Uremia


Article Author:
Michael Zemaitis
Lisa Foris
Shruti Chandra


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Phillip Hynes
Tehmina Warsi


Updated:
7/5/2019 9:38:50 PM

Introduction

Uremia, a clinical condition associated with worsening renal function, is characterized by fluid, electrolyte, and hormone imbalances in addition to metabolic abnormalities. The literal meaning of uremia is “urine in the blood,” and the condition develops most commonly in the setting of chronic and end-stage renal disease (ESRD), but may also occur as a result of acute kidney injury.

Putative uremic toxins include parathyroid hormone, macroglobulin, advanced glycosylation end products, and beta2 microglobulin, though no specific uremic toxin has been identified as responsible for all clinical manifestations of uremia.[1][2][3]

Etiology

Kidney disease can result from some conditions ranging from primary renal disorders, for example IgA nephropathy, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, polycystic kidney disease) to systemic disorders that can lead to renal damage. Systematic disorders can include diabetes mellitus, lupus, multiple myeloma, amyloidosis, Goodpasture disease, Thrombotic thrombocytopenic purpura, or hemolytic uremic syndrome.

The leading cause of ESRD in the United States is diabetes. Additional causes, listed in order of decreasing incidence, include hypertension, glomerulonephritis, interstitial disease, cystitis, and neoplasms.

Uremia may also result from acute kidney injury if the injury involves a sudden increase in urea or creatinine.[4][5][6]

Epidemiology

It is difficult to determine the exact prevalence of uremia in the United States because patients with ESRD typically begin dialysis before the development of uremic symptoms. Uremic symptoms typically arise once creatinine clearance is less than 10mL/min or 15mL/min in the case of diabetic patients.

There are approximately 354 out of a million individuals diagnosed with the end-stage renal disease each year. This number continues to rise as the life expectancy of those with ESRD is increasing. Improved survival in patients with diabetes or cardiovascular disease, in addition to increased access to renal therapy, has resulted in the highest increase in the incidence of ESRD in patients aged 75 years or above. On the other hand, the number of individuals under the age of 60 with ESRD is declining, except for African American or Native American patients with diabetic ESRD.

The majority of patients with ESRD are Caucasian (59.8%), the remainder is African American (33.2%), Asian (3.6%) or Native American (1.6%). The incidence of ESRD among black individuals, however, is 3.7 times higher than it is among the white population. Similarly, the incidence among Native Americans is 1.8 times greater than it is among whites.

Additionally, minority populations tend to initiate dialysis care at a later point in the course of renal disease, usually once there is already a significant decline in glomerular filtration rate (GFR). It is unknown, however, whether racial or ethnic background has an effect on predisposition to the development of uremic symptoms.

Men are 1.2 times more likely than women to develop ESRD, though women are 1.7 times more likely to delay initiation of dialysis. Women are also more prone to development of uremic symptoms at lower creatinine levels, due to the decreased amount of muscle mass and baseline serum creatinine levels that they have.[7][8][9]

Pathophysiology

When the kidneys are not functioning properly, dysfunction can occur in acid-base homeostasis, fluid and electrolyte regulation, hormone production and secretion, and waste elimination. Altogether, these abnormalities can result in metabolic disturbances and ultimately conditions such as anemia, hypothyroidism, hypertension, acidemia, hyperkalemia, and malnutrition.

Anemia associated with kidney disease is typically normocytic, normochromic, and hyperproliferative. It occurs as a result of decreased erythropoietin production by the failing kidneys. This is associated with a glomerular filtration rate (GFR) of less than 50 mL/min (unless the patient has diabetes, then they may have anemia at GFR less than 60mL/min) or when serum creatinine is greater than 2 mg/mL.

Additional factors associated with chronic kidney disease alone may additionally contribute to the development of anemia. These include iron or vitamin deficiencies, hyperparathyroidism, hypothyroidism, or a decreased lifespan of red blood cells.

The buildup of uremic toxins in the blood may additionally contribute to the development of coagulopathy as a result of reduced platelet adhesion to the vascular endothelial wall, increased platelet turnover, and a slightly reduced absolute number of platelets. A common finding in patients with ESRD is bleeding diathesis which is the increased susceptibility to bleeding and hemorrhage.

Another major metabolic complication associated with uremia and ESRD is acidosis because renal tubular cells are the primary regulators of acid-base homeostasis in the body. As kidney failure progresses, there is decreased secretion of hydrogen ions and impaired excretion of ammonium, and eventually buildup of phosphate and additional organic acids (e.g., lactic acid, sulfuric acid, hippuric acid). In turn, the resulting increased anion-gap metabolic acidosis may lead to hyperventilation, lethargy, anorexia, muscle weakness, and congestive heart failure (due to a decreased cardiac response).

