Molluscum Contagiosum


Article Author:
Talel Badri


Article Editor:
Grishma Gandhi


Editors In Chief:
Chaddie Doerr


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Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Kyle Blair
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Daniyal Ameen
Altif Muneeb
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes
Komal Shaheen
Sandeep Sekhon


Updated:
2/28/2019 8:16:14 PM

Introduction

Molluscum contagiosum, also called water warts, is a benign condition of the skin. The skin lesions of molluscum contagiosum are called mollusca. The typical lesion appears dome-shaped, round and pinkish purple in color.[1][2][3]

Etiology

A double-stranded DNA poxvirus called molluscum contagiosum virus (MCV) causes molluscum contagiosum. Four subtypes of the molluscum contagiosum virus are known, and the are MCV-1 (98% of cases) is mostly seen in children, while MCV-2 is mainly responsible for skin lesions in people living with HIV. MCV-3 and MCV-4 are present in Asia and Australia. Currently, it is not possible to have cultures of molluscum contagiosum virus.

Molluscum contagiosum lesions are transmitted by direct skin-to-skin (including sexual) or indirect (towels, underclothes, toys, razor, tattoo supplies) contact. Molluscum contagiosum may also disseminate by autoinoculation to normal skin after mollusca scraping by the patients. Transmission from sharing swimming pools and other wet environments is possible but not fully proven. In utero and prepartum transmissions are occasionally reported, resulting in congenital molluscum contagiosum or skin lesions developing during the early months of life.[4][5]

Epidemiology

Molluscum contagiosum is a common medical concern. In 2010, there were about 122 million cases. It occurs worldwide but seems to be more frequent in warm, humid regions. Molluscum contagiosum is diagnosed mainly in children aged two to five years, but also in sexually active teenagers and adults, and immunocompromised persons. Atopic dermatitis may increase the risk for developing molluscum contagiosum since it alters the skin barrier and immunity function. In people living with HIV (human immunodeficiency virus), the clinical prevalence of molluscum contagiosum may reach up to 18%. No gender predominance is noted.[6]

Pathophysiology

The incubation period ranges from two weeks to six months. Molluscum contagiosum virus infects only keratinocytes, and skin lesions are limited to the epidermis and do not have systemic dissemination. Molluscum contagiosum virus produces proteins inhibiting human antiviral immunity, thus preventing the development of innate immunity response, and contributing to the persistence of skin lesions.[7]

Histopathology

Molluscum contagiosum lesions have classic features under a microscope. The cup-shaped indentation of the epidermis into the dermis is usually seen. The proliferated rete ridges descend downwards and encircle the dermis. The epidermis is usually thickened and there is the presence of Henderson-Paterson bodies seen within the epidermis. It is these bodies that enclose the virus particles. 

History and Physical

Molluscum contagiosum causes mainly cosmetic concerns. Mollusca is usually asymptomatic but may be painful or itchy. In atopic persons, eczema lesions may develop around mollusca weeks after their occurrence. An inflammatory reaction, secondary to scratching or occurring when mollusca start to resolve, is frequent and should be distinguished from secondary bacterial infection. When scratched or removed, molluscum contagiosum can lead to bleeding under each single element.

Evaluation

The diagnosis of molluscum contagiosum is based on clinical examination. Lesions are firm, white to flesh-colored, dome-shaped, pearly papules, having a central umbilication from which one can express a cheesy material. Mollusca is usually one millimeter to one centimeter in diameter.[8][9]

In children, mollusca are located on the face, trunk, limbs and axillary areas. Palms and soles are not involved. In sexually transmitted forms, lesions are mainly observed in the anogenital area, abdomen, and inner thighs. There are rarely more than 20 to 30 elements over the skin and are usually grouped together. However, molluscum contagiosum may be extensive, mostly in immunocompromised persons.

The differential diagnosis of molluscum contagiosum in children includes syringoma, closed comedones (whiteheads), and warts (including anogenital ones).

In immunocompromised persons, molluscum contagiosum lesions may be atypical, have a greater size, and/or mimic malignancies, such as basal cell carcinoma or keratoacanthoma (for single lesions), or other infectious diseases, such as cryptococcosis and histoplasmosis (for extensive lesions).

In the case of a diagnosis difficulty, dermoscopy, reflectance confocal microscopy, and histopathology may be useful.

Dermoscopy of a molluscum shows a central white to a yellow amorphous area, with peripheral linear or branched vessels.

Reflectance confocal microscopy also shows a well-defined central area, which contains septa separating hypo-refractive roundish lobules. Histopathologically, these lobules consist of enlarged keratinocytes having an abundant cytoplasm containing viral inclusions (also called Henderson Paterson bodies) and a peripheral nucleus. The nearby epidermis shows a marked acanthosis.

