Turcot Syndrome


Article Author:
Ahmed Khattab


Article Editor:
Dulabh Monga


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Anantha Padmanabhan
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James Hughes
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Nazia Sadiq
Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
12/1/2018 11:47:05 PM

Introduction

Turcot syndrome (TS) is the association of primary brain tumors to colorectal cancer. Various definitions of Turcot (pronounced with a silent "t," i.e., Turc-oh) syndrome were proposed over the years. Jacques Turcot, a Canadian surgeon, who was among the first to draw attention to the syndrome, defined it as colorectal cancer (CRC) with primary brain tumors. He observed the syndrome in teenage siblings, who presented with a few polyps in the colon, followed by a primary central nervous system (CNS) tumor (a medulloblastoma and a pituitary adenoma, in his case).[1] They had no family history of the syndrome, but their parents were third cousins, leading to the thought that it may be an inherited autosomal recessive disease. Upon genetic analysis of these siblings in 1995 by Hamilton et al., a biallelic mismatch repair (MMR) gene mutation was found. It is now well-known that the coupling of CRC and brain tumors can present secondary to a number of different genotypes.[2]

There have been attempts to reclassify TS as mismatch repair cancer syndrome (MMRCS) or rename it as brain-tumor polyposis syndrome 1 and 2 (BTPS1 and BTPS2). These syndromes suggest a focus on defining the syndrome by the genetic presentation, involving findings in addition to CRC and primary brain tumors, such as cafe-au-lait spots, hematologic malignancies, among others. However, the original definition of TS is restricted to the phenotypic presentation of solely CRC plus primary brain tumors. Thus, it is now common to see TS1 and TS2, meaning CRC with primary CNS tumor secondary to either MMR gene mutations or APC gene mutations, respectively. BTPS is commonly used as a synonym to TS today, though BTPS is an expanded version which includes additional symptoms mentioned in this paper.

Hereditary non-polyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP) are the 2 most well-known inherited colorectal cancers. HNPCC is associated with mismatch repair (MMR) gene mutations. FAP is associated with an APC gene mutation. HNPCC is generally associated with Lynch syndrome. Gardner syndrome is associated with FAP. If a brain tumor arises in a patient with either HNPCC or FAP, then the patient is considered to have TS1 or TS2, respectively, although the association with either of these inherited mutations is not necessary.[2]

Etiology

The cause of Turcot syndrome is a mutation of several possible genes. The APC gene is a tumor suppressor gene which undergoes biallelic, or homozygous, deletion. Homozygous mutations of the MMR genes, or the mismatch repair genes, are the second cause of TS.[2]

Epidemiology

The incidence and prevalence of Turcot syndrome are difficult to ascertain considering the rarity of the condition and that it has had a shifting definition over the years. It is usually an inherited disease, in an autosomal recessive or autosomal dominant fashion, and that it can also arise sporadically.

There have been 148,900 new cases of inherited colorectal cancers in 2008. Of all the colorectal cancers diagnosed, up to 10%, at most, are inherited.[3] A small number of those inherited cancers, which are most commonly HNPCC or FAP, would be TS.

In patients with FAP, the relative risk of developing medulloblastoma is 92%. As a result, one APC mutation is present, by default, in FAP. APC mutations are not found in sporadic medulloblastomas; therefore, medulloblastoma presenting in a patient with an APC mutation is most likely Turcot syndrome.[4] About 40% of patients with Turcot syndrome develop a medulloblastoma. About 30% of families identified with FAP resulted from new mutations or mosaic inheritance as opposed to autosomal recessive inheritance.[2] Patients are born with the disease, but manifest with it in early adulthood or before. Approximately 75% to 80% of individuals with APC-associated polyposis conditions have an affected parent.[3]

Pathophysiology

Turcot syndrome can arise from mutations in the MMR genes (type I, associated with HNPCC) or the APC genes (type II, associated with FAP). Mutations of either gene can result in colorectal cancer and brain tumors; most commonly, glioblastomas and medulloblastomas.[4] Glioblastomas are associated with MMR gene mutations, specifically, in the hMLH1 DNA mismatch repair gene. Medulloblastomas are associated with APC gene mutations.[4] The mutations that result in the development of Turcot syndrome have generally been shown to be biallelic mutations, compared to the single allele, or heterozygous mutation manifestations in HNPCC and FAP.[5]

