Atrioventricular Block Second-Degree


Article Author:
Muhammad Asif Mangi


Article Editor:
Laura Napier


Editors In Chief:
Jeanie Skibiski
Kathrin Allen
Brian Cornelius


Managing Editors:
Carrie Smith
Abdul Waheed
Frank Smeeks
Kristina Soman-Faulkner
Scott Dulebohn
Sobhan Daneshfar
William Gossman
Pritesh Sheth
John Shell
Matthew Varacallo
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Richard Ciresi
Hajira Basit
Phillip Hynes


Updated:
4/17/2019 1:25:24 AM

Introduction

An electrical impulse from the sinoatrial node has to travel through the atria, to the atrioventricular node, and down the His-Purkinje system to reach the ventricles and create a ventricular contraction. This process is reflected on ECG as the PR interval which leads to a QRS complex. A delay in conduction in this system results in an atrioventricular conduction block or a prolongation of the PR interval on ECG. Conduction blocks are classified as either first-degree block, second-degree block, or third-degree block. The second-degree atrioventricular block is the focus of this article. There are two types of second-degree atrioventricular blocks: Mobitz type I, also known as, Wenckebach and Mobitz type II.[1][2][3][4][5]

Etiology

Mobitz type I (Wenckebach) is often a normal variant and seen in individuals with a high vagal tone without evidence of structural heart disease. However, this rhythm can result from inferior myocardial ischemia, medication toxicity (AV nodal blocking agents), hyperkalemia, cardiomyopathy (Lyme disease), or following cardiac surgery.

Common drugs that are known to cause AV block include beta blockers, digoxin, calcium channel blockers and many antiarrhythmic agents. Recently the immunosuppressant agent, fingolimod, used to treat relapsing multiple sclerosis was also found to cause AV block.

Mobitz type II is rarely seen in patients without structural heart disease. It is often associated with myocardial ischemia and fibrosis or sclerosis of the myocardium. This rhythm often progresses to third-degree atrioventricular block.

Epidemiology

There have not been large population-based studies on the prevalence of Mobitz type I or II atrioventricular blocks. At this time, there is no associated age, racial, or gender correlation. AV block is sometimes seen in athletes and in patients with congenital heart disorders.

Pathophysiology

In Mobitz type I (Wenckebach) there is a progressive prolongation of the PR interval (AV conduction) until eventually an atrial impulse is completely blocked. When an atrial impulse is completely blocked there will be a P wave without a QRS complex. This pattern is often referred to as a “dropped beat.” Mobitz type I occurs because each depolarization results in the prolongation of the refractory period of the atrioventricular (AV) node. When an atrial impulse comes through the AV node during the relative refractory period, the impulse will be conducted more slowly, resulting in a prolongation of the PR interval. Eventually, an impulse comes when the AV node is in its absolute refractory period and will not be conducted. This will manifest on the ECG as a P wave that is not followed by a QRS complex. This non-conducted impulse allows time for the AV node to reset, and the cycle continues. This phenomenon leads to a grouped beating.

 In Mobitz type II there is a constant PR interval across the rhythm strip both before and after the non-conducted atrial beat. Each P wave is associated with a QRS complex until there is one atrial conduction or P wave that is not followed by a QRS. Mobitz type II is often a problem in the infra-nodal conduction system, and therefore, is associated with a widened QRS complex, bundle-branch block, or fascicular block. Be aware that if more than one P wave is not conducted this is no longer a Mobitz type II and is considered a high degree AV block.

History and Physical

Questions should involve any history of cardiac disease both current and congenital, recent cardiac procedures and current medications. Patients with Mobitz type II often present with fatigue, dyspnea, chest pain, presyncope or syncope, and even sudden cardiac arrest.

Physical examination will often reveal bradycardia. Patients who have severe bradycardia resulting in hypotension and decreased cardiac output may be diaphoretic and pale. Patients who have a second-degree atrioventricular block secondary to myocardial ischemia may present with chest pain.

Evaluation

ECG is used to determine if a second-degree AV block is present. If ischemia is suspected based on the clinical picture and/or ECG findings, then cardiac biomarkers and chest radiography may be indicated. Serum electrolytes, calcium, and magnesium should be checked. If a patient is on digoxin, a level should be obtained to evaluate for toxicity. Routine imaging is not required for initial evaluation of second-degree atrioventricular block.[6][7][8][9]

Treatment / Management

Treatment for a Mobitz type I (Wenckebach) is often not necessary. Occasionally type I blocks may result in bradycardia leading to hypotension. If hypotension and bradycardia occur, type I blocks respond well to atropine. If unresponsive to atropine, pacing (transcutaneous or transvenous) should be initiated for stabilization. 

