Vein Obstruction


Article Author:
Corrine Packer
Scott Bickel


Article Editor:
Jeffery Dattilo


Editors In Chief:
Kranthi Sitammagari
Mayank Singhal


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
8/13/2019 3:09:06 PM

Introduction

The circulatory system can be divided based on blood vessels types. The venous system comprises blood vessels which carry blood from tissue and organs allowing a return to the heart. The majority of veins carry deoxygenated blood with the exceptions of the umbilical vein which is patent during fetal development, growth and closes after birth and the pulmonary vein. The 3 layers which constitute the structure of a vein are the outer connective tissue layer (tunica adventitia or tunica externa); the middle smooth muscle layer (tunica media); and the inner endothelial cell layer (tunica intima). The middle, smooth muscle layer is less muscular in veins compared to arteries allowing for increased capacitance; however, valves are needed to provide unidirectional flow.

Venous obstruction is partial or complete occlusion of the lumen and can be related to decreased flow and increased pooling. The most commonly seen is a deep vein thrombosis in the lower extremities — venous stasis results in increased viscosity and the formation of microthrombi. This is due to any factor which slows or obstructs the flow of venous blood. One of the most common causes is endothelial (intimal) damage secondary to intrinsic or secondary to external trauma. In a hypercoagulable state, a biochemical imbalance between procoagulant and anticoagulant factors occur. Chronic venous insufficiency is a manifestation of decreased vein wall contractility and vein valve dysfunction.

Other areas affected by venous obstruction include portal vein obstruction which is primary thrombosis of the portal vein.

Etiology

Venous thromboembolism (VTE) is a multifactorial disorder which can be due to inherited or acquired risk factors.

  • Inherited: Factor V Leiden is the most common condition. This condition might not cause blood clots on its own, only when combined with 1 or more other risk factors.[1]
  • Prolonged immobilization: Decreased activity of the soleus pump increase the risk of stasis and lead to thromboembolism formation. This is seen after prolonged bed rest, long plane flights, and intensive care unite (ICU) hospitalizations.
  • Direct or indirect injury to veins or from surgical procedures can increase the risk of clot formation.
  • Pregnancy can increase the risk by 2 mechanisms: Increase hypercoagulability as the concentration of clotting factors are affected these include fibrinogen, which can rise 3-times its normal value, thrombin levels increase, and Protein S, an anticoagulant, decreases.[2]
  • Birth control pills (oral contraceptives) or hormone replacement therapy: Oral contraceptives cause significant increases in fibrinogen levels.[3]
  • Obesity has been shown to be associated with an increased risk of venous thromboembolism.[4]
  • Smoking: Factor XIII, which stabilizes fibrin clots, is increased in smokers and exposure to nicotine may also increase plasminogen activator inhibitor-1 (a major regulator of fibrinolysis). Quantitative exposure to passive smoke has been positively correlated with blood coagulation activity.[3]
  • Cancer: Some forms of cancer increase substances that cause blood to clot. Certain cancer treatments also increase the risk of blood clots.
  • Heart failure: Decreased function leads to increased venous pooling and increased stasis.
  • Inflammatory bowel diseases including Crohn disease or ulcerative colitis increase the risk of deep vein thrombosis (DVT).

Epidemiology

Each year, there are about 4,000,000 surgical patients and 8,000,000 medical patients who are hospitalized in the United States at moderate or high risk for VTE.[5] In a global cross-sectional study, a large proportion of hospitalized patients were also at moderate or high risk for VTE, more specifically, 42% of medical patients and 64% of surgical patients.[6] Among hospitalized medical patients, the 4 risk factors most predictive of VTE in the Intermountain Healthcare database were: (1) previous VTE, (2) bed rest, (3) peripherally inserted central venous catheter, and 4) cancer.[7] Of particular importance is VTE in the outpatient setting. In a community study in Worcester, about three-fourths of patients developed VTE as outpatients. More than half had undergone surgery or had been hospitalized within the prior 3 months.[8] Cancer, severe infection, or congestive heart failure increased the likelihood of a poor outcome from VTE in the community setting.[9] In a population-based study in Norway, the incidence rate for all first VTE events was 1.43 per 1000 person-years. For DVT it was 0.93 per 1000 person-years with a 30-day case-fatality rate was 4.6% for DVT.  Incidence rates increased exponentially with age and were slightly higher in women than men.