A general summary of the pathological process is that tumor suppressor gene deletion leads normal colonic mucosa to transform into invasive carcinoma. Normal mucosa develops into polyps, then the polyps continue to develop into invasive cancer. There are several different types of polyps including non-neoplastic hamartomas, hyperplastic proliferation of the mucosa, and adenomatous polyps. Colorectal cancers generally arise from adenomatous polyps. It is adenomatous polyps that develop in type I and type II of Turcot syndrome. Homozygous MMR or APC gene mutations further the progression of the disease. These mutations manifest as tumors existing beyond the colon, namely brain tumors in TS.

In contrast to the single allelic loss of the APC gene which results in FAP, Turcot syndrome which results in colorectal cancer and brain tumors seems to require a biallelic loss of the APC gene[2] and in the MMR genes. Cancer develops either by the loss of tumor suppressor genes, the activation of oncogenes, or both. The APC gene is a tumor suppressor gene. When it is missing, it contributes to a lack of regulation in cell division. Hence, in FAP, there is an uncontrolled development of adenomatous colonic polyps that eventually turn invasive. These polyps found in TS2 can turn invasive by 20, and by 40 years of age, most of these patients will have developed cancer if the colon is not removed.[6] TS patients that develop deadly brain tumors do not tend to live that long.[7]

The APC gene mutation starts via KRAS protooncogene point mutations. This leads to hypomethylation of DNA which leads to proto-oncogene activation. Then there is a loss of the APC alleles, which is a tumor suppressor gene. The APC gene is found on the long arm of chromosome 5. There has also been mention of loss of the DCC gene on chromosome 18q and 17p. The specific MMR genes which undergo mutation are the MLH1 and MSH2 genes, and occasionally hPMS2.[5] These genes are also involved in the pathogenesis of HNPCC, but there they are found as heterozygous mutations as opposed to homozygous mutations that lead to brain tumor development that would qualify the disease as TS.

The medulloblastomas associated with TS2 come from neural stem cell precursors containing the homozygous APC mutation in the cerebellum.[8] Glioblastomas are generally found in TS1 associated with the homozygous MMR gene mutations.[9]

History and Physical

Although there are various genotypes that can cause Turcot syndrome, the phenotype is generally the same, by definition: colorectal cancer with a primary brain tumor.[1] Adenomatous polyps present at an early age, and they can be numerous or scarce. These patients can present with diarrhea/constipation and/or a positive FOBT. Most of the time, these patients will have a family history of early onset colorectal cancer. Either before or after the polyps are found, neurological symptoms secondary to the development of a brain tumor can present.[6] This can include vision problems, auditory issues, sensorimotor deficits, among other issues, depending on the location of the tumor. Tumors can also arise from the spinal cord, manifesting with symptoms of spinal cord compression.

There is a phenotypic spectrum in TS.[4] This spectrum exists because various gene mutation combinations can be inherited that result in different phenotypes, often overlapping. The foundational presentation is colorectal cancer coupled with a primary CNS tumor.

In TS1, patients can also present with hematologic malignancies, café au lait spots, glioblastoma multiforme as a result of various MMR gene mutations. Patients with these mutations have fewer polyps in the colon although on rare occasions they can have significant polyposis as well. The converse is true for TS2. In TS2, patients can also present with epidermal cysts, tumors in other areas of the body, medulloblastoma because of a homozygous APC gene mutation. This mutation results in very significant polyposis of the colon, with polyps numbering in the thousands.

In TS2 analyses, it was found that patients who expressed the colonic polyposis phenotype tended to manifest the disease after age 17, and those that did not express the colonic phenotype manifested the disease (via brain tumor) by the age of 10.[4] It is of note however that these patients could have developed the polyposis later, but that they simply did not survive until then. This demonstrates the concept of the phenotypic spectrum. There can be different manifestations of the disease at different times.

Patients present either with glioblastoma in TS1 and medulloblastoma in TS2. Patients can also present with pituitary adenomas, ependymomas, astrocytomas in rare cases.[4] Neurological signs and symptoms arise, depending on the location of the tumor.

