Hookworm


Article Author:
Alhassan Ghodeif


Article Editor:
Hanish Jain


Editors In Chief:
Casey Ciresi


Managing Editors:
Avais Raja
Orawan Chaigasame
Khalid Alsayouri
Kyle Blair
Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Navid Mahabadi
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beenish Sohail
Hajira Basit
Phillip Hynes
Sandeep Sekhon


Updated:
9/11/2019 1:03:26 PM

Introduction

Hookworms are nematode parasites which usually get transmitted through infested soil. They usually affect the poorest individuals in tropical and subtropical areas. Two species are mainly responsible for human infections, Ancylostoma duodenale, and Necator americanus. They can cause chronic infection of the intestinal tract, suck their host blood and hence leading to iron deficiency anemia in most cases. Moreover, pulmonary manifestations might occur by the effect of larval migration. While multiple medications are available to treat hookworm infections, prevention is still a vital step to fight complications.[1][2][3]

Etiology

Ancylostoma duodenale and Necator americanus are the principal species that infect humans. Ancylostoma ceylanicum is currently considered as a significant cause of zoonotic infections in some regions of Asia. However, it doesn’t cause blood loss. Ancylostoma caninum, a dog hookworm, might cause enteritis and ileitis. Ancylostoma braziliense is the primary cause of cutaneous larva migrans.[4][5]

Epidemiology

Worldwide, about 470 million people have hookworm infections. Infection predominates within developing countries and leads to huge losses of economic productivity due to anemia worsening the already existing poverty and disease.

Necator americanus is the major cause of hookworm infections worldwide while Ancylostoma duodenale tends to be endemic in the Mediterranean region and northern India and China.

Risk factors for developing hookworm infections include low socioeconomic background, exposure to infected soil, barefoot walking, poor sanitation, and personal hygiene. Children and pregnant women are at highest risk. Transmission is affected by multiple factors such as warm and moist climate, contaminated water supply, and poor sanitation.[1][4][6][7][8]

Pathophysiology

In soil, the hookworm eggs hatch and first-stage larvae called rhabditiform L1 larvae develop in few days. They molt twice to become the infective filariform L3 which is about 0.5 to 0.6 mm in length and can live for 3 to 4 weeks if suitable conditions were available. It waits in soil or on the grass to come into contact with human skin and initiate an infection.

The infection starts when larvae penetrate the victim's skin in a process which requires about 30 mins to 6 hours to complete according to species. Occasionally, larvae might use buccal mucosa to invade the host and make its way down to the circulation. Cutaneous penetration usually goes unnoticed but sometimes might cause what is called 'ground' itch.

Skin penetration occurs under a chemical process which starts by the production of proteolytic enzymes from certain glands in the larvae. Necator americanus produce proteases which could break connective tissue components such as collagen and elastin. On the other hand, Ancylostoma larvae produce hyaluronidase enzyme which cracks the dermal integrity and allow the larvae to migrate through the skin. One of the significant larval secretions is called Ancylostoma secreted proteins (ASPs) which is pivotal in the development of the parasite and represent about one-third of its secreted proteins.

After skin penetration, the larvae migrate passively through the bloodstream to the right side of the heart and hence to the pulmonary vasculature. During pulmonary migration, it might cause type-1 hypersensitivity reaction within the alveoli (Loeffler syndrome). They penetrate the alveoli and migrate through the bronchial tree to the pharynx and then to the intestinal tract.

Once the larvae reach the duodenum and after molting twice, they become now L5 immature worms which can use their teeth or cutting plates which line their buccal capsule to get fixed into the host's intestinal mucosa. Digestion of blood is helped by metalloproteases and anticoagulant peptides which maintain the flow of liquid blood through mucosal injury. However, the process by which hemoglobin gets consumed in the parasite gut is poorly understood.

Worms mature in 4 to 6 weeks into adult sexually differentiated worms. After mating, the female produces up to 30000 eggs per day which exit the host with feces to continue the life cycle.

Blood loss in heavily infected persons could reach up to 9.0 mL/day and occurs by two mechanisms; the first is through consumption of the parasite which accounts to a small portion of blood loss, the second and the main loss occurs through the attachment site by leakage around it. Iron deficiency anemia occurs when the host becomes no more able to compensate for blood loss, especially in heavy infections and nutritionally deprived individuals. The major risk factor for anemia is the worm burden, though, in children, anemia could occur with lower worm burden.

