Parkinson Disease


Article Author:
Saman Zafar


Article Editor:
Sridhara Yaddanapudi


Editors In Chief:
Casey Ciresi


Managing Editors:
Avais Raja
Orawan Chaigasame
Khalid Alsayouri
Kyle Blair
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Navid Mahabadi
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Abbey Smiley
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beenish Sohail
Hajira Basit
Phillip Hynes
Sandeep Sekhon


Updated:
2/11/2019 9:21:16 PM

Introduction

Parkinson disease is a neurodegenerative disorder that mostly presents in later life with generalized slowing of movements (bradykinesia) and at least one other symptom of resting tremor or rigidity. Other associated features are a loss of smell, sleep dysfunction, mood disorders, excess salivation, constipation, and excessive periodic limb movements in sleep (REM behavior disorder). [1][2][3]

Etiology

Over the past century, our understanding of the etiology of PD has evolved immensely. In 1919, it was first recognized that loss of pigmentation in the substantia nigra of the midbrain is a feature of the post-mortem brain examination of PD patients. In the 1950’s, it was further understood that the pigmented neurons that are lost in the substantia nigra are dopaminergic, and it is the loss of dopamine in subcortical motor circuitry that is implicated in the mechanism of the movement disorder in PD.[4][5]

Epidemiology

PD affects 1 to 2 people per 1000 at any time; the prevalence increases with age to affect 1% of the population above 60 years. 5% to 10% of patients have a genetic predisposition.

Pathophysiology

In 1999, several members of an Italian family in the New Jersey area were identified as suffering from PD, and the search for the genetic basis of this illness gained momentum. Studies on families with the rare autosomal dominant form of this disease led to a further breakthrough: That the primary etiology appears to be the accumulation of alpha-synuclein in various parts of the brain, primarily the substantia nigra, leading to degeneration and subsequent loss of dopamine in the basal ganglia that control muscle tone and movement. The accumulation of the alpha-synuclein protein may be secondary to a genetic predisposition, such as with the PARK-1 mutation identified in the Contursi kindred of New Jersey, or triggered by an unknown environmental agent. There has been some recent interest in establishing an infectious etiology that triggers off this alpha-synuclein accumulation, after reports that the earliest degenerative change in PD appears in the myenteric plexus on the GIT, from where it progresses up to involve the dorsal motor nucleus of the vagus nerve, the sleep centers in the pons, and then the midbrain. This interesting theory also addresses why PD patients typically suffer from gastrointestinal motility issues and REM sleep disorder, both of which can precede the motor manifestations of PD for many years.

Therefore, as our knowledge about the etiology of PD evolves, it is not enough to regard this disorder as primarily caused by a lack of dopamine in the substantia nigra. There appears to be a darker, more extensive pathophysiology behind this, and the non-genetic causes of alpha-synuclein deposition in the brain are a subject of active research.[6]

Histopathology

Loss of dopamine pigment in the substantia nigra is visible to the naked eye in cases of PD.

Histologically, PD is characterized by neuronal inclusions of alpha-synuclein in neuronal cell bodies (Lewy bodies) and within neuronal cell processes (Lewy neurites). The combination of Lewy bodies and Lewy neurites is sometimes referred to as Lewy-related pathology. The hallmark of any neurodegenerative disease is a selective neuronal loss, and loss in PD is most marked in the substantia nigra pars compacta. It has been known for many years, however, that Lewy bodies in PD extend well beyond the substantia nigra. Based on the distribution of alpha-synuclein pathology, Braak and co-workers have proposed a staging scheme for PD. In this scheme, neuronal pathology occurs early in the dorsal motor nucleus of the vagus in the medulla and the anterior olfactory nucleus in the olfactory bulb. As the disease progresses, locus ceruleus neurons in the pons and then dopaminergic neurons in the substantia nigra are affected. In later stages, pathology extends to the basal forebrain, amygdala, and the medial temporal lobe structures, with convexity cortical areas affected in the last stages. Subsequently, there have been proposals that autonomic neurons in the peripheral nervous system may be affected by the involvement of the central nervous system (CNS) which has prompted recognition that PD is a multiorgan disease process, not merely a disorder of the CNS. Moreover, it has fed the debate on cell-to-cell transmission of unknown transmissible agents, from the gut onwards to the brain through retrograde transmission in the vagus nerve.

