Acoustic Neuroma (Vestibular Schwannoma)


Article Author:
Joshua Greene


Article Editor:
Mohammed Al-Dhahir


Editors In Chief:
Linda Lindsay


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
11/25/2018 9:09:08 PM

Introduction

Acoustic neuromas are also called vestibular schwannoma, acoustic neurinoma, vestibular neuroma, and acoustic neurofibroma. These are tumors that evolve from Schwann cell sheath and can be either intracranial or extra-axial. They usually occur adjacent to the cochlear or vestibular nerve. Anatomically, acoustic neuromas tend to occupy the cerebellopontine angle. About 20% of internal carotid artery (ICA) tumors are meningiomas and may occur elsewhere in the brain. Bilateral acoustic neuromas also tend to be exclusively in individuals with type 2 neurofibromatosis.[1][2][3]

Etiology

Acoustic neuroma is allied to neurofibromatosis type 2 (defect on Chromosome 22) bilateral disease. Studies have shown that acoustic neuroma had a causative predisposition mutation. Radiation exposure may predispose a patient to the development of that condition as well.[4]

Epidemiology

Approximately 8% of all intracranial tumors which manifest clinically are attributed to schwannomas. The majority of acoustic neuromas are unilateral and sporadic. Bilateral acoustic neuromas are in fact genetic and constitute a bit less than 5% of all schwannomas. Acoustic neuromas in general, tend to present between the fourth to sixth decades of life. Acoustic neuromas developing in individuals with neurofibromatosis type 2 (NF II) are likely to present earlier, with a peak incidence around the third decade of life. Although rare, acoustic schwannomas can occur in children. There is a small female preponderance with an aggravation of problems during pregnancy. Hereditary acoustic neuroma occurs in NF II much more often compared to neurofibromatosis type 1 (NF I), although the latter is much more common. Unilateral acoustic neuroma has been reported exclusively in 24% of cases with NF I, while bilateral acoustic schwannoma is a hallmark of NF II. Both these conditions are autosomal dominant. The defective genetic locus has been localized to chromosome 17 in NF I and chromosome 22 in NF II.[5][6]

Histopathology

Grossly, the tumor is rubbery-firm with a pale, gray color. It shows different degrees of vascularity and has a well-defined capsule, which could be discoursed by the displaced and stretched nerve fibers. The cut section is usually pale gray and firm with a finely trabeculated appearance. Often, evidence of cystic degeneration, hemorrhage, xanthomatous changes and points of calcification may be present and are encountered in large tumors. These changes give a variegated appearance in consistency and color to the giant tumors. The blood supply of the tumor comes mainly from the internal auditory artery, which forks the surface of the tumor with several tiny branches. For larger tumors, there might be blood supply through small branches of the neighboring cerebellar and pontine arteries.

On light microscopy, the tumor is made up of spindle cells that have elongated nuclei and fibrillary cytoplasm. Those cells are arranged in two specific ways: Antoni A and Antoni B. Antoni A tissue is small, with a prominent, organized, interwoven course of elongated bipolar cells. Occasionally, the arrangement of the nuclei and fibers results in a spiral framework simulating that seen in meningiomas. Antoni B is represented by a random gathering of cells grouped around foci of cystic change, necrosis, old hemorrhage, and blood vessels. There is a variable amount of lymphocytic infiltration of this tissue. The Antoni B tissue type, generally seen in large tumors, is thought to be the outcome of ischemia. The consistency of the tumor is determined by the distant relative quantities of these two types. Although these are benign changes, as malignant transformation almost never happens, nuclear pleomorphism is typical in schwannomas. Mitotic figures are relatively rare. Necrosis, if found, is more due to a poor blood supply rather than fast development. Edema, development of micro or possibly macrocysts, xanthomatous alteration, and areas of calcification are attributed to the degenerative changes in the tumor tissue. Electron microscopy (EM) reveals the characteristic basement membrane of the Schwann cells as well as the presence of wide-spaced collagen.[7]

History and Physical

The signs and symptoms of acoustic neuroma are attributed to the involvement of the cranial nerve VIII, compressing surrounding cranial nerves, cerebellum, brainstem, as well as raised intracranial pressure (ICP). The majority of acoustic neuromas present with unilateral hearing loss due to cochlear nerve interruption or impairment of blood supply to the nerve. Other clinical features include tinnitus, decreased word understanding, vertigo, headaches, and facial numbness. With enough growth, the mass of CP angle will eventually compress the brainstem and cause gait abnormalities. The following is a summary of the detailed clinical features.

