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Sandeep Sekhon

6/1/2019 4:51:36 PM


An arterial pseudoaneurysm, AKA false aneurysm, is caused by damage to the arterial wall, resulting in locally contained hematoma with turbulent blood flow and a neck that typically does not close spontaneously once past a certain size. Unlike a true aneurysm, a pseudoaneurysm does not contain any layer of the vessel wall.  Instead, there is blood containment by a wall developed with the products of the clotting cascade.  Eventually, a wall forms from fibrin/platelet crosslinks that is ultimately weaker than those of a true aneurysm. The most common clinical presentation of a pseudoaneurysm is a femoral pseudoaneurysm following access for endovascular procedures. Other less common presentations include visceral pseudoaneurysms and aortic pseudoaneurysms.  This article will focus on these three entities.


  • The most common cause of femoral pseudoaneurysm is iatrogenic.  Iatrogenic causes include:
  • Arterial access for endovascular procedures (<1% incidence)
  • Anastomotic failure

Non-iatrogenic causes include:

  • Trauma
  • Infection
  • Pancreatitis with pseudocyst/pancreatic fistula 

Visceral artery pseudoaneurysms can occur with catheter-based interventions and are also associated with pancreatitis and pseudocysts. 

Aortic pseudoaneurysms are often the result of blunt or penetrating trauma, infection, atherosclerotic penetrating/degenerative lesions and at anastomotic sites following vascular bypass or repair.


Femoral pseudoaneurysms typically result from access for catheter-based interventions and carry an incidence of 0.6 to 4.8%.[1] With the increasing use of ultrasound for access, some society guidelines quote that the acceptable rate of pseudoaneurysm after percutaneous access should be less than 0.2%.[2]

Visceral artery pseudoaneurysms are associated with chronic pancreatitis.[3]  Splenic artery pseudoaneurysms were most common but least likely to rupture. 

Aortic pseudoaneurysms are often the result of trauma or penetrating aortic lesions. Of those with aortic injuries secondary to blunt trauma, an estimated 85% die before reaching medical care.  90% of blunt thoracic aortic injuries occur just distal to the aortic isthmus and are a result of deceleration injury from tethering to the ligamentum arteriosum [4]. Aortic pseudoaneurysm is considered a grade III aortic injury, now most commonly treated with TEVAR rather than open surgery [5]. Rarely, the cause of thoracic aortic pseudoaneurysms is advanced tuberculosis.[6] Research quotes pseudoaneurysms following aortobifemoral bypass at 3.8% in one 11-year series.[7]


Femoral pseudoaneurysms after percutaneous access can occur due to[8]:

  • Failures of closure devices
  • Laceration of the artery or branches of the common femoral artery by access needle
  • Inadequate pressure or length of time holding pressure post-procedure
  • Inadvertent access and/or dilation of the artery during venous procedures

Femoral graft anastomosis can also break down over time due to suture failure, or likely more commonly due to infection of the graft material.

Visceral pseudoaneurysms are very rare and are related to iatrogenic injury from surgery or endovascular procedures, or pancreatitis, which typically presents as a splenic artery pseudoaneurysm, which is due to the digestive action of pancreatic enzymes on the artery.[9] Unlike true aneurysms, visceral pseudoaneurysms appear in myriad locations.  One study found the distribution of visceral artery pseudoaneurysms to be: celiac axis and branches 39%, hepatic 39%, splenic 18%, and SMA 4%.[10]

Aortic pseudoaneurysms due to blunt trauma are theorized to be caused in large part by deceleration forces between the relatively free aortic arch against the relatively fixed descending aorta, especially at the point where the ligamentum arteriosum anchors the aorta to the pulmonary artery. This fact, in combination with the pinching effect between the sternum and the spine, and the water hammer effect caused by squeeze forces can cause partial to total rupture of the thoracic aorta.[4]

History and Physical

Typically, an iatrogenic femoral pseudoaneurysm presents as a painful, pulsatile mass.  The mass will frequently exhibit a bruit on auscultation.  If there is an arterio-venous fistula, the bruit may demonstrate a to-and-fro quality.  Enlarging pseudoaneurysms may exhibit pressure on the skin with pain with ultimately skin ischemia, necrosis, and hemorrhage.  Thrombus that forms within the sac may embolize distally.

Most visceral artery pseudoaneurysms (91%) present with symptoms of rupture.[11] Historically this was termed abdominal apoplexy.

Aortic and femoral pseudoaneurysms are rarely spontaneous.  Mycotic pseudoaneurysms are typically the result of repeated IV drug use.[12] Repair of these can be challenging, given the paucity of usable veins for conduit in drug abusers as well as grossly infected fields.


