Transient Synovitis


Article Author:
Christine Whitelaw


Article Editor:
Matthew Varacallo


Editors In Chief:
Shivajee Nallamothu
Matthew Varacallo
Joshua Tuck


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Frank Smeeks
Kristina Soman-Faulkner
Trevor Nezwek
Radia Jamil
Patrick Le
Sobhan Daneshfar
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Pritesh Sheth
Hassam Zulfiqar
Navid Mahabadi
Steve Bhimji
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Nazia Sadiq
Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
4/1/2019 7:43:36 PM

Introduction

Transient synovitis (TS) is an acute, non-specific, inflammatory process affecting the joint synovium.  TS of the hip is a common cause of hip pain in the pediatric patient population.  While the condition is a benign, self-limiting process, providers must recognize the critical importance of differentiating TS from an acute infectious process. 

Etiology

The exact etiology of TS is unknown.  The literature demonstrates multiple proposed etiologic theories but none of these postulated hypotheses have been conclusively substantiated.  Proposed risk factors include but are not limited to:[1][2]

  • preceding upper respiratory infection (URI)
  • preceding bacterial infection
    • poststreptococcal toxic synovitis
  • preceding trauma

Many pediatric patients will present with a history of preceding URI symptoms, or in the setting of recent trauma.  According to Kastrissianakis and Beattie, patients diagnosed with TS are more likely to have experienced preceding viral symptoms including vomiting, diarrhea, or common cold symptoms[2].  An earlier study reported that patients with TS demonstrated higher serum interferon concentration values[3].  Seasonal variation in association with TS diagnoses remains controversial.  One study reported a seasonal variation in the incidence of TS, with more cases presenting in October and fewer cases in February [4].  Studies investigating possible viral pathogen candidates, including parvovirus B-19 and human herpes simplex virus-6, have not been conclusive [5].

Other hypothesized risk factors include postvaccine or drug-mediated hypersensitivity reactions or certain allergic predispositions.  Another potential clinical association has been proposed for Legg-Calvé-Perthes disease (LCPD) and TS.  While this relationship remains controversial, some studies have reported increased incidence rates of LCDP following TS (up to 3%) compared to the relative LCPD incidence rate reporting in the general population (0.9 per 100,000 patients).[6]

Epidemiology

TS of the hip most frequently occurs in children ages 3 to 10 years old.  The average annual incidence of TS and the total lifetime risk is estimated to be at 0.2% and 3%, respectively [4].  A 2010 study from the Netherlands reported the mean age at presentation was 4.7 years[7].  While the majority of cases occur in pediatric patients between the ages of 3 and 10 years of age, the literature does demonstrate rare case presentations in both younger infants and the adult population [8][9][10].  The incidence rate in males is twice that of females, and about 1% to 4% of the time a patient may demonstrate bilateral involvement [11].   

Pathophysiology

The pathoanatomy underlying TS is relatively nonspecific.  The proposed pathologic cascade entails nonspecific inflammation targeting the synovial joint lining causing hypertrophic changes .  Typically one or multiple aforementioned risk factors can be elicited from the clinical history upon presentation.  The acute inflammatory phase clinically manifests as a pain that is self-limiting and resolves within 24 to 48 hours.  The natural history favors complete resolution of symptoms within 1 to 2 weeks, although recurrence rates can be as high as 20% [12][13][14][15].

History and Physical

History [14][15]

TS most commonly presents as acute unilateral limb disuse ranging from nonspecific hip pain or subtle limp to refusal to bear weight.  Depending on the age of the patient, the history may only be significant for the child or infant becoming increasingly agitated or crying more often than at baseline.  Therefore, heightened clinical suspicion is warranted in younger pediatric patients and infants.  In addition, examiners should elicit for any pain or discomfort localized or radiating to or from the lower back.  Oftentimes the clinician may only be able to rely on the history obtained from the parents or guardians.  Direct observation of the child in the emergency room or clinic can often yield valuable information.  A recent history of an upper respiratory tract infection, pharyngitis, bronchitis, or otitis media is often elicited and favors a diagnosis of TS. 

Physical examination [16][17][18][19]

Examination of the patient with unilateral hip pain usually reveals mild restrictions to range of motion, especially to the abduction and internal rotation position.  The patient may present with the hip in the flexed, abducted, and externally rotated position as this relaxes the hip joint capsule to decrease intra-articular pressure [20].  In some reports one-third of patients presented with normal range of motion on physical exam. 

