Bowel Adhesions


Article Author:
Nick Welle


Article Editor:
Bracken Burns


Editors In Chief:
Tod Aeby


Managing Editors:
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Frank Smeeks
Kristina Soman-Faulkner
Benjamin Eovaldi
Radia Jamil
Sobhan Daneshfar
Saad Nazir
William Gossman
Pritesh Sheth
Hassam Zulfiqar
Steve Bhimji
John Shell
Matthew Varacallo
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Hajira Basit
Phillip Hynes


Updated:
3/13/2019 3:58:03 PM

Introduction

Bowel adhesions are irregular bands of scar tissue that form between two structures that are normally not bound together. The bands of tissue can develop when the body is healing from any disturbance of the tissue that occurs secondary to surgery, infection, trauma, or radiation. While the abdominal adhesions that form are a normal response to the injury of the peritoneal surface, they are the cause of significant morbidity including adhesive small bowel obstruction (ASBO), infertility in females, chronic abdominal pain, and create a difficult environment for future surgeries.[1][2][3][4] Complications of subsequent surgery when adhesions are present may include: difficult abdominal access and distorted anatomy, inability to safely perform laparoscopic surgery, inadvertent injury to the small bowel, bladder, or ureters, increased duration of surgery, and increased blood loss.

Etiology

The most likely source of abdominal adhesions in the Western world is prior abdominal surgery. The surgeries most likely associated with adhesive small bowel obstruction are open gynecologic procedures, the formation of the ileal pouch-anal anastomosis, and lastly open colectomy.  Other causes of adhesions include (but not limited to) trauma, diverticulitis, Crohn disease, ventriculoperitoneal shunt (VP) shunt, peritonitis (e.g., tuberculous peritonitis), pelvic inflammatory disease, and abdominal or pelvic radiation. Congenital conditions such as malrotation may also be associated with adhesions known as Ladd's bands.

Epidemiology

Adhesions account for approximately one percent of all general surgical admissions and three percent of all laparotomies. It is estimated to cost the United States over $2 billion annually in the management of adhesion-related complications. Medical malpractice claims from cases involving adhesions most likely arise due to failure to warn patients during the consenting process of possible visceral injuries, failure to use specific preventative measures, and failure to diagnose or delayed diagnosis of complications.

Pathophysiology

When the peritoneal surface is injured during surgery or a traumatic event, a repair response is initiated. The formation of adhesions involves a complex interaction of cytokines and growth factors secreted by cells near the area of injury. The response to injury begins immediately with hemostasis and coagulation which release several chemical messengers. The most abundant messenger cells are the leukocytes, specifically the macrophage, and mesothelial cells.  [5][6]Macrophages send a signal that will attract new mesothelial cells that re-epithelialize the entire injured peritoneal surface (as opposed to traditional wound healing that heals from edge to edge). This response goes through an immediate inflammatory phase peaking on day four to five. The presence of adhesions is dependent mainly on the balance of fibrin deposition to degradation (fibrinolysis).

A fibrin gel matrix is necessary for the formation of adhesions. Several enzyme systems work to break apart fibrin in the peritoneum that is protective against adhesions, such as tissue plasminogen activator (tPA), that can remove the fibrin gel matrix and subsequently reduce the incidence of adhesions. The extent of fibrinolysis and contact of damaged surfaces are key events in the determination of the extent of adhesion formation. Incomplete fibrinolysis and poor resorption of degradation products allow connective tissue scarring and adhesions to develop ultimately allowing ingrowth of fibroblasts, capillaries, and nerves.

Toxicokinetics

History and Physical

The majority of patients having bowel adhesions are asymptomatic. Approximately 75% of all patients presenting with symptoms related to adhesive disease have a history of prior abdominal surgery. The remaining 25% have a history of intra-abdominal or pelvic inflammatory processes. Symptomatic patients typically manifest as intestinal obstruction (complete or partial), chronic pain, and infertility in females.

