Primary Hyperparathyroidism


Article Author:
Binod Pokhrel


Article Editor:
Steven Levine


Editors In Chief:
Casey Ciresi


Managing Editors:
Avais Raja
Orawan Chaigasame
Khalid Alsayouri
Kyle Blair
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Navid Mahabadi
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beenish Sohail
Hajira Basit
Phillip Hynes
Sandeep Sekhon


Updated:
5/13/2019 11:35:51 PM

Introduction

Primary hyperparathyroidism is a relatively common disorder that may cause significant renal and skeletal complications, although most patients diagnosed in recent decades have mild degrees of hypercalcemia and are often asymptomatic. Surgery remains the definitive treatment. However, conservative observation or medical therapy may be appropriate for selected patients.[1] A basic understanding of normal calcium homeostasis is essential in diagnosing and managing patients with hyperparathyroidism.

Etiology

 PTH-dependent Causes of Hypercalcemia

  • Primary Hyperparathyroidism

    • Single adenoma

    • Multigland disease

      • Familial causes of hyperparathyroidism

        • Multiple endocrine neoplasia Type 1

        • Multiple endocrine neoplasia Type 2

        • Familial hyperparathyroidism

        • Hyperparathyroidism-jaw tumor syndrome

    • Parathyroid carcinoma

  • Familial hypocalciuric hypercalcemia, autosomal dominant inactivating mutations of the calcium-sensing receptor

  • Adverse effect of treatment with lithium

PTH Independent Causes of Hypercalcemia

  • Malignancy

  • Granulomatous diseases

  • Hyperthyroidism

  • Thiazide therapy

  • Vitamin D intoxication

  • Milk-alkali syndrome

  • Adrenal insufficiency

  • Vitamin A intoxication

Epidemiology

Once considered a relatively rare disease associated with significant morbidity, primary hyperparathyroidism is now a relatively common disorder that is often asymptomatic. Prior to 1970, the diagnosis went unsuspected until patients presented with specific symptoms, typically nephrolithiasis or bone pain. Since then most patients are diagnosed with hyperparathyroidism when a serum calcium is incidentally discovered to be increased on a chemistry profile ordered as screening tests or for an unrelated problem. The current incidence in the United States has been estimated at a mean of 66 per 100,000 person-years in women, and from 13 to 36 per 100,000 person-years in men.[2]

Pathophysiology

Normal Calcium Homeostasis

Under physiologic circumstances, the concentration of calcium in the extracellular fluid is maintained within a very narrow range. Normal calcium homeostasis is dependent upon a complex set of hormonal regulatory mechanisms that include the effects of parathyroid hormone, vitamin D metabolites, and calcitonin on calcium transport in bone, kidney, and the gastrointestinal tract.

Approximately 50% of total serum calcium is protein-bound, principally to albumin. Forty-five percent is ionized, while a small proportion is complexed to anions such as phosphate and citrate. It is only the ionized calcium that is biologically active, yet most laboratories report total serum calcium levels. Measurements of ionized calcium are available. However, an approximate correction of serum calcium can be made by adjusting for differences in the serum albumin level.

Corrected calcium = Measured calcium + 0.8 x (4.0 - albumin)

Caution must be exercised in evaluating normal total serum calcium levels in patients with hypoalbuminemia. Such patients may have elevated ionized calcium levels and are truly hypercalcemic. Conversely, the ionized calcium is often normal when there is a low total calcium concentration in the presence of hypoalbuminemia. 

Parathyroid Hormone

Secretion of parathyroid hormone is inversely related to the concentration of ionized calcium in the extracellular fluid. The calcium-sensing receptor (CaSR) is a G-protein coupled receptor whose activity varies with changes in the types of serum calcium. As the calcium concentration in the extracellular fluid increases, this receptor is activated and parathyroid cells decrease secretion of parathyroid hormone. Conversely, the activity of the CaSR decreases and parathyroid hormone secretion increases as calcium levels decline. Mutations that inactivate the CaSR are the etiology of familial hypocalciuric hypercalcemia (FHH), an autosomal dominant disorder characterized by increased parathyroid hormone secretion, hypercalcemia, and hypocalciuria.

Parathyroid hormone activates the parathyroid hormone receptor increasing resorption of calcium and phosphorus from bone, enhancing the distal tubular resorption of calcium, and decreasing the renal tubular resorption of phosphorus. Also, parathyroid hormone plays an essential role in vitamin D metabolism, activating the vitamin D 1-alpha hydroxylase, which increases the renal synthesis of 1,25-dihydroxyvitamin D.

