Ventricular Fibrillation


Article Author:
Dipesh Ludhwani
Amandeep Goyal


Article Editor:
Mandar Jagtap


Editors In Chief:
Donald Kushner
Annabelle Dookie


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Kyle Blair
Trevor Nezwek
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Navid Mahabadi
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Abbey Smiley
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Daniyal Ameen
Altif Muneeb
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes
Komal Shaheen
Sandeep Sekhon


Updated:
7/12/2019 12:54:15 PM

Introduction

Arrhythmias originating from the ventricular myocardium or His-Purkinje system are grouped under ventricular arrhythmia (VA). This includes a subset of arrhythmias such as ventricular tachycardia (VT), ventricular fibrillation (VF), premature ventricular contractions (PVC), and ventricular flutter. Wide complex tachycardia (WCT) is used to define all tachyarrhythmia with QRS complex duration greater than 0.12 seconds. VF is a WCT caused by irregular electrical activity and characterized by a ventricular rate of usually greater than 300 with discrete QRS complexes on the electrocardiogram (ECG). QRS morphology in VF varies in shape, amplitude, and duration with a prominent irregular rhythm.[1] VF is an extremely dangerous rhythm significantly compromising cardiac output and ultimately leading to sudden cardiac death (SCD).

Etiology

VF is often linked to underlying structural heart disease. Three percent to 12% of cases of myocardial infarction (MI) develop VF during the acute phase.[2] MI patients with complete coronary occlusion on an angiogram, anterior wall infarction, atrial fibrillation, and pre-infarction angina are more prone to develop VF.[3] Many common conditions associated with VF include electrolyte abnormalities (hypokalemia/hyperkalemia, hypomagnesemia), acidosis, hypothermia, hypoxia, cardiomyopathies, family history of sudden cardiac death, congenital QT abnormalities, Brugada syndrome, and alcohol use. Patients with a history of VA especially sustained monomorphic or polymorphic VT may transition to VF in susceptible patients.[4] Genetic predisposition to VF is now increasingly recognized. The first genome-wide association was reported in the AGNES study identifying susceptibility locus for VF at 21q21.[5]

Epidemiology

In 2017 the American Heart Association (AHA) update estimated the total annual burden of Out of Hospital Cardiac Arrest (OHCA) at 356,500.  At least 23% of OHCA treated by Emergency Medical Service (EMS) have VF/VT as the initial rhythm. With more than 60% of cardiovascular deaths resulting from cardiac arrest, it remains the leading cause of death worldwide.[6] Modern advances in assistive devices such as implantable cardioverter-defibrillator (ICD) have had a significant impact on these numbers. Many studies have identified VF as the most common underlying arrhythmia in patients with SCD. Among patients hospitalized with acute MI, 5% to 10% have VF or VT, and another 5% will have VF or VT within 48 hours of admission.[7] The true incidence of VF is underestimated, as individuals who suffer OHCA are not covered in most of these studies. Based on Resuscitation Outcomes Consortium (ROC) data, survival to hospital discharge for VF patients was 31.4%.

Pathophysiology

VF occurs when parts of ventricular myocardium depolarize erratically in an uncoordinated manner. VF results from the following:

Abnormal Impulse Formation

  • Increased automaticity: Purkinje cells around ischemic areas during MI can initiate ventricular tachycardia.
  • Triggered activity: Early and late after depolarization can overcome refractory threshold and generate triggered potential causing extrasystoles.

Impulse Conduction

  • Functional and anatomical reentry circuits help sustain ventricular arrhythmia.

History and Physical

The most common presentation for VF is sudden collapse from cardiac arrest leading to SCD. This results from improper ventricular contraction resulting in low cardiac output. Patients may demonstrate signs of acute MI such as chest pain, shortness of breath, nausea, and vomiting before the event. Patients with a known history of coronary artery disease or congestive heart failure may show a worsening of chronic symptoms such as angina, dyspnea, orthopnea, paroxysmal nocturnal dyspnea, and pedal edema. At the time of presentation, patients are unconscious, unresponsive, and have no palpable pulse. Without prompt action, this leads to death within the next few minutes. Patients with ICD for primary or secondary prevention can experience shock from ICD firing at the time of experiencing VF.

Evaluation

Acute presentation of symptoms and ECG findings lead to the diagnosis.