Hyperkalemia may also occur in the setting of both acute or chronic renal failure. This condition becomes a medical emergency when serum potassium reaches a level greater than 6.5 mEq/L. This level may be exacerbated with excessive potassium intake or use of certain medications (e.g., potassium-sparing diuretics, angiotensin-converting enzymes (ACE) inhibitors, angiotensin-receptor blockers, beta blockers, NSAIDs). Acidosis resulting from renal failure may additionally contribute to the development of hyperkalemia.  

Hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone levels may additionally occur as a result of renal failure. Hypocalcemia occurs due to decreased production of active vitamin D (1,25 dihydroxyvitamin D) which is responsible for gastrointestinal (GI) absorption of calcium and phosphorus and suppression of parathyroid hormone excretion. Hyperphosphatemia occurs because of impaired phosphate excretion in the setting of renal failure. Both hypocalcemia and hyperphosphatemia stimulate hypertrophy of the parathyroid gland and resultant increased production and secretion of parathyroid hormone. Altogether, these changes in calcium metabolism can result in osteodystrophy (renal bone disease) and may lead to calcium deposition throughout the body (i.e., metastatic calcification).

Declining renal function can result in decreased insulin clearance, necessitating a decrease in dosage of antihyperglycemic medications to avoid hypoglycemia. Uremia may also lead to impotence in men or infertility (e.g., anovulation, amenorrhea) in women as a result of dysfunctional reproductive hormone regulation.

The buildup of uremic toxins may also contribute to uremic pericarditis, and pericardial effusions leading to abnormalities in cardiac function. Together with metastatic calcification as a result of declining renal function, these may contribute to worsening of underlying valvular dysfunction or suppression of myocardial contractility.[10][11]

History and Physical

Symptomatic uremia tends to occur once creatinine clearance decreases below 10 mL/min unless kidney failure develops acutely, in which case, some patients may become symptomatic at higher clearance rates.

Patients presenting with uremia typically complain of nausea, vomiting, fatigue, anorexia, weight loss, muscle cramps, pruritus, or changes in mental status. The clinical presentation of uremia can be explained by the metabolic disturbances associated with the condition.

Fatigue as a result of anemia is considered one of the major components of the uremic syndrome. 

Patients with a history of diabetes may report improved glycemic control but are at a greater risk of developing hypoglycemic episodes as kidney function worsens.

Hypertension, atherosclerosis, valvular stenosis and insufficiency, chronic heart failure, and angina may all develop as a result of a buildup of uremic toxins and metastatic calcification associated with uremia and ESRD.

Occult GI bleeding as a result of platelet abnormalities may present with nausea or vomiting. Uremic fetor, ammonia or urine-like odor of the breath, may also occur in uremic patients.

Evaluation

A diagnosis of renal failure is based on abnormalities in GFR or creatinine clearance.[12]

It is important to determine whether a patient presenting with uremic symptoms is experiencing acute or chronic renal failure, as acute kidney injury is reversible. Laboratory studies to evaluate for abnormalities in hemoglobin, calcium, phosphate, parathyroid hormone, albumin, potassium, and bicarbonate in addition to urinalysis (with microscopic examination) will help point towards any potential abnormalities.

A 24-hour urine collection may provide insight to both GFR and creatinine clearance, though this method is both burdensome and often inaccurate. Alternatively, a nuclear medicine radioisotope (iothalamate) clearance assay may be used to measure GFR. However, this test is also time-consuming and expensive relative to the Cockcroft-Gault formula [creatinine clearance = Sex times ((140 - Age) / (serum creatinine)) times (weight / 72)] or the Modification of Diet in Renal Disease formula [(GFR (mL/min/1.73 m) = 175 x (S) times (Age) times (0.742 if female) or times (1.212 if African American)] that are often used instead.

As per the National Kidney Foundation, patients presenting with chronic kidney disease are staged based on the estimated GFR (creatinine clearance) as calculated by the Modification of Diet in Renal Disease formula.