History and Physical

An earlier feature of PD is tremor, typically unilateral and present at rest, which is usually the reason for seeking help at the Neurology Clinic. After using the hands, such as to pick up a book, the tremor may vanish for some minutes, only to return when the patient is distracted and resting once again. This is the so-called re-emerging tremor that is typical of PD.

Although tremor is a prominent and early symptom of PD, it is not always present and is not a necessary feature for diagnosis.

Slowness, or bradykinesia, on the other hand, is a core feature of PD. Patients will notice it takes them longer to do simple tasks, their walking is slower, and their ability to respond to threats is compromised. In the clinic, patients demonstrate an inability to tap their index finger and thumb rapidly, tap their foot rhythmically on the floor, or walk steadily.

Rigidity is the third prominent feature on examination. Patients appear stiff, and they find it difficult to rise out of a chair without support. While walking there is reduced arm swing, more so on one side than the other, as PD typically is asymmetric at onset. On checking muscle tone, lead pipe and cogwheel rigidity can be appreciated.

A combination of bradykinesia and rigidity leads to some other characteristic features of PD, such as micrographia. Interestingly, the diminishing size of Hitler’s handwriting with the passage of time leads to a retrospective diagnosis that he may have suffered with PD.

The fourth prominent feature of PD is gait disturbance, although this is typically a late manifestation. Flexed posture, reduced arm swing, festination, march-a-petits- pas, camptocormia, retropulsion, and turning enbloc are popular terms to describe the gait in PD. In advanced PD, patients will have trouble rising from a chair without support, they take small, slow steps, they are unable to stop themselves from falling if pushed lightly, they cannot turn around without taking several small steps, and they tend to freeze when faced with certain stimuli such as a doorframe or a passer-by. With experience, a neurologist can diagnose a long-suffering PD patient from their progress to the office chair from the waiting room, although it has to be said that some other neurologic conditions such as normal pressure hydrocephalus can produce similar gait. Gait disorder is not an early feature of PD but is frequently described as it is easy to recognize and cinches the diagnosis in later stages.

Apart from the above four prominent features of PD in the clinic, patients are usually asked about constipation, drooling, mood disorder and depression, REM sleep disorder, and anosmia. These subtle symptoms frequently accompany the tremor/rigidity paradox of PD patients and reflect the underlying alpha-synuclein deposition- mediated neurodegeneration in parts of the brain other than the substantia nigra.

Evaluation

Evaluation of PD patients usually starts with history and physical examination geared to picking up the signs described above. Movement disorders clinics may employ the Unified Parkinson Disease Rating Scale to quantify patient mentation, behavior, mood, activities of daily living, tremor, motor examination, and complications of therapy.[7][8][9]

An essential part of the evaluation of PD is to exclude the effect of medications that can lead to extrapyramidal side effects and motor manifestations that are, at times, indistinguishable from classical PD. Typically, it is traditional antipsychotics that are implied. In these cases, the nonmotor manifestations of PD, such as anosmia, are not found.

It is also important to exclude other neurodegenerative conditions. Other alpha-synucleinopathies such as Lewy body disease and multiple system atrophy can present with PD but have subtle differences that distinguish them as separate disease entities. Similarly, tauopathies such as progressive supranuclear palsy can present with bradykinesia, rigidity, and gait disturbance. 

For example, all the diseases below may have the same motor manifestations of PD, but:

  • Progressive Supranuclear Palsy patients will have vertical gaze paralysis on examination.
  • Lewy Body Dementia will have the added features of onset with dementia and hallucinations.
  • Multisystem Atrophy will present with early onset autonomic dysfunction, pyramidal and cerebellar signs.