ECG Findings

  • Fibrillation waves of varying amplitude and shape.
  • No identifiable P waves, QRS complexes, or T waves
  • Heart rate anywhere between 150 to 500 per minute

VF storm: Identified by 3 or more episodes of VF or appropriate shocks from ICD within 24 hours

Patients surviving VF should have a thorough history and physical examination. A family history of unexplained cardiac death should be noted. Physicians should review c the patient's cardiac history and the medication list for arrhythmogenic drugs closely. They should also look for and correct reversible causes of VF such as electrolyte abnormalities, acidosis, and hypoxia. The healthcare professional should also evaluate patients for underlying ischemic heart disease with an echocardiogram and emergency angiogram. Of all OHCA, more than 50% have significant coronary artery disease on angiogram.[8]

Treatment / Management

Acute Management

Due to the high mortality rate and extreme acuity of the condition, VF patients warrant immediate attention. Healthcare professionals should immediately initiate guideline-directed management as per Advanced Cardiac Life Support (ACLS) protocol. There is a lower likelihood of survival if the healthcare professional deviates from the ACLS guidelines.[9] All patients with cardiac arrest should have an initial assessment while receiving quality CPR. Pulseless VT and VF are both shockable rhythm, and once the staff identifies the rhythm as VF, patients should be shocked immediately with 120 to 200 joules on a biphasic defibrillator or 360 joules using a monophasic. Patients receiving prompt defibrillation have shown improved survival (39.3%) compared to patients in whom defibrillation was delayed by 2 minutes or more (22.2%).[10] Administer epinephrine and amiodarone as per ACLS protocol in patients sustaining VF rhythm regardless of receiving 3 shocks. Amiodarone significantly improves survival to hospital admission without affecting survival to hospital discharge.[11] Identifying and addressing the cause of inciting event is equally important. Professionals should undertake cause-specific measures such as securing the airway, correcting electrolytes, administrating fluids, decompressing pneumothorax, draining tamponade while resuscitating the patient. Once the patient attains return of spontaneous circulation (ROSC), physicians should begin a definitive evaluation for coronary artery disease.

Preventative Management

Primary prevention has been a significant factor in reducing VF-related SCDs. Most VF transition from VT and other VA and hence identifying such arrhythmias at an early stage can help prevent VF. In patients with symptoms suspected to be related to VA, detection using ambulatory electrocardiography and implanted cardiac monitors is recommended. [7]. Healthcare professionals should offer family members of patients with inherited arrhythmia syndromes genetic testing and counseling for risk stratification.

Medication Therapy

Amiodarone is the most commonly studied antiarrhythmic for prevention of SCD. The overall effect of amiodarone on survival is controversial. Most studies have failed to show any added benefit when compared to placebo or ICD.[12] Sotalol, on the other hand, is associated with an increased risk of mortality by decreasing the defibrillation threshold. A meta-analysis published in 2007 showed a significant reduction in risk of SCD with statin treatment.[13] Lower SCD incidence has been reported in patients on chronic beta-blocker therapy for heart failure with reduced ejection fraction.

Defibrillators

Randomized control trials such as MADIT-I (Multicenter Automated Defibrillator Implantation Trial), MADIT-II, SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) have clearly demonstrated mortality benefits with ICD when compared to standard medical therapy. Trials comparing ICD with antiarrhythmic therapy such as AVID (Antiarrhythmic Versus Implantable Defibrillator) have shown similar results.

ICD placement is recommended for primary prevention of SCD in patients at increased risk of life-threatening VF/VT. ICD placement is also indicated for secondary prevention of SCD in patients with prior episodes of VF and sustained VT.

Differential Diagnosis

It is important to differentiate VF from pulseless electrical activity (PEA)/asystole as both these conditions are managed differently as per ACLS protocol. Other causes of sudden collapse such as aortic dissection and pulmonary embolism should be considered. The following conditions can be easily confused with VF on an ECG and should be ruled out.

  • Polymorphic ventricular tachycardia
  • Torsade de pointes
  • Ventricular flutter
  • Pulseless electrical activity
  • Accelerated idioventricular rhythm
  • SVT with aberrancy

Staging

Types of VF on ECG

  • Coarse VF: Majority of the waveforms measure 3 mm or greater
  • Fine VF: Majority of the waveforms measure less than 3 mm

Prognosis

Prognosis of VF depends on the time from onset to early intervention and defibrillation. Shorter delays are associated survival rates as high as 50%.[14] In patients with ST-elevation MI, early VF (fewer than 24 hours) is associated with increased mortality compared to late VF (longer than 24 hours).[15]

Complications

  • Anoxic brain injury
  • Post defibrillation arrhythmias
  • Injuries from CPR and resuscitation
  • Skin burns
  • Long terms disabilities
  • Myocardial injury
  • Death

Consultations

Consultations should include cardiology, electrophysiology, and interventional cardiology.