  • Stage 1 – normal GFR (90 mL/min or greater)
  • Stage 2 – mildly reduced GFR (60 mL/min to 90 mL/min)
  • Stage 3 – moderately reduced GFR (30 mL/min to 59 mL/min)
  • Stage 4 – severely reduced GFR (15 mL/min to -29 mL/min)
  • Stage 5 – ESRD (GFR < 15 mL/min or patient is on dialysis)

A renal ultrasound may be useful to determine the size and shape of the kidneys, and to evaluate for hydronephrosis or ureteral and/or bladder obstruction. This may occur as a result of kidney stones, neurologic abnormalities, trauma, pregnancy, prostate enlargement, retroperitoneal fibrosis, abdominal tumors (secondary to cervical or prostate cancers) or additional structural abnormalities. Early diabetic nephropathy, multiple myeloma, polycystic kidney diseases, and glomerulonephritis associated with human immunodeficiency virus (HIV) are all associated with enlarged kidneys on ultrasound.  Smaller kidneys are indicative of more chronic, irreversible changes as a result of long-standing kidney disease, ischemic nephropathy, or hypertensive nephrosclerosis.

If a patient presents with significant alterations in mental status, a brain computed tomography (CT) scan may be warranted. Uremic patients with a blood urea nitrogen (BUN) level greater than 150 mg/dL to 200 mg/dL are also at an increased risk of developing spontaneous subdural hematomas. Given the increased risk of bleeding and hemorrhage in uremia (especially in the setting of a fall or trauma), a CT scan of both the brain and abdomen may additionally be considered. An abdominal CT scan might help further elucidate the underlying cause of hydronephrosis if it was found on ultrasound without any obvious etiology.

Finally, magnetic resonance imaging (MRI) may be considered to assess for renal artery stenosis or thrombosis, or aortic and renal artery dissection- all potentially reversible causes of renal failure.

A renal biopsy may be helpful in determining reversibility or treatability of the renal injury, and may ultimately be required to make an accurate diagnosis of acute kidney injury or chronic kidney disease. However, a biopsy should not be performed in the case of small kidneys because of the associated comorbidities and increased risk of bleeding. 

Treatment / Management

Dialysis is indicated in a patient with symptomatic uremia (e.g., nausea, vomiting, hyperkalemia, metabolic acidosis) that is not treatable my medical means, and should be initiated as soon as possible, regardless of the patient’s GFR.[13][14][15]

Patients presenting with a uremic emergency (e.g., hyperkalemia, acidosis, symptomatic pericardial effusion, or uremic encephalopathy) require emergent dialysis which should be initiated gently to avoid dialysis disequilibrium syndrome (neurologic symptoms secondary to cerebral edema occurring during or shortly after the initiation of dialysis).

Ultimately, the best renal replacement therapy is renal transplantation, although practitioners may also consider long-term hemodialysis and peritoneal dialysis. Renal transplantation is associated with improvements in both survival and quality of life, and should be considered early (before the need for dialysis) as the waiting list for transplantation is often longer than two to three years.

Iron replacement should be initiated in patients with anemia of chronic kidney disease and underlying iron deficiency (as long as serum ferritin is greater than 100 mcg/mL). This can be done with dialysis treatments, or as oral therapy, if dialysis has not yet been initiated. Erythropoietic stimulating agents, such as erythropoietin or darbepoetin, may additionally be used in low doses (due to the increased risk of cardiovascular mortality) once hemoglobin levels reach below 10 g/dL.

Hyperparathyroidism and associated or isolated hypocalcemia and hyperphosphatemia can be treated with oral calcium carbonate or calcium acetate, oral vitamin D therapy, and oral phosphate binders (e.g., calcium carbonate, calcium acetate, sevelamer or lanthanum carbonate).

A dietitian should be consulted if dietary alterations are being considered.  Patients with chronic kidney disease should reduce potassium, phosphate and sodium intake to 2 g to 3 g, 2 g, and 2 g per day of each, respectively. Though there is some conflicting evidence regarding protein intake in patients with kidney failure, the current low-protein diet recommendations before initiation of dialysis are 0.8 g to 1 g of protein/kg of weight per day with an added gram of protein for each gram of protein lost in the urine in patients with nephrotic syndrome.

A low-protein diet is not recommended in patients with advanced uremia or malnutrition, as this type of diet can result in worsening of malnutrition and has been associated with increased risk of mortality with the initiation of dialysis.

Patients with a creatinine clearance of less than 20 mL/min should avoid excessive potassium intake and use certain medications with caution (e.g., potassium-sparing diuretics, angiotensin-converting enzymes (ACE) inhibitors, angiotensin-receptor blockers, beta blockers, NSAIDs).

Due to the buildup of uremic toxins and potentially increased risk of bleeding and hemorrhage, extra care needs to be taken when prescribing oral anticoagulants or antiplatelet medications to patients who have ESRD.

