Inflammatory Bowel Disease (IBD)


Article Author:
Christopher McDowell


Article Editor:
Muhammad Haseeb


Editors In Chief:
Sherri Murrell


Managing Editors:
Avais Raja
Orawan Chaigasame
Khalid Alsayouri
Kyle Blair
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Navid Mahabadi
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Abbey Smiley
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beenish Sohail
Hajira Basit
Phillip Hynes
Sandeep Sekhon


Updated:
1/2/2019 10:11:58 PM

Introduction

Inflammatory bowel disease (IBD) encompasses two types of idiopathic intestinal disease that are differentiated by their location and depth of involvement in the bowel wall. Ulcerative colitis (UC) involves diffuse inflammation of the colonic mucosa. Most often UC affects the rectum (proctitis), but it may extend into the sigmoid (proctosigmoiditis), beyond the sigmoid (distal ulcerative colitis), or include the entire colon into the cecum (pancolitis). Crohn disease (CD) results in transmural ulceration of any portion of the gastrointestinal tract (GI) most often affecting the terminal ileum and colon. Both diseases are classified by extent (mild, moderate, or severe) and location. CD also is classified by phenotype- inflammatory, structuring, or penetrating.[1][2][3]

Etiology

IBS occurs in genetically susceptible individuals after an inappropriate immune response to intestinal flora.

Epidemiology

The North American incidence of IBD ranges from 2.2 to 19.2 cases per 100,000 person-years for ulcerative colitis and 3.1 to 20.2 cases per 200,000 person-years for CD. Prevalence in the United States of adult ulcerative colitis was 238 per 100,000 population and 201 per 100,000 population from data in a large study based on insurance claims. IBD is much more prevalent in North America and Europe than Asia or Africa. Although most IBD occurs in people age 15 to 30 years, up to 25% of patients will develop IBD by adolescence. There appears to be a bimodal distribution with a second peak of 10% to 15% developing IBD after age 60.[4]

Pathophysiology

The intestinal immune system is key to the pathogenesis of IBD. The intestinal epithelium prevents bacteria or antigen entry into the circulation by sealed intracellular junctions. In IBD, these junctions are defective from either a primary barrier function failure or as a result of severe inflammation. Additional protective mechanisms include mucus production by Goblet cells and Paneth cells secretion of a-defensins with intrinsic antimicrobial activity. Excessive inflammatory reactions lead to continued deterioration of the epithelium and further exposure to intestinal microbes thereby furthering worsening the inflammation. 

UC predisposes patients to the extraintestinal involvement of the skin, eyes, and bones.  Most commonly these involved inflammatory arthropathies and primary sclerosing cholangitis. CD preferentially attacks the ileum and colon but can involve the esophagus, duodenum or stomach. Pediatric-onset cases have greater upper GI tract involvement. As in the case of UC, CD predisposes patients to extraintestinal manifestations including arthritis, aphthous stomatitis uveitis, erythema nodosum, and ankylosing spondyloarthropathy.[5][6]

Histopathology

Microscopic evaluation in active IBD patients reveals pronounced infiltration of the lamina propria with a mix of neutrophils, macrophages, dendritic cells, and natural killer T cells. Increased numbers and activation of these cells increased the level of tumor necrosis factor-a (TNF-a), interleukin-1b, interferon-g, and cytokines of the interleukins-23-TH17 pathway.

History and Physical

UC most commonly presents as bloody diarrhea with or without mucus. Patients commonly describe tenesmus, a sensation of incomplete evacuation, and abdominal pain. The physical exam may reveal predominantly left lower or left upper quadrant abdominal pain. Signs of an acute abdomen including guarding, rebound tenderness or percussion tenderness warrant investigation for toxic megacolon.

Presentations of Crohn’s disease vary considerably depending on the region of gastrointestinal involvement. Manifestations vary based the underlying etiology of inflammation, fistula formation, or stricture formation. The symptom complex of right lower quadrant pain, weight loss, and non-bloody diarrhea are suggestive of a Crohn’s flare-up. Fistula formation may result in fecaluria, pneumaturia, and rectovaginal fistulas.  Masses in the right lower quadrant suggest an abscess.

