Pupillary Light Reflex


Article Author:
Alison Belliveau
Anisha Somani


Article Editor:
Rimal Dossani


Editors In Chief:
Chaddie Doerr


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Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
8/15/2019 1:36:17 PM

Introduction

Eyes allow for visualization of the world by receiving and processing light stimuli. The pupillary light reflex constricts the pupil in response to light, and pupillary constriction is achieved through the innervation of the iris sphincter muscle.

Anatomy

Light travels through the cornea, anterior chamber, pupil, lens, and the posterior chamber, eventually reaching the retina. Photoreceptor cells in the outer layers of the retina, which are called rods and cones, convert light stimuli into neuronal impulses. These signals are then relayed to the bipolar cells, which interact with ganglion cells, which in turn coalesce to form the optic disc and optic nerve (CN II). The optic nerve sends impulses to the brain for further processing and image recognition.[1] These are the first steps of the pupillary light reflex afferent pathway. The optic nerve then forms the optic chiasm, which diverges into a left and right optic tract. At the optic chiasm, nasal retinal fibers will cross to the contralateral side of the optic tract, and the temporal retinal fibers continue on the ipsilateral side. Thus, the right optic tract will contain temporal retinal fibers from the right eye, as well as nasal retinal fibers from the left eye. The optic tracts join the brachium of the superior colliculus, and then signals travel to the pretectal area of the midbrain. Each pretectal area sends bilateral signals to the preganglionic parasympathetic nuclei in the midbrain called Edinger-Westphal nuclei.[2][3] There are a minority of axons that go to the hypothalamus and the olivary pretectal nucleus (OPN).[4] Efferent parasympathetic preganglionic fibers travel on the oculomotor nerve and synapse with the ciliary ganglion, which sends postganglionic axons to directly innervate the iris sphincter muscles. The contraction of the iris sphincter muscles leads to pupillary constriction (miosis).[3] This extensive pathway is being tested when a light is shined in the eyes. And, because of the crossing fibers, there is not only a direct pupillary reflex but also a consensual pupillary light reflex. Of note, the pupillary dark reflex involves a separate pathway, which ends with sympathetic fibers from long ciliary nerves innervating the dilator pupillae muscle.

Indications

Pupillary light reflex is used to assess the brain stem function. Abnormal pupillary light reflex can be found in optic nerve injury, oculomotor nerve damage, brain stem lesions, such as tumors, and medications like barbiturates.

Equipment

  • A pocket penlight is inadequate
  • Eyeshield
  • Finoff transilluminator with halogen light 
  • Ophthalmoscope

Personnel

  • Healthcare provider
  • Nurse

Preparation

The room lights should be dim, barely allowing you to see the iris and pupil. Keep the transilluminator ready and prepare the patient emotionally by explaining what are you going to do and what are the intended benefits of this test. Encourage patients to relax and alleviate their anxiety, if any.

Technique

Gently point the focal light into one eye, this is known as the direct pupillary light reflex. Then, withdraw the light for few seconds, followed by stimulating the same eye again but this time observe the indirect, or consensual, PLR in the opposite eye. It may be helpful to have the nurse control the light stimulus while you observe the unstimulated eye

Clinical Significance

Pupillary light reflexes are measured based on a 0 to 4+ gradient that considers the magnitude and speed of the light response. A normal, healthy adult patient is expected to have a 4+ response, which indicates a brisk, large response. A 3+ grading indicates a moderate response, 2+ is a small, slowed response, 1+ represents a tiny/just visible response, and a 0 indicates unresponsive pupils. Commonly, clinicians document PERRL–saying the pupils are equal, round, and reactive to light.