Simultaneous protein loss might occur and results in symptomatic hypoalbuminemia and hypoproteinemia, which can lead to anasarca and worsen malnutrition. 

Parasites can last for years in the host, and accordingly, it had to develop multiple strategies to ensure survival. The parasite uses broad-spectrum protease inhibitors to neutralize the effect of the host's immune defenses. While it helps the parasite to protect itself from proteolytic enzymes, it worsens malnutrition of the host by interfering with absorption. Moreover, it induces apoptosis of T lymphocytes and consequently, inhibition of local immune response. The down-regulated immune response to the parasite is mainly due to parasite-specific T cell hyporesponsiveness secondary to altered function of antigen-presenting cells, T cell apoptosis, and cytokines modulation.

Interestingly, in individuals with hookworm infections, same as other helminths, patients tend to have a wider variety of gut microbiota. This observation, along with immune regulatory mechanisms in hookworms, prompted research into the potential use of hookworms in the treatment of immune-mediated gastrointestinal disease like celiac disease and inflammatory bowel disease.[1][5][7][9][10]

History and Physical

Hookworm infections are usually asymptomatic. Symptoms usually relate to the stage of parasite development and the site of the affected host. It usually starts by the time of skin penetration in the form of localized erythematous reaction (ground itch).[6][10]

Hookworm related cutaneous larvae migrans (creeping eruptions) have links to zoonotic hookworms. It is endemic in many developing countries, while travelers and health professionals are the sectors that are usually affected in developed countries. It starts as erythematous papule which develops afterward into the characteristic serpiginous, 1 to 5 cm tunnels beneath the skin, which occur as larvae become unable to penetrate the deep layers of the skin and stay in its superficial layers. Infection often affects hands and feet as the usual contact site with soil.[1][11]

During the pulmonary stage, the infection might express itself in the form of cough, sneezing, bronchitis, hemoptysis, and eosinophilic pneumonia (Loeffler syndrome), usually self-limiting and doesn’t need any intervention. With peroral infection, nausea, vomiting, pharyngeal irritation, cough, and dyspnoea might occur (Wakana syndrome).

Once worms reach the small intestine, nonspecific abdominal symptoms might occur, such as abdominal pain and distension, diarrhea, occult fecal blood and occasionally melena. The small size of the parasite makes surgical complications unlikely.[1][10]

The major feature of hookworm infection is iron deficiency anemia secondary to blood loss either by direct parasite consumption or due to blood leakage from the parasite attachment site to the gut.[12]

Additionally, hypoalbuminemia might lead to edema formation and generalized anasarca. Occasionally, some patients crave soil and ingest dirt (geophagia).[1][10][7]

Evaluation

Clinical features of hookworm infections are usually non-specific and could be misleading. Proper understanding of the epidemiology, clinical features, and laboratory findings is crucial in diagnosis.[1][10]

Stool microscopy is the mainstay tool for diagnosis but with some limitations. It is useful in identifying and quantifying hookworm eggs. In hospitals, labs tend to use egg concentration techniques while for screening and public health control, simple tests as Kato-Katz techniques are options; those are usually used in epidemiological studies because they provide an indirect measure of worm burden. Precision is limited by variations in egg production, especially with less severe infections. IgG4 assay might identify recent infection but remains non-specific.[5][10]

Eosinophilia raises suspicion of hookworm infection but non-specific. Systemic and mucosal eosinophilia is widely present in hookworm infections. It is detectable in the blood even before reaching the intestine and peaks after adult worms reach intestinal mucosa.[1]

Capsule endoscopy might show parasites, but it is rarely used to diagnose infection. Computer-aided detection of hookworms on capsule endoscopy images is still challenging; the ultimate goal is to use automatic detection models to assist diagnosis more accurately than experienced endoscopists.[1][10][13]

Treatment / Management

The main drugs used for hookworm infections are mebendazole and albendazole. Data support 400 mg single-dose albendazole therapy over a 500 mg single dose of mebendazole. Three consecutive daily doses of either drug demonstrate superior cure and egg reduction rates, but it is less convenient for mass treatment campaigns. Alternatively, a 3-day regimen of 100 mg twice daily mebendazole is suitable for stable uncomplicated cases. Also, pyrantel pamoate 11 mg/kg (up to a maximum of 1 g) orally daily for three days could be an option.[1]