Patients with TS1 are children of consanguinity in 20% of cases, with no family history of brain tumors or colon cancer. It is categorized by lesser and larger polyps. It is associated with gliomas, and skin manifestations such as cafe au lait spots.[4] TS2 is less frequent and occurs typically in offspring of families with clustering of FAP. Medulloblastoma is the most common type of tumor here. The occurrence of colorectal cancer occurs later in TS2 than in TS1, and the skin lesions look more like epidermal cysts[10] rather than cafe au lait spots if present at all. Here, brain tumor can occur without polyposis, one theory is that the brain tumor just occurs much earlier than the polyposis and does not give it a chance to develop. The absence of polyposis and the absence of skin findings seem to suggest TS2 with a germ-line mutation as opposed to a somatic one.[4]

Evaluation

There is a lack of guidelines for the evaluation of patients with Turcot syndrome, in screening or diagnosis. Of greatest importance, is a family history. Children of parents, either one parent or both, who were diagnosed with colorectal cancer at an early age should certainly be monitored for pre-cancerous polyps.

The utility of genetic screening is debatable. Some argue that it should be performed on patients who are found to have pre-cancerous colorectal polyps, to detect the presence of Turcot syndrome and thus anticipate the development of a primary brain tumor and render early treatment, and vice versa. Those in favor of genetic testing refer to the preventability of death in this disease if it is anticipated. A pitfall of this kind of genetic testing is cost-effectiveness since no real statistics show many people with inherited or sporadic genetic mutations resulting in colorectal cancer develop brain tumors and even less information vice versa. Turcot syndrome can also manifest with several genotypes, making genetic testing more complex. If there is a family member identified with disease-causing mutations, then genetic testing either prenatally or during preimplantation could be beneficial.[11]

Other opinions state that the manifestation of either colorectal cancer or primary brain tumor in young age should warrant screening for the other, depending on which comes first. Again, there is little data to guide the decision to screen. In patients who have had a colectomy, there is a recommendation for upper gastrointestinal (GI) surveillance every 3 years for peri-ampullary cancer in the duodenum.[12]

Early serial colonoscopies should be a mainstay in patients with a family history of FAP, HNPCC, evidence of APC or MMR gene mutations. Screening until age 35 with proctosigmoidoscopy or testing DNA from peripheral mononuclear cells for mutation has generally been performed.[13] As far as brain tumors are concerned, screening is difficult. Imaging as frequently as once a year does not seem to be enough since medulloblastomas can arise and become fatal in as fast as six months.[14] Therefore, special attention should be made to neurologic signs and symptoms until guidelines can be established.

The goal of screening in TS, whether genetic or clinical, would be to prevent complications of the disease. Detecting genetic mutations in a patient identified with a primary brain tumor can allow for adequate screening for and thus prevention of colorectal cancer. Detecting genetic mutations in a patient with early diagnosed colorectal cancer can help us screen for primary brain tumors, allowing for early detection and treatment. Detecting these mutations in a patient with a family history, and without any disease manifestations, can allow for the prevention of any manifestations of the disease at all, which would be optimal.[11]

Since TS is very closely related to FAP and HNPCC, screening guidelines for these two diseases apply as well. The most important thing to do is recognize that there is inherited CRC in the family and that depending on the specific mutations, any of the syndromes can arise. Therefore, genetic screening can be a useful tool in the future to help prepare for the different manifestations of these various mutations, namely malignant brain tumors in the case of Turcot syndrome.[11]

Diagnosing Turcot syndrome is helpful because making correlations between brain tumors and colorectal cancer can help guide preventative action for either condition.[6] It also provides anticipatory guidance–to know and expect brain vs. colon cancer in patients that exhibit either clinical presentation; early diagnosis leads to early treatment. 

One of the most comprehensive guidelines for using a clinical presentation to diagnose patients with either TS1 or TS2 was suggested by Paraf et al. in 1997. They suggested the categorization of patients based on the presence or absence of 4 factors: (1) the phenotype of the polyps, (2) type of brain neoplasm, (3) presence of skin lesions, and (4) consanguinity.[4]

Treatment / Management

Treatment of patients with Turcot syndrome is fairly rudimentary. In the event of tumor development, surgical resection is the mainstay treatment. In patients presenting with adenomatous, precancerous colorectal polyps, especially if genetic confirmation exists, total colectomy is the conclusive way of preventing the development of colorectal cancer. In patients that develop brain tumors, surgical resection also applies. Surgery, chemotherapy, and occasionally radiation therapy have all been used in the treatment of patients with TS.