A full history and physical exam are necessary.  Most cases of femoral pseudoaneurysm are iatrogenic.  Physical exam findings of a pulsatile mass in the groin carries a 92% sensitivity and 93% specificity in the diagnosis of a femoral pseudoaneurysm.[13] Duplex ultrasonography remains the gold standard for diagnosis, as it can also evaluate for size, anatomy, and origin of pseudoaneurysms.  A CTA helps define the relation to surrounding structures, though this exam is unnecessary in straight forward cases. Understanding the characteristics of the pseudoaneurysm helps guide treatment

Visceral pseudoaneurysms can present with signs of bleeding and abdominal pain.  CT angiography or conventional angiography can help characterize the lesion. 

The diagnosis of aortic pseudoaneurysms is most commonly via CTA or conventional arteriography. They may have a history of previous open repair of dissection or aneurysm, blunt or penetrating trauma, infection, or genetic disorders which predispose to aneurysmal degeneration of the aorta such as Marfan syndrome or Ehlers-Danlos syndrome.

Treatment / Management

Femoral artery pseudoaneurysms caused by endovascular access used to be treated exclusively by surgical means, but in the last few decades, the paradigm has shifted to less invasive measures. Options for management include observation, ultrasound-guided compression, ultrasound-guided thrombin injection, and surgical repair — the characteristics of the false aneurysm guide treatment choice.

Femoral artery aneurysms less than 2 to 3 cm in diameter may undergo spontaneous thrombosis and regression with observation.  Those that are larger rarely spontaneously thrombose, though this is not an absolute rule.[14]

Ultrasound-guided thrombin injection is a well-established, minimally invasive method for treating pseudoaneurysms that are accessible. Several studies have reported a very high success rate (97% to 100%) for femoral pseudoaneurysms with a single treatment, even while patients are on anticoagulants and/or antiplatelet agents.[15] Risks of the procedure include embolization and PE, with a shorter aneurysm neck length correlating to a higher risk of embolic complication, with those with a less than 2 mm neck being at the highest risk. Overall, complications are very rare.  Ultrasound-guided thrombin injection is not recommended for pseudoaneurysms under 1 cm due to the theoretical risk of arterial embolization, though these can safely undergo an attempt at ultrasound-guided compression.[2]

Surgical management of femoral pseudoaneurysm is reserved for those who fail at least one unsuccessful duplex-guided compression or thrombin injection,[1] or for those with anastomotic disruptions. If surgical repair is required, blood should be typed and crossed, and available as inadvertent entry into the pseudoaneurysm before achieving proximal and distal control can result in massive bleeding.

Visceral artery pseudoaneurysms are typically treated by endovascular means first, with surgery reserved for failure; this is highly effective, with one study reporting a 98% success rate in control of pseudoaneurysms and ruptured true aneurysms.[11] Techniques include coiling, injections of procoagulant materials, and covered stent deployment to seal the origin of the pseudoaneurysm.

Aortic pseudoaneurysms are now preferably treated with TEVAR/EVAR.[16] Even in cases of mycotic pseudoaneurysm and tuberculous pseudoaneurysm of the aorta, prosthetic stent grafts can be lifesaving and avoid the need for a large open operation in already debilitated patients.[6]

Differential Diagnosis

Differential diagnosis of a femoral pseudoaneurysm includes:

  • Hematoma
  • Seroma
  • Infection/abscess


Conservative management of femoral pseudoaneurysms has higher rates of failure in the setting of dual antiplatelet therapy, but not for those receiving thrombin injection.[1] Ultrasound-guided thrombin injection for femoral pseudoaneurysms caused by vascular access has a high success rate (up to 97% to 100%), even in those taking anticoagulants or antiplatelet agents.  Those that fail can undergo a second attempt, and very few should require surgical correction.[2]

Though not studied well, endovascular repair of visceral pseudoaneurysm carries a high rate of technical success in small series.  Open repair/ligation is considered more durable, however, and may be a better option for younger patients.[3]

Traumatic aortic pseudoaneurysms treated via TEVAR have an excellent technical success rate (100%) with a low rate of device-related complications (2.4%) and conversion to open (2.4%).  Coverage of the left subclavian artery resulted in a 6% rate of delayed revascularization.[17]


Femoral pseudoaneurysms can rupture into the retroperitoneal space, causing significant bleeding that may not be immediately obvious, which can lead to death.

Complications of ultrasound-guided thrombin injection include distal embolization in up to 2% of patients, though few require any intervention.[18]

Complications of endovascular repair of visceral and aortic pseudoaneurysms are primarily those related to endovascular devices in general and will not be discussed in depth here.

Postoperative and Rehabilitation Care

Open repair of femoral pseudoaneurysms requires no special post-op care above normal care of vascular patients, and the need for rehabilitation is largely predicated on the patient’s overall condition prior to intervention.