In standard clinical testing conditions, the diameter of the pupils will usually range from two to five millimeters. Per decade of aging that occurs, there is a 0.3 mm decrease in the standard pupil diameter that has been associated with iris stiffening. The pupillary light response exhibits varying sensitivity to the chromic spectrum, indicating that the process of light recognition is significantly complex; it is not as simple as a binary response with detection of “light” versus “no light.” While there is a baseline fluctuation in the steady-state conditions for pupillary dilation, a concern for neurological abnormalities is considered in cases of marked pupillary changes, whether with constriction or dilation. One such condition is anisocoria, and it is estimated at 4% of the general population has anisocoria of greater than 1 millimeter, in which case neurological compromise must be ruled out. Pupillary latency occurs when the reaction time of the pupil is inversely related to the increase in light intensity from the stimulus; this can serve as a cue to a potential neurologic cause. Latency increases by approximately 1 millisecond per year with aging. Overall, normal pupillary response times are about one second for initial constriction and 5 seconds for dilation.[4]

Direct and consensual pupillary light reflexes test for appropriate neurological pathway connections and functioning of both cranial nerve II and III. Light entering the eye is processed through the pupillary light reflex, and signals directed to the iris sphincter muscle to adjust the amount of light that reaches the retina. While there are other reasons for variation in pupillary dilation and constriction, such as arousal leading to changes in the balance of the sympathetic and parasympathetic nervous systems, here we will focus on its relation to light exposure. Pupils can become mydriatic, or dilate, in response to potential disease, drug toxicity, trauma, increased intracranial pressure, brainstem damage, or nerve damage to cranial nerve II and/or III.[5]

Abnormalities also depend on where in the track the damage has been done. In the event of optic nerve damage, visual field defects or complete vision loss can occur. If this damage is before the optic chiasm, in the optic nerve, then there are deficits noted to bilateral ipsilateral monocular vision loss. This damage leads to a relative afferent pupillary defect (RAPD), known as a Marcus Gunn pupil, which is examined using the swinging flashlight test. Causes of a Marcus Gunn pupil include ischemic optic neuropathy, optic neuritis, nerve compression, trauma or through asymmetric glaucoma.

Unilateral optic neuropathies, most notably optic neuritis, can cause RAPDs. Optic neuritis is an anterior or posterior inflammatory demyelination of the optic nerve, leading to atrophy of optic nerve fibers and a RAPD. A RAPD can be detected in 96% of acute unilateral cases of optic neuritis.[4] Ischemic optic neuropathies, such as NAION and AION, can cause RAPDs via optic nerve ischemia and infarction secondary to optic nerve edema.[5][6] Asymmetric glaucoma can result in an RAPD, secondary to retinal nerve fiber layer loss.

RAPDs can occur due to ischemic retinal diseases such as BRVO, CRVO, BRAO, and CRAO secondary to death of photoreceptors and viable retina, ultimately leading to an uneven pupillary response.[2] Via the same mechanism of significant retinal cell death, retinal detachments can cause RAPDs. In 1987, a prediction model quantified the correlation between the sizes of RAPD to the amount of retina detached. Detachment of each peripheral quadrant correlated to 0.36 log units of pupillary defect. The detachment of the macula caused 0.68 log units of pupillary defect.

Argyll Robertson pupil, noted in tabes dorsalis from neurosyphilis, is the notable weak-to-absent pupillary light reflex bilaterally, though the pupils will still constrict for the near response. With the near response (accommodation) intact it can be assumed that the afferent and efferent pathways are grossly intact and that the deficit is related to degeneration in bilateral olivary pretectal nuclei or their projections.[6]

Compression damage to the optic chiasm leads to bitemporal hemianopia and is frequently related to a pituitary adenoma. Downstream to the optic chiasm, damage to the optic tract will produce contralateral homonymous hemianopia; for example, if there is damage to the left optic tract, there are right visual field deficits to both eyes. In the case of comatose patients, it has been noted that a majority of the patients had non-reactive, dilated pupils, and the one patient that had pinpoint pupils became vegetative. [4][7] Uncal herniation, in which the uncus protrudes over the edge of the tentorium, can lead to compression of CN III, suggesting current or impending brainstem compromise. Lesions within the efferent pathway, specifically the preganglionic fibers of the oculomotor nerve, can cause ipsilateral mydriasis and accommodation paralysis. One syndrome noted to have this finding is Weber Syndrome. If there is damage to the postganglionic fibers, tonic dilated pupil or Adie syndrome develops so that the constrictor muscles are hypersensitive to a cholinergic stimulus. If there is a disruption between the balance of parasympathetic and sympathetic innervation, such as in Horner syndrome where there is a loss of sympathetic stimulation, leading to miosis of the ipsilateral pupil.[6]

