Cilia Incarnata


Article Author:
Bhupendra Patel


Article Editor:
Raman Malhotra


Editors In Chief:
Jasleen Jhajj
Cliff Caudill


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Orawan Chaigasame
Carrie Smith
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Hajira Basit
Phillip Hynes
Tehmina Warsi


Updated:
4/1/2019 4:08:58 PM

Introduction

Eyelashes develop from ectoderm between weeks 22 and 26 of gestation. Although the length varies from person to person, they do not grow beyond a certain length and then fall off by themselves. They generally do not need trimming unless there is excessive growth (trichomegaly). If a person pulls a last out, it takes about 8 weeks to grow back. Eyelash hair is not affected by puberty. Eyelash follicles are 2.4-mm deep in the upper lid and 1.4 mm in the lower lid. There are more active lash follicles in the upper lid compared to the lower lid (41% vs. 15%).[1] The function of eyelashes is to protect the eyes from particulate matter. They are also highly innervated, making them sensitive (have been compared to cat's whiskers) to touch and again help protect the eyes. The human lower eyelid has 75 to 80 lashes in three to four rows, whereas the upper eyelid has 90t o 160 lashes scattered on five to six rows. Each lash has a hair shaft that extends outside the skin, a root that is under the skin and a bulb which is the enlarged terminal portion. The inferior portion of the bulb is in direct contact with the dermal papilla, which brings key mesenchymal-epithelial interactions in follicle cycling.

Unlike the scalp which has epidermis, dermis, and hypodermis, eyelid skin is thinner with only the epidermis and dermis. Lash follicles also do not have arrector pili muscles which straighten hair in response to cold or intense emotions.

Definition of Conditions

Cilia incarnata is the misdirection of eyelashes whereby they grow under the skin through to the surface or posteriorly to the conjunctival surface instead of emerging normally from the eyelid margin.

Two types are recognized:

  1. Cilium incarnatum internum
  2. Cilium incarnatum externum  

Etymology: Latin Derivatives

Cilium is a neuter noun whose plural is cilia or cilii).

Incarnata is the neuter plural of incarnatus which is the perfect passive participle of incarno, which means "to make or become flesh."

Incarnatum is the first supine of incarno. 

Internum is the adjective neuter form meaning "internal" or "inward."

Externum is the adjective neuter form meaning "external" or "outward."

The word incarno, from which incarnata and incarnatum are derived imply inflamed, or red and fleshy, as in the Crimson Clover named Trifolium incarnatum because of its deep crimson color. In the conditions under discussion, there is no inflammation or redness of the eyelid in either of the conditions and cilium incarnatum internum only causes irritation of the cornea and sometimes a conjunctival inflammation, but no fleshy or inflamed appearance.

With that in mind, a more accurate description of these two conditions, derived from the Latin would be as follows:

Cilium crescere internum: literally meaning lash growing inward

Cilium crescere externum: literally meaning lash growing outward.

Etiology

In both conditions, cilium incarnatum internum, and cilium incarnatum externum, the lash root is normal. Bloch[2] postulated that the eyelashes in these two conditions grow underneath the conjunctiva and subsequently emerge through the tarsus, irritating the bulbar conjunctiva and cornea or grow outward under the skin because the lash encounters an obstruction in the process of its growth, forcing the lash to take the path of least resistance. It is possible that if a growing lash misdirects into a subcutaneous plane, it may proceed subcutaneously (externum) or curve and grow further inward (internum) but a physical impediment to the growth of such lashes does not appear to occur, in that no lesions or local inflammation observed in either of these conditions.

Epidemiology

Both these conditions are uncommon. Only a few cases have been reported in the literature. We feel this is both because the diagnosis may be easily missed if there are minimal symptoms, or just under-reported when encountered and treated.

Whereas cilia incarnata internum will present with symptoms of a foreign body, patients with cilia incarnata externum will generally by asymptomatic. Some females may present with a complaint of a cosmetically unacceptable bump, but without any other symptoms. Therefore, these external buried lashes will only be picked up if one looks carefully under the biomicroscope. There has been no evidence that rubbing of eyelids (in floppy eyelid syndrome, for example) or trauma predispose patients to either of these conditions.

