Corneal Foreign Body

Article Author:
Anthony Camodeca

Article Editor:
Eric Anderson

Editors In Chief:
Casey Ciresi

Managing Editors:
Avais Raja
Orawan Chaigasame
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Radia Jamil
Erin Hughes
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Navid Mahabadi
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beenish Sohail
Hajira Basit
Phillip Hynes
Sandeep Sekhon

1/10/2019 6:52:41 PM


Corneal foreign bodies account for the second most common form of ocular trauma, with corneal abrasions being number one. In general, major morbidity such as visual acuity loss is not common. Many corneal foreign bodies are superficial, and benign, albeit uncomfortable.


The etiology of corneal foreign bodies vary. Most commonly it is a combination of a lack of protective eye-wear and high-risk activities. This includes grinding, hammering, drilling, and welding. In addition to these common causes, unexpecting causes are also seen, such as debris from driving or walking.


The incidence of a corneal foreign body varies based on the text, but a Swedish study revealed the incidence of eye injuries was 8.1 per 1000, with 40% composed of corneal or conjunctival foreign bodies. The majority of these occur at work while performing high-risk activities as mentioned previously. Noncompliance with well-fitting eye protection was common. In fact, during the 1991 Gulf War, data from one army field hospital showed 14% of the injuries seen were due to ocular trauma. Of these, 17% were corneal foreign bodies, and only 3% of the injured patients were wearing their provided protective goggles.[1]


The cornea is the anterior surface of the eye. It has attachments circumferentially to the sclera, at the level of the limbus. There are five total layers, with the top layer undergoing disruption in the setting of corneal abrasions, but a foreign body can lodge in any of the five layers. Foreign bodies can continue forward, creating an open globe injury, but that is outside the scope of this chapter.


Histopathology of the cornea will reveal five epithelial type layers. The first and outmost is called the epithelium. Classically this is 5-6 cell layers thick, consisting of epithelial cells. Below lies a single layer of basal epithelial cells referred to as Bowman’s layer. The stroma is the thickest layer, the thickest layer, comprises keratocytes. Beneath this lies Descemet membrane, and finally a monolayer of corneal endothelium cells, derived from neural crest cells. The five-layered cornea contains no vasculature and derives its nutrients from the aqueous humor of the anterior chamber itself. On microscopic exam, disruption with a foreign body can occur at any level.[2]

History and Physical

The history of present illness will typically be consistent with a sudden onset event. Persistent discomfort without relief causes people to seek care. History of visual acuity deficits is uncommon, although this may be perceived as such since the patient will have copious tearing and difficulty with keeping their eye opened. Accompanying symptoms are consistent with a generalized ocular inflammatory response, which will consist of tearing, redness, foreign body sensation, inability to find comfort with the eye opened or closed, and photophobia and blurred vision without overt visual acuity deficit. Most patients will report a high-risk activity such as hammering or grinding, and some will tell you the location of the foreign body.

Caution regarding permitting patients to guide your inspection is in order since although most patients will localize their pain from corneal foreign bodies, this has been shown to be inaccurate.

If present for greater than 24 hours, WBCs may migrate into the cornea/ anterior chamber, as a sign of iritis. Gross hyphema, however, may indicate globe perforation. Other gross exam findings may show eyelid edema, as well as generalized or focal injection of the conjunctiva.


All suspected corneal foreign bodies, or ocular trauma in general, should be evaluated in a systematic, thorough, and meticulous. It is recommended to develop a standard routine eye examination to avoid the common mistake of focusing on the most obvious finding and missing something more subtle.

First, all ocular trauma patients should be administered adequate pain control to assist in obtaining an accurate and thorough exam.

Following pain control, the exam should start with what is often referred to as the three vital signs of the eye. This exam criterion is well documented as the visual acuity, pupillary exam, consisting of shape, reactivity, equality, accommodation as well as any afferent pupillary defects seen. The third is the pressure of the anterior chamber. This should be obtained with care although may be skipped in some cases where globe perforation or rupture is highly suspected.

All patients suspected of having a corneal foreign body should also undergo a slit lamp examination. Care should be taken to inspect the entire eye as well as flipping the upper lid, as foreign bodies can hide under the tarsal plate and introduce micro-trauma with every blink of the eye. This should first be without fluorescein dye; inspecting the lids and lashes, the conjunctiva, the sclera, looking for injection, chemosis, anterior chamber depth, cell and flare within the anterior chamber, and as well as any readily apparent foreign bodies.

Upon adding the fluorescein, again a general inspection should be performed, looking for any corneal abrasions or lacerations. The dye will also allow you to perform the Seidel test, which when positive, indicates globe perforation. In a positive test, you would expect to see a flow of aqueous humor as a waterfall appearance at the site of trauma. Another more subtle finding which indicates a positive Seidel test is a lighter color dye in one location due to the dilution of the dye by the aqueous humor. This is a finding in very small globe perforations.