Transient mydriasis can be associated with tricyclic antidepressants, typical antipsychotics, and selective serotonin reuptake inhibitors, but usually these are not long-term consequences. Topiramate, used for migraines, has been associated with acquired myopia and angle-closure glaucoma.[8] The fixed dilation of pupils noted in coma patients was related to the increased intracranial pressure (ICP) in which an association was noted in 1866 from Von Leyden’s animal experiments. Through continued research over the next 50 years or so, it was noted that the fixed dilation of pupils was noted to be a sign of acute mass effect in relation to in the ICP.[9]

Tumors in the retina, optic nerve, and brain can also cause RAPDs. In children, the most common intraocular tumors are benign, developmental cysts. The most common malignant intraocular tumor is retinoblastoma.[9] Tumors or lesions affecting the optic chiasm or midbrain can cause decreased signals reaching the Edinger-Westphal nuclei, leading to pupillary constriction. In children, the most common intracranial tumor detected is a glioma. They account for 75% of intracranial tumors in children. Also common in children are astrocytomas, medulloblastomas, and ependymomas.

Another cause of RAPD is severe amblyopia, characterized as amblyopia of 20/100 to 20/400. Clinically, RAPDs are found in severe amblyopia with BCVA 20/400 or worse. While the etiology of a RAPD in amblyopia is poorly understood, significant risk factors include anisometropia, early age of onset with a history of strabismus, level of visual acuity at the conclusion of treatment, and extended periods of occlusion therapy.[10]

Pupillary escape is a phenomenon that can occur in the setting of a diseased optic nerve or retina. When light is shone onto the affected pupil, there will be a transient pupillary constriction and then a slow dilation to the original size.[11]

In cases in which one pupil is unable to constrict (such as due to a third nerve palsy), the “reverse RAPD test” can be performed, with direct and consensual responses compared in the reactive pupil. If the reactive pupil constricts more during the direct response, then the RAPD is in the unreactive eye. If the reactive pupil constricts more during the consensual response, then the RAPD is in the unreactive eye.[12] Emergency clinicians often encounter patients with the triad of pinpoint pupils, respiratory depression, and coma related to opioid overuse. Opioids are used for pain relief by interacting with opioid receptors, including mu, delta, and kappa. With significant respiratory depression resulting in hypoxia, pupils can become dilated. Oxygenation causes the pupils to revert to the original pinpoint presentation caused by the opioid. For stabilization, one of the medications given to these patients is naloxone, an opioid antagonist, which has a peak effect at approximately 10 minutes. Repeated dosing is frequently required and can be given up to 5 mg per hour. If there is a dilation of the pupil with the administration of naloxone, this also eliminates organophosphate poisoning, which can present similarly. Pupillary changes are used to recognize when the effects of naloxone are waning because of how the pupils will begin to constrict again, indicating that the opioid has not yet been metabolized out of the body. There is also the concern in the event of minimal reaction that the patient may be affected by other central nervous system depressants or have hypoxic brain damage.[10]

Nursing Actions and Interventions

The nurse has a crucial role in assisting the clinician before the test by preparing the patient. During the test, she assists the clinician by holding the light source and helps the clinician observe the changes in the opposite pupil. After the test, the nurse alerts the clinician, if any untoward changes in the condition of the patient. The nurse confirms that the patient is fully informed about his care plan and gives the patient all the necessary contact details.

