Penetrating Head Trauma

Article Author:
Titilola Alao

Article Editor:
Muhammad Waseem

Editors In Chief:
Kranthi Sitammagari
Mayank Singhal

Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes

2/11/2019 9:37:15 PM


Penetrating brain injury (PBI) is a traumatic brain injury (TBI) which is a significant cause of mortality in young individuals. PBI includes all traumatic brain injuries other than blunt head trauma and constitutes the most severe of traumatic brain injuries.[1][2][3][4]


Based on the speed of penetration, it can be classified into two categories:

  • High-velocity penetration: Examples include injuries caused by bullets or shell fragments, from direct trauma or shockwave injury to surrounding brain tissue due to a stretch injury.
  • Low-velocity penetration: Examples include a knife or other sharp objects, with direct trauma to brain tissue.


Traumatic brain injury (TBI) is one of the leading causes of death in the United States. Although penetrating trauma is less common than closed head trauma, it carries a worse prognosis. Most deaths from traumatic brain injury are due to firearm injuries. In the United States, approximately 20,000 gunshot injuries to the head occur annually.[5][6]


The consequences of penetrating head injury depend on the following factors:

  • Intracranial path and location: High mortality resulting from those that cross the midline, pass through the ventricles, or come to rest in the posterior fossa
  • Energy and speed of entry: These factors depend on the properties of the weapon or missile. They result from energy being transferred from an object to the human skull and the underlying brain tissue. There is a high mortality rate associated with high-velocity projectiles. The kinetic energy involved is related to the square of the velocity. Three mechanisms of injuries have been reported.
  1. Laceration and crushing
  2. Cavitation
  3. Shockwaves
  • Size and type of the penetrating object: Usually, large missiles or missiles that fragment within the cranial vault cause more fatalities
  • Circumstances or events surrounding the injury
  • Other associated injuries

Primary injuries occur immediately. Secondary injuries occur following the time of the injury. The final neurologic outcome is influenced by the extent and degree of secondary brain injury. Therefore, the primary goal in the emergency department is to prevent or reduce conditions that can worsen outcomes, such as hypotension, hypoxia, anemia, and hyperpyrexia.

The amount of damage to the brain depends on the kinetic energy imparted to the brain tissue. This, in turn, depends on the following factors:

  1. Trajectories of both the missile and the bone fragments through the brain
  2. Changes in intracranial pressure at the time of impact.

History and Physical

The presentation depends on the mechanism, site of the lesions, and associated injuries.

History should include:

  • Date and time of injury
  • Duration of loss of consciousness (LOC) if present
  • Seizure at the time of impact
  • Any co-morbidity (if existing)
  • Anticoagulants and antiplatelet agents used

Initial physical examination includes primary and secondary trauma survey with evaluation of other distracting injuries. A complete physical examination should be performed including a neurological examination. This should include documentation of Glasgow coma scale (GCS). The involvement of cranial nerves should be assessed, and motor/sensory examination should be performed. It is important to realize that neurologic injury may be manifest distant to the site of impact. If unable to fully and formally assess cranial nerves secondary to lack of patient cooperation, it is important to, at least, document any findings relevant to the patient’s neurologic.


In the pre-hospital setting, or in non-trauma facilities, stabilize, but, do not remove penetrating objects such as knives. Patients should be transported quickly to a location capable of providing definitive care. Early recognition of high-risk mechanisms, early imaging, and early evaluation at a level 1 trauma center may improve outcome.[7][8]

In the emergency department, resuscitation and stabilization should be provided. Manage ABCDE’s using Advanced Trauma Life Support (ATLS) guidelines. Perform a primary survey to identify any life-threatening injury. Stabilize, focusing on the airway, breathing, and circulation, including external hemorrhage, while establishing and maintaining cervical spine immobilization. Early activation of a trauma team may help to provide prompt recognition of polytrauma. The target is to maintain a systolic blood pressure of at least 90 mm Hg.

Following initial resuscitation and stabilization, an inspection of the superficial wound should be performed. Identify the entrance wound (and exit wounds, if present). Beware that blood-matted hair may cover these wounds. When a patient presents with a gunshot wound to the head, the other parts of the body including neck, chest, and abdomen should be inspected carefully for other gunshot wounds. Beware that injuries to the heart or great vessels in the chest or abdomen may be even more life-threatening.