Due to the involvement of Cranial Nerve VIII

  • Auditory
  1. Hearing impairment: the most common symptom, slowly progressive, high frequency retrocochlear sensorineural type. May pass unnoticed due to its insidious onset. May be examined in the physical through speech discrimination, using tuning forks of wide-range frequencies, Weber’s test as well as Rinne’s test.
  2. Tinnitus: also a common symptom, can be intermittent
  • Vestibular: Instability while moving the head and nystagmus

Due to compression of other Cranial Nerves

  • Facial nerve: usually minimal with late presentation except for very large tumors. Depending on the degree of engagement of the nerve, the symptoms may include twitching, increased lacrimation and facial weakness
  • Trigeminal Nerve: paraesthesia in the trigeminal distribution, tingling of the tongue, impairment of the corneal reflex, and less commonly pain which may mimic typical trigeminal neuralgia
  • The glossopharyngeal and vagus nerves: palatal paresis, hoarseness of voice and dysphagia

Due to Cerebellar Compression

  • Occurs in large tumors
  • Symptoms include gait ataxia and incoordination of the upper limb, and rarely dysarthria

Due to Brainstem Compression/Torsion

  • Symptoms include pyramidal weakness, contralateral cranial nerves involvement, and nystagmus

Due to Raised ICP

These include, but are not limited to, headache, nausea, vomiting, increased blood pressure, decreased mental abilities, confusion, disturbance of level of consciousness, and papilledema.

Evaluation

The diagnosis of an acoustic neuroma is made with a contrast MRI or a CT scan. Contrast is essential; otherwise, the non-enhanced scan can miss small tumors. If hearing impairment is present, audiometric tests are needed. Auditory brainstem evoked response is not used frequently to screen for acoustic tumors as it can miss small malignancies.[8][9][10]

Treatment / Management

Acoustic neuroma may be treated by:

  • Observation if small and in elderly patients with numerous comorbidities
  • Stereotactic radiotherapy or
  • Open craniotomy. The type of treatment depends on surgeon experience and patient preferences. After surgery, MRI is required within 6-12 months to document the extent of tumor removal and serve as a baseline. The most common complications of surgery include injury to the anterior inferior cerebral artery, hemorrhage, cerebellar trauma, facial paralysis, hearing loss (the most common)and hydrocephalus.

Differential Diagnosis

Acoustic neuroma accounts for around 80% to 90% of cerebellopontine angle (CPA) lesions. Differential diagnosis of an acoustic neuroma include:

  • Meningioma (5% to 10% of CPA lesions)
  • Ectodermal inclusion tumors
  1. Epidermoid (5% to 7% of CPA lesions)
  2. Dermoid
  • Metastases
  • Neuroma from cranial nerves other than cranial nerve VIII:
  1. Trigeminal neuroma.
  2. Facial nerve neuroma
  3. Neurinoma of the lowest four cranial nerves (IX, X, XI, XII)
  • Arachnoid Cyst
  • Neurenteric Cyst
  • Cholesterol granuloma (distinct from epidermoid)
  • Aneurysm
  • Dolichobasilar ectasia
  • Extensions of nearby lesions in the CP angle:
  1. Brainstem or cerebellar glioma
  2. Pituitary adenoma
  3. Craniopharyngioma
  4. Chordoma and tumors of skull base
  5. Fourth ventricle tumors (ependymoma, medulloblastoma)
  6. Choroids plexus papilloma from the fourth ventricle through Foramen of Luschka
  7. Glomus jugulare tumor
  8. Tumors of temporal bone

Complications

Most complications are related to the surgery and include the following:

  • Injury to the anterior or posterior intracerebral arteries
  • Neurological injury
  • Brain herniation
  • Brain hemorrhage
  • Injury to the cerebellum
  • Facial paralysis
  • Hearing loss

Pearls and Other Issues

Recurrence is not common after removal, but tinnitus may worsen in some patients. Hearing loss and facial paralysis may improve with time. 

The pre-operative distinction between a meningioma and an acoustic schwannoma is important for technical and prognostic reasons.

Enhancing Healthcare Team Outcomes

Acoustic neuromas are not common tumors in clinical practice. However, they often present with unilateral hearing loss and thus healthcare workers should consider the lesion in the differential diagnosis. The tumor once diagnosed is best managed by a multidisciplinary team that includes a neurosurgeon, neurologist, ENT surgeon, and a hearing specialist. After surgery, tinnitus is a common problem in at least 10-20% of patients. The recurrence rate after excision is less than 5%. Facial nerve paralysis appears to occur in about 15-30% of patients but most make a complete recovery over time. Hearing loss occurs in more than 50% of patients and may not improve over time. Residual hearing loss has a significant impact on the quality of life. [11][12][13] (Level V)


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Acoustic Neuroma (Vestibular Schwannoma) - Questions

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What is the only identifiable risk factor for the development of acoustic neuromas?