Pathophysiology

Venous thrombosis pathogenesis is based on the triad of Virchow proposed in 1865. The triad includes venous stasis, changes in the vessel wall, and/or changes in the blood leading to a hypercoagulability state which can increase the risk of obstruction.[10]

History and Physical

Venous obstruction is most commonly seen in the form of deep venous thrombosis (DVT). Patients present with unilateral or bilateral leg swelling after prolonged stasis, for example, plane travel or another long period of inactivity. Other symptoms include leg pain, which can occur in 50% of patients and is aggravated by dorsiflexion. Edema, if present, is one of the most specific symptoms of DVT. There is no correlation to the pain and tenderness to the size of the thrombus.

Finding are usually confined to the affected limb. These include tenderness to the calf with a positive Homans sign which is a pain with passive dorsiflexion). Leg swelling of 2 centimeters or more in the affected limb is suggestive of DVT, and a positive D-dimer test shows the highest correlation to DVT.[11]

Symptoms of portal vein thrombosis include right upper quadrant pain, nausea, and/or fever. Patients may have progressive ascites and ischemia of intestine due to microthrombi propagation of blood vessels. Intestinal suffusion secondary to acute portal hypertension can also be present.

Evaluation

Evaluation of DVT includes blood tests to help stratify patients with the risk for deep venous thrombosis (DVT) include D-dimer assay; levels of antithrombin III (ATIII), N-terminal pro-brain natriuretic peptide (NT-proBNP), and C-reactive protein (CRP); and erythrocyte sedimentation rate (ESR). Studies have shown all patient presenting with a positive D-dimer and leg swelling have confirmed DVT on evaluation.[11]

Radiologic investigations include an ultrasound of the affected leg and pelvis. It may require additional evaluation in some patients with either CT (computed tomography) scan or MRI (magnetic resonance imaging).

Investigation for portal vein thrombosis includes laboratory test: coagulation studies to rule out inherited coagulation disorders, liver function test, and radiographic imaging. Ultrasound is the first line modality, and this can be done endoscopically. Further imaging modalities are MRI or MRA and possible CT scan.

Treatment / Management

Management of VTE is to prevent further extension of DVT proximally and the prevention of pulmonary embolism. Treatment is divided into an initial active treatment phase of 3 months and a subsequent secondary phase.[12] Anticoagulation during the initial treatment shows a reduction in the risk of embolization in patients with proximal DVT or PE and reduces the risk of death in patients with PE.[13]

Initial treatment consists of the administration of an anticoagulant. Anticoagulants include low molecular weight heparin (LMWH) or fondaparinux or unfractionated heparin (UFH) for a minimum of 5 days, with early administration of a vitamin-K antagonist (VKA) like warfarin.[14] An international normalized ratio (INR) of at least 2 is achieved on 2 consecutive days, because of the slow onset of action of the antithrombotic effect of VKAs.[15] After the first 3 months, management is based on the risk of bleeding compared to the risk of recurrent thrombosis. Thrombectomy of venous obstruction is less frequently performed, and often, an IVC filter is placed in patients in whom anticoagulation is contraindicated.

Treatment for portal venous obstruction includes thrombolysis using tissue-type plasminogen activator (tPA) through the transhepatic route, followed by prolonged anticoagulation therapy with warfarin for at least 3 months.

Differential Diagnosis

  • Venous thromboembolism: Trauma, edema, cellulitis
  • Portal vein obstruction: Cirrhosis, Budd-Chiari, sarcoidosis

Prognosis

If treated appropriately, the overall prognosis of VTE is good. 

The overall mortality has been reported to be less than 10% in chronic pulmonary vein thrombosis.[16]

Complications

Complication of VTE is pulmonary embolism of the pulmonary artery which can lead to death. 

Portal vein thrombosis complications include splenomegaly, esophageal- and gastric varices with or without bleeding, portal hypertensive gastropathy, and ascites. 

Enhancing Healthcare Team Outcomes

Veins in almost any organ can be thrombosed or occluded. In many cases, because of collateral formation, symptoms do not occur immediately. However, the problem with vein thrombosis is the potential for the clot to embolize. Each year thousands of patients die from a pulmonary embolism, and in most cases, the cause is an embolic blood clot from the extremities. Healthcare workers including nurse practitioners must be aware of the complications of vein obstruction, particularly in the leg and pelvic veins, central neck veins, hepatic veins, and the superior mesenteric veins. In many cases, a duplex ultrasound will reveal the vein obstruction, and appropriate patient referral is necessary.


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Vein Obstruction - Questions

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A 65-year-old female, current smoker, with a history of active breast cancer with recent mastectomy, hypertension, and diabetes begins complaining of chest pain and shortness of breath three days into her intensive care unit (ICU) stay. Her vitals shows a blood pressure of 146/88 mmHg, a pulse of 112/min, and oxygen saturation of 94% on room air. Which of the following are significant risk factors for venous thrombosis in this patient?



