msom/kg)

  • Can help differentiate among hypertonic, isotonic, and hypotonic hyponatremia.
  • True hyponatremic patients are hypotonic.
  • If hypotonic then go to step 2.

Step 2: Urine osmolality

  • Urine osmolality less than 100 mOsm/kg indicates primary polydipsia or reset osmostat.
  • Urine osmolality greater than 100 mOsm/kg usually indicates a high ADH state, go to step 3.

Step 3: Volume status (ECF status)

  • Hypovolemic vs euvolemic vs hypervolemic.
  • If hypovolemic then go to step 4.

Step 4: Urine Sodium concentration

  • Urine sodium less than 10 mmol/L indicates extrarenal loss of urine (remote diuretic use and remote vomiting).
  • Urine sodium greater than 20 mmol/L suggests renal loss of urine (diuretics, vomiting, cortisol deficiency and salt wasting nephropathies).

Other tests that might help in differentiating the causes include

  • Serum TSH
  • Serum ACTH
  • Serum Urea
  • Liver function tests
  • Chest X-ray or CT chest
  • CT head

Treatment / Management

Treatment of hyponatremia depends upon degree of hyponatremia, duration of hyponatremia, severity of symptoms and volume status.

Acute symptomatic hyponatremia:

  • Severely symptomatic hyponatremia: Sodium chloride 3% 100 mL intravenous (IV) bolus (repeat up to twice if symptoms persist).
  • Mild to Moderately symptomatic hyponatremia: Sodium chloride 3% slow infusion (use sodium deficit formula to calculate the rate of infusion but recalculate rate with frequent sodium monitoring).

Chronic asymptomatic hyponatremia [0]

  • Hypovolemic hyponatremia: Isotonic fluids administration and holding of any diuretics.
  • Hypervolemic hyponatremia: Treat underlying condition, restrict salt and fluids and administer loop diuretics.
  • Euvolemic hyponatremia: Fluid restriction to <1 li per day.

Drugs: Selective Vasopressin 2 receptor antagonists are being used recently. They increase excretion of water in the kidneys without effecting sodium there by increase serum sodium levels. These medications are used in patients with euvolemic and hypervolemic conditions (except liver failure) if above measure do not help. 

The goal of correction: Correct sodium by no more than 10-12 mEq/L in any 24 hour period.

Risk factors for osmotic demyelination syndrome (ODS): Hypokalemia, liver disease, malnutrition, alcoholism.

Limits of correction:

  • High-risk for ODS: less than 8 mEq/L in any 24 hour period
  • Average-risk for ODS: less than 10 mEq/L in any 24 hour period

Differential Diagnosis

True hyponatremia is associated with hypoosmolality. Conditions causing hyperosmolar hyponatremia and iso-osmolar hyponatremia (pseudo-hyponatremia) should be differentiated first.

  • Hyperglycemia
  • mannitol
  • hyperlipidemia and
  • hyperproteinemia

Differential diagnosis for hypo-osmolar hyponatremia include:

  • Gastroenteritis
  • Diuretic use
  • CHF
  • Liver failure
  • Psychogenic polydipsia
  • Renal causes
  • SIADH
  • Adrenal crisis
  • Hypothyroidism

Prognosis

Prognosis in patients with hyponatremia depends on severity of hyponatremia and underlying condition causing it. Prognosis is poor in patients with severe hyponatremia, acute hyponatremia and elderly patients. 

Complications

If left untreated or inadequately treated patients with hyponatremia can develop rhabdomyolysis, altered mental status, seizures and even coma.

Rapid correction of chronic hyponatremia (>10-12 mEq/L of sodium in 24 hrs) can lead to Osmotic demyelination syndrome.

Osmotic demyelination syndrome, formerly known as central pontine myelinolysis is a complication of rapid correction sodium in patients with chronic hyponatremia. In patients with hyponatremia, brain adapts to fall in serum sodium level (without developing cerebral edema) in about 48 hours. As a result, patients with chronic hyponatremia are mostly asymptomatic. Once brain adapts to low serum sodium, rapid correction of sodium leads to osmotic demyelination syndrome. Clinical manifestations are typically delayed by few days and comprises several irreversible neurological symptoms including seizures, disorientation, and even coma. "Locked-in" syndrome occurs in severely affected patients. These patients are awake but unable to move or communicate. 

Consultations

It is very important to consult a Nephrologist in a patient with severe hyponatremia or rapid decrease in sodium or persistent hyponatremia. 