In terms of investigations, PD remains one of the few medical conditions where clinical examination remains sufficient for formal diagnosis. MRI is useful in narrowing the differential and excluding other conditions that may present with a similar examination, such as normal pressure hydrocephalus or subcortical stroke. In certain situations, a DAT scan may be used to identify loss of dopaminergic uptake in the basal ganglia. However, the interpretation of this test can be challenging, and the routine use of this test is to be discouraged.

Practically, one of the best ways of establishing a diagnosis of PD in a patient with suggestive symptoms is a clear response to Levodopa treatment. This is either short-lived or not well seen with overlapping syndromes.  [8][10][11]

Treatment / Management

Pharmacologically, this is typically Levodopa (combined with Carbidopa, which decreases side effects and improves CNS bioavailability). A dopamine agonist (Pramipexole, Ropinirole) may be started in younger patients; it may not be as effective as Levodopa but will have fewer side effects. Anticholinergics or Amantadine may be used if the predominant symptom to be controlled is a tremor.

A multidisciplinary approach to the management of PD is essential. Patients do much better when a structured physical therapy program geared to PD is employed; they can be taught to improve their balance and gait, improve their stability, and maintain an active life. Some unique features of this movement disorder have been exploited to advantage; patients do well with music therapy in physical fitness programs, cycling, and boxing. Patients who cannot walk may find themselves able to dance. Depression, carer fatigue, constipation, REM sleep disorder, paranoia and psychosis as side effects of the medication or part of the primary disease, and all need to be addressed.

Patients responding well to pharmacological treatment may grow resistant with time, develop abruptly on/off motor symptoms, or suffer from disabling dyskinesia as a side effect. Varying the pharmacokinetics of Levodopa has sometimes helped, such as newer formulations of delayed release Levodopa or a continuous GI pump infusion form of Levodopa. The addition of other medications and balancing the timing of the medication can have a huge effect on the patient.

For some patients who do not respond to all measures, there is increasing availability of deep brain stimulation techniques to stabilize the balance of excitatory and inhibitory signals to the subthalamic nucleus or the globus pallidus. Although not entirely understood why this has such a positive effect on treatment failures in PD, it is now a new hope for advanced PD patients and an area of active progress.[12][13][14]

Differential Diagnosis

  • Essential tremor
  • Huntington chorea
  • Dementia with Lewy bodies
  • Progressive supranuclear palsy
  • Neuroacanthocytosis
  • Normal Pressure Hydrocephalus

Prognosis

The rate of progression of the disease may be predicted based on the following:

  • Males who have postural instability of difficulty with gait.
  • Patients with older age at onset, dementia, and failure to respond to traditional dopaminergic medications tend to have early admission to nursing homes and diminished survival.
  • Individuals with just tremor at initial presentation tend to have a protracted benign course.
  • Individuals diagnosed with the disease at older age combined with hypokinesia/rigidity tend to have a much more rapid progression of the disease.

Complications

  • Depression
  • Dementia
  • Laryngeal dysfunction
  • Autonomic dysfunction
  • Kyphosis leading to cardiopulmonary impairment

Postoperative and Rehabilitation Care

All patients diagnosed with PD need long-term follow up because of the progressive behavior and motor abnormalities. Slight adjustments in medications are needed in most patients. In addition, many patients develop erratic behavior like impulsivity, psychosis, paranoia, and somnolence.