Enhancing Healthcare Team Outcomes

Cardiac arrest is a near-death experience impacting not only the patient but family members too. A variety of health care professionals should be involved from the onset of arrest up to hospital discharge. Studies have continuously demonstrated the importance of Interprofessional communication and teamwork while resuscitating patients. Successful resuscitation is an outcome of good communication and understanding your responsibilities. (LOE-1) Physicians, nurses, pharmacists, laboratory technicians all come together and commit to the success of the team.

Post-resuscitation care brings further contributions from consultants such as a cardiologist, electrophysiologists, and neurologists.

Unfortunately, mortality associated with VF/SCA remains high. Involving family in every step of management is pivotal as it helps in providing a holistic picture. Seeking help from chapel when deciding about goals of care can help the family make difficult decisions.

Patient outcomes can be improved by spreading awareness about the condition and by identifying patients at risk. The outcome of cardiac arrest and subsequently VF depends on time from the arrest to first intervention. Educating the general population about the basics of resuscitation can help avoid delay in treatment and improve patient outcomes especially in OHCA. Identifying and establishing roles amongst various team members can improve outcomes among In-hospital cardiac arrest (IHCA). Mock drills to assess for preparedness can help enhance the quality of resuscitation efforts.


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Ventricular Fibrillation - Questions

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What is the initial biphasic defibrillator dose for ventricular fibrillation in adults?



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Which is not a part of the treatment for a surgical patient who develops ventricular fibrillation in the operating room?



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What is the initial treatment for a patient with ventricular fibrillation?



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What is the initial therapy for a patient with known ventricular fibrillation?



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Which of the following is not used for refractory ventricular fibrillation?

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Which of the following is the most common arrhythmia in patients with cardiac arrest?



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What is the most successful treatment modality for ventricular fibrillation?



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Ventricular fibrillation is treated the same as which rhythm?



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Which of the following heart rhythms would need immediate defibrillation?

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What is the best management option in a patient status-post ventricular fibrillation?



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You are caring for a child with a congenital heart defect, and the ventricular fibrillation alarm starts to sound throughout the unit. The child is resting in the caregiver's lap with a strong brachial pulse palpable. What should you do immediately?



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Which is true regarding ventricular fibrillation?



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The most serious of cardiac dysrhythmias is characterized by irregular, uncoordinated, ineffective, and rapid twitching movements of which of the following?



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A client in the intensive care unit develops ventricular fibrillation. What possible complications may occur in clients with ventricular fibrillation? Select all that apply.



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A patient presents to the emergency department with chest pain. Suddenly at triage, he collapses and develops ventricular fibrillation. Which of the following noncardiac causes can result in this arrhythmia? Select all that apply.



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On the cardiology floor, an elderly client who had open-heart surgery develops the rhythm shown in the image on postoperative day 5. The primary nurse who is in the room performing an assessment and who is not Advanced Cardiac Life Support (ACLS) certified should do which of the following to manage care for this client as immediate priority actions? Select all that apply.

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During cardiopulmonary resuscitation, a nurse notes on the monitor the cardiac rhythm shown in the image. Which medications listed can be useful during the resuscitation? Select all that apply.

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Which other arrhythmia is managed similarly to ventricular fibrillation (VF)?



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A 56-year-old female with past medical history of ischemic cardiomyopathy collapses suddenly at the supermarket. Luckily a paramedic notices this and initiates CPR. Primary rhythm as noted on the monitor is shown in the image. Which is the best next step?

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Which of the following finding is seen on an EKG in ventricular fibrillation?



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Ventricular Fibrillation - References

References

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Bardy GH,Lee KL,Mark DB,Poole JE,Packer DL,Boineau R,Domanski M,Troutman C,Anderson J,Johnson G,McNulty SE,Clapp-Channing N,Davidson-Ray LD,Fraulo ES,Fishbein DP,Luceri RM,Ip JH, Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. The New England journal of medicine. 2005 Jan 20     [PubMed]
Levantesi G,Scarano M,Marfisi R,Borrelli G,Rutjes AW,Silletta MG,Tognoni G,Marchioli R, Meta-analysis of effect of statin treatment on risk of sudden death. The American journal of cardiology. 2007 Dec 1     [PubMed]
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