Epidural Hematoma


Article Author:
Ali Khairat


Article Editor:
Muhammad Waseem


Editors In Chief:
Casey Ciresi


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
11/15/2018 11:44:36 PM

Introduction

An epidural hematoma (EDH) is an extra-axial collection of blood within the potential space between the outer layer of the dura mater and the inner table of the skull. It is confined by the lateral sutures (especially the coronal sutures) where the dura inserts. It is a life-threatening condition, which may require immediate intervention and can be associated with significant morbidity and mortality if left untreated. Rapid diagnosis and evacuation are important for a good outcome.[1][2][3]

Etiology

It occurs in approximately 10% of traumatic brain injuries (TBI) requiring hospitalization. Both by traumatic and non-traumatic mechanisms can cause an epidural hematoma.[4][5]

The majority of cases related to a traumatic mechanism are a result of head injury due to motor vehicle collisions, physical assaults, or accidental falls.

Non-traumatic mechanisms include the following:

  • Infection/Abscess
  • Coagulopathy
  • Hemorrhagic Tumors
  • Vascular Malformations

Epidemiology

An epidural hematoma occurs in 2% of all head injuries and up to 15% of all fatal head traumas. Males are more often affected than are females. Furthermore, the incidence is higher among adolescents and young adults. The mean age of affected patients is 20 to 30 years, and it is rare after 50 to 60 years of age. As an individual's age advances, the dura mater becomes more adherent to the overlying bone. This decreases the chance that a hematoma can develop in the space between the cranium and dura.[6]

Pathophysiology

Arterial Injury

Most epidural hematomas result from arterial bleeding from a branch of the middle meningeal artery. The anterior meningeal artery or dural arteriovenous (AV) fistula at the vertex may be involved.[7][8]

Venous Injury

Up to 10% of EDHs are due to venous bleeding following the laceration of a dural venous sinus.

In adults, up to 75% of EDHs occur in the temporal region. However, in children, they occur with similar frequency in the temporal, occipital, frontal, and posterior fossa regions.

A skull fracture is present in the majority of patients with EDH. These hematomas often present beneath a fracture of the squamous part of the temporal bone.

If this condition occurs within the spine, this entity is described as a spinal epidural hematoma.

Based on radiographic progression, it can be classified into one of the following

  • Type I: Acute; occurs on day 1 and associated with a “swirl” of un-clotted blood
  • Type II: Subacute occurring between days 2 to 4 and usually solid
  • Type III: Chronic occurring between days 7 to 20; mixed or lucent appearance with contrast enhancement

History and Physical

The typical presentation is an initial loss of consciousness following trauma, a complete transient recovery (“often termed as a lucid interval”), culminating in a rapid progression of neurological deterioration. This occurs in 14% to 21% of patients with an EDH.  However, these patients may be unconscious from the beginning or may regain consciousness after a brief coma or may have no loss of consciousness. Therefore, the presentations range from a temporary loss of consciousness to a coma. Beware that the lucid interval is not pathognomonic for an EDH and may occur in patients who sustain other expanding mass lesions. The classic lucid interval occurs in pure EDHs that are very large and demonstrate a CT scan finding of active bleeding. The presentation of symptoms depends on how quickly the EDH is developing within the cranial vault. A patient with a small EDH may be asymptomatic, but this is rare. Also, an EDH may also develop in a delayed fashion.

A posterior fossa EDH is a rare event. This kind of EDH may account for approximately 5% of all posttraumatic intracranial mass lesions. Patients with posterior fossa EDH may remain conscious until late in the evolution of the hematoma, when they may suddenly lose consciousness, become apneic, and die. These lesions often extend into the supratentorial compartment by stripping the dura over the transverse sinus, resulting in a significant amount of intracranial bleeding.

This enlarging hematoma leads to eventual elevation of intracranial pressure which may be detected in a clinical setting by observing ipsilateral pupil dilation (secondary to uncal herniation and oculomotor nerve compression), the presence of elevated blood pressure, slowed heart rate, and irregular breathing. This triad is known as the “Cushing reflex.” These findings may indicate the need for immediate intracranial intervention to prevent central nervous system (CNS) depression and death.