Evaluation

Diagnosing IBD requires a combination of clinical findings, inflammatory laboratory markers, imaging findings, and endoscopic biopsies. Hematologic findings include microcytic anemia, leukocytosis, and thrombocytosis, Inflammatory markers such as the erythrocyte sedimentation rate (ESR) and high-sensitivity C-reactive protein (hsCRP) are commonly elevated.[7][8]

Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) have all been used in the diagnosis of IBD or to assess for complications. US usage in trained individuals can evaluate the right lower quadrant for ileal disease. MRI can evaluate for rectal fistulas. Most commonly, CT is employed to evaluate for perforation or bowel obstruction. CT enterography can be helpful in assessing for strictures or in operative planning.

Endoscopy evaluation with either esophagogastroduodenoscopy, colonoscopy, or both is essential to obtaining biopsies to confirm a diagnosis of IBD.

Treatment / Management

The goal of treatment is to induce remission for either UC or CD. Treatment of IBD is divided into the management of the mild, moderate, and severe disease. Agents formerly reserved for the more severe disease are now employed sooner. UC treatment depends greatly on the extent of disease and presence of extraintestinal manifestations. For those with mild to moderate disease limited to the rectum, aminosalicylate agents like mesalamine are mainstays. Mesalamine is administered rectally but may be combined with oral therapy to induce or maintain remission. For those patients with the moderate disease who are refractory to mescaline, oral glucocorticoids or immunomodulators such as TNF-a monoclonal antibodies (infliximab) may be an option. Up to 25% of all UC patients will require total colectomy for the uncontrolled disease. Proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice for elective cases.[9][10][11]

CD treatment depends on the portion of the GI tract involved, the degree of fistulizing or structuring, and any extraintestinal complications. Treatment of mild ileocecal disease is usually begun with mesalamine, which can be further augmented with the use of oral budesonide, a steroid with significant first-pass metabolization to limit systemic side effects. For more extensive disease, systemic steroid therapy with prednisone is necessary. The goal is to wean these steroids within six weeks. In those patients who cannot wean, an immunomodulating agent is added.  6-mercaptopurine (Purinethol), azathioprine (Imuran), or low-dose methotrexate. In those patients with moderate to severe disease, anti-tumor necrosis factor (anti-TNF) should be initiated. Before initiating biologic therapy, patients must complete purified protein derivative (PPD) to assess for latent tuberculosis. Surgical treatment may be necessary for those with severe fistulizing disease including diverting ostomy.[1][12][13]

Differential Diagnosis

In patients presenting with new diarrhea, infectious etiologies of diarrhea including parasites Escherichia coli 0157:H7 and Clostridium difficile must be ruled out first. Other colitis etiologies should be considered including, but not limited to, microscopic, lymphocytic, and collagenous. Those presenting with abdominal pain must have other causes considered as well including, but not limited to, appendicitis, irritable bowel disease, celiac disease and functional abdominal pain.

Prognosis

Prognosis for both UC and CD depends on the extent of disease and treatment response. The stool markers lactoferrin and calprotectin are useful in determining postoperative recurrence of CD. Some evidence exists that these can also be used to predict future flares.

Continued surveillance for dysplasia is critical for long-standing UC patients. Cumulative risk of colorectal cancer is estimated to be as high as 30% for those with the disease of 30 years or more. The extraintestinal manifestation of primary sclerosing cholangitis leads to liver failure.[14][15]

Complications

 Intestinal

  • Hemorrhage
  • Strictures
  • Colon perforation
  • Anal fistulas
  • Pelvic or perirectal abscesses
  • toxic megacolon
  • Cholangiocarcinoma, colon cancer

Extra Intestinal

  • Osteoporosis
  • Deep vein thrombosis
  • Anemia
  • Gallstones
  • Primary sclerosing cholangitis
  • Aphthous ulcers
  • Arthritis
  • Iritis
  • Pyoderma gangrenosum

Postoperative and Rehabilitation Care

Patients with IBD need life long follow up for their disease. There is no particular diet or supplement that has been shown to delay or prevent the symptoms of the disease.

Pearls and Other Issues

  • UC and CD are differentiated histologically by the depth of involvement in the bowel wall.
  • Both forms of IBD can develop with extraintestinal manifestations.

