Isthmic Spondylolisthesis


Article Author:
Matthew Burton


Article Editor:
Fassil Mesfin


Editors In Chief:
Shivajee Nallamothu
Matthew Varacallo
Joshua Tuck


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Frank Smeeks
Kristina Soman-Faulkner
Radia Jamil
Patrick Le
Sobhan Daneshfar
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Pritesh Sheth
Hassam Zulfiqar
Navid Mahabadi
Steve Bhimji
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Nazia Sadiq
Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
3/22/2019 12:55:20 AM

Introduction

The lumbar spine in the sagittal plane should maintain an alignment in which each vertebral body is aligned with the vertebral body above and below.  In other words, the anterior inferior endplate of the vertebral body above should be aligned with the anterior superior endplate of the vertebral body below.  Spondylolisthesis occurs when there is an anterior subluxation or “slippage” of the vertebral body above on the vertebral body below. In most cases, symptoms associated with spondylolisthesis are chronic.  The primary symptom of chronic spondylolisthesis is back pain, with or without leg pain. When spondylolisthesis occurs acutely in the setting of traumatic or metastatic tumors, patients can present with neurological examination deficits including a loss of bowel and bladder function. The classification system utilized to categorize the degree of subluxation of the vertebral bodies is the Meyerding Classification, which quantifies the percentage of subluxation of the vertebral body above on the vertebral body below. Classification of Spondylolisthesis is based on the degree of slippage in the lumbar spine. Grade 1 is less than 25%, Grade 2 is 25% to 50%, Grade 3 is 50% to 75%, Grade 4 is 75% to 100%, and Spondyloptosis is > 100% [1].

There are many causes of spondylolisthesis including congenital, degenerative, traumatic, pathologic, iatrogenic, and isthmic. Isthmic spondylolisthesis, which will be the topic of this discussion, refers to a defect in the pars interarticularis that then results in anterior subluxation over time, most commonly at L5-S1 followed by L4-5.  The resulting anterior subluxation can produce back pain, central canal stenosis, and lateral recess or foraminal stenosis.

Etiology

The most common etiology for isthmic spondylolisthesis is instability of unilateral or bilateral pars interarticularis. The pars interarticularis, or pars, is the bony structure which connects the lamina, pedicle, and transverse processes of the vertebral bodies. Importantly, the facet joints of the superior and inferior vertebrae also are connected by the pars. Thus, a defect in this structure would effectively “disconnect” the vertebral body above from the vertebral body below. This disconnection allows the anterior subluxation seen in spondylolisthesis. Many biomechanical studies indicate that the pars is subjected to the greatest force of any structure in the lumbar spine; therefore, it is susceptible to stress fractures which may heal and fracture repeatedly over time. These injuries can induce non-healing fractures or an elongated pars without a defect which likely indicates repeated fracture healing. Pars fractures are believed to be the result of repetitive motion. Thus, risks associated with pars defects include activities associated with repetitive flexion/extension, axial loading, and rotational loading (i.e., golfers, baseball and football players, gymnasts).

Epidemiology

The incidence of isthmic spondylolisthesis is generally reported as between 4% to 8% of the general population. It is three times as common in males as it is in females. An interesting cross-sectional study utilizing the Framingham Heart Study participant of 3529 patients showed that 20% of patients with CT finding of bilateral pars defect showed no evidence of spondylolistheisis[2]. In addition, this cross-sectional study showed that the incidence of spondylolisthesis increases significantly from the fifth decade of life to the eighth decade of life . 

Pathophysiology

The anterior subluxation of the vertebral body can cause a decrease in the diameter of the spinal canal (spinal stenosis). The slippage also can result in accelerated degeneration of the intervertebral disc.  Furthermore, the subluxation can lead to hypertrophy of the facet joints and ligamentum flavum posteriorly which can result in stenosis of the lateral recess and neural foramina. There also can be traction placed on the exiting nerve roots which commonly affects the exiting nerve root below the pedicle of the vertebral body above the level of the spondylolisthesis. These affects can result in back pain, neurogenic claudication, and radiculopathy.

History and Physical

Many cases of isthmic spondylolisthesis are asymptomatic.  However, the most common symptom of presentation is low back pain, which may be mechanical in nature. Patients also can present with neurogenic claudication symptomatology such as back and leg pain and discomfort associated with walking. These symptoms need to be differentiated from vascular claudication, which is exacerbated by ambulation and gets better with rest.  Other patients can present with symptoms of specific dermatome of lumbar radiculopathy depending on the compressed nerve root and the amount of subluxation or stenosis. Physical examination can show different degrees of findings ranging from normal to paraplegia. However, the most common findings are depressed deep tendon reflexes, positive straight leg signs, and diminished sensations. Some patients can have specific pain-related weakness of lower extremities. Usually, patients with chronic isthmic spondylolisthesis do not present with significant motor weakness; however, acute isthmic spondylolisthesis can present with paralysis and loss of bowel and bladder function.

Evaluation

Radiological evaluation is not indicated upon initial presentation of low back pain because of its self-limiting nature. However, serious conditions such as tumor or infection should be ruled out with a high-quality history and physical examination. Should the back pain not respond to conservative management then plain x-rays, including oblique views, may be used to assess the bony quality and alignment of the lumbar spine. Should the initial presentation also consist of radicular symptoms or symptoms of neurogenic claudication, then the neural elements must be evaluated with an MRI or CT myelogram of the lumbar spine. 