Endovascular repair of pseudoaneurysms is generally well-tolerated, and the patient should remain flat for 2 to 4 hours post-procedure with monitoring for the development of subsequent access site pseudoaneurysm.  Repairs that involve the deployment of stent/graft devices will require long term follow-up with a vascular surgeon for surveillance imaging.


A vascular surgeon consultation is necessary for all pseudoaneurysms.  A vascular surgeon or interventional radiologist can perform ultrasound-guided compression and thrombin injection, but only a vascular surgeon can treat femoral artery pseudoaneurysms that require surgery.

Deterrence and Patient Education

There are no specific recommendations for deterrence for pseudoaneurysms.  The patient should be made aware of the signs and symptoms of recurrence.

Pearls and Other Issues

Femoral pseudoaneurysm after vascular access is a common problem and are addressable with via less invasive means than open surgery.  Pseudoaneurysms that occur at vascular anastomosis mandate open repair and revision.  Visceral pseudoaneurysms are uncommon, and diagnosis of these is often during an investigation for vague symptoms of abdominal pain, or with CTA imaging with signs of bleeding.  Aortic pseudoaneurysms are rarely spontaneous and result either from infection or trauma.

Enhancing Healthcare Team Outcomes

Management of pseudoaneurysm depends on its etiology and location.  Nurses and physicians should routinely palpate the groin area after patients undergo cardiac catheterization, as pseudoaneurysms are not uncommon. A femoral pseudoaneurysm can be treated by the vascular surgeon or by interventional radiology with thrombin injection depending on local practice patterns.  Endovascular repair of visceral artery pseudoaneurysms may be performed by a vascular surgeon or interventional radiologist as well.  Aortic pseudoaneurysms are typically the domain of the vascular surgeon as there is a possible need for open repair and subsequent follow-up. Only the vascular surgeon can perform open repairs of all types of pseudoaneurysms.


Management of pseudoaneurysms requires an interprofessional team approach, including physicians, specialists, and specialty-trained nurses all collaborating across disciplines to achieve optimal patient results. [Level V]

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Pseudoaneurysm - Questions

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A 35-year-old relatively healthy man was involved in a high-speed single car motor vehicle collision. He was the restrained driver; airbags did deploy. His passenger died at the scene. He was brought to the hospital for evaluation. A physical exam and CT head and neck, chest, abdomen, and pelvis revealed a fractured sternum, multiple rib fractures, a small left-sided hemothorax, free fluid and a small amount of free air in the abdomen, and a 2.5 cm pseudoaneurysm at the aortic isthmus. Labs are significant for a hemoglobin of 7.6 g/dL, creatinine of 1.3 mg/dL, and lactate of 3.4 mg/dL. What is the next step in treatment?

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A 56-year-old man with a history of alcohol use disorder and recurrent bouts of pancreatitis presents with severe abdominal pain, hypotension, and tachycardia. Lipase is elevated over 1000 U/L. White blood cell count is 14,000/microL, and hemoglobin is 6.5 g/dL. He is cachectic appearing and pale. He has tenderness to palpation in the epigastrium. His last admission for pancreatitis was two weeks ago, and at that time he had a CT scan without contrast that was concerning for a small peripancreatic fluid collection which may represent a developing pseudocyst. He denies any bloody emesis or hematochezia. What should be done next?

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A 73-year-old man who is on aspirin and clopidogrel underwent a left heart catheterization 7 days ago presents with a groin mass that has been growing slowly over the last 4 days. The mass is moderate in size, slightly tender without any overlying skin changes, and has a palpable pulsatility. Groin duplex ultrasound which confirms a 3 cm pseudoaneurysm with its origin at the proximal deep femoral artery (profunda). What success rate should be quoted for the procedure recommended?

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A 74-year-old patient who is well known to the practice presents with a 4-month history of left groin swelling. He is a vasculopath and has previously undergone a left to right femoral-femoral bypass for right-sided iliac occlusive disease ten years ago. He states that the mass is not painful but has been growing steadily in size. On examination, there is a roughly 4 cm pulsatile mass in the left groin. It is not tender, and there are no skin changes. A duplex arterial ultrasound of the right groin confirms a 4 cm mass with turbulent flow and a “ying-yang” sign in the left groin at the proximal graft anastomosis and a patent and a functioning femoral-femoral bypass with no surrounding fluid. He is experiencing no fever, chills, or erythema. He is not experiencing any symptoms of claudication or embolization. What is the next step?

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A 65-year-old male presents to the office complaining of pain and swelling in his left groin. He recently underwent cardiac catheterization thru the left groin two weeks ago. Physical examination shows a large pulsatile mass in the left groin, and there are overlying skin changes on the mass. Which of the following is the next best step in the management of this patient?