History and Physical

Cilium Incarnatum Internum

Most patients with cilium incarnatum internum will present with a history of a foreign body sensation. The onset is usually sudden and often only a few days old. Some patients will observe that the eye is more uncomfortable in a particular gaze, depending upon the site of the lash protruding through the tarsal conjunctiva. Examination of the eye may reveal punctate keratopathy with conjunctival inflammation which may be mistaken for episcleritis and the patient may have photophobia because of the keratitis. Unless the physician examines the eyelid margin and the everted eyelid margin carefully with the biomicroscope, these lashes may be missed. Sometimes, just a dark spot showing the tip of the lash protruding through the tarsal conjunctiva may be visible.

Any patient presenting with either keratitis, unilateral conjunctivitis, conjunctival injection, photophobia, or episcleritis should be examined on the slit lamp to exclude trichiasis, foreign bodies, and cilium incarnatum internum.

Cilium Incarnatum Externum

These are usually asymptomatic although some patients may present with a complaint of a bump, indicating the elevation around the buried eyelash. Sometimes, a patient may complain of a sharp discomfort on rubbing his eyelid, especially if the tip of the hair comes through the skin, which is usually not the case. There is usually no evidence of inflammation, ulceration or bleeding. The lash can usually be identified coursing under the eyelid skin (see photograph).

Evaluation

Assessment of cilia incarnata requires the taking of a careful history and biomicroscopic examination with magnification of at least X 15 to be able to see the offending lash or lashes and the changes on the tarsal conjunctiva, limbus and cornea. Application of a fluorescein stain is often useful. However, no other special tests are needed. 

Treatment / Management

For both conditions, simple epilation of the lash usually cures the patient. Having removed such lashes in 12 patients over the last 20 years, we have never had a patient return with a recurrence of the condition. However, some physicians state that treatment with cryotherapy or radiofrequency cautery may be necessary if the lash returns. The reason most of these patients do not need a more definitive treatment with the radiofrequency treatment or cryotherapy is that the problem is with the misdirection of the lash and the root is in a normal position. Based upon our experience, the chance of the lash facing "resistance" again and growing again in this abnormal fashion is low. 

In cilium incarnatum externum, it is sometimes necessary to incise the overlying eyelid skin to get access to the buried eyelash, after which epilation is simple. In cilium incarnatum internum, it may be difficult to grasp the tip of the lash if only a small end is protruding. Usually, with an injection of local anesthetic, the lash and the root can be traced and the lash removed. Again, sometimes it is necessary to make a small incision on the tarsal conjunctiva or the tarsus to allow access to the buried lash. The use of radiofrequency or cryotherapy is rarely needed.

Differential Diagnosis

Specific conditions that should be considered when encountering cilia incarnata.

Several conditions present with eyelashes growing abnormally, from abnormal locations, in abnormal directions, or with different characteristics. Discussion of these various conditions will allow the reader to understand the differential diagnosis when examining such patients.

Trichiasis

Definition

Trichiasis is normal lashes growing inward. In other words, the problem is with lash growth direction and not with the lash follicle position. There are often more lashes in the presence of surrounding inflammation, for example in the presence of trachoma. It is an acquired condition, where eyelashes that grow normally, are turned inward and are usually as­sociated with some pathological in-turn­ed condition of the lid. These patients will also present with a foreign body sensation and have corneal irritation.

Causes

Most trichiatic lashes affect the lower eyelid centrally except in trachoma or chemical burns, where both eyelids may be affected. Most patients will have bilateral trichiasis. The cause of the trichiasis is usually scarring of the lid margin secondary to inflammation. Trichiasis can cause infections and scarring of the cornea with eventual corneal opacification. Trachoma is the result of Chlamydia trachomatis infection and a common cause of trichiasis in sub-Saharan Africa. Other causes of trichiasis include blepharitis, meibomian gland dysfunction, vernal keratoconjunctivitis, chemical or thermal burns, Herpes zoster, actinic elastosis, atopic diseases, eczema, and leprosy. Ocular cicatricial pemphigoid disease, Stevens-Johnson syndrome and trauma, including surgery can cause trichiasis. Basal cell carcinoma or, indeed any eyelid malignancy can cause trichiasis as well as loss of lashes. Sometimes one will see trichiasis at a site of a prior chalazion which may or may not have been surgically drained: the collapsed meibomian gland can cause a local change in the architecture with lashes turning in. Slit-lamp examination is vital when evaluating trichiasis. It is important to look for fornix shortening with symblepharon formation as this will indicate a cicatrizing process. Trichiasis is differentiated from involutional entropion, where the eyelid margin turns in and causes normal lashes to rub against the cornea. This is often termed secondary trichiasis or pseudo-trichiasis.