Treatment / Management

People frequently seek treatment for cosmetic reasons, to avoid social stigma, or because they have concerns of transmission to other individuals. The treatment depends on the patient’s (or their parents) preferences. Because the condition is usually self-limiting, awaiting spontaneous resolution should be considered. However, the patients should be aware that the resolution of molluscum contagiosum may take several months. Even though many treatments had been proposed for molluscum contagiosum, none has proven its effectiveness. Current treatment options include physical removal of mollusca, topical medications, and systemic treatment.[10][11][12]

Physical removal is based mainly on cryotherapy with liquid nitrogen or curettage. Techniques might be associated. Laser treatment (carbon dioxide or pulsed dye laser) may also be used but not as a first-line therapy. Physical removal is usually painful and may require local anesthesia. Postoperative scarring is possible.

Doctors recommend many topical treatments for molluscum contagiosum. Podophyllotoxin (contraindicated in pregnant women), potassium hydroxide, salicylic acid (associated or not with povidone iodine), benzoyl peroxide, and tretinoin are used as home treatments and must be applied to each lesion. They are used with the aim to induce an inflammatory reaction, thus accelerating recovery. In recent analysis, imiquimod, which is used as a modulator of the immune system, and cantharidin, a blistering topical applied by the physician, have not been found to be more effective than other vehicles.

The use of oral cimetidine has been described as a safe alternative to physical removal in children who fear pain (except for facial involvement). However, a recent meta-analysis did not show any difference with cimetidine. Cidofovir, a DNA polymerase inhibitor, has been used successfully in immunosuppressed persons, but it may induce nephrotoxicity and neutropenia when used intravenously. In people living with HIV/AIDS, molluscum contagiosum is best managed with highly active antiretroviral therapy (HAART).

Differential Diagnosis

  • Keratoacanthoma
  • Lichen planus
  • Epidermal cyst
  • Pyoderma
  • Verruca vulgaris
  • Folliculitis
  • Cutaneous fungal disorders like histoplasmosis and sporotrichosis
  • Basal cell cancer
  • Condyloma acuminatum
  • Varicella zoster

Complications

  • Inflammation or infection (cellulitis)
  • Irritation
  • Conjunctivitis if the lesions are on the eyelids
  • Abscess

Pearls and Other Issues

Most molluscum contagiosum lesions in non-compromised persons resolve spontaneously within an average duration of six to 12 months. However, the course of molluscum contagiosum may take as long as four years. During that period, some mollusca may heal without any intervention, while others occur. Unlike other viruses, molluscum contagiosum virus no longer exists within the body after healing. However, it remains possible to develop molluscum contagiosum again after repeated contact with an infected person or a contaminated fomite. Scarring is unusual in molluscum contagiosum unless lesions are scratched or scrapped. In immunocompromised persons, a longer duration and resistance to therapy are common. Malignant transformation has never been reported.

Enhancing Healthcare Team Outcomes

The management of molluscum contagiosum is best done with a multidisciplinary team that also includes the primary care provider and nurse pactitioner. The important thing is that these lesions spontaneously resolve in most patients; thus patient education is vital. Patients should be told that there is a small risk of autoinoculation or infection of others. For those who decide to be treated, more than one session may be required. This information is important for the patient as it prevents them from seeking unnecessary therapies and making unreasonable demands. Parents should not keep children out of school, but the infected skin area can be covered with a garment. Since this virus can be sexually transmitted, the patient should be encouraged to practice safe sex and use barrier methods for protection. [13][14][15](Level V)

Outcomes

In the majority of patients, molluscum contagiosum resolve without any residual scars. The disorder is benign and spontaneous resolution is the usual outcome, but it may take 12-24 months. In some individuals, the lesions may persist for 3-5 years and may be disfiguring. Recurrences occur in one-third of patients. In patients with HIV or those who are immunocompromised, the lesions are generalized and occur when the CD4 counts are low. In these patients, spontaneous resolution of the lesions is rare.[16][17][18] (Level V)


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Molluscum Contagiosum - Questions

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Which of the following does not cause oral lesions in patients with HIV?



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Which of the following is considered a sexually transmitted disease in adults?



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A 22-year-old male with HIV has numerous umbilicated lesions on his face. The lesions are not itchy but are dark red in color. Biopsy of the lesions reveals intracytoplasmic inclusion bodies that the pathologist calls Henderson Paterson bodies. What is the most likely diagnosis?



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What is the best treatment of a patient with molluscum contagiosum?



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What causes Molluscum contagiosum?



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A male with HIV presents with multiple 1 to 3 mm discrete flesh colored dome shaped umbilicated papules on the groin, face, and trunk. He says he has been sexually active and noticed the outbreak of these lesions 3 weeks ago. He has no other symptoms except mild itching. What is the most likely diagnosis?