Evaluation

Imaging studies such as a CT scan comprise the mainstay of diagnosis. Laboratory studies such as INR, partial thromboplastin time (PTT), thromboplastin time (PT), and liver function test (LFT) may be obtained to assess for increased bleeding risk or underlying coagulopathies.[9]

CT Scan

CT scan is the most common imaging modality to assess for intracranial bleeding. Its popularity is related to its widespread availability in emergency departments. The majority of EDHs are identifiable on a CT scan. The classic presentation is a biconvex or lens-shaped mass on brain CT scan, due to the limited ability of blood to expand within the fixed attachment of the dura to the cranial sutures. EDHs does not cross suture lines.

Generally, radiologists use a standard formula for estimating the amount of blood present in an EDH.  It is as follows:

ABC/2

A: The maximum hemorrhage diameter on the CT slice with the largest area of hemorrhage

B: The maximum diameter 90 degrees to A on the same CT slice

C: The number of CT slices with hemorrhage multiplied by the slice thickness in centimeters

There are, however, other CT findings that may need to be taken into account when evaluating EDH. For example, continued bleeding may be indicated by areas of low density, or a "swirl-sign." The latter may be used for prognosis, and often indicates the need for surgical intervention. If the EDH abuts brain tissue that is hemorrhagic or contused, it may appear shallow, and thus, may be overlooked if the CT scan is not carefully examined.

Several factors may lead to a non-diagnostic CT scan. These are as follows:

  • A low-density blood collection may result from severe anemia (thus leading to misinterpretation).
  • Arterial extravasation may be reduced secondary to severe hypotension.
  • A positive finding on CT requires that enough blood accumulate for visualization. If the CT is obtained too soon after trauma, there may not be sufficient accumulation for appropriate interpretation.
  • If the EDH is secondary to venous bleeding, blood accumulation may be slow. This could potentially result in difficulty with CT interpretation.

MRI

Brain MRI is more sensitive than a CT scan, particularly when assessing for EDH in the vertex. It should be obtained when there is high clinical suspicion for EDH, accompanying a negative initial head CT scan.

In the situation of a suspected spinal EDH, a spinal MRI is the preferred imaging modality, as it affords higher resolution versus a spinal CT.

Angiography

When evaluating EDHs located in the vertex, the healthcare professional should evaluate for the presence of a dural arteriovenous (AV) fistula that may have arisen from the middle meningeal artery. Angiography may be required to evaluate the presence of such a lesion fully.

Treatment / Management

EDH is a neurosurgical emergency. It, therefore, requires urgent surgical evacuation to prevent irreversible neurological injury and death secondary to hematoma expansion and herniation. A neurosurgical consultation should be the urgently obtained as it is important to intervene within 1 to 2 hours of presentation.[10][11][12]

The priority is to stabilize the patient, including the ABCs (airway, breathing, circulation), and these should be addressed urgently.

Surgical Intervention is recommended in patients with:

  • Acute EDH
  • Hematoma volume greater than 30 ml regardless of Glasgow coma score (GCS)
  • GCS less than 9 with pupillary abnormalities like anisocoria

Operative Management

In patients with acute and symptomatic EDHs, the treatment is craniotomy and hematoma evacuation. Based on the available literature, “trephination” (or burr hole evacuation) is often a crucial form of intervention if more advanced surgical expertise is unavailable; it may even decrease mortality. However, the performance of a craniotomy, if feasible, can provide a more thorough evacuation of the hematoma.

Non-Operative Management

There is a scarcity of literature comparing conservative management with surgical intervention in patients with EDH. However, a non-surgical approach may be considered in a patient with acute EDH who has mild symptoms and meets all of the criteria listed below:

  • EDH volume of less than 30 ml
  • Clot diameter of less than 15 mm
  • Midline shift of less than 5 mm
  • GCS greater than 8 and on physical examination, shows no focal neurological symptoms.

If the decision is made to manage acute EDH non-surgically, close observation with repeated neurological examinations and continuous surveillance with brain imaging is required, as the risk for hematoma expansion and clinical deterioration is present. The recommendation is to obtain a follow-up head CT scan within 6 to 8 hours following brain injury.

Differential Diagnosis

  • Transient ischemic attack
  • Seizure
  • Intracranial abscess
  • Intracranial mass

Prognosis

In general, patients with pure EDHs have an excellent prognosis of a functional outcome after surgical evacuation, when it is rapidly detected and evacuated. A delay in diagnosis and treatment increases the morbidity and the mortality.

EDHs caused by arterial bleeding develop rapidly and can be detected quickly. But those due to a dural sinus tear develop more slowly. Thus, clinical manifestations may be delayed, with a resultant delay in recognition and evacuation. Generally, an EDH volume greater than 50 cm prior to evacuation results in a worse neurological outcome and consequent mortality.