History and Physical

In past decades most patients were diagnosed when they had complaints of nephrolithiasis, bone pain, or bone deformity. Now, most patients with primary hyperparathyroidism are asymptomatic, diagnosed when hypercalcemia is incidentally discovered on a chemistry profile. Patients should be asked about any history of kidney stones, bone pain, myalgias or muscle weakness, symptoms of depression, use of thiazide diuretics, calcium products, vitamin D supplements, or other symptoms associated with the multiples etiologies of hypercalcemia.[3] A familial syndrome should be considered when primary hyperparathyroidism is diagnosed at an early age, or there is a family history of hypercalcemia, pituitary adenomas, pancreatic islet cell tumors, pheochromocytomas, or medullary thyroid cancer.

The physical examination of a patient with primary hyperparathyroidism is usually normal. However, the physical examination can be helpful in finding abnormalities that could suggest other etiologies of hypercalcemia. Parathyroid adenomas are rarely palpable on physical examination, but the presence of a large, firm mass in the neck of a patient with hypercalcemia should raise suspicion of a parathyroid carcinoma.

Evaluation

Patients with primary hyperparathyroidism and other causes PTH-dependent hypercalcemia often have frankly elevated levels of PTH, while some will have values that fall within the reference range for the general population. A normal PTH in the presence of hypercalcemia is considered inappropriate and still consistent with PTH-dependent hypercalcemia. PTH levels should be very low in those patients with PTH-independent hypercalcemia.

A comprehensive clinical evaluation complemented by routine laboratory and radiologic studies should be sufficient to establish a diagnosis of primary hyperparathyroidism in a patient with persistent hypercalcemia and an elevated serum level of parathyroid hormone. It is uncommon for clinically occult malignancies to cause hypercalcemia. Most patients with malignancy-associated hypercalcemia are known to have cancer, or cancer is readily detectable on initial evaluation, and PTH levels will be suppressed.

A review of previous medical records can often be of significant value in establishing the cause of hypercalcemia. Most patients with hyperparathyroidism have persistent or intermittent hypercalcemia for many years before a definitive diagnosis is established. Very few diseases, other than hyperparathyroidism, will allow a healthy appearing individual to be hypercalcemic for more than a few years without becoming clinically obvious.[3]

List of tests for primary hyperparathyroidism: 

  • Total calcium

  • Albumin

  • Calculation of the “corrected” serum calcium. Approximately 50% of total serum calcium is protein-bound, principally to albumin and only free or ionized fraction is biologically active. Corrected calcium = Measured calcium + 0.8 x (4.0 - albumin) (calcium measured in mg/dL; albumin measured in g/dL)

  • Ionized calcium in selected cases when there are questions about the accuracy of the corrected calcium

  • Parathyroid hormone

  • Phosphorus

  • BUN and creatinine

  • Alkaline phosphatase

  • 25-hydroxyvitamin D

  • Urine calcium and creatinine

  • Imaging to screen for renal calcifications or urolithiasis

  • Bone densitometry (DXA) including measurement at the distal 1/3 radius

  • EKG

  • Genetic testing in selected individuals if there is suspicion of a genetic syndrome

  • Parathyroid scan and neck ultrasound. These tests are not considered diagnostic because there can be false negative results. They should not be ordered when there are no plans for surgery. They should be ordered when there are plans for surgery to assist the surgeon as a “roadmap” in localizing enlarged parathyroid gland.

The need for other studies such as PTHrP levels, serum or urine protein electrophoresis, 1,25-dihydroxyvitamins D levels, thyroid tests, bone scans, or mammography can be individualized and are usually only needed in those with PTH-independent hypercalcemia.[4]

Treatment / Management

Surgery remains the definitive treatment for primary hyperparathyroidism, but non-operative surveillance may be the appropriate option for some, particularly for patients who are elderly with mild hypercalcemia and no significant complications. Medical treatment with bisphosphonates or cinacalcet can be useful in selected patients. The decision whether to recommend surgery is based on age, the degree of hypercalcemia, and the presence or absence of complications due to hyperparathyroidism. Surgery is the treatment of choice for those with recurrent kidney stones.

Since 1990, several workshops have been convened to develop guidelines to assist physicians in the management of asymptomatic hyperparathyroidism. Surgical and medical experts, internationally recognized for their experience in managing patients with hyperparathyroidism, reviewed the evidence-based medical literature and a consensus of their opinions was disseminated to the medical community. The most recent guidelines were published in 2014.[5]

The current guidelines state that surgery should be recommended for asymptomatic primary hyperparathyroidism when:[6]

  • Serum calcium is more than 1 mg/dL greater than the upper limit of normal

  • Age younger than 50 years

  • Osteoporosis

  • GFR less than 60 mL/min

  • Urine calcium greater than 400 mg/24 hours

  • Evidence of renal calcification or stones

Left untreated, many patients with primary hyperparathyroidism have progressive loss of cortical bone while successful surgery leads to a substantial increase in bone mineral density, an effect that can persist for up to 15 years.