While TS remains a diagnosis of exclusion, provocative maneuvers such as the basic log roll or performing the Patrick test if the patient is able to tolerate.  The latter is also known as the FABER test for flexion, abduction and external rotation and this maneuver is performed by having the patient flex the leg with the thigh abducted and externally rotated. Pain on the ipsilateral anterior side is indicative of a hip disorder on that side. If the pain is elicited on the contralateral side posteriorly around the sacroiliac joint, it suggests pain mediated by dysfunction in that joint.

Evaluation

Comprehensive evaluation and diagnostic workup should include a white blood cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and hip radiography and ultrasonography.  

A 2017 systematic review and meta-analysis highlighted demographic, clinical, and laboratory variables seen in pediatric patients presenting with TS, septic arthritis (SA), or lyme arthritis (LA) of the hip.  The authors noted several key findings that can aid in the clinical differentiation: [21]

  • Febrile at presentation
    • Over 50% of patients with SA
    • 30% of patients with TS
    • 23% of patients with LA
  • Refusal to bear weight
    • Over 60% in patients diagnosed with either TS or SA
    • Only 33% of patients diagnosed with LA
  • Inflammatory markers
    • ESR range for SA patients was 44 - 64 mm/hr
    • ESR range for TS patients was 21 - 33 mm/hr
    • ESR range for LA patients was 37 - 46 mm/hr
  • Synovial fluid aspiration results
    • Synovial WBC counts (cells/mm3) demonstrated a similar trend as noted with measured ESR levels at presentation
      • TS (5,644 - 15,388)
      • LA (47,533 - 64,242)
      • SA (105,432 - 260,214) 
  • Peripheral WBC count was simlilar between each of the diagnostic groups

TS remains a diagnosis of exclusion, although these studies have highlighted the diagnostic utility of a synovial fluid aspiration and analysis.  

Additional laboratory workup includes a CRP greater than 2 mg/dl, which has been shown to be an independent risk factor for septic arthritis.  A urinalysis and culture are typically normal. Because procalcitonin levels remain low during bouts of inflammatory disease, an increase should raise suspicion of septic arthritis. Depending on the history, consider antinuclear antibody, rheumatoid factor, HLA-B27, and tuberculosis skin testing [22]

In a Lyme endemic area, only 5% of children with acute, nontraumatic hip pain had a Lyme infection, so routine serology is not necessary. It should be performed if an alternative diagnosis such as septic/pyogenic arthritis is being considered and in those with an atypical clinical course [23].

Although plain films may be normal for months after onset of symptoms, the medial joint space is typically slightly wider in the affected hip indicating the presence of fluid. One-half to two-thirds of patients with transient synovitis may have an accentuated pericapsular shadow [9]

Ultrasound is extremely accurate for detecting an intracapsular effusion. Ultrasound-guided hip aspiration not only relieves pain and limitation of movement but it often provides a rapid distinction from septic arthritis. Ultrasound-guided hip aspiration should be done in all individuals in whom ultrasonography has exhibited evidence of an effusion, and any of the following predictive criteria are present:

  • Temperature greater than 99.5 F
  • ESR greater than or equal to 20 mm/hr
  • Severe hip pain and spasm with movement

If the aspirate has a positive gram stain, more than 90% polymorphonuclear cells, or a glucose less than 40 mg/dL or markedly different from the serum glucose, the patient is more likely to have septic arthritis and not transient synovitis.

In settings in which routine aspirations of effusions is not performed, a dynamic contrast-enhanced MRI may help differentiate transient synovitis from septic arthritis.

Bone scintigraphy demonstrates mildly elevated uptake; however, it does not help differentiate etiologies.

Multiple algorithms and previously reported step-by-step guidelines are available in the literature [9][24][25][26].