Treatment

Simple epilation and use of a bandage contact lens will give immediate relief. Surgical treatment should be deferred until any active inflammation is controlled. Techniques used to treat these trichiatic lashes include the use of the radiofrequency needle to the depth of the root of the lashes (2.4-mm deep in the upper lid and 1.4 mm in the lower lid), cryotherapy, and monopolar electrolysis (which is used less frequently now because of associated collateral injury to tissues). 

Distichiasis

Definition

There is a separate set of eyelashes behind the normal row of lashes. These lashes are often softer and finer and without pigmentation. There may be a fully formed additional row of lashes, or there may be a sporadic series of lashes.

Causes

Congenital distichiasis can be autosomal dominant: the second row of lashes grows out of the meibomian glands. Instead of differentiating into meibomian glands, pilosebaceous units differentiate into hair follicles. The meibomian glands (modified sebaceous glands) are very rudimentary, and sometimes only acini are present. In the autosomal lymphedema-distichiasis syndrome, patients will have distichiasis, limb lymphedema, cleft palate, extradural cysts, cardiac deformities, and photophobia. Distichiasis may also be seen in mandibulofacial dystonia. Setleis syndrome has focal facial dermal dysplasia with upper eyelid lashes present in multiple rows or eyelashes may be completely absent. Secondary causes of distichiasis are similar to those seen in trichiasis, namely, blepharitis, caustic injuries, meibomian gland dysfunction, meibomianitis, ocular cicatricial pemphigoid, and Stevens-Johnson syndrome.

Treatment

Treatment includes epilation with forceps, epilation with electrolysis, cryoprobe, electrocautery, radiofrequency, trephination or folliculectomy. In some patients, the lids have to be split surgically to individually treat the second row of lashes. Some patients may need the application of a mucous membrane graft, especially if there is mucocutaneous keratinization. 

Tristichia and Tetrastichiasis

This is a very rare occurrence of three or four rows of lashes, respectively. 

Eyelash in Meibomian Gland or Punctum (Termed "pseudocilium" as it is not a true lash with a true root and the term allows us a defined diagnosis with one word)

Definition

A loose lash will be seen coming out of an isolated meibomian gland or the punctum. 

Causes

A loose lash is thought to find its way into the opening of a meibomian gland or into the punctum. Cases have been described with the root on the outside and also with the root on the inside of the meibomian gland. It is felt that this is a simple case of a lost lash finding its way into a meibomian gland or the punctum with no other underlying disease. The lash tends to sit in the gland or the punctum very loosely with no surrounding attachments (unlike in distichiasis and other conditions causing metaplastic changes in the meibomian glands). Also, it is generally a solitary lash that will be found. 

Treatment

Simple removal of the lash from the meibomian gland or the punctum is curative. 

Hypertrichosis

Definition

an increase in hair beyond the normal variation for a patient's age, sex or ethnicity. Eyelash hypertrichosis is known as trichomegaly.

Causes

Congenital hypertrichosis languinosa and congenital generalized hypertrichosis cause generalized hypertrichosis that involves the periocular region and most of the body. Numerous other conditions and syndromes are associated with hypertrichosis (or trichomegaly) including neurofibroma, Cornelia de Lange syndrome, Goldstein Hutt syndrome, Phenylketonuria, Type I oculocutaneous albinism, tyrosinemia, among others.

Acquired trichomegaly is seen secondary to irritation or inflammation. It may be caused by endocrine and metabolic diseases as well as a paraneoplastic process, therefore a thorough investigation for malignancy is needed. Trichomegaly is also seen in anorexia nervosa, dermatomyositis, hypothyroidism, malnutrition, pregnancy, pretibial myxedema, porphyria, systemic lupus erythematosus, vernal keratoconjunctivitis, and uveitis. HIV/AIDS may cause trichomegaly as well as madarosis. Many drugs have been associated with trichomegaly, causing thickening and even curling. The most common of them being prostaglandin analogs used to treat glaucoma (eg latanoprost, bimatoprost), epithelial growth factor receptor tyrosine kinase inhibitors (eg erlotinib), zidovudine, cyclosporine, topiramate, tacrolimus, and interferon-alpha.