Otherwise, there is no way developed to reverse inherited genetic mutations. Therefore, treatment targeting Turcot syndrome is largely preventative or defensive.[13] There has been a suggestion that the development of Turcot syndrome in patients with either HNPCC or FAP may be a result of environmental factors inciting mutations in additional loci.[4] Future research may shed light on what these additional mutations may be or the environmental factors that may cause them.

Differential Diagnosis

Since Turcot syndrome can present first with either polyposis of the colon or primary brain tumor, the differential list depends upon what presents first. Polyposis of the colon can be familial adenomatous polyposis (FAP), fewer precancerous polyps present at an early age can be hereditary nonpolyposis colorectal cancer (HNPCC). Mutations of the APC gene can sometimes present with cafe au lait spots, which may resemble the neurofibromatosis syndromes.[14] Colorectal cancer besides a brain tumor may not be the whole picture; patients may continue to develop tumors, especially hematologic malignancies, which could categorize them as having constitutional mismatch repair deficiency syndrome (CMMRDS).[5]

Prognosis

Much of the information about the prognosis of TS has been gained from analyses of reported cases. The overall survival for children with medulloblastoma alone with treatment is 52% at 10 years.[15] In patients with APC mutations or TS2, 7 of 8 patients who died in a familial analysis done by Hamilton et al. died because of a brain tumor.[2]

Since there are several deadly comorbidities in TS, the prognosis depends on the disease presentation. One case report describes a patient with glioblastoma multiforme early in life that was resected and radiated who subsequently developed adenocarcinoma of the colon. The patient survived into his 60s.[16]

Patients who develop any malignancy that metastasizes have a poor prognosis. Inherited MMR or APC mutations cause CRC 70% to 100% of the time if no treatment or prevention is applied.

Prognosis may be worse in those patients that present with both CNS tumor, specifically, glioma, and CRC. The development of glioblastoma multiforme seems to render TS patients the worst prognosis, with an average survival being 27 months.[17]

Also of note, FAP patients who undergo a prophylactic colectomy most frequently end up dying because of duodenal cancer, usually located in the peri-ampullary region of the duodenum.[18]

Consultations

Turcot syndrome is an oncology syndrome. The genes involved are oncogenes and/or tumor suppressor genes. These mutations result in various malignancies of which colorectal cancers are most well-known. Interprofessional evaluation is necessary for optimal outcomes. This includes expertise management from geneticists, gastroenterologists, colorectal surgeons, neurosurgeons, radiation oncologists, and medical oncologists.

Deterrence and Patient Education

Individuals with known disease should be educated about the inheritance patterns of the disease. This guides patients to make informed decisions about having children. Parents with known disease should be educated about the possibility of existing children manifesting the disease. Therefore, they should follow closely with their doctors for colon, brain, or other cancer screening.[12] Patients found to have early onset colorectal cancer or polyposis evidencing FAP, HNPCC, or other, should be educated about the genetics and pathogeneses of the diseases, and the potential for tumors and cancers to arise at diverse sites.[5][14]

Enhancing Healthcare Team Outcomes

Heightened levels of interprofessional communication are of utmost importance in the care of patients with TS. As mentioned in the consultations section above, this severe cancer-predisposing condition involves many organ systems and thus many specialists. Screening and treatment guidelines have been developed mostly by Level V evidence. Therefore, having each specialist communicate about its choice of screening and treatment plans allows for a coherent plan of action, without placing an unnecessary burden on the patient. These patients are young, so communication with the patient and parents is imperative. Having organized plans of action that are coordinated in an interprofessional fashion will allow for greater compliance and better outcomes for the patient.


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Turcot Syndrome - Questions

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What is the major difference between familial polyposis coli and Turcot syndrome?



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Turcot syndrome type 1, also known as brain tumor-polyposis syndrome type 1, most commonly is associated with which type of brain tumor?



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A 9-year-old girl presents to the hospital with low back pain, incontinence, and perianal numbness. Her 20-year-old brother just had four polyps removed from his colon that were malignant. Their parents are third cousins, although they are both healthy. Which kind of testing would confirm the diagnosis?