Consultations

  • Psychiatrist
  • Neurosurgeon
  • Speech therapist
  • Urologist
  • Dietitian
  • Gastroenterologist
  • ENT
  • Physical therapist

Pearls and Other Issues

Guidelines

  • Sildenafil may be prescribed for erectile dysfunction
  • Constipation can be managed with polyethylene glycol
  • Somnolence can be managed with modafinil
  • Methylphenidate for excessive fatigue

Enhancing Healthcare Team Outcomes

Multidisciplinary Management

PD is the most common motor disorder in the U.S. The disorder has no cure and is progressive. The condition can present with motor abnormalities and a variety of psychiatric and autonomic problems. Almost every organ is affected by this disorder, and as the disease progresses, management can be difficult. Besides physicians, nurses, pharmacists, social workers, and physical therapists play a vital role in the daily management of these patients. Nurses have many roles when it comes to looking after PD patients. The first is the education of the patient and family and encouraging them to participate in decisions regarding the treatment. In addition, nurses are often the first to spot difficulties in daily living and hence should make the appropriate referrals or recommendations. Nurses also provide psychosocial support and referral to a therapist, if required. Finally, the nurse plays a key role in assessing the risk of falls and making referrals to a physical therapist for an ambulatory device. Other issues commonly encountered in these patients that require attention include dysphagia, cognitive decline, depression, and somnolence. Finally, the nurse should provide information on end of life care, financial planning, disability application and referral to a nursing home. [15][16] (Level V)

Since most PD patients are on multiple medications, the pharmacist has to closely monitor the drugs to ensure that they are safe and not causing any adverse reactions. 

Outcomes

PD is a progressive disease with no cure. The lifespan is reduced compared to the general population. However, the rate of disease progression is not always easy to predict. In the later stages of the disease, falls, gait difficulties and dementia are common. The quality of life for most patients with PD is poor. [17][18][15] (Level V)


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Parkinson Disease - Questions

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A 55-year-old male has progressively been getting worse with his daily living activities. In the clinic, he is found to have a festinating gait. What is the most likely diagnosis?



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An adult male is found to have a positive glabellar reflex. What disease may be developing?



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A 65-year-old with a shuffling gait may have what condition?

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Loss of pigmented dopaminergic neurons and presence of Lewy bodies is usually seen in which of the following disorders?



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Which of the following has been closely associated with the development of Parkinson disease?



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Which of the following is the most common initial presentation of Parkinson disease?



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Which of the following autonomic dysfunction symptoms are present in patients with Parkinson disease?



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Medications in patients with Parkinson disease usually provide relief for what time period?



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Which of the following medications is an appropriate treatment for a patient with Parkinson disease who has developed hallucinations?



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A patient is examined and found to have cogwheel rigidity. What is the most likely cause?



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A 65-year-old male with a flat affect is very slow in his movements. When he walks, he is stooped over and takes very small steps. His arm swing is diminished, and he appears to be shuffling. What type of gait problem is being described?



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Which of the following is true of Parkinson disease?



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A patient with Parkinson disease is give carbidopa. What is its mechanism of action?



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In Parkinson disease, there is loss of dopaminergic neurons in which of the following?



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Chronic exposure to what heavy metal has been linked to Parkinson disease?



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Symptoms of Parkinson disease arise when what percentage of dopaminergic neurons are destroyed?



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Cog wheeling is a feature of which disorder?



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Micrographia is a common feature in patients with which of the following?



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Hallucinations are quite common when parkinsonian patients develop dementia. Which medication can be used to treat this complication?



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What is the most striking gross finding in Parkinson disease?



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What is the most common drug used to treat Parkinson disease?



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Bradykinesia is indicative of which medical disorder?



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A 59-year-old man with advanced Parkinson disease has progressively lost effective response to multiple Parkinson medications and has begun to develop adverse effects. Functional activities of daily living are impaired. In considering surgical options, which of the following is not an accepted surgical intervention for advanced Parkinson?



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Pathologic findings of Parkinson disease in substantia nigra cells are most likely to exhibit which of the following?



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A Parkinson patient has been effectively treated with levodopa therapy for the last 5 years. Suddenly, he begins to have episodic periods of increased rigidity and marked inability to move. What is the term for the development of this symptom?



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A 50-year-old man presents with a right arm tremor at rest that improves with action, dragging of his right leg, rigidity in his right arm, and asymmetric bradykinesia. What is his most likely diagnosis?