Cardiology and Gastroenterology consultation might be necessary in patients with CHF and hepatic failure, respectively.

 

 

Deterrence and Patient Education

Patients with hyponatremia should be followed by closely at discharge by both Primary care physician and Nephrology. Follow up labs ordered as needed and patients needing fluid restriction should be educated appropriately. 

Pearls and Other Issues

  • Hyponatremia is a common electrolyte abnormality.
  • Hyponatremia can range from an asymptomatic condition to a life-threatening condition. 
  • Hyponatremia can occur with hypovolemic or hypervolemic or euvolemic states.
  • Common causes include diuretics, vomiting, diarrhea, CHF, renal and liver disease.
  • Degree and duration of hyponatremia along with severity of symptoms determine how fast to correct sodium.
  • Do not correct more than 10-12 mEq/L in 24 hours except in patients with severe symptoms and rapidly decreased sodium levels.
  • Too rapidly correcting sodium levels can lead to Osmotic demyelinating syndrome.

Enhancing Healthcare Team Outcomes

Hyponatremia is a common electrolyte abnormality. Sodium levels needs to be closely monitored as this could be a life-threatening condition if left untreated. This is even more important in patients with renal disease and those who are on diuretics. Good interprofessional communication between primary care physician and nephrologist is needed to keep a close eye on sodium and correct/treat as needed. 


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Hyponatremia - Questions

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What treatment is appropriate for an asymptomatic patient with a sodium level of 112 after head trauma?



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A 65-year-old undergoes surgery, and his fluid is adequately replaced. He makes urine at 25 cc/hr. Postoperatively he receives D5 dextrose with 0.45 percent NS at 150 cc/hr. What is the most likely metabolic abnormality in this patient 24 hours after surgery?



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In a patient with hyponatremia, when do gross neurological symptoms occur?



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What laboratory study is not required in the assessment of hyponatremia?



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Which of the following factors is most important when treating hyponatremia?



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Which of the following problems is associated with rapid correction of hyponatremia?



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At what level of serum sodium is one likely to develop seizures?



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A woman status post colectomy is on IV antiemetics and D5 and half normal saline. On post-operative day two she becomes obtunded and is found to have the following labs: Na 114 mEq/L, K 3.5 mEq/L, Cl 88 mEq/L, HCO3 22 mEq/L, BUN 4 mg/dL, creatinine 1.3 mg/dL. What is the next best step?



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Which is NOT a symptom of hyponatremia?



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Which of the following is the treatment of choice for severe hyponatremia?



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A 6-month-old female has had vomiting and diarrhea for 4 days and has been given just water. She has a seizure and her sodium is 117 mEq/L and glucose is 75 mg/dL. What should be done first?



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A 62-year-old female diabetic presents for colonoscopy but is confused. She is taken to the emergency room where she is noted to have a nonfocal neurologic exam, normal cardiopulmonary exam, but dry mucous membranes. Laboratories show sodium is 123 meq/L and serum osmolality of 272 mmol/kg. Select the most probable cause of her condition.



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Three days after a colon resection, a 45-year-old male has a serum sodium level of 120 mEq/L. Which of the following is the most appropriate management plan for this patient?



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Which of the following is the most common electrolyte disorder seen in hospitals in the USA?



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Which symptoms are not consistent with hyponatremia?



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Who is least likely to have true hyponatremia?



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Who is least likely to have hypervolemic hyponatremia?



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Which is not true regarding acute hyponatremia?



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Which laboratory interpretation in the setting of hyponatremia is correct?



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Which of the following is least important when considering treatment for hyponatremia?



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Which is type of hyponatremia is not correctly described?



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A 4-month-old previously healthy child is brought in after jerking movements of the legs and arms 30 minutes before presenting to the emergency room. The triage nurse reports the infant had another episode in the waiting room. The child is sleepy. No additional seizures are noted. Anterior fontanelle is flat, vital signs are normal, and the patient is afebrile. Serum sodium is 116-mEq/L. Select appropriate management.



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A 4-month-old previously healthy child is brought in after jerking movements of the legs and arms 30 minutes before presenting to the emergency room. The child has been cared for by his grandmother for the past 6 days and fed nothing but formula. The triage nurse reports the infant had another episode in the waiting room. The child is sleepy. Anterior fontanelle is flat, vital signs are normal, and the patient is afebrile. Serum sodium is 116 mEq/L. Which of the following would be most helpful history?