The Kocher criteria remain a helpful set of clinical risk factors differentiating SA and TS in pediatric patients presenting with hip pain.  The criteria include the increasing diagnostic probability in favor of the former, yielding a 99.6% probability favoring SA as a diagnosis when all four criteria are met:

  • WBC > 12,000 cells per microliter of serum
  • Inability or refusal to bear weight
  • Febrile (> 101.3 degrees fahrenheit or 38.5 degrees celsius)
  • ESR > 40 mm/hr

When none of the above risk factors are present upon presentation, the probability of the patient having SA of the hip drops below 0.2%.  A subsequent study incorporated CRP measurements into the clinical workup.  Caird et al. performed a Level I study that concluded that a temperature above 38.5 was the best predictor of septic arthritis followed in decreasing order by CRP (>1mg/dL), ESR, refusal to bear weight, and serum WBC count [16].

Treatment / Management

Following the appropriate diagnosis of TS made following a thorough, comprehensive diagnostic workup, management involves supportive care and rest from activity.  NSAIDs can be used for pain control.  Other modalities include the application of heat and/or massage modalities.  In the setting of clinical concern or when the diagnosis is unclear, admitting the patient for observation can allow for serial observation following an initial period of supportive management. 

Symptoms generally improve after 24 to 48 hours.  Complete resolution of symptoms often takes up to 1 to 2 weeks in up to 75% of patients.  The remainder may have less severe symptoms for several weeks. If significant symptoms persist for seven to 10 days after the initial presentation, consider other diagnoses. Patients with symptoms for more than a month have been found to have a different pathology.

Differential Diagnosis

Patients presenting with acute hip pain should be ruled out for alternative diagnoses, especially those that could potentially lead to devastating sequelae if not diagnosed relatively quickly.  These conditions include osteomyelitis, septic arthritis, primary or metastatic lesions, Legg–Calve–Perthes disease (LCPD), and slipped capital femoral epiphysis (SCFE).  Other diagnoses include Lyme arthritis, pyogenic sacroiliitis, and juvenile rheumatoid arthritis.

Prognosis

In total, TS of the hip recurs in up to 20% to 25% of patients.  Patient should be educated regarding the increased risk of recurrence in the setting of a previously documented diagnosis of TS.  One study reported the subsequent recurrence rates in patients with a previously documented diagnosis of TS were 69%, 13%, and 18% at one-, two-year, and long-term follow-up, respectively [27].    

Complications

The major complication associated with TS is recurrence of symptoms.

Pearls and Other Issues

Sequelae include coxa magna and mild degenerative changes of the femoral neck. Coxa magna is observed radiographically as an overgrowth of the femoral head and broadening of the femoral neck. Coxa magna leads to dysplasia of the acetabular roof and subluxation. An incidence rate of coxa magna of 32.1% has been reported in the first year following transient synovitis.

Legg-Calve-Perthes disease develops in 1% to 3% of individuals.

The recurrence rate of transient synovitis is 4% to 17%; most recurrences develop within six months [6]

Enhancing Healthcare Team Outcomes

The diagnosis of TS is difficult because there are no specific tests. The disorder is best managed by a multidisciplinary team that includes an orthopedic surgeon, radiologist, primary care provider, nurse practitioner, physical therapist and sports physician. The treatment in most cases is supportive with pain control. The patient should be educated on the importance of a healthy weight and regular exercise. Despite adequate treatment, the risk of recurrence is high. [27](level V)


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Transient Synovitis - Questions

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A 4-year-old boy is brought to the emergency room as he refuses to walk secondary to leg pain. It started last night but is worse today. He says that it hurts to move the leg and hurts to walk. The child has no significant past medical history but did have an upper respiratory infection last week. On examination, there is a limited range of motion on one side of his hip, especially to abduction. What is the most likely diagnosis?



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A 4-year-old boy is brought to the emergency room because he is limping. The parents noticed it yesterday but it is worse today. The patient says that his hip and upper leg hurt. On examination, there is a limited range of motion of one hip, especially to abduction. He is afebrile. For the initial workup, which of the following is least appropriate?



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What is the most appropriate treatment for a 5-year-old patient with transient synovitis of the hip?



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A 2-year-old has a limp for 48 hours. The child has sustained no trauma and has no other symptoms. The only physical finding is that the left hip is tender on range of motion. Bilateral hip radiographs are normal. What is the most likely diagnosis?