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A 15-year-old male is found to have medulloblastoma with significant polyposis of the colon. What is the most likely genotype for this presentation?



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A 17-year-old female presents with significant polyposis of the colon. Her parents are both healthy, but she has an extended family history of early-onset colon cancer. Genetic testing is positive for heterozygous APC gene mutation. She is diagnosed with familial adenomatous polyposis and undergoes a total colectomy. What is the most important screening modality for this patient going forward?



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Turcot Syndrome - References

References

Hamilton SR,Liu B,Parsons RE,Papadopoulos N,Jen J,Powell SM,Krush AJ,Berk T,Cohen Z,Tetu B, The molecular basis of Turcot's syndrome. The New England journal of medicine. 1995 Mar 30     [PubMed]
TURCOT J,DESPRES JP,ST PIERRE F, Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases. Diseases of the colon and rectum. 1959 Sep-Oct     [PubMed]
Paraf F,Jothy S,Van Meir EG, Brain tumor-polyposis syndrome: two genetic diseases? Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1997 Jul     [PubMed]
Haggar FA,Boushey RP, Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinics in colon and rectal surgery. 2009 Nov     [PubMed]
Ramachandra C,Challa VR,Shetty R, Constitutional mismatch repair deficiency syndrome: Do we know it? Indian journal of human genetics. 2014 Apr     [PubMed]
Gorovoy IR,de Alba Campomanes A, A potential life-saving diagnosis--recognizing Turcot syndrome. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 2014 Apr     [PubMed]
Fritch Lilla SA,Yi JS,Hall BA,Moertel CL, A novel APC gene mutation associated with a severe phenotype in a patient with Turcot syndrome. Journal of pediatric hematology/oncology. 2014 Apr     [PubMed]
Lusis EA,Travers S,Jost SC,Perry A, Glioblastomas with giant cell and sarcomatous features in patients with Turcot syndrome type 1: a clinicopathological study of 3 cases. Neurosurgery. 2010 Sep     [PubMed]
Bruwer Z,Algar U,Vorster A,Fieggen K,Davidson A,Goldberg P,Wainwright H,Ramesar R, Predictive genetic testing in children: constitutional mismatch repair deficiency cancer predisposing syndrome. Journal of genetic counseling. 2014 Apr     [PubMed]
Groen EJ,Roos A,Muntinghe FL,Enting RH,de Vries J,Kleibeuker JH,Witjes MJ,Links TP,van Beek AP, Extra-intestinal manifestations of familial adenomatous polyposis. Annals of surgical oncology. 2008 Sep     [PubMed]
Stoffel EM,Mangu PB,Gruber SB,Hamilton SR,Kalady MF,Lau MW,Lu KH,Roach N,Limburg PJ, Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Jan 10     [PubMed]
Durno C,Boland CR,Cohen S,Dominitz JA,Giardiello FM,Johnson DA,Kaltenbach T,Levin TR,Lieberman D,Robertson DJ,Rex DK, Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017 May     [PubMed]
Crawford JR,MacDonald TJ,Packer RJ, Medulloblastoma in childhood: new biological advances. The Lancet. Neurology. 2007 Dec     [PubMed]
Stavrou T,Bromley CM,Nicholson HS,Byrne J,Packer RJ,Goldstein AM,Reaman GH, Prognostic factors and secondary malignancies in childhood medulloblastoma. Journal of pediatric hematology/oncology. 2001 Oct     [PubMed]
Rutz HP,de Tribolet N,Calmes JM,Chapuis G, Long-time survival of a patient with glioblastoma and Turcot's syndrome. Case report. Journal of neurosurgery. 1991 May     [PubMed]
Dipro S,Al-Otaibi F,Alzahrani A,Ulhaq A,Al Shail E, Turcot syndrome: a synchronous clinical presentation of glioblastoma multiforme and adenocarcinoma of the colon. Case reports in oncological medicine. 2012     [PubMed]
Bisgaard ML,Bülow S, Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts. American journal of medical genetics. Part A. 2006 Feb 1     [PubMed]
Trimbath JD,Griffin C,Romans K,Giardiello FM, Attenuated familial adenomatous polyposis presenting as ampullary adenocarcinoma. Gut. 2003 Jun     [PubMed]

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