Telogen Effluvium


Article Author:
Elizabeth Hughes


Article Editor:
Dahlia Saleh


Editors In Chief:
Melissa Max
Danyae Lee
Manouchkathe Cassagnol


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Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
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Saad Nazir
William Gossman
Hassam Zulfiqar
Steve Bhimji
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Nazia Sadiq
Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
7/3/2019 11:04:26 PM

Introduction

Telogen effluvium is a form of nonscarring alopecia characterized by diffuse, often acute hair shedding.[1][2][3][4][5]

Etiology

Telogen effluvium is a reactive process, triggered by metabolic stress, hormonal changes, or medications. Common triggering events are acute febrile illness; severe infection; major surgery; severe trauma; postpartum hormonal changes, particularly a decrease in estrogen; hypothyroidism; discontinuing estrogen-containing medication; crash dieting; low protein intake; heavy metal ingestion; and iron deficiency. Many medications have been linked to telogen effluvium, but the most common are beta-blockers, retinoids (including excess vitamin A), anticoagulants, propylthiouracil, carbamazepine, and immunizations.

Epidemiology

Telogen effluvium can occur in people of any age, any gender, and any racial background. The exact prevalence of telogen effluvium is not known, but it is considered to be quite common. A large percentage of adults experience an episode of telogen effluvium at some point. Telogen effluvium can occur in either sex, though women have a greater tendency to experience this condition because of postpartum hormonal changes. Also, women are more disturbed by hair shedding than men and are therefore more likely to seek medical attention. [6][7][8][9]

Pathophysiology

Telogen effluvium is triggered when a physiologic stress causes a large number of hairs in the growing phase of the hair cycle (anagen) to abruptly enter the resting phase (telogen). The growth of the telogen hairs ceases for 1 to 6 months (on average 3 months), though this cessation of growth is not noticed by the patient. When the hairs reenter the growth phase (anagen), the hairs which had been suspended in the resting phase (telogen) are extruded from the follicle, and hair shedding is observed.

Histopathology

Histologic findings in telogen effluvium are best seen in transverse sections of a punch biopsy. 

  • The number and density of hair follicles is usually normal, but there is an increased percentage of the hair follicles that are in the categen or the telogen phase. 
  • If 25% of the follicles are in telogen phase, the diagnosis of telogen effluvium is confirmed. 
  • The percentage of telogen hairs should not typically be higher than 50%.

History and Physical

Patients will report hair shedding, usually without other symptoms, with a relatively abrupt onset. By definition, in acute telogen effluvium, shedding lasts less than six months; often the period of shedding is much shorter. A careful history will identify a causative event (see etiology section) occurring approximately 3 months before the onset of the shedding (range from 1 to 6 months). Quite often the patient has fully recovered from the acute illness and fails to see the connection between the illness with the hair loss.

The physical examination is grossly normal, as it is difficult for the casual observer to appreciate the loss of hair volume. It can be helpful to compare the patient's current appearance with old pictures. If the patient presents during the acute shedding, a gentle pull test yields at least four hairs removed with each pull. However, if the patient presents after the acute shedding has passed, the pull test may be normal. Careful examination of the scalp will show an increased percentage of short anagen hairs growing close to the scalp.

Evaluation

Usually, a careful history and physical examination are sufficient to diagnose telogen effluvium. Biopsy, if taken during the acute shedding phase (when the pull test is positive), can confirm an increase in the percentage of telogen hairs. If there is a concern for a hormonal condition (such as hypothyroidism), a chronic metabolic illness, or iron deficiency, testing for these conditions is indicated.[10][11]

Laboratory Testing

Chronic telogen effluvium sometimes has a metabolic cause. 

  • Hypothyroidism
  • If symptoms of hypothyroidism are present, a thyrotropin test is warranted. 

Iron Deficiency

  • Iron deficiency should be evaluated with a CBC count, serum iron, iron saturation, and ferritin. 
  • Blood is more important to survival than hair, so the body will shed hair before red cell indices become microcytic. 
  • Ferritin behaves as an acute phase reactant, and inflammation can result in normal ferritin levels in an individual who is iron deficient. 
  • A low ferritin confirms iron deficiency; a normal ferritin level does not exclude iron deficiency. 
  • Iron saturation is the most sensitive indicator of iron deficiency.

Syphilis

  • If syphilis is considered as a cause, a rapid plasma reagin or VDRL test should be performed.

Biopsy

  • Scalp biopsy is the most useful test to confirm the diagnosis, but it is seldom necessary if gentle hair pull produces numerous telogen hairs.
  • Telogen hairs can be identified by a white bulb and no gelatinous hair sheath.
  • If a patient is unwilling to allow a scalp biopsy, serial hair collections can be obtained. 
  • The patient should be instructed to collect all shedding hair in a 24-hour period. The patient should avoid washing the hair during the collection. This process should be repeated every week for a total of 3 or 4 collections.
  • Collecting 100 hairs or more hairs in a 24-hour period suggests telogen effluvium. If the collections are performed over several weeks while the telogen effluvium is improving, the number of hairs collected may decrease. 

