Anatomy, Pterygopalatine Fossa

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Zachary Cappello

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4/7/2019 8:50:47 PM


The pterygopalatine fossa (PPF) is a cone-shaped depression deep to the infratemporal fossa and posterior to the maxilla on both sides of the skull. The fossa is located between the pterygoid process and the maxillary tuberosity, close to the orbital apex. This space communicates with both the nasal and oral cavities, the infratemporal fossa, the orbit, the pharynx, and the middle cranial fossa through eight foramina. Three-dimensional understanding of this space is crucial for the rhinologist and skull-base surgeon for both the control of epistaxis and the removal of skull base lesions. The pterygopalatine space approach is used to treat lesions in the spaces posterior to the maxillary sinus, including the pterygopalatine space and lateral sphenoid recess. Pathologic processes in this space are rare, with the most common disease processes being juvenile nasopharyngeal angiofibroma, neurogenic tumors, a perineural extension of sinonasal malignancy, and meningoencephaloceles.[1][2]

Structure and Function

While not serving a particular function, this space allows for the transit of several important structures through different foramina. The foramen rotundum connects the PPF to the middle cranial fossa. The pterygoid canal, also known as the vidian canal, connects the PPF to the middle cranial fossa as well. The palatovaginal canal connects the PPF with the nasal cavity and nasopharynx. Anteriorly, the inferior orbital fissure connects the PPF to the orbit. Medially, the sphenopalatine foramen provides access to the nasal cavity. Laterally, the pterygomaxillary fissure connects the PPF to the infratemporal fossa. Finally, inferiorly, the greater palatine canal connects the PPF to the oral cavity.[3][4]

The pterygopalatine fossa also contains multiple important structures. This fossa contains the pterygopalatine ganglion. Nerve roots from the maxillary nerve suspend this ganglion. The PPF contains the terminal third of the maxillary artery. In addition, the maxillary nerve (CN V2) and the vidian nerve, or the nerve of the pterygoid canal, which is a combination of the greater petrosal nerve and the deep petrosal nerve traverse through the PPF as well.

The PPF is bounded by the maxillary, palatine, and sphenoid bones. The posterior wall of the maxillary sinus comprises the anterior border, and the palatine bone makes up its floor and anteromedial wall. The roof is made up of the sphenoid bone. More specifically, the sphenoid body and the orbital process of the palatine bone make up the superior boundary. The posterior wall of the maxillary antrum makes up the anterior boundary. The pterygoid process and greater wing of the sphenoid make up the posterior boundary. The medial boundary is made up of the palatine bone and nasal mucoperiosteum. Finally, the temporalis muscle via the pterygomaxillary fissure makes up the lateral boundary of the PPF.

The vascular and nervous structures are located anteroinferiorly and posterosuperior, respectively within the pterygopalatine fossa. The sphenopalatine artery, which is a branch of the internal maxillary artery, is found between the sphenoid and palatine bones and enters the nasal cavity at the sphenopalatine foramen. The maxillary division of the trigeminal nerve and the vidian nerve enter from the posterior wall of the PPF. The maxillary division of the trigeminal nerve moves through the foramen rotundum. The vidian nerve traverses through the pterygoid canal. They come together to form the pterygopalatine ganglion and then branch into the infraorbital nerve and the greater and lesser palatine nerves. The infraorbital nerve exits through the inferior orbital fissure and the greater and lesser palatine nerves pass through the greater and lesser palatine foramina respectively.

Posterior to the PPF, pneumatization of the lateral portion of the sphenoid bone can result, forming a lateral sphenoid recess. This finding is observed in 25% to 48% of individuals. The roof of the lateral sphenoid recess can lie directly beneath the temporal lobe, and this is a common location for middle cranial fossa encephaloceles.