Finally, nephrotoxic medications (e.g., NSAIDs, aminoglycoside antibiotics) should be avoided in all patients with renal disease.  To avoid nephrotoxicity, N-acetylcysteine may be administered before administration of intravenous contrast for radiologic imaging, although alternative modes of imaging like MRI should be considered in these patients, to avoid the risk of acute kidney injury altogether.[16]

Differential Diagnosis

  • Diabetic nephropathy
  • Acute glomerulonephritis
  • Chronic kidney disease
  • Hypertensive renal disease
  • Renal artery stenosis

Complications

  • Hyperpigmented skin
  • Severe itching
  • Pericarditis plus effusion
  • Pulmonary edema
  • Valvular calcification

Pearls and Other Issues

Uremic Encephalopathy occurs in patients with acute or chronic renal failure, once the estimated GFR (eGFR) declines and stays below 15 mL/min.  It is important to recognize the signs and symptoms early, as untreated uremic encephalopathy can progress to coma, while symptoms are easily reversible with dialysis. Early symptoms of uremic encephalopathy include nausea, anorexia, restlessness, drowsiness, and slowing of concentration and cognitive functions. As uremic encephalopathy progresses, patients typically become more disoriented, confused, and may exhibit bizarre behavior and emotional instability.  Eventually, severe uremic encephalopathy will result in stupor and coma. Physical examination may reveal altered mental status, signs of cranial nerve involvement (e.g., nystagmus), or papilledema. Patients may additionally display hyperreflexia, clonus or asterixis, and eventually, coma.

A patient with uremic encephalopathy should improve clinically, following initiation of dialysis. However, electroencephalographic (EEG) findings such as slowing or loss of alpha frequency waves, disorganized signals, slow background activity with intermittent bursts of theta and delta waves may not improve instantly. Improvement may take several months, and one may not ever return completely back to normal. Treating uremic encephalopathy involves addressing many of the same parameters as are addressed when treating any patient with ESRD for example, correcting associated anemia, regulation of calcium or phosphate imbalances, monitoring the adequacy of dialysis.

Enhancing Healthcare Team Outcomes

Once uremia has been diagnosed, patient education is vital. The healthcare provider, nephrologist, a transplant surgeon and the pharmacist should work in a multidisciplinary team to educate the patient on dialysis, renal transplant and the potential complications of these therapies. The pharmacist should ensure that the patient is on no medications that are nephrotoxic and ensure that the patient is on EPO for the anemia, calcitriol, iron and phosphate binders. The diabetic nurse should educate the patient about the importance of blood glucose control. The dietitian should educate the patient on a low protein diet. Finally, the nurse should always make sure that any patient with uremia going for an imaging study that requires contrast is adequately hydrated. If possible, another imaging modality that does not use contrast should be selected. [17][18][19] (Level V)

Outcomes

In general, the prognosis for patients with uremia is poor unless they are treated with renal replacement therapy such as transplantation or dialysis. When the cause of uremia is a reversible cause, the prognosis is better than in patients with an irreversible cause. Uremic patients require frequent admission to the hospitals and have high morbidity and mortality without treatment. While dialysis has improved treatment, vascular access is still a major problem in the long run. In addition, there are not enough kidney donors. Patients with uremia are also at a high risk for adverse cardiac events and stroke compared to the general population. Finally, the cost of care for a dialysis patient is prohibitively expensive costing the healthcare system billions of dollars each year.  [20][21](Level V)


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Uremia - Questions

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A 45-year-old male is seen in the emergency room. Blood work reveals a prothrombin time (PT) of 12 s, partial thromboplastin time (PTT) of 34 s, platelet count of 333,000 and a template bleeding time that is 4 times normal. Which of the following is the most probable diagnosis in this patient?



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Which is NOT a clinical presentation of uremia?



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Which is not a characteristic of uremia?



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Uremia is usually seen with which of the following levels of creatinine clearance?