A systematic meta-analysis showed that the efficacy of single-dose oral albendazole, mebendazole, and pyrantel pamoate against hookworm infections was 72% (95% CI, 59%-81%; 742 patients), 15% (95% CI, 1%-27%; 853 patients), and 31% (95% CI, 19%-42%; 152 patients).[14]

Treatment efficacy varies according to the severity of infection, geographical distribution, and age groups. Both mebendazole and albendazole are usually safe with few transient side effects such as dizziness, headache, and abdominal upset.[1][15]

Pregnant and lactating women have an increased risk of anemia from hookworm infections. Albendazole and mebendazole were both pregnancy category C under the prior FDA system; data on their use in pregnant women are limited. It is not known whether albendazole or mebendazole get excreted in human milk. While albendazole requires caution in breastfeeding, the WHO allows the use of mebendazole in lactating women.[16]

Treatment failure can occur. Although the etiology is unclear, repeated use of the same medication raises the question of drug resistance. Pyrantel pamoate and levamisole are alternative treatments, but neither has equal efficacy with albendazole.

Cutaneous larvae migrans is usually self-limited and confined to the skin. However, treatment is sometimes needed, and It responds well to oral Albendazole or ivermectin.

Coadministration of deworming and iron supplementation has a greater impact on anemia, especially in nutritionally deficient populations. In a study of 746 school children, multi-nutrient supplements along with anthelminthic medications increased Hb, irrespective of initial Hb, and nutritional status.[16][17]

Blood transfusion might be necessary for patients with severe anemia. Other nutritional support and monitoring of response are indicated in severely affected individuals. 

There is no sufficient available data to guide long term monitoring of treatment. As the failure of treatment and reinfection are real threats, we suggest that follow up of clinical symptoms and anemia along with stool testing would be advised. A follow up at 1, 4, and 12 months seems to be appropriate in this context.[1][18] 

Differential Diagnosis

Other intestinal causes of iron deficiency anemia have to be excluded, such as malabsorption, erosions, ulcers, and gastrointestinal malignancies. Moreover, the differential diagnosis includes other helminthic infestations which share common features with hookworm infections such as ascariasis, schistosomiasis, and strongyloidiasis.

Cutaneous manifestations require differentiation from other similar conditions like contact dermatitis, migratory myiasis, scabies infection, and cercarial dermatitis.[5]

Prognosis

Hookworm infection tends to cause morbidity rather than mortality. In adults, anemia, and malnourishment lead to reduced productivity with subsequently increased poverty.

In pregnancy, demand increases for iron and subsequently, the risk is higher in this class of patients with effect on both the mother and her fetus wellbeing. School children are at risk of decline in cognitive function and school achievement. In contrast, preschool children suffer less from the threat of anemia and malnutrition.

There are growing concerns regarding treatment failure, especially after mass drug administration campaigns. There is no sufficient data to illustrate the effect of deworming interventions on quality of life. Additionally, there is a need to develop a new generation of broad-spectrum agents and to assess the efficacy of combination therapy on the outcome further.

Reinfection is another challenge in the treatment of hookworms. Moderate reinfection rates post-treatment support the concept of repeated drug regimens in highly endemic areas. In a study of 405 school children, 18 weeks follow up post-treatment showed that reinfection rate was 25.0 % for hookworms (95 % CI: 15.5–36.6).[1][5][19]

Complications

Adult hookworm infection complications often include iron deficiency anemia; however, rarely, it may include an overt GI bleed. Other associated complications include cutaneous larvae migrans and eosinophilic pneumonia.[18]

Deterrence and Patient Education

Mass drug administration campaigns are effective in reducing the prevalence and burden of the infection. However, after stopping the medication reinfection rates are usually high.

Prevention is mainly through health education campaigns regarding food sanitation, safe drinking water, hand washing, and footwear.[10][20]

Vaccine production still under development and clinical trials. It is intended to prevent infections in highly endemic areas with the worst burden of the disease. The vaccine elicits neutralizing antibodies that interfere with adult worms’ survival in the gut and its ability to consume the host's blood.[1][15]

Reduction of poverty and increased economic development have done more to eliminate hookworm infection than any other factor, but obviously, that would not be easy.[7]

Pearls and Other Issues

  • Hookworm infections currently considered one of the most underfunded neglected tropical diseases.
  • Millions of people get infected with the parasite around the world especially in poorer tropical countries
  • Ancylostoma duodenale and Necator americanus are the main species that infect humans. A. ceylanicum, A. caninum, and A. braziliense are other minor causes.
  • Hookworm infections are usually asymptomatic; symptoms vary depending on the stage of the life cycle, from cutaneous ground itch to respiratory symptoms and until the main feature of iron deficiency anemia and in rare occasions intestinal bleeding.
  • Diagnosis depends on both epidemiological, clinical and microscopic evaluation.
  • Management is mainly by either single-dose albendazole or multi-dose mebendazole. Mass treatment is useful in endemic areas
  • Health education and sanitation are the mainstay way of preventing the disease. The vaccine is not available currently but under ongoing research and development.