Once the slit lamp examination is completed, there are other exams and diagnostics that you may choose to obtain as an adjunct. This may include a full dilated funduscopic exam or CT imaging to assess for intraocular or even intracranial foreign body. Limited bedside ultrasound is also useful to assess for vitreous hemorrhage or retinal detachment, although again, extreme caution is recommended, as any pressure to the globe may cause extrusion of inner contents through a possible globe perforation.

Treatment / Management

With any possible penetrating ocular injury, such as corneal abrasion, foreign body, or globe perforation, the mainstay of initial treatment is pain control, removal of contact lenses, and protection of the eye to prevent further trauma. Ocular patches are not recommended in the initial management, however protective eye shields may be helpful in children, or altered patients, to prevent further trauma from digitization.

Pain management can is obtainable with topical, oral, intramuscular, or intravenous medications. The most efficacious is topical tetracaine. However, overuse of this can lead to long-term cornea breakdown, and its use reserved for the initial hour or two.

Cycloplegic eye drops may be helpful, as well as placing a patch over the unaffected eye, to minimize as much pupillary movement as possible. Topical ketorolac has also recently shown to be of benefit. However, this is avoided in the pregnant population.

Finally, systemic pain relief may be necessary if the patient cannot tolerate your examination. However, caution should be used with this approach, as dependence and misuse synrome have become more prevalent in recent years.

Foreign body removal should commence as soon as possible; within 24 hours is ideal, as, after this time, the foreign body can become embedded within the stroma of the cornea, and this makes removal more difficult. If the foreign body is thought to be or has physical exam findings consistent with full stromal thickness, the object should be removed on an emergent basis by an ophthalmologist.

There are many ways to remove a foreign body, but there is a consensus that a step-wise approach is most reasonable. The following techniques are the recommendations after thorough examination rules out globe perforation.

Simple irrigation and a moist cotton swab is the first step. The majority of recent and superficial foreign bodies can be successfully removed this way. If this is unsuccessful, the bevel of a needle is usable under slit lamp guidance. The physician may use their personal preference, but most texts recommend a 25-30 gauge needle connected to a TB-syringe for the utmost control.[3]

Another method to remove is with an ophthalmic corneal burr, also referred to as a spud, or more commonly the “Alger brush.” This has a couple of distinct functions. As it rotates, it can be used to essentially flick out the foreign body, although more commonly it is used to shave down the rust ring from a metallic foreign body.

When a foreign body is full thickness or intra-ocular, there are limited options. If the object is thought to be inert, such as glass or plastic, the patient can be observed serially. All metallic foreign bodies should be removed regardless of the depth, as they react with the stroma, causing a rust ring. Small rust rings can be left, as they will often go away on their own, or they can be serially shaved away as the stroma continues to regenerate. Central corneal foreign bodies or rust rings should undergo aggressive removal, as they have the most impact on future vision. Secondary iritis can a finding with inadequate removal of rust rings.

Upon successful removal off the corneal foreign body, treatment consists of pain control, follow up, and consideration given to prophylactic antibiotics. When choosing an antibiotic, contact lens wearers should have anti-pseudomonas coverage. In one study, 90% of the bacteria cultured from corneal foreign bodies was sensitive to fluoroquinolone drops.[4] Pain relief with topical ketorolac has not shown to impair corneal healing. Cycloplegics can also be used for comfort, although atropine should be avoided, as this can last up to 2 weeks. Lubricating eye drops are also helpful. There has been considerable controversy over employing an eye patch. It is contraindicated in contact lens wearers, as well as organic foreign bodies, as they can increase the rate of infection, although patches have not shown to be of benefit in time to corneal healing, or reduction in symptomatic days. After removal of a foreign body, treatment is the same as an abrasion, and a prospective, three-arm, randomized study showed patching showed no difference in days to comfort or healing.[5]

Differential Diagnosis

With any painful red eye, with a foreign body sensation, other etiologies must be ruled out. A broad differential diagnosis is helpful. The following differential for corneal foreign bodies includes but is not limited to:

  • Corneal abrasion or laceration
  • Globe perforation or rupture
  • Intra-ocular foreign body
  • Retinal or vitreous; detachment or hemorrhage
  • Uveitis/Iritis, Endophthalmitis
  • Ultraviolet keratitis
  • Exposure/ chemical injuries

Infectious causes, such as corneal ulcers, herpes zoster ophthalmicus, herpes simplex keratoconjunctivitis, or other simple viral or bacterial conjunctivitis.

Toxicity and Side Effect Management

Most complications, toxicities, and side effects occur with metallic foreign bodies. Full-thickness foreign bodies leading to globe perforation comes with its particular complications; however, that is outside the scope of this topic.