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In Parkinson disease, there is a loss of which of the following types of neurons?



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What activity is most beneficial for gait disturbances in patients with Parkinson disease?



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Why are phenothiazines be not given to patients with Parkinson disease?



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What is the drug of choice to alleviate Parkinsonian tremors in a 71 year old?



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What is the drug of choice to alleviate Parkinsonian tremors in a 39 year old?



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Which is true of Parkinson disease?



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What is the first symptom of Parkinson disease?



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Which of the following is the major aim of treatment for patients with Parkinson disease?



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A 65 year old female has involuntary twitching of her right hand. She initially noticed the problem about a year ago. She is able to stop the "twitching" by staring at the hand and concentrating. This does not cause any impairment of activities. The left hand is not affected. No other neurologic symptoms are reported. A right hand tremor is noted, especially when the patient is distracted. There is slight bradykinesia on the right. What is the most likely finding on further examination?



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A 64 year old female has a progressive neurologic condition that forced her to retire from her factory job early. She has symptoms of rigidity, tremor, and bradykinesia that improve somewhat with levodopa and carbidopa. These findings are worse on the right side. What is likely to happen to her resting tremor when she falls asleep?



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Which fact about Parkinson disease is correct?



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What is primary mode of therapy with the Parkinsonian patient?



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What should be done for patients who stop improving with long-term therapy of controlled release levodopa?



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Select the patient that would be the best candidate for treatment of Parkinson disease with deep brain subthalamic stimulation.



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A 63-year-old left-handed female complains of shaking of her right hand for 6 months. It is worst at rest but she can stop the tremor by concentrating. It does not interfere with her life. She denies and problems with speech, swallowing, or behavior. Exam shows a resting tremor of the right hand, mildly tremulous handwriting, and contralateral activation causes bilateral cogwheel rigidity. Rapid alternating movement on the right is bradykinetic. Select the structure that is probably involved.



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A 65-year-old male with Parkinson disease has had symptoms for 10 years and is no longer responding to medications. He is unable to do activities of daily living. Electrical stimulation of which areas would most likely improve his symptoms?



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A 76-year-old male presents with a tremor that has been progressive over the past year. It mostly affects the right hand. Exam shows a right upper extremity-resting tremor with mild rigidity. There is bradykinesia. Select the best initial medication for this patient.



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What is the most common speech pathology seen with Parkinson disease (PD)?



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A patient has been treated successfully for years for Parkinson disease but suddenly has acute episodes of severe rigidity and bradykinesia. The episodes resolve spontaneously and suddenly. What is the most likely cause?



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A 66-year-old female presents with left hand stiffness and dragging of her left leg. Exam shows a resting tremor of the left hand that disappears with intent. Cogwheel rigidity of the left arm is noted. Movements on the left are slower than on the right. What is the most likely diagnosis?



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Which of the following is a diagnostic characteristic of Parkinson disease?



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A patient with dementia and advanced Parkinson disease is transferred to the emergency department with acute mental status changes, tachycardia, and tachypnea. He is afebrile and normotensive, but his exam shows right middle lobe rhonchi and oxygen saturation of 87 percent. The chest radiograph shows a right middle lobe infiltrate. What is the most likely diagnosis?



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Which of the following is the foremost sign of Parkinson disease?



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A patient with advance Parkinson disease complains of fatigue during the day. Which of the following would be the best intervention?



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Parkinson disease is treated with dopamine agonists to improve movement. Which side effect can occur with the dopamine stimulation?



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Which of the following would not be an OT goal for a patient with Parkinson disease?



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Which of the following findings are seen with Parkinson disease?



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Select the true statement about Parkinson disease.



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A 62-year-old man is diagnosed with Parkinson disease. He has mild to moderate symptoms that are affecting his quality of life. Select the correct statement about initiation of treatment.



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Which of the four most common motor symptoms of Parkinson disease is atypical?