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A 4-month-old previously healthy child is brought in after jerking movements of the legs and arms 30 minutes before presenting to the emergency room. The child has been cared for by his grandmother for the past 6 days and fed nothing but formula. The triage nurse reports the infant had another episode in the waiting room. The child is sleepy. Anterior fontanelle is flat, vital signs are normal, and the patient is afebrile. Serum sodium is 116 mEq/L. Seizures are controlled with infusion of 3 percent saline. What is the next step in management?



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A 4-month-old presents with generalized seizures and is found to have euvolemic hyponatremia. The differential includes water intoxication and SIADH. Select the true statement about urine electrolytes.



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A 4-month-old is brought to the emergency room with seizures and found to have serum sodium of 116 mEq/L. Three percent saline is used to stop the seizures. How long should it take to correct the serum sodium to a safe level?



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A 4-month-old is found to have severe hyponatremia. Which complication could result from too rapid correction?



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Which of the following patients are at greatest risk for too rapid correction of hyponatremia?



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Which of the following is not a cause of hyponatremia in children?



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Which tests would best assist in the diagnosis of hyponatremia in a child?



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Which of the following is true about the use of hypotonic fluids in hospitalized infants?



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What is the usual initial sign of hyponatremia?



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A 17-year-old college student presents to the emergency department with severe diarrhea for 2 days. He tried to keep himself hydrated by drinking sports drinks at home. His vitals include a supine blood pressure of 100/60 mmHg with a heart rate of 94 beats/min and a standing blood pressure of 70/40 mmHg with a heart rate of 130 beats/min. His jugular veins are flat, lungs clear to auscultation, and there is no peripheral edema. Laboratory results are sodium 129 mEq/L, potassium 3.1 mEq/L, TCO2 18 mmol/L, urine osmolality 413 mOsm/kg, urine sodium 23 mEq/L, and urine potassium 13 mEq/L. What is the most likely cause of hyponatremia in this patient?



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67 year-old homeless man with a PMH of alcohol dependence was admitted for right leg cellulitis. He drinks a 6-pack of beer every day and barely eats solid food. On exam: BP=120/60, HR=73, RR=12. He appears very malnourished. No JVD. Lungs are clear to auscultation. Right leg is erythematous, edematous, and tender to palpation. No edema on left leg. Neurologic exam is completely normal. Laboratory data: Na=108 mEq/L, UOsm=65 mOsm/kg. What is the most appropriate therapeutic intervention at this point?



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A patient with chronic hyponatremia has a serum sodium of 110 mEq/L and is given 2 L of 0.9 normal saline at 100 mL/hr. Which of the following sets of urine electrolytes will predict a higher rise in serum sodium?



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A 62-year old male presents 2 days after a left knee replacement surgery with a sodium of 120. What is the most likely explanation for this finding?



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A 56-year old is admitted with a sodium of 115 mEq/dL. Within hours of admission, he starts to experience seizures. What is the best course of treatment?



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What is the common early presentation of hyponatremia in the post-anesthesia care unit (PACU)?



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A 2-month-old male previously healthy who was born term, spontaneous vaginal delivery without complications presents to the emergency department (ED) for lethargy and a shaking episode. This is the mother's first child and she is a single parent who is currently unemployed. She states that for the past day, the patient has been sleeping a lot more than usual and this morning when she went to wake the patient, she noticed that he had a generalized tonic-clonic episode that lasted four minutes. The mother called emergency medical services who gave the child intranasal midazolam but by the time the patient arrived the ED, he resumed another generalized tonic-clonic episode. Mom states that he has been afebrile, he got his two-month vaccines about a week ago, she denies any trauma and denies any possibility that he has gotten into anything. The mother is not on any medications and the baby is formula fed taking 2 to 3 ounces every 3 hours. He has been having more than four wet diapers a day and stooling well. What is the diagnosis?



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A 65-year-old female with history of metastatic small cell lung cancer comes to the emergency room because of multiple episodes of seizures, confusion, and marked swelling on face and extremities. The sodium level is below 110 mEq/L. What type of fluid should be administered to this patient at this time?



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Hyponatremia - References

References

Martin J,Burnier M,Lu H, [Approach to the syndrome of inappropriate antidiuretic hormone secretion (SIADH)]. Revue medicale suisse. 2018 Nov 21     [PubMed]

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