For patients where observation is the selected course of action, periodic monitoring with measurement of serum and urine calcium, renal function, and bone densitometry is required. If there is worsening hypercalcemia or development of complications, then surgery should be recommended.[7]

Medical Treatment

Some patients who are not surgical candidates may benefit from medical management of primary hyperparathyroidism.

  • Bisphosphonates can increase bone mineral density in those with osteoporosis or osteopenia.

  • Agonists to the calcium-sensing receptor, such as cinacalcet will lower PTH and calcium levels. However, they do not increase bone density.[8]

Pearls and Other Issues

Primary hyperparathyroidism preferentially reduces cortical bone density and increases fracture risk at sites where cortical bone predominates, such as the distal forearm, with relative sparing of trabecular bone. For this reason, those with hyperparathyroidism should have a dual-energy x-ray absorptiometry that includes the distal third radius, a site composed almost exclusively of cortical bone, in addition to measurements at the spine and hip.

Primary hyperparathyroidism is associated with some psychological complaints including depression, anxiety, fatigue, irritability, lassitude, and sleep disturbance. There is an inconsistent improvement in psychological parameters, and quality of life following parathyroidectomy and patient numbers in high-quality studies are small.[9]

When there is a family history of hyperparathyroidism consider the possibility of multiple endocrine neoplasia types 1 or 2a or familial hypocalciuric hypercalcemia (FHH), an autosomal dominant inactivating mutation of the calcium-sensing receptor. Urine calcium excretion with the calculation of the fractional excretion of calcium is the best initial test to differentiated familial hypocalciuric hypercalcemia from primary hyperparathyroidism. Patient with familial hypocalciuric hypercalcemia is typically asymptomatic without renal stones or osteoporosis. Subtotal parathyroidectomy does not cure this problem and total parathyroidectomy results in hypoparathyroidism.[10]

Enhancing Healthcare Team Outcomes

Primary hyperparathyoidism is a relatively common disorder. Because hypercalcemia can affect many organs, the condition is best managed by an interprofessional team that includes a radiologist, endocrinologist, surgeon, internist and a nephrologist. Patients who are asymptomatic can be observed but all symptomatic patients need surgery. Follow up can be by the primary care provider or nurse practitioner and should involve renal function, bone density, calcium levels and mood changes.

If hypercalcemia is left untreated it can have severe adverse effects on many organs. After surgery, most patients have a good outcome.


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Primary Hyperparathyroidism - Questions

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A 75-year-old presents complaining of anorexia, nausea, abdominal pain, and muscle weakness. Laboratory tests show an elevated calcium level. What is the most likely diagnosis?



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Which of the following electrolyte abnormalities is invariably present in primary hyperparathyroidism in children?



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A 63-year-old female is brought in by her husband with multiple complaints. She had mild depression, abdominal pain, excessive sleepiness, proximal muscle weakness, and slowing of movements. There is obvious atrophy of proximal limb musculature. Complete blood count is normal but chemistry panel shows calcium of 12.1 mg/dL and creatinine of 2.4 mg/dL. She was diagnosed with pseudogout 2 months ago. What is the most likely diagnosis?



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A 72-year-old female with no significant past medical history has isolated elevated calcium, but no symptoms. Repeat level is also increased. Select the most likely etiology.



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An asymptomatic patient is found to have hypercalcemia on routine laboratories. Serum calcium is 12.2 mg/dL and phosphate is 2.2 mg/dL. Complete blood count, electrolytes, albumin, and renal function are all normal. Select the most likely diagnosis.



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A healthy 52-year-old female is found on routine labs to have a calcium of 11.5 mg/dL and phosphate of 3.1 mg/dL. Select the most likely cause.



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What percentage of patients with a diagnosis of primary hyperparathyroidism is secondary to multiple adenomas?



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A 50 year old male complains of muscle weakness, intermittent right flank pain, nausea, and fatigue. Laboratories show decreased serum phosphorus, increased calcium, increased urinary calcium, microhematuria, elevated parathyroid hormone, and normal parathyroid hormone-related protein. Select the most probable diagnosis.



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What is the most important and prominent feature to occur if the parathyroid glands are removed from an animal?



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A 73-year-old woman is incidentally noted to have a serum calcium of 10.8 mg/dL (normal 8.6 to 10.3) and albumin of 3.9 g/dL on routine lab tests done during an annual physical examination. On review of her previous medical records, her calcium has varied from 9.9 to 11.0 mg/dL over the past seven years. Her parathyroid hormone level is 107 pg/mL (normal 15 to 65), and urine calcium is 265 mg/24 hours. A dual energy x-ray absorptiometry shows she has osteoporosis of the distal one-third of the radius and hips. You recommend surgery because she has osteoporosis, but she refuses and requests medical therapy. Which one of the following is the best choice?