Treatment for a Mobitz type II involves initiating pacing as soon as this rhythm is identified. Type II blocks imply structural damage to the AV conduction system. This rhythm often deteriorates into complete heart block. These patients require transvenous pacing until a permanent pacemaker is placed. Unlike Mobitz type I (Wenckebach), patients that are bradycardic and hypotensive with a Mobitz type II rhythm often do not respond to atropine.

Differential Diagnosis

Differential diagnosis includes congenital heart block, sinoatrial exit block, non-conducted premature atrial complexes, first-degree atrioventricular block, myocardial infarction, medication toxicity, and third-degree atrioventricular block.

Prognosis

The prognosis for Mobitz type I (Wenckebach) is excellent. This is usually asymptomatic and requires no intervention in asymptomatic patients.

The prognosis for Mobitz type II varies based on the cause of the rhythm. Patients require placement of implanted pacemaker devices to avoid complications of Mobitz type II AV blocks such as decreased cardiac output, symptomatic bradycardia, and sudden cardiac arrest.

Complications

  • Complete heart block
  • Syncope
  • Dizziness
  • Chest pain
  • Death

Postoperative and Rehabilitation Care

All patients with AV block need lifelong follow up.

Consultations

Once an AV block has been identified, the cardiologist should be consulted for management.

Pearls and Other Issues

It can often be challenging to separate the two types of second-degree AV blocks. A rhyme is often used to remember type I or Wenckebach: “longer, longer, longer, DROP, now you have a Wenckebach.” This rhyme is alluding to the progressive prolongation of the PR interval before a non-conducted beat or the lack of a QRS complex after a P wave.

When a Mobitz type I has a fixed conduction ratio of 2:1, meaning 2 conducted beats to one non-conducted beat, it is difficult to differentiate between type I and type II. In this scenario, it is recommended to assume the worst-case scenario and call this rhythm a “non-typeable second-degree AV block.” This should be managed like a type II with transcutaneous or transvenous pacing until further workup can be completed.

Enhancing Healthcare Team Outcomes

The diagnosis and management of second degree heart block is made by a multidisciplinary team that includes a cardiologist, ICU nurse, and an internist. When patients are diagnosed with a heart block, appropriate referral to a cardiologist is highly recommended. [10]

The prognosis for Mobitz type I (Wenckebach) is excellent. This is usually asymptomatic and requires no intervention in asymptomatic patients.

The prognosis for Mobitz type II varies based on the cause of the rhythm. Patients require placement of implanted pacemaker devices to avoid complications of Mobitz type II AV blocks such as decreased cardiac output, symptomatic bradycardia, and sudden cardiac arrest.


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Atrioventricular Block Second-Degree - Questions

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Which of the following is true of type I second-degree atrioventricular (AV) block?



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A 25-year-old patient has frequent episodes of flushing, nausea, and syncope. EKG during the episodes reveals several non-conducted P waves. What is the next step in his management?



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For which of the following conditions would cardioversion be the inappropriate choice for management?



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A 68-year-old female presents with chest pain and shortness of breath. ECG shows a heart rate of 110, first-degree AV block, episodes of type 1 secondary AV block, and left bundle branch block. Which of the following would not be appropriate?



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What is the progressive prolongation of the PR interval until a QRS complex is not generated on an electrocardiogram?



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What is the next best step in management for a patient with a second-degree atrioventricular block and congestive heart failure?



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What EKG finding is characterized by progressive prolongation of the PR interval until eventually a QRS complex is not generated?



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A 65-year-old male presenting with worsening dyspnea on exertion and a known ejection fraction of 35% whose vitals are shown heart rate 55 bpm, blood pressure 100/70 mmHg, respiratory rate 30, and oxygen saturation 93%. EKG is significant for type II second-degree atrioventricular block. What is the next best step in management of this patient?



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Atrioventricular Block Second-Degree - References

References

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Li X,Xue Y,Wu H, A Case of Atrioventricular Block Potentially Associated with Right Coronary Artery Lesion and Ticagrelor Therapy Mediated by the Increasing Adenosine Plasma Concentration. Case reports in vascular medicine. 2018;     [PubMed]
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Barold SS,Van Heuverswyn FE,Timmers L,Stroobandt RX, Mobitz type II second-degree atrioventricular block during dobutamine stress echocardiography. True or false? Echocardiography (Mount Kisco, N.Y.). 2014 Aug;     [PubMed]
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