A subgaleal hematoma can become extensive because blood easily dissects through the loose areolar tissue; such a hematoma can be a cause of hemodynamic compromise. Apply a sterile dressing to both the entrance and exit wounds. Assess whether there is any oozing of cerebrospinal fluid (CSF), blood, or brain parenchyma from the wound. Evaluate for hemotympanum, which may indicate a basilar skull fracture. Examine all orifices for retention of foreign bodies, the missile, teeth, and bone fragments.

Perform neurological examination, including GCS and document well. Evaluating for signs suggesting raised intracranial pressure is critical. The initial signs and symptoms may be nonspecific and include a headache, nausea, vomiting, and papilledema.

Perform a careful examination of the neck, chest, abdomen, pelvis, and extremities. Assume multiple injuries in cases of penetrating trauma. Obtain a detailed history including the “AMPLE” history with an emphasis on events surrounding the injury. Also, determine the weapon type and/or caliber of the weapon.

CT Scan

If the patient is hemodynamically stable, obtain a Computed Tomography (CT) scan of the head to evaluate for the presence of a mass lesion (hematoma) or cerebral edema. It can be obtained when the patient is stabilized and ready to be transported to the radiology department. A CT scan can adequately identify the extent of the intracranial injury and can also determine the relationship between the penetrating object and the intracranial structures. However, a radiolucent object, such as a wooden object, may be missed by the CT scan. In patients with penetrating head trauma, a large mass or hematoma may be evident. If ICP is increased, aqueductal stenosis is present, and the third but not fourth ventricle is enlarged.

Certain factors are important in critical decision making and have prognostic implications. These may include the following:

  • Sites of entry and exit wounds
  • Presence of intracranial fragments
  • Missile track and its relationship to both blood vessels and air-containing skull-base structures
  • Presence of intracranial air
  • Trans-ventricular injury
  • Basal ganglia and brain stem injury
  • Whether the missile track cross the midline
  • Presence of multi-lobar injury
  • Presence of basal cistern effacement
  • Brain parenchymal herniation
  • Presence of any associated mass effects 

Plain Radiograph

Maybe useful as it provides information about the following:

  • Shape of the penetrating object
  • Skull fractures (if present)
  • Intracranial foreign object (if present)

Computed Tomographic Angiography (CTA)

If a vascular injury is suspected, noninvasive investigative CTA should be obtained after patient stabilization. 

MRI Scan 

Additionally, an MRI Scan may be obtained if penetrating objects are suspected to be wooden objects. It should not be performed if intracranial metallic fragments are present. Such a procedure is contraindicated. However, if no bullets or intracranial metallic fragments are present, then an MRI scan of the brain can be performed in a stable patient. This can provide information about the posterior fossa structures and the extent of possible shared injuries.

Treatment / Management

Patients with penetrating head trauma require both medical and surgical management.[9][10][11]

Medical Management

A low threshold for obtaining surgical consultation should be considered in cases of penetrating head trauma. Beware that many patients with penetrating head trauma will likely require operative intervention.

Indeed, do not remove any penetrating object from the skull in the emergency department until trauma and neurosurgical evaluation is obtained. Also, the protruding object should be stabilized, and provision should be made to protect it from movement during transportation of the patient, to prevent further injury.

Assess the need for endotracheal intubation.

  • Inability to maintain adequate ventilation
  • Inability to protect the airway due to depressed level of consciousness
  • Neck or pharyngeal injury

Normalize PCO2. Avoid hyperventilation, because it leads to vasoconstriction and a subsequent reduction in the cerebral perfusion pressure (CPP). This may worsen long-term neurological outcome. Beware that hyperventilation is only a temporizing measure for the reduction of elevated intracranial pressure (ICP). Avoid hyperventilation during the first 24 hours after injury when cerebral blood flow (CBF) often is reduced.

Monitor intracranial pressure (ICP) particularly in patients with GCS less than 8. Consider head elevation to 30 degrees. This can improve venous drainage and may decrease ICP. The target is to maintain intracranial pressure (ICP) less than 20 mmHg to 25 mmHg and CPP greater than 70 mmHg. Since cerebral blood flow (CBF) is difficult to measure continuously, the CPP is measured as a surrogate. Treatment typically is indicated for ICP greater than or equal to 20 mmHg to 25 mmHg, with guideline goals of ICP less than 20 mmHg and cerebral perfusion pressure (CPP) 50 mmHg to 70 mmHg.