Enhancing Healthcare Team Outcomes

There are several gaps in our knowledge regarding the care of patients with IBD. Even though many advances have been made in treatment, a number of patients continue to miss out on these treatments. The best care for patients with IBD is from an interprofessional team that is dedicated to this pathology and is fully aware of the latest guidelines. Patients with IBD lead an unpredictable life with constant flare-ups and hence the interprofessional team should establish dedicated phone and support lines staffed by nurses and pharmacists. A network of healthcare providers should be easily accessible to deal with emergencies. Physician and allied healthcare collaboration are vital if one is to avoid delay in treatment. The goal is to halt the disease before widespread bowel damage and disability occurs. Furthermore, patient and healthcare communication should be improved and the patients should be supported during times of crises. Finally, evidence suggests that there is a great need to establish centers of excellence so that patients receive a consistent level of quality care across different healthcare settings.[16][17] (Level V)

Outcomes

The mortality of patients with IBD is about 1.5 -5 times higher compared to the general population. Patients with Crohn disease suffer the highest morbidity and mortality. The major cause of death include infections, the progression of disease, surgical complications, and multiorgan involvement. More important, patients with IBD also have a high rate of colorectal cancer. Patients who develop pancolitis have the highest risk of colon cancer within two decades. Hence screening colonoscopy is recommended at 1-2 year intervals.[18]

In addition to the disease, these patients are also managed with potent medications like steroids and biological agents, which have a host of adverse effects. Thus, the importance of the pharmacist who should be alert for any adverse reaction. Patients with IBD are also at risk for asthma or COPD.

Finally, IBD has enormous mental morbidity. Many patients develop depression, suicidal tendencies, and anxiety. thus, at every visit, the nurse should monitor the patient's mental status and make appropriate referrals.[19][20]

The quality of life for most patients is poor to okay.


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Inflammatory Bowel Disease (IBD) - Questions

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Which feature most reliably differentiates Crohn disease from ulcerative colitis?



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What is the one major difference between Crohn disease and ulcerative colitis?



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Which is not an extra-intestinal manifestation of inflammatory bowel disease (IBD)?



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In what age group are the vast majority of patients diagnosed with inflammatory bowel disease?



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What is the one major difference between Crohn disease and ulcerative colitis (UC)?



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Which of the following is not true about articular manifestations of inflammatory bowel disease?



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A female complains of a 3 week history of grossly bloody diarrhea with mucus and abdominal pain. She has had symptoms off and on for 4 months accompanied by a 10 pound weight loss. She has no travel history and does not drink well water. The working diagnosis is inflammatory bowel disease (IBD). Which of the following is the incorrect statement about IBD?



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A 26 year old female is surgically treated for a large perirectal abscess. She does well but a month later returns with swollen nodules on the anterior lower legs bilaterally. White blood cell count, thyroid stimulating hormone, and hemoglobin A1c are all normal but erythrocyte sedimentation rate is 60 mm/hour. Select the most probable complication that could occur.



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A 31-year-old female presents with progressive abdominal discomfort. Most days she has diarrhea but on occasion she has constipation. She also reports bloating and flatulence. Stress and eating seem to increase symptoms while defecation improves her condition. A physical exam is essentially normal. Labs show white blood cell count 7000 cells/microliter, hemoglobin 10 grams/dL, hematocrit 30%, platelets, 200,000, and erythrocyte sedimentation rate of 49 mm/hr. Stool shows no blood but is positive for lactoferrin. What is the next step in management?



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Which of the following dietary treatments are recommended in children with inflammatory bowel disease?



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Extra-intestinal manifestation of inflammatory bowel disease commonly occurs in all but which of the following organs?



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Extraintestinal manifestations of inflammatory bowel disease (IBD) include all of the following EXCEPT:



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Which of the following can be utilized in the treatment of inflammatory bowel disease (IBD)?



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Which of the following is not an extraintestinal manifestation of inflammatory bowel disease?



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Crohn disease and ulcerative colitis have which of the following in common?



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Which is the one major difference between Crohn versus ulcerative colitis?



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On presentation, what is the one major difference between Crohn and ulcerative colitis (UC)?



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In a patient with inflammatory bowel disease, which life style measure do you highly recommend?



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A 48-year old with a long-standing history of irritable bowel syndrome (IBS) now presents with some blood in her stools. She says she has no loss of weight, her bowel habits have always been varied, and she feels fine otherwise. What test should be done?



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Which of the following is a way to distinguish ulcerative colitis (UC) from Crohn disease?



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Inflammatory Bowel Disease (IBD) - References

References

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