Metallic foreign bodies cause a previously described rust ring. This can progress to reactive iritis, causing significant pain and vision loss, and put the patient at risk for a secondary infection, or keratitis.

These complications and side effects can be managed effectively by prompt foreign body removal, rust ring removal, and close outpatient follow up with an ophthalmologist.


The prognosis for corneal foreign bodies varies with location and depth and type of substance. Superficial and peripheral corneal foreign bodies have an excellent prognosis, without long-term vision deficits, in most cases.

Centrally located, or full thickness corneal foreign bodies still have an excellent long-term prognosis, however, are associated with more complications, and require closer and more frequent follow-up appointments.

All centrally located rust rings come with a greater risk of visually significant scarring. However, close and frequent follow up can help avoid this outcome.


Complications are uncommon although they are serious. These consist mostly of reactive iritis due to corneal foreign bodies not removed within 24 hours or also seen with retained rust rings. There is also the risk of visually significant scarring with centrally located foreign bodies, especially with retained rust rings.


All patients with a corneal foreign body require close follow-up with an ophthalmologist.

Patients with peripherally located corneal foreign bodies, without retained foreign material, can follow up as an outpatient in 2-3 days.

Centrally located corneal foreign bodies or retained rust rings should be seen immediately (ideally), although within 24 hours of the event is reasonable.

Retained inert foreign bodies should be followed up with regularly, with exact timing determined on a case by case basis, which is also the case with intra-ocular foreign body

Once the patient is back to their baseline, once yearly ophthalmologic follow up is the recommendation, unless otherwise specified.

Deterrence and Patient Education

Most corneal foreign bodies directly result from non-compliance with well-fitting safety goggles. Patients should receive education on wearing these while performing high-risk activities, and the appropriate fit, as loose-fitting or inadequate protective eyewear can also result in ocular trauma.

Pearls and Other Issues

It is important to recall that when examining a patient with ocular trauma, finding one site of traumatic injury does not rule out additional corneal foreign bodies elsewhere.

Always complete your examination in a standard, routine, thorough, and meticulous manner.

Always remember to flip the upper eyelid and remove contact lenses before the examination.

Enhancing Healthcare Team Outcomes

Any patient with a corneal foreign body comes into contact with multiple health care providers. Many of these patients arrive at the emergency department. Here, nurses will perform triage and they may already notice an irregular pupil, and opted to cover the eye to protect it like an open globe. They may also take out an intra-ocular pressure meter, which will guide the exam. As one retrospective chart review study showed, intra-ocular pressure was one determining factor in open globe outcomes. (Level IV)[6] Patients may also seek the counsel of pharmacists who will instruct them on the proper use of eye drops. Interprofessional teamwork is essential. Once the initial stages of this condition are under control, close follow up with a specialist is needed. Many health-care providers play an essential role. 

  • Image 7370 Not availableImage 7370 Not available
    Image courtesy S Bhimji MD
Attributed To: Image courtesy S Bhimji MD

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Corneal Foreign Body - Questions

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A young male presents after brushing a metal grill one hour prior to presentation with concerns for a corneal foreign body, which of the following physical observations would add to the diagnosis?

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A child has a small foreign body removed from his cornea. After removal, the child appears comfortable in a brightly lit room. What other treatment is necessary?

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What should the post-discharge instructions be for a patient from whom a deep corneal foreign body is removed without complication?

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Which method is best in detecting intraocular ferrous foreign bodies?

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If a foreign object strikes the cornea, the eyelid will close. The cell bodies of the internuncial neurons involved in this reflex are located in the:

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Corneal Foreign Body - References


Heier JS,Enzenauer RW,Wintermeyer SF,Delaney M,LaPiana FP, Ocular injuries and diseases at a combat support hospital in support of Operations Desert Shield and Desert Storm. Archives of ophthalmology (Chicago, Ill. : 1960). 1993 Jun     [PubMed]
DelMonte DW,Kim T, Anatomy and physiology of the cornea. Journal of cataract and refractive surgery. 2011 Mar     [PubMed]
Beyer H,Cherkas D, Corneal foreign body removal using a bent needle tip. The American journal of emergency medicine. 2012 Mar     [PubMed]
Menghini M,Knecht PB,Kaufmann C,Kovacs R,Watson SL,Landau K,Bosch MM, Treatment of traumatic corneal abrasions: a three-arm, prospective, randomized study. Ophthalmic research. 2013     [PubMed]
Macedo Filho ET,Lago A,Duarte K,Liang SJ,Lima AL,Freitas Dd, Superficial corneal foreign body: laboratory and epidemiologic aspects. Arquivos brasileiros de oftalmologia. 2005 Nov-Dec     [PubMed]
Margo JA,Feldman S,Addis H,Bodanapally UK,Ellish N,Saeedi O, Open Globe Injuries Presenting With Normal or High Intraocular Pressure. Eye     [PubMed]


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