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Which of the following is true about dementia in patients with Parkinson disease?



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Patients with untreated Parkinson disease have been evaluated with cerebral blood flow studies while doing paced movement using a joystick. To what area is decreased blood flow observed?



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What is the most disabling symptom of Parkinson disease (PD)?



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What is the most prevalent neurobehavioral change in patients with Parkinson disease?



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Which of the following is seen with Parkinson disease (PD) but not progressive supranuclear palsy (PSP)?



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Ropinirole, a centrally acting dopamine receptor agonist, is used for the treatment of restless legs syndrome (RLS or Ekbom syndrome). Given its mechanism of action, they could treat what with ropinirole?



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A 60-year-old man who walks with his head and shoulders stooped forward and shuffling feet has which of the following?



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Which of the following would not increase safety for a patient with moderate Parkinson disease?



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Which of the following is a common initial treatment for Parkinson disease?



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A patient has Hoehn and Yahr stage 3 Parkinson disease is taking a combination of levodopa and carbidopa. She is receiving physical therapy for fall prevention due to recent and sudden increase in falls after an increase in medication. Which of the following impairments is most likely contributing to the patients increased balance problems?



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Which metallic element has been associated with the development of Parkinson disease?



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After tapping on the forehead of a 65-year old the patient has uncontrollable blinking. This is a classic feature of patients with which of the following?



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A 72-year-old man with Parkinson disease presents with psychotic behavior. The patient is currently taking levodopa/carbidopa to control his Parkinson disease symptoms. Which of the following would best treat the psychotic behavior?



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A 65-year-old male presents with muscle rigidity and mask-like faces that first appeared 6 months ago. The family states that he has a shuffling gait and a habit of dropping objects. On exam, the patient has a stooped posture and appears unstable when he walks. His handwriting is shown in the below image. A medication to treat his motor dysfunction is prescribed. At the same time, what should be recommended to improve his handwriting?

(Move Mouse on Image to Enlarge)
  • Image 6583 Not availableImage 6583 Not available
    Image courtesy S Bhimji MD
Attributed To: Image courtesy S Bhimji MD



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A 69-year-old male is brought in by his family. His posture and gait are shown in the image below. The family states that for the past 4 months he has had a tremor in his left hand, his body movements have slowed down, and he has become somewhat rigid in his movement. A motor disorder is diagnosed. These patients also develop a number of non-motor symptoms before the onset of motor symptoms. In the history, most patients with this disorder usually admit to what nonmotor symptom?

(Move Mouse on Image to Enlarge)
  • Image 6287 Not availableImage 6287 Not available
    Image courtesy S Bhimji MD
Attributed To: Image courtesy S Bhimji MD



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Which of the following are motor symptoms of a patient with Parkinson disease? Select all that apply.



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Which of the following are non-motor symptoms of a patient with Parkinson disease? Select all that apply.



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A 72-year-old male presents with his daughter due to him seeming distracted, "out of it", and exhibiting rubbing of his thumb and forefingers together. On exam, he also appears off-balanced. The daughter reports this to be the state her father has been in for the past couple of weeks. Which of the following explains these symptoms?



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Parkinson Disease - References

