Post Craniotomy Headache


Article Author:
Bruno Subbarao


Article Editor:
Blessen Eapen


Editors In Chief:
Chaddie Doerr


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
5/6/2019 12:02:40 AM

Introduction

A craniotomy is a neurosurgical technique, whereby part of the skull is opened or removed for access to treat conditions such as brain tumors, aneurysms, and arterio-venous malformations. Post-craniotomy headaches (PCH) are one of the most frequently encountered adverse events after craniotomy, appearing in over two-thirds of patients undergoing the procedure[1]. PCH fall under the category of secondary headaches and can present unique challenges in diagnosis and management[2]. This article gives a brief overview of the current literature regarding this headache subtype.

Etiology

There are many hypotheses of which can contribute to the pain response following craniotomy. One of the more straightforward mechanisms is the direct trauma from the surgery itself to the soft tissue, musculature, bone, or meninges. Other potential causes include nerve injury, debris from drilling bone irritating the internal structures and meninges, adherence of muscle to the dura mater, formation of neuroma in the surgical scar, central sensitization, and aberrant nerve regeneration[3].

Risk Factors

Risk factors for PCH may include age, gender, and the previous history of headaches have been disputed and remain in question. However, neurosurgical duration of greater than 4 hours has been associated with a higher prevalence of PCH. Some studies suggest that incidence increases with certain surgical approaches, for example, craniectomies have a higher incidence than craniotomies or cranioplasties, and suboccipital approach have a higher incidence than translabyrinthine approach[4][5].

Although psychiatric disorders are not risk factors for PCH, the presence of uncontrolled anxiety or depression may increase the intensity and frequency of PCH, while worsening quality of life[6].

Epidemiology

Unfortunately, due to methodological differences, inconsistencies in definition, and multiple surgical approaches, retrospective reviews found an incidence range that varied from zero to 100%. However, looking broadly, a majority of those studies report that greater than 30% of craniotomy patients suffered from PCH[7].

Chronic PCH, which is commonly seen with excision of acoustic neuromas, has an incidence of 28.4% at 3 years postoperatively[8].

History and Physical

A true description of PCH has been scant and perhaps nonspecific, but some research suggests that on history, patients may report a continuous, pulsatile or pounding pain of variable intensity that appears within seven days of the surgery. Other common characteristics include symptoms on the same side as the surgical incision and improvement of symptoms over time[6].

As with all headaches, it is imperative to rule out red flag signs including but not limited to paralysis, papilledema, drowsiness, confusion, memory impairment, loss of consciousness, focal neurologic signs, neck stiffness, sudden onset excruciating pain, and/or personality changes.

Some evidence points to scar neuromas as a potential trigger for headaches. Thus, it is important to assess the scar site on physical exam and evaluate for reproduction of headache pain with palpation[9].

Evaluation

PCH is primarily diagnosed through history and physical examination. However, imaging may be warranted if intracranial pathology is suspected or red flags are found on examination. If so, a non-contrast head CT scan would be an appropriate first step.

The current criteria for diagnosis according to the International Classification of Headache Disorders 3 Beta edition is as follows:

A. Any a headache fulfilling criteria C and D

B. Surgical craniotomy has been performed

C. A headache is reported to have developed within 7 days after one of the following:

  • The craniotomy
  • Regaining of consciousness following the craniotomy
  • Discontinuation of medication(s) that impair the ability to sense or report a headache following the craniotomy

D. Either of the following:

  • A headache has resolved within 3 months after the craniotomy
  • A headache has not yet resolved but 3 months have not yet passed since the craniotomy

E. Not properly accounted for by another ICHD-3 diagnosis.

Of note, persistent headache attributed to craniotomy differs from the acute headache criteria by the fact that it persists for more than 3 months after the craniotomy. About a quarter of patients who develop an acute headache attributed to craniotomy go on to experience a persistent headache attributed to craniotomy. When a headache following craniotomy becomes persistent, the possibility of a medication-overuse headache should be considered[10].

Treatment / Management

Unfortunately, research remains lacking in regards to current strategies to manage PCH. Therefore, options for consideration include the use of typical medications seen in the treatment of headaches with similar phenotypes. A list of these medications is beyond the scope of this review, but, in the neurological population, care must be taken when using medications that may obscure the ability to monitor neurologic responses[11].

This is of particular importance when opioids are prescribed. They remain a heavily relied upon option for moderate to severe pain, even with the risk of addiction, cognitive clouding, and respiratory depression. Worth noting is the ability to combine other analgesics with opioids to lessen the chance of adverse events. Some combinations in past studies include fentanyl and ketorolac or tramadol and diclofenac[8].  

Regarding prophylaxis, one single center, randomized, the blinded trial found that a preoperative dose of 100 mg of diclofenac decreased the intensity of a headache on postoperative day 1, and up to post-op day 5 for patients with infratentorial surgeries. Still, caution must be exercised due to the potential to increase the risk of bleeding with the use of non-steroidal anti-inflammatory medications[1].