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A patient with a flesh-colored umbilicated papule on the face has the lesion excised and examined under a microscope. The histology reveals the presence of Henderson Patterson bodies. What is the most likely diagnosis?



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What is the first-line treatment for a patient with two small molluscum contagiosum lesions?



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Which of the following statements about molluscum contagiosum is TRUE?



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An HIV infected child has multiple, centrally umbilicated lesions over the face. What is the most likely cause of these skin lesions?

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What is the likely diagnosis for patients with small, asymptomatic, discrete dome-shaped papules with mild umbilication?



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A 3-year-old is brought in with new skin lesions present for several weeks. The child does not seem to notice them. They are flesh colored and measure about 3 millimeters with a central depression. They are present on the trunk and groin. Which of the following is true?

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What is the treatment of choice for molluscum contagiosum?



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What causes Molluscum contagiosum?



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A 17-year-old girl presents to the emergency department accompanied by law enforcement. The patient is emaciated and covered in flesh-colored, dome-shaped, pearly lesions on her trunk, thighs, and genitalia. She was recovered in a home handcuffed to a bed during a human trafficking raid. What skin infection is suspected?

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Which of the following does not have intranuclear viral inclusions?



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A 27-year-old has just been diagnosed with HIV after having practiced unsafe sex for years. Which of the following is the most common adnexal manifestation of HIV?



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Molluscum Contagiosum - References

References

Müller CSL,Laue M,Kremer K,Becker S,Vogt T,Smola S, Molluscum-contagiosum-Virus in einer Epidermalzyste. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 2018 Sep     [PubMed]
Nyati A,Gupta S,Jain SK,Yadav D,Patidar BL,Sharma M, A retrospective study of the pattern of sexually transmitted infections from a tertiary care hospital of Rajasthan. Indian journal of sexually transmitted diseases and AIDS. 2017 Jul-Dec     [PubMed]
Clebak KT,Malone MA, Skin Infections. Primary care. 2018 Sep     [PubMed]
Peterson AR,Nash E,Anderson BJ, Infectious Disease in Contact Sports. Sports health. 2018 Aug 14     [PubMed]
Rosner M,Zloto O, Periocular molluscum contagiosum: six different clinical presentations. Acta ophthalmologica. 2018 Aug     [PubMed]
Leung AKC,Barankin B,Hon KLE, Molluscum Contagiosum: An Update. Recent patents on inflammation     [PubMed]
Ruby KN,Perry AE,Linos K, Expanding the Morphologic Heterogeneity of Stromal Changes in Molluscum Contagiosum Infection. The American Journal of dermatopathology. 2018 Jan 11     [PubMed]
Rayala BZ,Morrell DS, Common Skin Conditions in Children: Skin Infections. FP essentials. 2017 Feb     [PubMed]
Lacarrubba F,Verzì AE,Dinotta F,Scavo S,Micali G, Dermatoscopy in inflammatory and infectious skin disorders. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia. 2015 Oct     [PubMed]
Rush J,Dinulos JG, Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. Current opinion in pediatrics. 2016 Apr     [PubMed]
Fernando I,Pritchard J,Edwards SK,Grover D, UK national guideline for the management of Genital Molluscum in adults, 2014 Clinical Effectiveness Group, British Association for Sexual Health and HIV. International journal of STD     [PubMed]
Brown M,Paulson C,Henry SL, Treatment for anogenital molluscum contagiosum. American family physician. 2009 Oct 15     [PubMed]
Goldman L, Dermatologic surgery in an ambulatory surgery center: ten years' experience. Cutis. 1984 Jul     [PubMed]
Vakharia PP,Chopra R,Silverberg NB,Silverberg JI, Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. American journal of clinical dermatology. 2018 Aug 10     [PubMed]
Olsen JR,Gallacher J,Piguet V,Francis NA, Development and validation of the Molluscum Contagiosum Diagnostic Tool for Parents: diagnostic accuracy study in primary care. The British journal of general practice : the journal of the Royal College of General Practitioners. 2014 Aug     [PubMed]
Al-Dawsari NA,Masterpol KS, Cantharidin in Dermatology. Skinmed. 2016     [PubMed]
Singh A,Thappa DM,Hamide A, The spectrum of mucocutaneous manifestations during the evolutionary phases of HIV disease: an emerging Indian scenario. The Journal of dermatology. 1999 May     [PubMed]
van der Wouden JC,van der Sande R,Kruithof EJ,Sollie A,van Suijlekom-Smit LW,Koning S, Interventions for cutaneous molluscum contagiosum. The Cochrane database of systematic reviews. 2017 May 17     [PubMed]

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