  • Adhesions are responsible for most cases of intestinal obstruction in Western countries. Any patient with prior abdominal or pelvic surgery presenting with obstruction should be suspected of having bowel adhesions. Most commonly these patients describe nausea, vomiting, cramping, and obstipation. Periumbilical pain with cramping every 4 or 5 minutes is typical. More focal pain may indicate peritoneal irritation. A sudden onset of severe pain may suggest acute intestinal ischemia and possible perforation. The physical exam may demonstrate a patient who is dehydrated, has a distended abdomen, and variations to bowel sound on auscultation (can be high-pitched tinkling or absent sounds depending on whether or not the bowel is distended with air or fluid).
  • Chronic abdominal pain or pelvic pain can be attributed to adhesions. While this relationship is poorly understood, there is evidence that extensive adhesions may limit the natural mobility of organs resulting in a visceral pain.
  • Adhesions can be a source of infertility in females. Interference with ovum capture and transport or from tubal or intrauterine adhesions can hinder sperm transport and embryo implantation.

For any patient with suspicion of symptoms related to adhesions, a complete physical evaluation of the abdomen should be performed. Symptoms of obstruction and certainly of peritonitis should prompt surgical consultation.

Evaluation

Typically, an adhesion diagnosis is made when clinical suspicion and a detailed history indicate prior risk factors. Direct examination of the abdomen in the form of laparoscopy or laparotomy is the only direct way to confirm the diagnosis of adhesions. Imaging such as plain films, ultrasound, magnetic resonance, computed tomography, and small bowel contrast study can be used; however, these are less reliable than direct visualization for identifying bowel adhesions causing obstruction, but can be of value in making the diagnosis of obstruction. [7][8]Signs such as the "fat-bridging sign," a cord-like formation that contains mesenteric fat forms a connection across the peritoneum; twisting or whirling of the mesentery (whirl sign); and anchoring of the omentum are specific signs of obstruction that can be seen in patients presenting with obstruction from adhesions.

The typical laboratory evaluation includes a complete blood count (CBC), complete metabolic panel (CMP), and lactic acid. Although these are non-specific, they may help indicate severity. Arterial blood gas (ABG) and blood cultures should be considered in those with systemic signs including fever, tachycardia, hypotension and altered mental status. Metabolic alkalosis is often seen secondary to vomiting, but also, metabolic acidosis may be seen secondary to bowel ischemia.

Treatment / Management

Most of the treatment is centered around the manifestations of the symptoms, such as bowel obstruction secondary to adhesions. Initial treatment of these patients includes intravenous fluid resuscitation and electrolyte replacement. Nasogastric decompression may also be of benefit. Surgical consult should also be obtained for possible surgery (adhesiolysis) if necessary. Oral intake should be minimized in outpatient situations, and those requiring hospitalization should have nothing by mouth. Often nasogastric tube placement is necessary for bowel decompression and the management of nausea and vomiting. Pain control is done with intravenous (IV) pain medications. However, unrelenting pain is often an indication for surgery. Further indications for surgical intervention include complete bowel obstruction, closed-loop obstruction, ischemia, necrosis, or perforation of the bowel wall. These complications of obstruction are based on clinical and radiological examination and should be taken to the operating room for abdominal exploration in a timely fashion if warranted. [9][10][11][9]Patients with peritonitis should have a prompt surgical consultation. Patients with more of a chronic disease process such as Crohn disease presenting with mechanical obstruction may be observed and at times followed as an outpatient.

Definitive management for bowel adhesions causing symptoms is laparoscopy or laparotomy with adhesiolysis. As mentioned previously these procedures are not without risks and full disclosure of risks vs. benefit should be undertaken with the patient/family when feasible.

Pearls and Other Issues

An area of research and a vast field for improvement includes the prevention of peritoneal adhesions. While pharmacologic methods have not been approved for use, the focus has been placed on the barrier agents to prevent adhesions and the technical aspect of the surgeon. The fundamentals behind prevention include: minimizing injury, creating a barrier between injured surfaces, preventing excessive coagulation of the serous exudate, removing or dissolving deposited fibrin, minimizing fibroblastic response to tissue injury, enhance recombinant tissue plasminogen activator and novel fibrinolytic.

