Basilar Migraine


Article Author:
Renu Kadian


Article Editor:
Anil Kumar


Editors In Chief:
Kranthi Sitammagari
Mayank Singhal


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
4/1/2019 9:59:33 PM

Introduction

A migraine with predominant brainstem aura symptoms is known as a basilar migraine. Bickerstaff first described it in 1961. Other names for it are basilar artery migraine, basilar-type migraine, brainstem migraine, vertebrobasilar migraine, and Bickerstaff migraine. It was named basilar migraine because it was thought to be caused by spasm of the basilar artery. However, there is no proven evidence of vascular pathology for a basilar migraine, and it is now believed to be due to the firing of nerves in the brainstem. It is now recognized as a subtype of migraine with aura and is preferably called "a migraine with brainstem aura."

Aura refers to short-lived sensory symptoms experienced just before or during the acute migraine episode. About one-fourth of all migraine patients experience typical aura symptoms. A migraine with brainstem aura (a basilar migraine) is a rare subtype of a migraine with aura that presents with symptoms originating from brainstem or both cerebral hemispheres at the same time.[1][2][3][4]

Etiology

Exact etiology of migraine with brainstem aura is not known. Like other types of migraine, environmental factors play a role. The genetic role is suggested, but no definite linkage has been found yet. Common triggers (like in other types of a migraine) include strong smells, loud noises, weather changes, excessive sleep, lack of sleep, increased stress, intense physical exertion, oral contraceptives, foods like cheese, alcohol, caffeine, and certain food preservatives like MSG.[1][2][3][4]

Epidemiology

Actual prevalence and incidence are unknown. It is more common in females than males. It can occur at all ages but is more common in adolescence and young adults. Age of onset is usually 7 to 20.

Pathophysiology

Basilar migraine was initially thought to have vascular pathology caused by short-term spasms of the basilar artery. However, the vascular hypothesis could not be proved, and it is now believed that like other migraine types, the basilar migraine is related to nerves.

Basilar migraine is now believed to be a type of migraine with aura. The aura is a result of cortical spreading depression, which is a self-propagating wave spreading across the cerebral cortex due to depolarization of neurons and glia. Location of aura symptoms in a basilar migraine is brainstem or both occipital hemispheres; whereas, in migraine with typical aura, it mainly involves unilateral hemisphere.

There is little data regarding the genetic basis of a basilar migraine. Basilar type aura may be triggered by genes involved in a Migraine with typical aura. Some reports suggest that FHM gene may be involved in a basilar migraine without hemiplegia. However, no definitive genetic linkage is identified. [5][6]

History and Physical

Brainstem aura symptoms include vertigo, dysarthria, diplopia, tinnitus, impaired hearing, lack of coordination, confusion, and sometimes loss of consciousness. The most common symptom is vertigo. Most patients also have typical aura symptoms like photopsia, loss of vision, paresthesia, speech and language problems like word finding difficulty, language comprehension, and difficulty reading. Some patients may have associated anxiety and hyperventilation which can lead to misdiagnosis. All aura symptoms are completely reversible. Aura symptoms can last few minutes to an hour followed by an occipital headache that may last hours to days. Rarely, migraine with brainstem aura occurs without a headache. Prodromal symptoms of migraine-like mood swings, irritability, tiredness, nausea, and neck pain should not be confused with aura symptoms. There are no motor or retinal symptoms in migraine with brainstem aura and symptoms like weakness, paralysis, loss of vision in one eye should prompt evaluation for an alternate diagnosis.

Symptoms can be very frightening especially when they occur the first time or until a definite diagnosis is made. Symptoms of brainstem aura can mimic some serious disease like stroke, tumors, and infections, so it is important to seek medical attention the first time or if there is any change in symptom severity and frequency. Symptoms of migraine with brainstem aura are usually more frightening than harmful, as they are completely reversible.

Diagnosis

The International Classification of headache disorders outlined the following criteria for the diagnosis of a basilar migraine.

  • (A) Symptoms not attributed to another disorder
  • (B) At least 2 attacks that fulfill criteria C, D, or E
  • (C) Aura with more than 1 of the following symptoms: dysarthria, vertigo, tinnitus, hearing impairment, diplopia, ataxia, decreased level of consciousness, bilateral paresthesia, with no motor or retinal symptoms and completely reversible symptoms
  • (D) At least one1of the following: At least 1 aura symptom occurring gradually over 5 minutes or more and/or 2 or more symptoms occurring in succession over 5 minutes or more, each aura symptom lasts more than 5 minutes, but less than 60 minutes, at least 1 aura symptom is unilateral
  • (E) Migraine without aura begins during the aura or within 1 hour. [5][6][7][8][9][6]

Evaluation

Brain imaging like MRI head, MRA head or CT angiography is usually indicated to rule out other pathologies like stroke, AV malformations, and tumors. EEG is indicated to rule out seizures especially when there is confusion and decreased the level of consciousness. Rarely, 24-hour Holter monitoring is required to rule out arrhythmias.