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Pseudoaneurysm - References


Stone PA,Campbell JE,AbuRahma AF, Femoral pseudoaneurysms after percutaneous access. Journal of vascular surgery. 2014 Nov;     [PubMed]
Regus S,Lang W, Rupture Risk and Etiology of Visceral Artery Aneurysms and Pseudoaneurysms: A Single-Center Experience. Vascular and endovascular surgery. 2016 Jan;     [PubMed]
Stone PA,Martinez M,Thompson SN,Masinter D,Campbell JE,Campbell Ii JR,AbuRahma AF, Ten-Year Experience of Vascular Surgeon Management of Iatrogenic Pseudoaneurysms: Do Anticoagulant and/or Antiplatelet Medications Matter? Annals of vascular surgery. 2016 Jan;     [PubMed]
Creasy JD,Chiles C,Routh WD,Dyer RB, Overview of traumatic injury of the thoracic aorta. Radiographics : a review publication of the Radiological Society of North America, Inc. 1997 Jan-Feb;     [PubMed]
Azizzadeh A,Keyhani K,Miller CC 3rd,Coogan SM,Safi HJ,Estrera AL, Blunt traumatic aortic injury: initial experience with endovascular repair. Journal of vascular surgery. 2009 Jun;     [PubMed]
Dogan S,Memis A,Kale A,Buket S, Endovascular stent graft placement in the treatment of ruptured tuberculous pseudoaneurysm of the descending thoracic aorta: case report and review of the literature. Cardiovascular and interventional radiology. 2009 May;     [PubMed]
Littooy FN,Steffan G,Steinam S,Saletta C,Greisler HP, An 11-year experience with aortofemoral bypass grafting. Cardiovascular surgery (London, England). 1993 Jun;     [PubMed]
Azmoon S,Pucillo AL,Aronow WS,Ebrahimi R,Vozzolo J,Rajdev A,Kalapatapu K,Ro JH,Hjemdahl-Monsen C, Vascular complications after percutaneous coronary intervention following hemostasis with the Mynx vascular closure device versus the AngioSeal vascular closure device. The Journal of invasive cardiology. 2010 Apr;     [PubMed]
Martins A,Gonçalves Á,Passos P,Cardoso M,Torres R,Almeida T,Midões A, Splenic Artery Pseudoaneurysm. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2018 Jul;     [PubMed]
Tulsyan N,Kashyap VS,Greenberg RK,Sarac TP,Clair DG,Pierce G,Ouriel K, The endovascular management of visceral artery aneurysms and pseudoaneurysms. Journal of vascular surgery. 2007 Feb;     [PubMed]
Etezadi V,Gandhi RT,Benenati JF,Rochon P,Gordon M,Benenati MJ,Alehashemi S,Katzen BT,Geisbüsch P, Endovascular treatment of visceral and renal artery aneurysms. Journal of vascular and interventional radiology : JVIR. 2011 Sep;     [PubMed]
Jayaraman S,Richardson D,Conrad M,Eichler C,Schecter W, Mycotic pseudoaneurysms due to injection drug use: a ten-year experience. Annals of vascular surgery. 2012 Aug;     [PubMed]
Kent KC,McArdle CR,Kennedy B,Baim DS,Anninos E,Skillman JJ, Accuracy of clinical examination in the evaluation of femoral false aneurysm and arteriovenous fistula. Cardiovascular surgery (London, England). 1993 Oct;     [PubMed]
Schneider C,Malisius R,Küchler R,Lampe F,Krause K,Bahlmann E,Kuck KH, A prospective study on ultrasound-guided percutaneous thrombin injection for treatment of iatrogenic post-catheterisation femoral pseudoaneurysms. International journal of cardiology. 2009 Jan 24;     [PubMed]
Kent KC,McArdle CR,Kennedy B,Baim DS,Anninos E,Skillman JJ, A prospective study of the clinical outcome of femoral pseudoaneurysms and arteriovenous fistulas induced by arterial puncture. Journal of vascular surgery. 1993 Jan;     [PubMed]
Kim CS,Choi YH,So YH,Choi JS, A Spontaneous Abdominal Aortic Pseudoaneurysm Treated with N-butyl Cyanoacrylate and Coil Embolization: A Case Report. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2018 Feb 20;     [PubMed]
Azizzadeh A,Ray HM,Dubose JJ,Charlton-Ouw KM,Miller CC,Coogan SM,Safi HJ,Estrera AL, Outcomes of endovascular repair for patients with blunt traumatic aortic injury. The journal of trauma and acute care surgery. 2014 Feb;     [PubMed]
Morgan R,Belli AM, Current treatment methods for postcatheterization pseudoaneurysms. Journal of vascular and interventional radiology : JVIR. 2003 Jun;     [PubMed]


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