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A 45-year-old man diagnosed with asymptomatic primary hyperparathyroidism has a calcium of 10.6 mg/dL (8.6-10.3), albumin 4.0 g/dL, parathyroid hormone (PTH) 125 pg/mL (15-65), and creatinine 0.9 mg/dL (0.8-1.1). Urine calcium excretion is 311 mg/24 hours. His dual energy x-ray absorptiometry has following T scores: lumbar spine T -0.6, hip T -1.5, distal one-third of the radius T -1.3. He has no history of kidney stones. Why should surgery be recommended?



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A 57-year-old man is referred for evaluation of hypercalcemia. Calcium is 11.2 mg/dL (8.6-10.3), albumin 4.1 g/dL, parathyroid hormone (PTH) 134 pg/mL (15-65), and glomerular filtration rate (GFR) 56 ml/min. Review of medical records shows his corrected serum calcium ranging from 9.6 to 11.8 mg/dL for the past four years. Dual energy x-ray absorptiometry shows osteopenia, and no renal stones are seen on an ultrasound of the kidneys. 24-hour urine calcium excretion is 246 mg. You recommend an ultrasound of the neck and parathyroid scan followed by parathyroid surgery. However, the patient adamantly refuses to consider surgery. What should be done next?



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A 38-year-old female with a past medical history of severe gastroesophageal reflux was diagnosed with primary hyperparathyroidism. A parathyroid scan showed a left inferior parathyroid adenoma. She was referred for parathyroidectomy and successfully underwent the procedure two weeks ago. Her intraoperative parathyroid hormone decreased from 232 pg/mL to 34 pg/mL. During her workup of hypercalcemia, she had a dual-energy x-ray absorptiometry which showed osteoporosis of the left distal one-third of the radius. There were no signs of a fragility fracture. What needs to be done regarding her osteoporosis?



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A patient has a parathyroid adenoma. Which of the following findings would be expected? Select all that apply.



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Primary Hyperparathyroidism - References

References

Incidence and prevalence of primary hyperparathyroidism in a racially mixed population., Yeh MW,Ituarte PH,Zhou HC,Nishimoto S,Liu IL,Harari A,Haigh PI,Adams AL,, The Journal of clinical endocrinology and metabolism, 2013 Mar     [PubMed]
Differentiating familial hypocalciuric hypercalcemia from primary hyperparathyroidism., Shinall MC Jr,Dahir KM,Broome JT,, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2013 Jul-Aug     [PubMed]
Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop., Silverberg SJ,Lewiecki EM,Mosekilde L,Peacock M,Rubin MR,, The Journal of clinical endocrinology and metabolism, 2009 Feb     [PubMed]
Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop., Bilezikian JP,Brandi ML,Eastell R,Silverberg SJ,Udelsman R,Marcocci C,Potts JT Jr,, The Journal of clinical endocrinology and metabolism, 2014 Oct     [PubMed]
Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop., Silverberg SJ,Clarke BL,Peacock M,Bandeira F,Boutroy S,Cusano NE,Dempster D,Lewiecki EM,Liu JM,Minisola S,Rejnmark L,Silva BC,Walker MD,Bilezikian JP,, The Journal of clinical endocrinology and metabolism, 2014 Oct     [PubMed]
What predicts adverse outcomes in untreated primary hyperparathyroidism? The Parathyroid Epidemiology and Audit Research Study (PEARS)., Yu N,Leese GP,Donnan PT,, Clinical endocrinology, 2013 Jul     [PubMed]
The surgical management of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop., Udelsman R,Åkerström G,Biagini C,Duh QY,Miccoli P,Niederle B,Tonelli F,, The Journal of clinical endocrinology and metabolism, 2014 Oct     [PubMed]
Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a prospective, randomized trial., Bollerslev J,Jansson S,Mollerup CL,Nordenström J,Lundgren E,Tørring O,Varhaug JE,Baranowski M,Aanderud S,Franco C,Freyschuss B,Isaksen GA,Ueland T,Rosen T,, The Journal of clinical endocrinology and metabolism, 2007 May     [PubMed]
The long-term benefit of parathyroidectomy in primary hyperparathyroidism: a 10-year prospective surgical outcome study., Pasieka JL,Parsons L,Jones J,, Surgery, 2009 Dec     [PubMed]
Prospective, randomized, controlled trial of parathyroidectomy versus observation in patients with "asymptomatic" primary hyperparathyroidism., Perrier ND,Balachandran D,Wefel JS,Jimenez C,Busaidy N,Morris GS,Dong W,Jackson E,Weaver S,Gantela S,Evans DB,Grubbs EG,Lee JE,, Surgery, 2009 Dec     [PubMed]

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