Nursing Monitoring

  • Vital signs
  • Clarity of vision
  • Discharge the patient, only if they are fully recovered from the effect of mydriatics

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Pupillary Light Reflex - Questions

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A 25-year-old healthy woman presents to the clinic for a regular eye examination. She has no complaints. The clinician performs a standard ocular examination. As light is shone onto her left pupil, both pupils constrict. Which of the following drug mechanisms would directly inhibit this response?



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A 60-year-old man presents with his right eye looking down and out with a dilated pupil that is unreactive to light, while the left eye appears unaffected. He has a history of hypertension, hypercholesterolemia, and diabetes, all poorly controlled. CT angiogram reveals an aneurysm running alongside the affected nerve that is causing his pathology. When shining a light in the patient's right eye, there is a diminished pupillary response. Given the affected nerve, which part of the eye is causing this abnormality?



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A 54-year-old man presents to the hospital with right-sided ptosis, almost complete ophthalmoplegia of the right eye, and a miotic right pupil. MRI head and neck, and MRV are obtained, revealing a meningioma in the dural venous sinus bordered by the right temporal and right sphenoid bones. Which of the following is most likely affected resulting in his pupillary findings?



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A 30-year-old woman presents with right eye vision loss and pain worsened with eye movement, which started four days ago. She has a history of left eye blurry vision two years ago that resolved after one month, as well as numbness and tingling of her left arm six months ago that resolved after three weeks. MRI of brain and orbit with and without contrast reveals a single lesion. Which of the following would be expected on examination?



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A man comes into a clinic with “shooting and burning pain” in his legs, as well as difficulty walking. He has no past medical history and takes no medications. He is sexually active with several partners and does not use condoms. On exam, the clinician notices his feet slap the ground as he walks. When the clinician shines a light into both of his eyes, his pupils do not constrict. However, when they ask him to follow their finger as it moves closer to his nose, his pupils constrict. Given his symptoms and the specific pathway that is causing his ocular signs, what area of the brain is likely affected?



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Pupillary Light Reflex - References

References

Pupillary light reflex as a new prognostic marker in patients with heart failure., Nozaki K,Kamiya K,Matsue Y,Hamazaki N,Matsuzawa R,Tanaka S,Maekawa E,Kishi T,Matsunaga A,Masuda T,Izumi T,Ako J,, Journal of cardiac failure, 2018 Sep 20     [PubMed]
Understanding the effects of mild traumatic brain injury on the pupillary light reflex., Ciuffreda KJ,Joshi NR,Truong JQ,, Concussion (London, England), 2017 Nov     [PubMed]
Neurological Prognostications for the Therapeutic Hypothermia among Comatose Survivors of Cardiac Arrest., Kongpolprom N,Cholkraisuwat J,, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2018 Jul     [PubMed]
Shumway CL,Wade M, Anatomy, Head and Neck, Eye Extraocular Muscles 2018 Jan;     [PubMed]
Smith AM,Czyz CN, Neuroanatomy, Cranial Nerve 2 (Optic) 2018 Jan;     [PubMed]
Lynch G, Using Pupillometry to Assess the Atypical Pupillary Light Reflex and LC-NE System in ASD. Behavioral sciences (Basel, Switzerland). 2018 Nov 21;     [PubMed]
Bloom J,Czyz CN, Anatomy, Head and Neck, Eye Iris Sphincter Muscle 2018 Jan;     [PubMed]
Richa S,Yazbek JC, Ocular adverse effects of common psychotropic agents: a review. CNS drugs. 2010 Jun;     [PubMed]
Koehler PJ,Wijdicks EF, Fixed and dilated: the history of a classic pupil abnormality. Journal of neurosurgery. 2015 Feb;     [PubMed]
Henry J,Volans G, ABC of poisoning. Analgesics: opioids. British medical journal (Clinical research ed.). 1984 Oct 13;     [PubMed]
Cox TA, Pupillary escape. Ophthalmology. 2003 Feb;     [PubMed]
Broadway DC, How to test for a relative afferent pupillary defect (RAPD). Community eye health. 2016;     [PubMed]

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