Other interventions have been studied, either for PCH or post-craniotomy pain in general, but warrant more research before standardizing their use in these patients. These include transcutaneous electrical acupuncture stimulation, nerve blocks, gabapentinoids, COX inhibitors, and dexmedetomidine, a presynaptic alpha two adrenoceptor antagonist.

In the chronic phase, a shift to more non-pharmacological adjuncts may be considered. Alternatives to consider are physical therapy, acupuncture, TENS units, hot or cold packs, massage, or bio-behavioral interventions. A small case series of four patients demonstrated a benefit with the use of Botulinum toxin-A to treat delayed onset PCH, but similar to the other approaches; more research is needed[1].

Differential Diagnosis

  • Post-surgical cerebrospinal fluid leak
  • Hydrocephalus
  • Intracranial hemorrhage
  • Other headache types including cervicogenic, tension, cluster, and migraine
  • A medication-overuse headache
  • Meningitis or other infection
  • Temporomandibular joint disorder

Pearls and Other Issues

  • Post-craniotomy headaches (PCH) appear in over two-thirds of patients undergoing the procedure 
  • Diagnosis is made primarily through use of ICHD 3-beta criteria
  • Risk factors include a choice of surgical approach and length of surgery. 
  • Anxiety and depression may exacerbate symptom intensity
  • Management in the acute phase may be best guided by treatment of headaches of a similar phenotype
  • Management in the chronic phase may best be achieved through non-pharmaceutical adjuncts

Enhancing Healthcare Team Outcomes

Post craniotomy is quite common after surgery but making the diagnosis is difficult as there are many serious causes of headaches post craniotomy which first need to be ruled out. The condition is best managed by a multidisciplinary team that includes a neurosurgeon, neurologist, internist, pharmacist and a mental health nurse. Once the serious causes have been ruled out, it is best to use non pharmacological therapy to relieve the headaches. Use of narcotics in post craniotomy patients is not recommended. Psychotherapy or some type of cognitive behavior therapy may be useful.

 


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Post Craniotomy Headache - Questions

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A 53-year-old male had a left acoustic neuroma resected 5 months ago and has had severe, throbbing left-sided headaches that began the week of the resection. He rarely had headaches before surgery. His headaches are without associated symptoms and are not positional. The only relief he gets is from narcotic analgesics. What is the next best step in management?



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Which of the following is part of the diagnostic criteria for acute post-craniotomy headaches according to the International Classification of Headache Disorders 3-beta?



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Risk factors for post-craniotomy headaches have been hotly contested. However, research does show that the presence of this comorbidity may worsen intensity of symptoms, and decrease the quality of life.



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Which class of medication is indicated for the treatment of moderate to severe pain, but caution must be exercised in using them to treat post-craniotomy headaches secondary to their addictive potential, ability to cause respiratory depression, and capability of obscuring neurologic responses?



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To diagnose post-craniotomy headache, one must obtain a thorough history and physical exam. Although physical exam findings can be variable, which of the following is seen?



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Post Craniotomy Headache - References

References

Pain following craniotomy: reassessment of the available options., Haldar R,Kaushal A,Gupta D,Srivastava S,Singh PK,, BioMed research international, 2015     [PubMed]
Post-craniotomy headache: a clinical view with a focus on the persistent form., Rocha-Filho PA,, Headache, 2015 May     [PubMed]
The risk of headache attributed to surgical treatment of intracranial aneurysms: a cohort study., Magalhães JE,Azevedo-Filho HR,Rocha-Filho PA,, Headache, 2013 Nov-Dec     [PubMed]
Scar neuromas as triggers for headache after craniotomy: clinical evidence., Ferreira Kdos S,Dach F,Speciali JG,, Arquivos de neuro-psiquiatria, 2012 Mar     [PubMed]
Post-craniotomy headache: A proposed revision of IHS diagnostic criteria., Rocha-Filho P,Gherpelli J,de Siqueira J,Rabello G,, Cephalalgia : an international journal of headache, 2010 Feb 22     [PubMed]
Post-craniotomy headache: characteristics, behaviour and effect on quality of life in patients operated for treatment of supratentorial intracranial aneurysms., Rocha-Filho PA,Gherpelli JL,de Siqueira JT,Rabello GD,, Cephalalgia : an international journal of headache, 2008 Jan     [PubMed]
Retrospective study of postcraniotomy headaches in suboccipital approach: diagnosis and management., Soumekh B,Levine SC,Haines SJ,Wulf JA,, The American journal of otology, 1996 Jul     [PubMed]
Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition.,, Cephalalgia : an international journal of headache, 2018 Jan     [PubMed]
Postcraniotomy headache., Molnár L,Simon É,Nemes R,Fülesdi B,Molnár C,, Journal of anesthesia, 2014 Feb     [PubMed]
Lutman B,Bloom J,Nussenblatt B,Romo V, A Contemporary Perspective on the Management of Post-Craniotomy Headache and Pain. Current pain and headache reports. 2018 Aug 14;     [PubMed]
Potter R,Probyn K,Bernstein C,Pincus T,Underwood M,Matharu M, Diagnostic and classification tools for chronic headache disorders: A systematic review. Cephalalgia : an international journal of headache. 2018 Oct 18;     [PubMed]

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