Treatment / Management

Treatment of acute attack is symptomatic. An acute attack of a basilar migraine is usually managed with NSAIDs and anti-emetics like prochlorperazine or metoclopramide. Aura symptoms should be used as a signal for initiating early acute treatment.

Triptans and ergotamines were excluded in the earlier trials for the treatment of a basilar migraine and have not been well studied. Recent reports have shown benefits and improvement in a headache with triptans. Many believe that these medications can be used in abortive therapy of migraine with brainstem aura like in migraine with typical aura, but traditionally triptans and ergotamines are avoided in a basilar migraine because of the risk of increasing cerebral ischemia. Safety and effectiveness of triptans and ergotamines is not confirmed yet due to lack of data.

Principles of preventive therapy are generally the same as with other types of a migraine. It is important to identify and modify the triggers if possible. Maintaining a headache diary helps to keep track of frequency, duration, and severity of symptoms and identify triggers. Modification of triggers like food, noise, stress, regular exercise, well-balanced diet, and stress management can help prevent migraine attacks. All patients with frequent, disabling headaches should be considered for preventive therapy.

Verapamil and topiramate are the most commonly used medications for preventing migraine with brainstem aura. Propranolol has traditionally been avoided as it can affect the cerebral blood flow.

Non-pharmacological therapies like relaxation, acupuncture, massage, cognitive behavior therapy, and biofeedback techniques are also helpful for prevention, like with other types of migraines.[5][6][10]

Differential Diagnosis

  • A basilar migraine can mimic a hemiplegic migraine and migraine with typical aura.
  • Other differentials that should be excluded before a clinician makes a definite diagnosis of a basilar migraine include Meniere disease, vestibular disease, transient ischemic attack (TIA), stroke, brainstem atrioventricular (AV) malformation, tumors, and meningitis.[7]

Prognosis

Brainstem aura migraine is often more disabling than migraine without aura and migraine with typical aura, because of increased severity and longer duration of symptoms. The frequency of brainstem aura decreases with age, and they often evolve in more typical patterns with age.

Migraines with aura have a slightly higher risk of stroke than migraine without aura; however, there is no evidence that migraine with brainstem aura has a higher risk of stroke than migraine with typical aura.

Smoking and use of estrogen contraceptives further increase the risk of stroke, and risk factor modification should be reinforced to all patients.[1][7][8][9]

Enhancing Healthcare Team Outcomes

Basilar migraines are challenging to diagnose and treat. They require an interprofessional team of a neurologic headache specialist, nurse experienced with headache management and patient education, and pharmacist to assist with medication management to obtain the best results. [Level V]


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Basilar Migraine - Questions

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Which migraine type may be a contraindication for triptan use?



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Select the medication shown effective for preventive treatment in children of basilar type migraines.



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Which of the following symptoms is least likely in basilar type migraine?



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Select the correct statement about a basilar-type migraine.



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Which of the following is not a symptom of migraine with brainstem aura?



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What is another name for a Bickerstaff migraine?



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Which of the following is not true about migraine with brainstem aura?



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Which of the following is true about brainstem migraine headache?



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Basilar Migraine - References

References

A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine., Mathew PG,Krel R,Buddhdev B,Ansari H,Joshi SG,Spinner WD,Klein BC,, Headache, 2016 Apr 8     [PubMed]
[Basilar type migraine: clinical features, differential diagnosis]., Stulin ID,Kunel'skaia NL,Tardov MV,Bań≠bakova EV,Chugunova MA,Zaoeva ZO,Tardova IM,, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014     [PubMed]
Kaniecki RG, Basilar-type migraine. Current pain and headache reports. 2009 Jun;     [PubMed]
Monday LA, [Basilar migraine]. The Journal of otolaryngology. 1977 Aug;     [PubMed]
Kuhn WF,Kuhn SC,Daylida L, Basilar migraine. European journal of emergency medicine : official journal of the European Society for Emergency Medicine. 1997 Mar;     [PubMed]
Moreno MS,Díez-Tejedor E, [Basilar artery migraine]. Neurologia (Barcelona, Spain). 1997 Dec;     [PubMed]
Zhang Y,Kong Q,Chen J,Li L,Wang D,Zhou J, International Classification of Headache Disorders 3rd edition beta-based field testing of vestibular migraine in China: Demographic, clinical characteristics, audiometric findings and diagnosis statues. Cephalalgia : an international journal of headache. 2016 Mar;     [PubMed]
Ying G,Fan W,Li N,Wang J,Li W,Tan G,Zhou J, Clinical characteristics of basilar-type migraine in the neurological clinic of a university hospital. Pain medicine (Malden, Mass.). 2014 Jul;     [PubMed]
Kirchmann M,Thomsen LL,Olesen J, Basilar-type migraine: clinical, epidemiologic, and genetic features. Neurology. 2006 Mar 28;     [PubMed]
Kozubski W, [Basilar-type migraine: pathophysiology, symptoms and signs, and treatment]. Neurologia i neurochirurgia polska. 2005;     [PubMed]

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