References

Mirpour S,Turkbey E,Marashdeh W,El Khouli R,Subramaniam RM, Impact of DAT-SPECT on Management of Patients Suspected of Parkinsonism. Clinical nuclear medicine. 2018 Aug 27     [PubMed]
Alexoudi A,Alexoudi I,Gatzonis S, Parkinson's disease pathogenesis, evolution and alternative pathways: A review. Revue neurologique. 2018 Aug 18     [PubMed]
Kabra A,Sharma R,Kabra R,Baghel US, Emerging and alternative therapies for Parkinson disease: an updated review. Current pharmaceutical design. 2018 Aug 20     [PubMed]
Ehgoetz Martens KA,Shine JM,Walton CC,Georgiades MJ,Gilat M,Hall JM,Muller AJ,Szeto JYY,Lewis SJG, Evidence for subtypes of freezing of gait in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2018 Jul     [PubMed]
Chung SJ,Yoo HS,Lee HS,Oh JS,Kim JS,Sohn YH,Lee PH, The Pattern of Striatal Dopamine Depletion as a Prognostic Marker in De Novo Parkinson Disease. Clinical nuclear medicine. 2018 Aug 27     [PubMed]
Gratton C,Koller JM,Shannon W,Greene DJ,Snyder AZ,Petersen SE,Perlmutter JS,Campbell MC, Emergent Functional Network Effects in Parkinson Disease. Cerebral cortex (New York, N.Y. : 1991). 2018 Jun 6     [PubMed]
Berg D,Adler CH,Bloem BR,Chan P,Gasser T,Goetz CG,Halliday G,Lang AE,Lewis S,Li Y,Liepelt-Scarfone I,Litvan I,Marek K,Maetzler C,Mi T,Obeso J,Oertel W,Olanow CW,Poewe W,Rios-Romenets S,Schäffer E,Seppi K,Heim B,Slow E,Stern M,Bledsoe IO,Deuschl G,Postuma RB, Movement disorder society criteria for clinically established early Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2018 Aug 25     [PubMed]
Creaby MW,Cole MH, Gait characteristics and falls in Parkinson's disease: A systematic review and meta-analysis. Parkinsonism     [PubMed]
Odin P,Chaudhuri KR,Volkmann J,Antonini A,Storch A,Dietrichs E,PirtoŇ°ek Z,Henriksen T,Horne M,Devos D,Bergquist F, Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson's disease. NPJ Parkinson's disease. 2018     [PubMed]
Shen Y,Huang JY,Li J,Liu CF, Excessive Daytime Sleepiness in Parkinson's Disease: Clinical Implications and Management. Chinese medical journal. 2018 Apr 20     [PubMed]
Goodarzi Z,Hanson HM,Jette N,Patten S,Pringsheim T,Holroyd-Leduc J, Barriers and Facilitators for Guidelines with Depression and Anxiety in Parkinson's Disease or Dementia. Canadian journal on aging = La revue canadienne du vieillissement. 2018 Jun     [PubMed]
Rogers G,Davies D,Pink J,Cooper P, Parkinson's disease: summary of updated NICE guidance. BMJ (Clinical research ed.). 2017 Jul 27     [PubMed]
Biundo R,Weis L,Fiorenzato E,Antonini A, Cognitive Rehabilitation in Parkinson's Disease: Is it Feasible? Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2017 Nov 1     [PubMed]
Rosenquist PB,Youssef NA,Surya S,McCall WV, When All Else Fails: The Use of Electroconvulsive Therapy for Conditions Other than Major Depressive Episode. The Psychiatric clinics of North America. 2018 Sep     [PubMed]
Eggers C,Dano R,Schill J,Fink GR,Timmermann L,Voltz R,Golla H,Lorenzl S, Access to End-of Life Parkinson's Disease Patients Through Patient-Centered Integrated Healthcare. Frontiers in neurology. 2018     [PubMed]
Espay AJ,Aybek S,Carson A,Edwards MJ,Goldstein LH,Hallett M,LaFaver K,LaFrance WC Jr,Lang AE,Nicholson T,Nielsen G,Reuber M,Voon V,Stone J,Morgante F, Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders. JAMA neurology. 2018 Jun 4     [PubMed]
Wanneveich M,Moisan F,Jacqmin-Gadda H,Elbaz A,Joly P, Projections of prevalence, lifetime risk, and life expectancy of Parkinson's disease (2010-2030) in France. Movement disorders : official journal of the Movement Disorder Society. 2018 Aug 25     [PubMed]
Ophey A,Eggers C,Dano R,Timmermann L,Kalbe E, Health-Related Quality of Life Subdomains in Patients with Parkinson's Disease: The Role of Gender. Parkinson's disease. 2018     [PubMed]

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