Surgical Management

A major reason for surgical intervention is the presence of a hematoma. Large hematomas should be evacuated promptly. Early decompression with conservative debridement of the brain may be needed. In most cases, removal of a deep-seated bullet may not be required. However, there are certain indications when removal should be considered. These are:

  • Penetrating injury through pterion, orbit, or posterior fossa
  • Presence of intracranial hematoma
  • Presence of pseudoaneurysm at the time of initial exploration

A craniotomy is needed for low-velocity missile wounds in which the object is still protruding from the head. Some critical factors can determine the outcome for those who survive the initial injury; they depend on prompt and early surgical intervention as well as the ability to provide high-level neurocritical care.

Pearls and Other Issues

Avoid the use of a nasogastric tube if there may be a skull-base fracture. i.e., there is a risk of intracranial tube insertions or risk of significant bleeding during surgical removal of the penetrating object.

Beware that traumatic aneurysms are more susceptible to rupture than are congenital aneurysms.

Avoid using the entry or exit wounds when planning scalp incisions.

Enhancing Healthcare Team Outcomes

Penetrating head trauma is best managed by a multidisciplinary team that consists of a neurosurgeon, emergency department physician, neurologist, intensivist, neurosurgical nurses, physical therapy and an internist. When the brain is injured, this can lead to impairment in almost every organ system. Tke key is to prevent further complications like pressure sores, DVT, failure to thrive, aspiration pneumonia and contractures. Healthcare workers should be proactive and involve speech, occupational and physical therapists early on in treatment. The overall outlook for patients with penetrating head trauma depends on age, comorbidity, extent and site of brain injury and presence of neurological deficits at the time of presentation. Even those who survive, the recovery can take months or years. Residual neurological deficits are common in surviviors.[12] (Level V)

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Penetrating Head Trauma - Questions

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A 17-year-old girl is brought to the emergency department (ED) after being stabbed in the head by her father with a butcher knife. Her blood pressure is 125/82 mmHg, and pulse rate is 94/min. The patient is tearful and reports that her father has always been abusive; however, she does not know why he attacked her. Upon physical examination, she is alert and awake, Glasgow coma scale is 15. There is a knife handle protruding from the scalp from the left parietooccipital area. In the ED, she is complaining of a headache and has one episode of vomiting. Which of the following is the best next step in the management of this patient?

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Penetrating Head Trauma - References


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Puffenbarger MS,Ahmad FA,Argent M,Gu H,Samson C,Quayle KS,Saito JM, Reduction of Computed Tomography Use for Pediatric Closed Head Injury Evaluation at a Nonpediatric Community Emergency Department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2018 Nov 14;     [PubMed]
Voss JO,Thieme N,Doll C,Hartwig S,Adolphs N,Heiland M,Raguse JD, Penetrating Foreign Bodies in Head and Neck Trauma: A Surgical Challenge. Craniomaxillofacial trauma     [PubMed]
Maragkos GA,Papavassiliou E,Stippler M,Filippidis AS, Civilian Gunshot Wounds to the Head: Prognostic Factors Affecting Mortality: Meta-Analysis of 1774 Patients. Journal of neurotrauma. 2018 Nov 15;     [PubMed]
McGrew PR,Chestovich PJ,Fisher JD,Kuhls DA,Fraser DR,Patel PP,Katona CW,Saquib S,Fildes JJ, Implementation of a CT scan practice guideline for pediatric trauma patients reduces unnecessary scans without impacting outcomes. The journal of trauma and acute care surgery. 2018 Sep;     [PubMed]
Milton J,Rugino A,Narayan K,Karas C,Awuor V, A Case-Based Review of the Management of Penetrating Brain Trauma. Cureus. 2017 Jun 12;     [PubMed]
Cristofori I,Pal S,Zhong W,Gordon B,Krueger F,Grafman J, The Lonely Brain: Evidence from studying patients with penetrating brain injury. Social neuroscience. 2018 Dec 3;     [PubMed]


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