Enhancing Healthcare Team Outcomes

The diagnosis and management of hookworm infections necessitate an interprofessional approach including histopathologist, infectious disease specialist, gastroenterologist, and general practitioner. Patients usually present to their general practitioner with general non-specific symptoms or anemia. Diagnosis requires a high index of suspicion with careful history and examination, especially in non-endemic areas, besides a thorough analysis of stool samples from experienced histopathologists. Referrals might be necessary for both infectious diseases specialists or gastroenterologists, and both have to be mindful of such a diagnosis for suggestive presentations. Treatment requires collaboration between pharmacists, nurses, and physicians.

The pharmacist has to educate the patient about drug compliance. Ideally, an infectious disease specialty pharmacist can consult on the medication regimen, verifying dosing, offering alternative agents in the event of treatment failure, and ensuring there are no drug interactions that could compromise therapeutic effectiveness. Also, nurses should educate travelers about hygiene and other safety issues when entering shallow waters in the tropics. Nursing can also assess for the effectiveness of medical treatment on subsequent patient encounters, and inform the clinical team members if a potential therapy change is necessary.

Prevention requires cooperation between public health specialists, general practitioners, and local authorities to improve sanitation and living conditions while raising awareness between affected patients and populations at risk. In the case of hookworm infections, the interprofessional team can expand beyond the usual players, since it can present a public health issue in endemic areas, which will require even more broad-based collaboration among different healthcare team members to drive individual and population outcomes effectively. [Lervel V]


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Hookworm - Questions

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A 32-year-old lady presents to the clinician with difficult breathing and exercise intolerance for the past six months. On further questioning, she reveals that she has no overt bleeding and her menses are regular and lasts for 3-4 days each month with no complaints of heavy flow. She is a housewife, but she helps her family in their rice field during the harvest season. She doesn't smoke or drink alcohol. On examination, she looks pale, and her vital signs showed a blood pressure of 110/75 mmHg, a pulse of 116 beats per minute, respiration of 19 breaths per minute and a temperature of 98 degrees Fahrenheit. A soft systolic murmur over the apex is present. The rest of the examination is unremarkable. Laboratory investigations reveal a hemoglobin 7.4 g/dl, mean corpuscular volume 68 fl, a white cell count of 7.5 10^9/L and serum ferritin of 27 ng/mL. She claims she was treated previously with iron supplements by her family physician due to recurrent anemia. Which parasitic infection is most likely still causing her anemia?



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A 45-year-old farmer had felt itching in his right foot which resolved spontaneously but shortly after he started to feel difficult breathing and wheeze. He was breathless at rest, respiratory rate 26 per minute, oxygen saturation 94% on 28% oxygen. On auscultation, there were bilateral expiratory wheezes. Blood tests showed; hemoglobin 8.7 g/dl, mean corpuscular volume 72 fl, eosinophils 2.3% with white cell count 7.2 10^9/L, ferritin 27 ng/mL, and C reactive protein 4 mg/l. Chest x-ray showed bilateral pulmonary infiltrates. Bronchoalveolar lavage showed pulmonary eosinophilia and filariform larvae on sputum examination. What would be the drug of choice for treatment of this patient's probable diagnosis?



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A 36-year-old farmer presents to the clinic complaining of difficulty breathing and palpitations. On examination, the patient looks pale, with an otherwise normal examination. His ECG shows ST-depression in leads V1-3. A complete blood count shows a hemoglobin of 8.6 g/dL, white cell count of 4500/microL with marked eosinophilia, and a troponin of 0.3 ng/mL. He also shows an itchy lesion in his right foot that started about 2 months ago. What is the most likely diagnosis?