Factors that may influence outcome are as follows:

  • Patient age
  • Time lapsed between injury and treatment
  • Immediate coma or lucid interval
  • Presence of pupillary abnormalities
  • GCS/motor score, on arrival

CT findings (hematoma volume, the degree of midline shift, the presence of signs of active hematoma bleeding, or associated intra-dural lesions)

Postoperative ICP

Several markers that correlate with a poor prognosis of EDH include the following:

  • A low GCS before surgery, or on arrival
  • Abnormal pupil examination, in particular, un-reactive pupils (unilateral or bilateral)
  • Advanced age
  • The time between neurological symptoms and surgery
  • Elevated ICP in the post-operative period

Certain head CT findings can correlate with a poor prognosis:

  • Hematoma volume of greater than 30 to 150 ml
  • A midline shift greater than 10 to 12 mm
  • “Swirl sign” indicating an active bleed
  • Associated intracranial lesions (such as contusions, intracerebral hemorrhage, subarachnoid hemorrhage and diffuse brain swelling)

Complications

  • Mass effect: compression of the brain if bleeding is significant
  • Herniation
  • Seizures

Consultations

Following services should be immediately consulted as the outcome is time-dependent:

  • Trauma surgery
  • Neurosurgery

Pearls and Other Issues

  • EDH is a neurosurgical emergency
  • Suspect EDH if there is a history of head trauma leading to a period of loss of consciousness.
  • Patients with small EDH may be asymptomatic
  • Generally, occurs with a skull fracture, but may occur without bone fracture
  • EDH does not cross suture lines
  • Although lucid interval is commonly described but not pathognomonic and may occur in patients with expanding mass lesions
  • Patients with EDH may be unconscious, may regain consciousness after a brief loss of consciousness or may have no loss of consciousness; Patients with small EDH may be asymptomatic
  • If rapidly detected and evacuated, the functional outcome is excellent

Enhancing Healthcare Team Outcomes

Epidural hematoma is a relatively common presentation to the emergency department, and if not diagnosed is associated with a high mortality. The condition is best managed by a multidisciplinary team that includes the emergency room physician, the trauma team, radiologist, neurologist, neurosurgeon, intensivist and the ICU nurses. The condition has been associated with mortality rates in excess of 15%. The key prognostic feature is the level of consciousness at the time of presentation. Both bilateral epidural hematomas and posterior fossa epidural hematomas carry a very high mortality. The key to treating this condition is preventing it in the first place. Healthcare workers should educate the public on the importance of head safety equipment when playing sports or while working.[13][14]


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Epidural Hematoma - Questions

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An epidural hematoma is most commonly due to an injury of which artery?



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A 65-year-old male is hit on the head with a baseball bat. He temporarily loses consciousness and then recovers 20 minutes later. To ensure that everything is fine, he is seen in the emergency department where he promptly collapses again and becomes unresponsive. The pathology behind his disorder is most likely related to which of the following?

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In which area are most epidural hematomas from trauma located?



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Which of the following statements about head trauma is false?



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A healthy 24-year-old is involved in a motor vehicle accident. He loses consciousness but regains it within a few hours and appears normal to friends. He later presents to the emergency room very lethargic, weak, and with a dilated left pupil. The patient most likely has which of the following conditions?



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Following a motorcycle accident, an adult presents alert and fully oriented even though he was unconscious at the scene. He suddenly loses consciousness and dilates his left pupil. MRI is done. What is the most likely diagnosis?



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Traumatic rupture of the middle meningeal artery causes which of the following?



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What is the main bleeding source in an epidural hematoma?



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A patient with head trauma has an epidural hematoma in the temporoparietal region. Which vessel(s) was injured?



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Which of the following is not a common feature of epidural hematomas?

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Which is true regarding epidural hematoma?



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Which is not associated with epidural hematoma?



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A 5-year-old female has a fall from the monkey bars and has a brief period of unconsciousness. She develops depressed consciousness in the emergency department, focal seizures, and unilateral dilation of a pupil. Select the most important step in management.



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What is the source of blood in an epidural hematoma?



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Which can result from injury to the middle meningeal artery?



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A 44-year-old male is thrown off his motorbike and hits his head with the light pole at the intersection. EMS is called and he is unresponsive. His vitals remain stable. He has a few lacerations on the leg and face. EMS decided to intubate him at the scene because his GCS is 9. By the time they reach the emergency department, he has fully regained consciousness and is alert. He is extubated in the ER and being prepared for a CT scan. While waiting for his CT he becomes confused. Based on this history, he may have suffered what type of injury?