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A well-appearing 2 year old male presents to your office limping. Mom denies any fever or injuries but reports upper respiratory tract symptoms that resolved 3 days ago. On exam, there is limited range of motion of the right hip, and the child is refusing to bear weight. The most likely diagnosis is:



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Transient Synovitis - References

References

Transient synovitis of the hip: which investigations are truly useful?, Dubois-Ferrière V,Belaieff W,Lascombes P,de Coulon G,Ceroni D,, Swiss medical weekly, 2015     [PubMed]
Transient synovitis, septic hip, and Legg-Calvé-Perthes disease: an approach to the correct diagnosis., Cook PC,, Pediatric clinics of North America, 2014 Dec     [PubMed]
The use of CRP within a clinical prediction algorithm for the differentiation of septic arthritis and transient synovitis in children., Singhal R,Perry DC,Khan FN,Cohen D,Stevenson HL,James LA,Sampath JS,Bruce CE,, The Journal of bone and joint surgery. British volume, 2011 Nov     [PubMed]
Transient synovitis of the hip: more evidence for a viral aetiology., Kastrissianakis K,Beattie TF,, European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2010 Oct     [PubMed]
Review for the generalist: evaluation of pediatric hip pain., Houghton KM,, Pediatric rheumatology online journal, 2009 May 18     [PubMed]
Lyme arthritis presenting as transient synovitis of the hip., Saulsbury FT,, Clinical pediatrics, 2008 Oct     [PubMed]
Factors distinguishing septic arthritis from transient synovitis of the hip in children. A prospective study., Caird MS,Flynn JM,Leung YL,Millman JE,D'Italia JG,Dormans JP,, The Journal of bone and joint surgery. American volume, 2006 Jun     [PubMed]
Differentiation between septic arthritis and transient synovitis of the hip in children., Yagupsky P,, The Journal of bone and joint surgery. American volume, 2005 Feb     [PubMed]
Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children., Kocher MS,Mandiga R,Zurakowski D,Barnewolt C,Kasser JR,, The Journal of bone and joint surgery. American volume, 2004 Aug     [PubMed]
Differentiation between septic arthritis and transient synovitis of the hip in children with clinical prediction algorithms., Luhmann SJ,Jones A,Schootman M,Gordon JE,Schoenecker PL,Luhmann JD,, The Journal of bone and joint surgery. American volume, 2004 May     [PubMed]
Significance of laboratory and radiologic findings for differentiating between septic arthritis and transient synovitis of the hip., Jung ST,Rowe SM,Moon ES,Song EK,Yoon TR,Seo HY,, Journal of pediatric orthopedics, 2003 May-Jun     [PubMed]
Transient synovitis: is there a need to aspirate hip joint effusions?, Skinner J,Glancy S,Beattie TF,Hendry GM,, European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2002 Mar     [PubMed]
Evaluating the child with acute hip pain ("irritable hip") in a Lyme endemic region., Bachur RG,Adams CM,Monuteaux MC,, The Journal of pediatrics, 2015 Feb     [PubMed]
Pediatric Lyme Arthritis of the Hip: The Great Imitator?, Cruz AI Jr,Aversano FJ,Seeley MA,Sankar WN,Baldwin KD,, Journal of pediatric orthopedics, 2017 Jul/Aug     [PubMed]
A guideline for differential diagnosis between septic arthritis and transient synovitis in the ED: a Delphi survey., Lee JH,Park MS,Kwon H,Chung CY,Lee KM,Kim YJ,Kim K,, The American journal of emergency medicine, 2016 Aug     [PubMed]
What is the clinical course of transient synovitis in children: a systematic review of the literature., Asche SS,van Rijn RM,Bessems JH,Krul M,Bierma-Zeinstra SM,, Chiropractic & manual therapies, 2013 Nov 14     [PubMed]
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Lockhart GR,Longobardi YL,Ehrlich M, Transient synovitis: lack of serologic evidence for acute parvovirus B-19 or human herpesvirus-6 infection. Journal of pediatric orthopedics. 1999 Mar-Apr     [PubMed]
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Ehrendorfer S,LeQuesne G,Penta M,Smith P,Cundy P, Bilateral synovitis in symptomatic unilateral transient synovitis of the hip: an ultrasonographic study in 56 children. Acta orthopaedica Scandinavica. 1996 Apr     [PubMed]
Uziel Y,Butbul-Aviel Y,Barash J,Padeh S,Mukamel M,Gorodnitski N,Brik R,Hashkes PJ, Recurrent transient synovitis of the hip in childhood. Longterm outcome among 39 patients. The Journal of rheumatology. 2006 Apr     [PubMed]

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