Surgical Considerations

When considering endoscopic resections of sinonasal cancer, the oncologic principle of clearance of margins must be the primary goal. Sinonasal tumors that originate in both the maxillary sinus and the ethmoids/skull base can have both direct and perineural spread into the pterygopalatine and infratemporal fossa.[5][6][5]

The primary site of disease is managed first, and then the margins are cleared in the PPF. A medial maxillectomy is performed initially with inferior and middle turbinate removal. This allows for complete visualization of the maxillary sinus. After creating the transmaxillary corridor, the trans pterygopalatine fossa approach proceeds by elevating the mucosa that overlies the medial pterygoid wedge to expose the sphenopalatine artery. The sphenopalatine artery is then ligated, and the associated mucosa is resected down off of the medial pterygoid plate. With this down, the bone of the posterior maxillary wall is removed, and the descending palatine artery is cauterized and ligated. It should be noted that sacrifice of the palatine artery is not always necessary for access and tumor removal within the PPF, but it can be taken to gain access to the more lateral and deeper infratemporal fossa. The Vidian nerve is then encountered and often sacrificed. With this done and the orbital process of the palatine bone drilled away, the entire fossa is mobile and can be resected or pushed laterally to gain access to the infratemporal fossa and pterygoid musculature.

Prior to undergoing surgical resection, it is important to obtain proper imaging of the paranasal sinuses and skull base. High-resolution CT images should be obtained using a stereotactic navigational protocol. Neurogenic tumors of the PPF will usually enlarge the bony openings as they pass through foramina. An MRI may also be beneficial. An MRI will reveal skull base soft tissue structures, including the perineural spread of a sinus or skull base neoplasm.

Clinical Significance

Several potential complications are specifically related to performing surgery in the PPF. Damage to the Vidian nerve can result in chronic xerophthalmia. Removal of the pterygoid plates or muscles can leave the patient with chronic trismus. CN V2 damage is possible when performing surgery in either the PPF or infratemporal fossa. Finally, and possibly most importantly, there can be carotid artery injury. While the carotid injury is unlikely when performing only PPF resection, if the dissection is carried into the infratemporal fossa, identification of the carotid artery is crucial.[7][8]

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Anatomy, Pterygopalatine Fossa - Questions

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A 24-year-old female presents with sharp, shooting pain on the right side of her face. She states that her pain is triggered by brushing her teeth and chewing. She is diagnosed with trigeminal neuralgia. The affected nerve travels through the foramen rotundum and leads into which of the following structures?

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Which bone does not form a boundary of the pterygopalatine fossa (PPF)?

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Anatomy, Pterygopalatine Fossa - References


Chung HJ,Moon IS,Cho HJ,Kim CH,Sharhan SSA,Chang JH,Yoon JH, Analysis of Surgical Approaches to Skull Base Tumors Involving the Pterygopalatine and Infratemporal Fossa. The Journal of craniofacial surgery. 2019 Jan 10;     [PubMed]
Nair AS,Rayani BK, Sphenopalatine ganglion block for relieving postdural puncture headache: technique and mechanism of action of block with a narrative review of efficacy. The Korean journal of pain. 2017 Apr;     [PubMed]
Ilahi S,Ilahi TB, Physiology, Pineal Gland 2019 Jan;     [PubMed]
Derinkuyu BE,Boyunaga O,Oztunali C,Alimli AG,Ucar M, Pterygopalatine Fossa: Not a Mystery! Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. 2017 May;     [PubMed]
McCann A,Alvi SA,Newman J,Kakarala K,Staecker H,Chiu A,Villwock JA, Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone. The Annals of otology, rhinology, and laryngology. 2019 Feb;     [PubMed]
Yang L,Hu L,Zhao W,Zhang H,Liu Q,Wang D, Endoscopic endonasal approach for trigeminal schwannomas: our experience of 39 patients in 10 years. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2018 Mar;     [PubMed]
Xue Z,Liu J,Bi ZY,Yi ZQ,Bao SD,Liu PN,Yang ZJ, Evolution of transmaxillary approach to tumors in pterygopalatine fossa and infratemporal fossa: anatomic simulation and clinical practice. Chinese medical journal. 2019 Apr 5;     [PubMed]
Piastro K,Scagnelli R,Gildener-Leapman N,Pinheiro-Neto CD, Outcomes of sphenopalatine and internal maxillary artery ligation inside the pterygopalatine fossa for posterior epistaxis. Rhinology. 2018 Jun 1;     [PubMed]


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