X-ray is a good study to evaluate the degree of slippage. Oblique view x-ray of the lumbar spine is a good tool to assess the pars defect.  CT Scan of the lumbar spine is the definitive study to assess the pars defect. MRI is the study of choice for evaluation of soft tissue structures including intervertebral discs, ligamentum flavum, the thecal sac, nerve roots, and the conus medullaris in the lumbar spine. MRI is needed for patients who fail conservative treatments and are planning a surgical intervention.

Treatment / Management

Isthmic spondylolisthesis with low back pain should initially be managed conservatively. NSAIDs, muscle relaxers, physical therapy, and epidural steroid injections are some of the conservative options.  Should the back pain persist despite conservative management, or if the severity is such that quality of life is significantly affected, then referral to a specialist for evaluation is indicated. When the presentation consists of symptoms of neurogenic claudication or radiculopathy, then imaging of the neural elements of the lumbar spine is indicated along with referral to a specialist. Surgical treatment options consist of decompression of the neural elements alone versus decompression with internal fixation for bony fusion to prevent further subluxation [3]. In addition, for patients who present with acute symptoms due to trauma or malignancies, emergent surgical referrals are indicated [4].[5][6][7]

Enhancing Healthcare Team Outcomes

Low back pain is commonly encountered by the nurse practitioner, primary caregiver, emergency department physician, and internist. Isthmic spondylolisthesis is also a common cause of back pain and the diagnosis is confirmed by the radiologist. The initial management of the condition is with conservative measures but when patients fail to respond, a referral to an orthopedic surgeon is recommended. Surgical treatment options consist of decompression of the neural elements alone versus decompression with internal fixation for bony fusion to prevent further subluxation [3]. In addition, for patients who present with acute symptoms due to trauma or malignancies, emergent surgical referrals are indicated [4].

Unfortunately, many patients continue to have a recurrence of pain because no treatment works consistently or reliably. Surgery only benefits a few patients and is associated with serious complications. Thus the primary care provider should emphasize lifestyle changes, regular exercise, discontinuation of tobacco and a healthy body weight.[8][9]


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Isthmic Spondylolisthesis - Questions

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A 17-year-old male football player notes worsening low back pain. He states the pain is worse during football practice. He will sometimes note an electric shock down his right leg when getting on all fours during football practice. He states heating pads, ice packs, and NSAIDs improve the pain. Imaging is obtained which reports "Grade III spondylolisthesis." Which part of the vertebrae has the defect causing this spondylolisthesis?



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What is the most common level for isthmic spondylolisthesis in the lumbar spine?



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A 25-year-old female college runner presents with acute back pain, but no leg pain. An x-ray of the lumbar spine showed bilateral L5 pars interarticularis lucency indicating fractures without spondylolisthesis. What is the best course of treatment in this patient?



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What is incorrect about the incidence of isthmic spondylolisthesis?



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Isthmic Spondylolisthesis - References

References

The Role of the Features of Facet Joint Angle in the Development of Isthmic Spondylolisthesis in Young Male Patients with L5-S1 Isthmic Spondylolisthesis., Eroglu A,, World neurosurgery, 2017 May 23     [PubMed]
A Study to Assess the Functional Outcome of Decompression and Posterior Lumbar Interbody Fusion of Low Grade Spondylolisthesis of Lumbar Vertebra., Hegde D,Mehra S,Babu S,Ballal A,, Journal of clinical and diagnostic research : JCDR, 2017 Mar     [PubMed]
What Surgical Treatment Is Best for Isthmic Spondylolisthesis?: Commentary on an article by Peter Endler, MD, et al.: "Outcomes of Posterolateral Fusion with and without Instrumentation and of Interbody Fusion for Isthmic Spondylolisthesis. A Prospective Study"., Chapman J,Oskouian RJ,, The Journal of bone and joint surgery. American volume, 2017 May 3     [PubMed]
McCunniff PT,Yoo H,Dugarte A,Bajwa NS,Toy JO,Ahn UM,Ahn NU, Bilateral Pars Defects at the L4 Vertebra Result in Increased Degeneration When Compared With Those at L5: An Anatomic Study. Clinical orthopaedics and related research. 2016 Feb;     [PubMed]
Joelson A,Diarbakerli E,Gerdhem P,Hedlund R,Wretenberg P,Frennered K, Self-Image and Health-Related Quality of Life Three Decades After Fusion In Situ for High-Grade Isthmic Spondylolisthesis. Spine deformity. 2019 Mar;     [PubMed]
Harris IA,Traeger A,Stanford R,Maher CG,Buchbinder R, Lumbar spine fusion: what is the evidence? Internal medicine journal. 2018 Dec;     [PubMed]
Endler P,Ekman P,Ljungqvist H,Brismar TB,Gerdhem P,Möller H, Long-term outcome after spinal fusion for isthmic spondylolisthesis in adults. The spine journal : official journal of the North American Spine Society. 2019 Mar;     [PubMed]
Nowakowski A,Labaziewicz L,Skrzypek H, [Algorithm in low back pain management in adults]. Chirurgia narzadow ruchu i ortopedia polska. 1998;     [PubMed]
Noorian S,Sorensen K,Cho W, A systematic review of clinical outcomes in surgical treatment of adult isthmic spondylolisthesis. The spine journal : official journal of the North American Spine Society. 2018 Aug;     [PubMed]

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