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Uremia - References

References

Tsai HM, Atypical Hemolytic Uremic Syndrome: Beyond Hemolysis and Uremia. The American journal of medicine. 2018 Aug 23     [PubMed]
Wang AY,Kalantar-Zadeh K,Fouque D,Wee PT,Kovesdy CP,Price SR,Kopple JD, Precision Medicine for Nutritional Management in End-Stage Kidney Disease and Transition to Dialysis. Seminars in nephrology. 2018 Jul     [PubMed]
Mair RD,Sirich TL,Meyer TW, Uremic Toxin Clearance and Cardiovascular Toxicities. Toxins. 2018 Jun 2     [PubMed]
Martins JM,Magriço R, Uremic Frost in End-Stage Renal Disease. The New England journal of medicine. 2018 Aug 16     [PubMed]
Puentes SS,Dunstan M, Escherichia coli Complications in Pediatric Critical Care. Critical care nursing clinics of North America. 2018 Mar     [PubMed]
Perna AF,Pizza A,Di Nunzio A,Bellantone R,Raffaelli M,Cicchella T,Conzo G,Santini L,Zacchia M,Trepiccione F,Ingrosso D, ADAM17, a New Player in the Pathogenesis of Chronic Kidney Disease-Mineral and Bone Disorder. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2017 Nov     [PubMed]
Gedney N,Kalantar-Zadeh K, Dialysis Patient-Centeredness and Precision Medicine: Focus on Incremental Home Hemodialysis and Preserving Residual Kidney Function. Seminars in nephrology. 2018 Jul     [PubMed]
Bentata Y,El Maghraoui H,Benabdelhak M,Haddiya I, Management of hypercalcaemic crisis in adults: Current role of renal replacement therapy. The American journal of emergency medicine. 2018 Jun     [PubMed]
Bentata Y,Hamdi F,Chemlal A,Haddiya I,Ismaili N,El Ouafi N, Uremic pericarditis in patients with End Stage Renal Disease: Prevalence, symptoms and outcome in 2017. The American journal of emergency medicine. 2018 Mar     [PubMed]
Raghavan R,Eknoyan G, Uremia: A historical reappraisal of what happened
. Clinical nephrology. 2018 May     [PubMed]
Kingma JG,Simard D,Rouleau JR,Drolet B,Simard C, The Physiopathology of Cardiorenal Syndrome: A Review of the Potential Contributions of Inflammation. Journal of cardiovascular development and disease. 2017 Nov 29     [PubMed]
Massy ZA,Liabeuf S, Middle-Molecule Uremic Toxins and Outcomes in Chronic Kidney Disease. Contributions to nephrology. 2017     [PubMed]
Leong SC,Sao JN,Taussig A,Plummer NS,Meyer TW,Sirich TL, Residual Function Effectively Controls Plasma Concentrations of Secreted Solutes in Patients on Twice Weekly Hemodialysis. Journal of the American Society of Nephrology : JASN. 2018 Jul     [PubMed]
Rehman KA,Betancor J,Xu B,Kumar A,Rivas CG,Sato K,Wong LP,Asher CR,Klein AL, Uremic pericarditis, pericardial effusion, and constrictive pericarditis in end-stage renal disease: Insights and pathophysiology. Clinical cardiology. 2017 Oct     [PubMed]
Pasini A,Benetti E,Conti G,Ghio L,Lepore M,Massella L,Molino D,Peruzzi L,Emma F,Fede C,Trivelli A,Maringhini S,Materassi M,Messina G,Montini G,Murer L,Pecoraro C,Pennesi M, The Italian Society for Pediatric Nephrology (SINePe) consensus document on the management of nephrotic syndrome in children: Part I - Diagnosis and treatment of the first episode and the first relapse. Italian journal of pediatrics. 2017 Apr 21     [PubMed]
Leurs P,Machowska A,Lindholm B, Timing of dialysis initiation: when to start? Which treatment? Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2015 Mar     [PubMed]
Hu H,Patel S,Hanisch JJ,Santana JM,Hashimoto T,Bai H,Kudze T,Foster TR,Guo J,Yatsula B,Tsui J,Dardik A, Future research directions to improve fistula maturation and reduce access failure. Seminars in vascular surgery. 2016 Dec     [PubMed]
Nigwekar SU, Multidisciplinary approach to calcific uremic arteriolopathy. Current opinion in nephrology and hypertension. 2015 Nov     [PubMed]
Chan M,Kelly J,Batterham M,Tapsell L, A high prevalence of abnormal nutrition parameters found in predialysis end-stage kidney disease: is it a result of uremia or poor eating habits? Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2014 Sep     [PubMed]
Vanholder R,Van Laecke S,Glorieux G,Verbeke F,Castillo-Rodriguez E,Ortiz A, Deleting Death and Dialysis: Conservative Care of Cardio-Vascular Risk and Kidney Function Loss in Chronic Kidney Disease (CKD). Toxins. 2018 Jun 12     [PubMed]
Lin HT,Liu FC,Lin JR,Pang ST,Yu HP, Impact of the pretransplant dialysis modality on kidney transplantation outcomes: a nationwide cohort study. BMJ open. 2018 Jun 4     [PubMed]

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