Treatment

Treatment, when needed, is similar to the treatments outlined under trichiasis if there is associated trichiasis or the increased hair causes irritation of the eye.  

Eyelash Ptosis

Definition

Downward sloping or bending of upper eyelid lashes and follicles. 

Causes

The most typical causes are the use of prostaglandin analog drops for glaucoma which cause trichomegaly and secondary mechanical lash ptosis and the floppy eyelid syndrome which causes eyelash ptosis and loss of eyelash parallelism. Patients with the floppy eyelid syndrome are easily diagnosed as they will give a history of weight loss and gain, the eyelids are floppy and evert easily, and there is a papillary conjunctival inflammation with discharge. These patients will be obese and frequently have obstructive sleep apnea. Patients present with discharge, irritation, redness and corneal ulcer formation. Other causes of eyelash ptosis include congenital ptosis, acquired ptosis, dermatochalasis with anterior lamellar slide, and congenital lamellar acanthosis. Upper eyelid margin entropion may appear as apparent eyelash ptosis. This is often seen in patients with facial nerve palsy.

Normal eyelash position and direction is dictated by the orbicularis oculi muscle, the associated Riolan muscle, the tarsal plate, and eyelid elastin. Injury or deformity of these structures results in lash ptosis. Abnormal elastin in floppy eyelid syndrome is thought to contribute to lash ptosis. Eyelash ptosis of the lower lids (upward slanting lashes) is seen in the condition of congenital epiblepharon and patients with thyroid orbitopathy, although this is more of a mechanical malposition caused by surrounding structures (the orbicularis in epiblepharon and proptosis and periorbital edema in thyroid orbitopathy).

Treatment

Treatment depends upon the cause. We tell all patients with the floppy eyelid syndrome that a permanent cure is defined and long-term weight loss. Indeed, we have seen impressive improvement without any surgical treatment when a patient successfully loses and maintains the decreased weight. Conservative treatments like ointment use and wearing of a shield give little relief. Surgical resection of redundant rubbery upper and lower eyelids in a full-thickness manner is reserved for recalcitrant cases, with the proviso that this does not cure the condition and merely helps to create a firmer eyelid to protect the cornea.  Cessation of prostaglandin analogs causes a reversal of the lash changes within a few months in patients with glaucoma drop-induced lash ptosis. 

Cilium Inversum (meaning "upside down lash")[3][4][5]

Definition

The finding is exactly that seen in cilium incarnatum internum, in that a lash will grow inwards. Historically, this term, cilium inversum was used when the condition was congenital. However, it has also been used interchangeably with findings which are exactly those seen in cilium incarnatum internum in adults: Tibbles (in 1923 in the BMJ) first reported of its occurrence in a woman of 21 years, who after having the trouble of irritation for three weeks presented two such in-­growing eyelashes. One was at the posterior border of the lid margin and the other one appearing in the sub­tarsal sulcus. Duke-Elder (1952) men­tions Schrieber (1924) as the next one to report it. No mention of such cases is found in literature after that. Authors of this article propose that this term is dropped as it simplifies matters to call the condition "congenital cilium incarnatum internum."

Treatment

Simple epilation cures the condition.  

Ectopic or Accessory Cilia[6]

Definition

Lashes that are found outside their normal area that is the eyelid margin. Weigmann first described ectopic cilia in 1936.

Causes

Lashes may grow through the eyelid with the root of the lashes in the tarsal plate but not at the lid margin. This is seen congenitally, but can also occur secondary to trauma, in which case accessory cilia have been found in eyelids as well as intraocularly. There has been a report of positive family history in one case report of ectopic cilia growing through the upper part of the eyelid.[6] Ectopic or accessory cilia are caused by an abnormal location of the lash follicles, unlike cilia incarnata. With accessory cilia, histology will reveal the presence of apocrine sweat glands attached to the follicle, which is necessary to diagnose the hairs as eyelashes.

Treatment

Treatment depends upon the location, the number of lashes and the effects. Essentially surgical, laser or cryotherapy treatments are used to remove the abnormal lashes permanently.  

Buried Lash with Granuloma

Definition

A loose lash may bury itself through the conjunctiva and cause local inflammation. This may be seen on the tarsal conjunctiva, or, more infrequently, in the forniceal conjunctiva.   