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A 17-year-old male patient is brought into the emergency department after being involved in a motor vehicle accident. On physical exam, his right eye is abducted and pointing downward. The patient is too somnolent to test motor and sensation. After initial stabilization efforts, he is taken for a CT scan and diagnosed with a right-sided epidural hematoma and a resulting transtentorial herniation. What are additional physical exam findings that should be expected in this patient?



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Which of the following is an indication for immediate surgical intervention in a patient with an epidural hematoma?



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After falling off a bicycle, a 17-year-old presented to the emergency department with head trauma and having sustained a loss of consciousness (LOC). On examination, the patient was alert and oriented but did not recall falling from bicycle and had a right temporal scalp hematoma. The patient was sent for a brain CT scan, which showed right epidural hematoma. Which vessel is most likely to have been injured in this intracranial hemorrhage?



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Epidural Hematoma - References

References

Rosenthal AA,Solomon RJ,Eyerly-Webb SA,Sanchez R,Lee SK,Kiffin C,Davare DL,Hranjec T,Carrillo EH, Traumatic Epidural Hematoma: Patient Characteristics and Management. The American surgeon. 2017 Nov 1     [PubMed]
Babu JM,Patel SA,Palumbo MA,Daniels AH, Spinal Emergencies in Primary Care Practice. The American journal of medicine. 2018 Oct 3     [PubMed]
Kanematsu R,Hanakita J,Takahashi T,Park S,Minami M, Radiological features and clinical course of chronic spinal epidural hematoma Report of four cases and literature review. World neurosurgery. 2018 Aug 23     [PubMed]
Tamburrelli FC,Meluzio MC,Masci G,Perna A,Burrofato A,Proietti L, Etiopathogenesis of Traumatic Spinal Epidural Hematoma. Neurospine. 2018 Mar     [PubMed]
Fernández-Abinader JA,González-Colón K,Feliciano CE,Mosquera-Soler AM, Traumatic Brain Injury Profile of an Elderly Population in Puerto Rico. Puerto Rico health sciences journal. 2017 Dec     [PubMed]
Chicote Álvarez E,González Castro A,Ortiz Lasa M,Jiménez Alfonso A,Escudero Acha P,Rodríguez Borregán JC,Peñasco Martín Y,Dierssen Sotos T, Epidemiology of traumatic brain injury in the elderly over a 25 year period. Revista espanola de anestesiologia y reanimacion. 2018 Jul 24     [PubMed]
Burjorjee JE,Rooney R,Jaeger M, Epidural Hematoma Following Cessation of a Direct Oral Anticoagulant: A Case Report. Regional anesthesia and pain medicine. 2018 Apr     [PubMed]
Bonow RH,Barber J,Temkin NR,Videtta W,Rondina C,Petroni G,Lujan S,Alanis V,La Fuente G,Lavadenz A,Merida R,Jibaja M,Gonzáles L,Falcao A,Romero R,Dikmen S,Pridgeon J,Chesnut RM, The Outcome of Severe Traumatic Brain Injury in Latin America. World neurosurgery. 2018 Mar     [PubMed]
Flaherty BF,Moore HE,Riva-Cambrin J,Bratton SL, Repeat Head CT for Expectant Management of Traumatic Epidural Hematoma. Pediatrics. 2018 Sep     [PubMed]
Bhorkar NM,Dhansura TS,Tarawade UB,Mehta SS, Epidural Hematoma: Vigilance beyond Guidelines. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2018 Jul     [PubMed]
Gutowski P,Meier U,Rohde V,Lemcke J,von der Brelie C, Clinical Outcome of Epidural Hematoma Treated Surgically in the Era of Modern Resuscitation and Trauma Care. World neurosurgery. 2018 Oct     [PubMed]
Basamh M,Robert A,Lamoureux J,Saluja RS,Marcoux J, Epidural Hematoma Treated Conservatively: When to Expect the Worst. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2016 Jan     [PubMed]
Aguilar MI,Brott TG, Update in intracerebral hemorrhage. The Neurohospitalist. 2011 Jul     [PubMed]
Jeong YH,Oh JW,Cho S, Clinical Outcome of Acute Epidural Hematoma in Korea: Preliminary Report of 285 Cases Registered in the Korean Trauma Data Bank System. Korean journal of neurotrauma. 2016 Oct     [PubMed]

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