Surgical techniques include:

  • Gentle tissue handling: meticulous hemostasis and gentle, minimal tissue handling are paramount. Preventing serosal injury by minimizing trauma, excess bleeding, and ischemia, and keeping the surgical field moist is recommended.
  • Laparotomy sponges are abrasive and should be avoided. When abdominal or pelvic packing is required place laparotomy sponges in sterile plastic bags or drapes to minimize tissue injury and adhesion formation.
  • Preventing foreign body reaction to excess suture, lint, or talc minimizes fibrin deposition. Silk sutures should be avoided as they are fibrogenic.
  • Adhesion occurrence is similar regardless of the closure of the peritoneum after laparotomy.
  • Laparoscopic surgery minimizes tissue handling and creates smaller abdominal incisions both of which minimizes bowel adhesions. However, this does not guarantee the prevention of adhesions; and longer surgery time and higher insufflation pressure can increase the risk of adhesions.

Enhancing Healthcare Team Outcomes

The management of bowel obstruction is with a multidisciplinary team that includes nurses, a general surgeon, anesthesiologist, and a gastroenterologist. One of the causes of bowel obstruction is adhesions. While in some cases the bowel obstruction caused by adhesions may spontaneously resolve, some patients may require surgery to lyse the adhesions. Unfortunately, recurrences are common and some patients may require repeat adhesiolysis. [8](Level V)


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Bowel Adhesions - Questions

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Bowel Adhesions - References

References

Turcu F,Arnăutu O,Copaescu C, Adhesiolysis-Related Challenges for Laparoscopic Procedures after Ventral Hernia Repair with Intraperitoneal Mesh. Chirurgia (Bucharest, Romania : 1990). 2019 Jan-Feb;     [PubMed]
Kono K,Wada E,Nishioka T,Kinuta Y,Mizukami Y,Furuichi K,Sato S, [A Case of Encapsulated Peritoneal Sclerosis Associated with a Ventriculo-Peritoneal Shunt]. No shinkei geka. Neurological surgery. 2019 Feb;     [PubMed]
Al-Ghassab RA,Tanveer S,Al-Lababidi NH,Zakaria HM,Al-Mulhim AA, Adhesive Small Bowel Obstruction due to Pelvic Inflammatory Disease: A Case Report. Saudi journal of medicine     [PubMed]
Lebert P,Ernst O,Zins M, Acquired diverticular disease of the jejunum and ileum: imaging features and pitfalls. Abdominal radiology (New York). 2019 Feb 13;     [PubMed]
Junga A,Pilmane M,Ābola Z,Volrāts O, The Distribution of Vascular Endothelial Growth Factor (VEGF), Human Beta-Defensin-2 (HBD-2), and Hepatocyte Growth Factor (HGF) in Intra-Abdominal Adhesions in Children under One Year of Age. TheScientificWorldJournal. 2018;     [PubMed]
Giusto G,Iussich S,Tursi M,Perona G,Gandini M, Comparison of two different barbed suture materials for end-to-end jejuno-jejunal anastomosis in pigs. Acta veterinaria Scandinavica. 2019 Jan 5;     [PubMed]
Pirotte B,Inaba K,Schellenberg M,Recinos G,Lam L,Benjamin E,Matsushima K,Demetriades D, Intraoperative Consultations to Acute Care Surgery at a Level I Trauma Center. The American surgeon. 2019 Jan 1;     [PubMed]
Behman R,Nathens AB,Mason S,Byrne JP,Hong NL,Pechlivanoglou P,Karanicolas P, Association of Surgical Intervention for Adhesive Small-Bowel Obstruction With the Risk of Recurrence. JAMA surgery. 2019 Jan 30;     [PubMed]
Long B,Robertson J,Koyfman A, Emergency Medicine Evaluation and Management of Small Bowel Obstruction: Evidence-Based Recommendations. The Journal of emergency medicine. 2019 Feb;     [PubMed]
Quah GS,Eslick GD,Cox MR, Laparoscopic versus open surgery for adhesional small bowel obstruction: a systematic review and meta-analysis of case-control studies. Surgical endoscopy. 2018 Nov 20;     [PubMed]
Ozturk E,van Iersel M,Stommel MM,Schoon Y,Ten Broek RR,van Goor H, Small bowel obstruction in the elderly: a plea for comprehensive acute geriatric care. World journal of emergency surgery : WJES. 2018;     [PubMed]

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