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A 65-year-old female from West Africa presented to the hospital with a history of intermittent black tarry stool for three weeks. On examination, she looks pale, her pulse is 98/min, and her blood pressure is 100/62 mmHg. Blood tests showed hemoglobin of 74 g/dl, the mean corpuscular volume of 62 fL, white cell count of 9200/ mm3, eosinophils 2.1%, and ferritin 24 ng/mL. Both gastroscopy and colonoscopy were done but did not show any evidence of bleeding. Capsule endoscopy was ordered, which revealed small white parasites attached to the intestinal mucosa. Besides iron deficiency anemia, what other complications could be found in this patient?



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A 12-year-old boy presents with an increase in school absenteeism, fatigue, epigastric pain, diarrhea, and anorexia after spending a vacation in Pakistan with his family. He had developed skin rash over his legs during the latter part of the trip which spontaneously resolved without having other symptoms. It is further revealed that he had received all the prophylaxis and vaccines before leaving the U.S.A. Physical exam is remarkable for conjunctival pallor, mild tachycardia with no evidence of rash over extremities. Laboratory test shows a Hemoglobin of 9.8g/dl, white blood cell count of 4.8/mL, and platelets 285,000/mL. Which of the following is the next best step in the management of this patient?



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Hookworm - References

References

Loukas A,Hotez PJ,Diemert D,Yazdanbakhsh M,McCarthy JS,Correa-Oliveira R,Croese J,Bethony JM, Hookworm infection. Nature reviews. Disease primers. 2016 Dec 8;     [PubMed]
Wei KY,Yan Q,Tang B,Yang SM,Zhang PB,Deng MM,Lü MH, Hookworm Infection: A Neglected Cause of Overt Obscure Gastrointestinal Bleeding. The Korean journal of parasitology. 2017 Aug;     [PubMed]
Periago MV,Bethony JM, Hookworm virulence factors: making the most of the host. Microbes and infection. 2012 Dec;     [PubMed]
Albonico M,Savioli L, Hookworm: a neglected resurgent infection. BMJ (Clinical research ed.). 2017 Oct 24;     [PubMed]
Brooker S,Bethony J,Hotez PJ, Human hookworm infection in the 21st century. Advances in parasitology. 2004;     [PubMed]
Parija SC,Chidambaram M,Mandal J, Epidemiology and clinical features of soil-transmitted helminths. Tropical parasitology. 2017 Jul-Dec;     [PubMed]
Hotez PJ,Brooker S,Bethony JM,Bottazzi ME,Loukas A,Xiao S, Hookworm infection. The New England journal of medicine. 2004 Aug 19;     [PubMed]
Pearson MS,Tribolet L,Cantacessi C,Periago MV,Valero MA,Jariwala AR,Hotez P,Diemert D,Loukas A,Bethony J, Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines. The Journal of allergy and clinical immunology. 2012 Jul;     [PubMed]
Jourdan PM,Lamberton PHL,Fenwick A,Addiss DG, Soil-transmitted helminth infections. Lancet (London, England). 2018 Jan 20;     [PubMed]
Loukas A,Prociv P, Immune responses in hookworm infections. Clinical microbiology reviews. 2001 Oct;     [PubMed]
Hotez PJ,Beaumier CM,Gillespie PM,Strych U,Hayward T,Bottazzi ME, Advancing a vaccine to prevent hookworm disease and anemia. Vaccine. 2016 Jun 3;     [PubMed]
Sharma V,Gunjan D,Chhabra P,Sharma R,Rana SS,Bhasin DK, Gastrointestinal bleeding in the tropics: Look for the hookworm. Tropical doctor. 2017 Jan;     [PubMed]
Bieri FA,Gray DJ,Williams GM,Raso G,Li YS,Yuan L,He Y,Li RS,Guo FY,Li SM,McManus DP, Health-education package to prevent worm infections in Chinese schoolchildren. The New England journal of medicine. 2013 Apr 25;     [PubMed]
Jiraanankul V,Aphijirawat W,Mungthin M,Khositnithikul R,Rangsin R,Traub RJ,Piyaraj P,Naaglor T,Taamasri P,Leelayoova S, Incidence and risk factors of hookworm infection in a rural community of central Thailand. The American journal of tropical medicine and hygiene. 2011 Apr     [PubMed]
Feldmeier H,Schuster A, Mini review: Hookworm-related cutaneous larva migrans. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2012 Jun     [PubMed]
Wu X,Chen H,Gan T,Chen J,Ngo CW,Peng Q, Automatic Hookworm Detection in Wireless Capsule Endoscopy Images. IEEE transactions on medical imaging. 2016 Jul     [PubMed]
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