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A 50-year-old female presents to the emergency department with right lower leg pain, redness, and increased swelling compared to left. She is wheelchair-bound and is currently on hormone replacement therapy for menopausal symptoms. What are the next best steps of management?



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A 78-year-old male with a history of intracranial hemorrhage and hypertension is admitted to the ICU for acute anemia from a gastrointestinal hemorrhage. Two days into his admission, he complains of left lower leg “tightness” and pain. He has an elevated D-dimer, and ultrasound reveals a non-compressible popliteal vein. What is the next best step in the management of this patient?



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A 26-year-old female presents with right leg pain. She recently started taking birth control pills and just returned from a 10-hour flight last night. Which combination of physical exam findings would be most suggestive of her most likely diagnosis?



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A 62-year-old male presents to the emergency department with acute right upper quadrant abdominal pain and distention, fever, and nausea. His lab studies so far show elevated D-dimer and liver function tests. Which sign or symptom is most likely to be seen in this patient, later on, as a complication of his suspected condition?



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Vein Obstruction - References

References

James AH, Venous thromboembolism in pregnancy. Arteriosclerosis, thrombosis, and vascular biology. 2009 Mar     [PubMed]
Tapson VF, The role of smoking in coagulation and thromboembolism in chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2005     [PubMed]
Hirmerova J,Seidlerova J,Subrt I, The association of factor V Leiden with various clinical patterns of venous thromboembolism-the factor V Leiden paradox. QJM : monthly journal of the Association of Physicians. 2014 Sep     [PubMed]
Yang G,De Staercke C,Hooper WC, The effects of obesity on venous thromboembolism: A review. Open journal of preventive medicine. 2012 Nov     [PubMed]
Pinjala R, Venous thromboembolism risk     [PubMed]
Anderson FA Jr,Zayaruzny M,Heit JA,Fidan D,Cohen AT, Estimated annual numbers of US acute-care hospital patients at risk for venous thromboembolism. American journal of hematology. 2007 Sep     [PubMed]
Woller SC,Stevens SM,Jones JP,Lloyd JF,Evans RS,Aston VT,Elliott CG, Derivation and validation of a simple model to identify venous thromboembolism risk in medical patients. The American journal of medicine. 2011 Oct     [PubMed]
Spencer FA,Lessard D,Emery C,Reed G,Goldberg RJ, Venous thromboembolism in the outpatient setting. Archives of internal medicine. 2007 Jul 23     [PubMed]
Spencer FA,Goldberg RJ,Lessard D,Reed G,Emery C,Gore JM,Pacifico L,Weitz JI, Factors associated with adverse outcomes in outpatients presenting with pulmonary embolism: the Worcester Venous Thromboembolism Study. Circulation. Cardiovascular quality and outcomes. 2010 Jul     [PubMed]
Esmon CT, Basic mechanisms and pathogenesis of venous thrombosis. Blood reviews. 2009 Sep     [PubMed]
Johanning JM,Franklin DP,Thomas DD,Elmore JR, D-dimer and calf circumference in the evaluation of outpatient deep venous thrombosis. Journal of vascular surgery. 2002 Nov     [PubMed]
Kearon C, A conceptual framework for two phases of anticoagulant treatment of venous thromboembolism. Journal of thrombosis and haemostasis : JTH. 2012 Apr     [PubMed]
BARRITT DW,JORDAN SC, Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial. Lancet (London, England). 1960 Jun 18     [PubMed]
Kearon C,Akl EA,Comerota AJ,Prandoni P,Bounameaux H,Goldhaber SZ,Nelson ME,Wells PS,Gould MK,Dentali F,Crowther M,Kahn SR, Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb     [PubMed]
Torbicki A,Perrier A,Stavros K,Giancarlo A,Nazzareno G,Pruszczyk P,Frank B,Brady AJ,Daniel F,Uwe J,Walter K,Mayer E,Remy-Jardin M,Bassand JP, [Guidelines on the diagnosis and management of acute pulmonary embolism]. Giornale italiano di cardiologia (2006). 2009 May     [PubMed]
Ponziani FR,Zocco MA,Campanale C,Rinninella E,Tortora A,Di Maurizio L,Bombardieri G,De Cristofaro R,De Gaetano AM,Landolfi R,Gasbarrini A, Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment. World journal of gastroenterology. 2010 Jan 14     [PubMed]

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