Causes

Granuloma caused in reaction to a lash which acts as a foreign body.

Treatment

Although simple removal of the lash may be curative, there have been instances where the root needs to be more aggressively removed to cure the condition. 

Vellus Hair Cyst Eyelid/Orbit[7]

Definition

Cysts lined by squamous epithelium filled with vellus hairs and keratin. There have been rare instances of these reported in the eyelid and one recent report of such a lesion in the orbit.

Causes

Granuloma caused in reaction to a lash which acts as a foreign body.

Treatment

Complete removal of the cystic lesion is needed, via an orbitotomy if necessary.

Prognosis

Cilia incarnata is eminently curable with the simple removal of the offending lash, as long as an accurate diagnosis has been made.[8] Patients have presented with ongoing foreign body sensation, where the diagnosis was not made, possibly because of failure to closely examine the eyelid margin in its external and in the everted position with the biomicroscope.

Pearls and Other Issues

When a patient complains of a lesion on the outer lid margin, consider cilium incarnatum externum as a possibility by examining the area around the roots of the lashes with the biomicroscope (see illustration).

If a patient presents with superficial keratopathy, conjunctival injection, a foreign body sensation or conjunctival injection, look at the eyelid margin and the sulcus behind the eyelid margin carefully and with high magnification, looking for the tip of a lash that may be presenting itself and causing the irritation. Sometimes, only a small pigmented spot may be seen. At other times, the lash is obvious as it has grown over time (see illustration).

Enhancing Healthcare Team Outcomes

All family practice and emergency clinicians (nurse practitioners, physician assistants, and physicians) should be taught how to use a slit-lamp, which allows examination under magnification (as much as 40 times) as these lashes can otherwise be easily missed.

Optometrists and ophthalmologists should be shown examples of these conditions, so they are aware of what the findings look like and how to address the problem. An interprofessional team working to diagnose and treat the condition will yield the best results. (Level V)


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Cilia Incarnata - Questions

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A 38-year-old female presents with a bump on the upper eyelid which she noticed two months ago (see image). It has not changed. Her dermatology provider does not know what it is and wants her to be seen by an eye specialist, as he thinks it may be a cancer because of its raised appearance. What is the correct diagnosis?

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A 42-year-old male complains of eye irritation which started a few weeks ago and has lessened but is still present (see image). He denies a history of trauma to the eye or periorbital region. What is the diagnosis?

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A 52-year-old female has been referred to you for biopsy of a lesion on the left upper eyelid, which has apparently appeared in the last three weeks (see image). She has a family history of basal cell carcinomas and is concerned this might be a tumor. What is your next step?

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A 6-year-old girl is brought in with a complaint of light-sensitivity and discomfort, which "has been going on for a long time" (see image). Her two brothers and father have similar symptoms. What is the diagnosis?

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A 62-year-old female presents with an uncomfortable left eye ever since she had treatment for a growth on the left lower eyelid two years previously (see image). She says she is "tired of having to have lashes pulled all the time." What is the diagnosis?

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Cilia Incarnata - References

References

Elder MJ, Anatomy and physiology of eyelash follicles: relevance to lash ablation procedures. Ophthalmic plastic and reconstructive surgery. 1997 Mar     [PubMed]
Goyal T,Varshney A,Bakshi SK, Ectopia cilia with pedigree analysis: Second case report in the world. Indian journal of human genetics. 2014 Apr     [PubMed]
Choi R,MacLean KD,Davidson HC,Patel BCK, Vellus Hair Cyst of the Orbit. Ophthalmic plastic and reconstructive surgery. 2017 May/Jun     [PubMed]
Belfort R,Ostler HB, Cilia incarnata. The British journal of ophthalmology. 1976 Aug     [PubMed]
Makabe R, [2 cases of cilium inversum]. Klinische Monatsblatter fur Augenheilkunde. 1971 Sep     [PubMed]
Sen DK,Mohan H,Gupta DK, Cilium inversum. The British journal of ophthalmology. 1969 Mar     [PubMed]
AGARWALA HS, Cilium inversum. American journal of ophthalmology. 1963 Mar     [PubMed]
BLOCH FJ, Minor anomalies in position of the eyelashes. Archives of ophthalmology (Chicago, Ill. : 1929). 1947 Jun     [PubMed]

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