Treatment / Management

Acute telogen effluvium is a self-limited condition. If the causative event is identified by history and has been adequately treated, there is no further treatment required. If a hormonal or dietary imbalance or metabolic illness is present, hair growth will return after these factors are corrected. If a medication is the cause of the shedding, hair growth will restart after the medication is withdrawn. 

Hair transplantation has no role in the treatment of telogen effluvium.

While topical minoxidil has not been proven to promote recovery of hair in telogen effluvium, it has theoretical benefit. Patients who wish to take an active role in their treatment may choose to use minoxidil.

Differential Diagnosis

The differential diagnoses includes:

  • Alopecia Areata
  • Anagen Effluvium
  • Androgenetic Alopecia
  • Scarring Alopecia
  • Syphilis
  • Trichotillomania

Prognosis

Morbidity is generally limited to mild cosmetic changes which are mild. Mortality has not been reported.

  • Telogen effluvium has a major impact on those affected by the disease. 
  • Prognosis for a good recovery of hair density occurs acute telogen effluvium.
  • A good cosmetic outcome is also expected in chronic telogen effluvium, even if the hair shedding continues.

Pearls and Other Issues

It may take up to 6 months for hair growth to restart, and even longer for the growth to be appreciable by the patient. Patients often require reassurance of the normal recovery of their hair while the hair reenters anagen and grows normally. Patients may also worry that normal grooming of their hair worsens the hair shedding. Patients should be reassured that their hair is normal and that they can wash and style their hair as usual.

Enhancing Healthcare Team Outcomes

The diagnosis and management of hair loss is with a multidisciplinary team that includes a dermatologist, primary care provider, nurse practitioner, and an internist. One type of hair loss is Telogen effluvium, which is a form of nonscarring alopecia characterized by diffuse, often acute hair shedding. In most cases, no cause is ever found. In any case, patients need to be educated that the condition is self-limiting. There is no need to prescribe hair growth medications or refer the patient for a hair transplant. The hair growth will return but it may take a few months or even a year. For most patients, the outcome is good. [12][13](Level V)

 

 


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Telogen Effluvium - Questions

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Hair loss associated with stressful condition is called:



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What should be done for a postpartal woman who complains of significant hair loss?



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A female patient presents with concern about hair loss. She reports volume loss and more hair on her pillow and in the shower drain. Exam shows no discrete areas of alopecia, but 25 hairs pull out easily. Which of the following is correct?



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Which of the following tests should be done in a patient with telogen effluvium?



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How long does it take for alopecia associated with telogen effluvium to fully recover?



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A new patient presents complaining of hair loss. There is diffuse thinning of the hair, and when the hair is pulled, it comes out easily. More than 50% of the hairs are in the telogen stage. Which diagnosis is highest on the differential?



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Telogen Effluvium - References

References

Nistico S,Tamburi F,Bennardo L,Dastoli S,Schipani G,Caro G,Fortuna MC,Rossi A, Treatment of telogen effluvium using a dietary supplement containing Boswellia serrata, Curcuma longa, and Vitis vinifera: Results of an observational study. Dermatologic therapy. 2019 Jan 28;     [PubMed]
Sari Aslani F,Heidari Esfahani M,Sepaskhah M, Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts. Iranian journal of pathology. 2018 Summer;     [PubMed]
Sahin G,Pancar GS,Kalkan G, New pattern hair loss in young Turkish women; What's wrong in their daily life? Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2019 Jan 5;     [PubMed]
Stoehr JR,Choi JN,Colavincenzo M,Vanderweil S, Off-Label Use of Topical Minoxidil in Alopecia: A Review. American journal of clinical dermatology. 2019 Jan 2;     [PubMed]
Daly T,Daly K, Telogen Effluvium With Dysesthesia (TED) Has Lower B12 Levels and May Respond to B12 Supplementation Journal of drugs in dermatology : JDD. 2018 Nov 1;     [PubMed]
Sant'Anna Addor FA,Donato LC,Melo CSA, Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium. Clinical, cosmetic and investigational dermatology. 2018;     [PubMed]
Udompanich S,Chanprapaph K,Suchonwanit P, Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus. American journal of clinical dermatology. 2018 Oct;     [PubMed]
Saleh D,Cook C, Anagen Effluvium 2018 Jan;     [PubMed]
Motosko CC,Bieber AK,Pomeranz MK,Stein JA,Martires KJ, Physiologic changes of pregnancy: A review of the literature. International journal of women's dermatology. 2017 Dec;     [PubMed]
Mirallas O,Grimalt R, The Postpartum Telogen Effluvium Fallacy. Skin appendage disorders. 2016 May;     [PubMed]
Malkud S, Telogen Effluvium: A Review. Journal of clinical and diagnostic research : JCDR. 2015 Sep;     [PubMed]
Mubki T,Rudnicka L,Olszewska M,Shapiro J, Evaluation and diagnosis of the hair loss patient: part I. History and clinical examination. Journal of the American Academy of Dermatology. 2014 Sep;     [PubMed]
Hamm H, [Acquired alopecia in childhood]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 2013 May;     [PubMed]

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