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The highest incidence of cerebrospinal fluid leak occurs with which approach when resecting an acoustic neuroma?



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Acoustic neuromas typically involve which cranial nerve?



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What is the expected hearing preservation rate with fractionated stereotactic radiation in a patient with a small acoustic neuroma and excellent hearing before treatment?



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Which technological advancements have led to the development of fractionated stereotactic radiation for acoustic neuromas?



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Which of the following statements is incorrect regarding the translabyrinthine approach to the removal of acoustic neuromas?



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Which of the following statements is incorrect regarding acoustic neuromas?



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A 65-year-old man complains of unsteadiness and vertigo with head motion after an acoustic neuroma is removed from his left ear. In consideration of vestibular rehabilitation, what should the appropriate therapy involve?



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Vestibular schwannomas can be observed in which of the following locations?



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Where are the majority of acoustic neuromas found?



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Other than vestibular schwannoma in the cerebellopontine angle, what are the three most common tumors in order of occurrence?



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A 58-year-old woman presents with gait imbalance, tinnitus, and right-sided hearing loss. MRI confirms an acoustic neuroma. Which of the following is true?



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Which cranial nerve is most commonly involved with schwannoma?



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An adult patient with vertigo of peripheral origin will also most likely have which clinical feature?



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Which of the following is not an early symptom of an acoustic neuroma (vestibular schwannoma)?



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What is the typical presentation of an acoustic neuroma?



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What is the most common neoplasia found at the cerebellopontine angle?



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A 53-year-old male presents with unilateral hearing loss, tinnitus, and mild unsteadiness. Which of the following tumors is the most likely etiology?



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Which cranial nerve is most often involved with schwannoma?



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Which of the following diseases is characterized by bilateral acoustic neuromas?



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A patient has a one-week history of vertigo, tinnitus, dizziness, and right-sided gait ataxia. Electronystagmography or calorics using cold-water in the left ear cause right-beating nystagmus, and warm water causes left-beating nystagmus. There is no response to cold caloric testing of the right ear. Select the most likely diagnosis.



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What cranial nerve is involved with vestibular schwannoma?



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What is the most probable diagnosis of a patient with progressive, nonfluctuating, unilateral hearing loss with unilateral tinnitus and unsteadiness?



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An MRI of the brain is seen. The radiologist appears to have highlighted the site of the pathology. From clinical studies, what is the least likely symptom associated with this lesion?

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What is the most common tumor of the internal auditory canal?



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Acoustic Neuroma (Vestibular Schwannoma) - References

References

West N,Sass H,Møller MN,Cayé-Thomasen P, Facial nerve schwannomas presenting with vestibular dysfunction: a case series. Acta neurochirurgica. 2018 Oct 29     [PubMed]
Meola A,Chang SD, Bilateral Vestibular Schwannomas in Neurofibromatosis Type 2. The New England journal of medicine. 2018 Oct 11     [PubMed]
Braunstein S,Ma L, Stereotactic radiosurgery for vestibular schwannomas. Cancer management and research. 2018     [PubMed]
Zhao F,Yang Z,Chen Y,Zhou Q,Zhang J,Liu J,Wang B,He Q,Zhang L,Yu Y,Liu P, Deregulation of the Hippo Pathway Promotes Tumor Cell Proliferation Through YAP Activity in Human Sporadic Vestibular Schwannoma. World neurosurgery. 2018 Sep     [PubMed]
Miller AB,Morgan LL,Udasin I,Davis DL, Cancer epidemiology update, following the 2011 IARC evaluation of radiofrequency electromagnetic fields (Monograph 102). Environmental research. 2018 Nov     [PubMed]
Koo M,Lai JT,Yang EY,Liu TC,Hwang JH, Incidence of Vestibular Schwannoma in Taiwan from 2001 to 2012: A Population-Based National Health Insurance Study. The Annals of otology, rhinology, and laryngology. 2018 Oct     [PubMed]
Landegger LD,Sagers JE,Dilwali S,Fujita T,Sahin MI,Stankovic KM, A Unified Methodological Framework for Vestibular Schwannoma Research. Journal of visualized experiments : JoVE. 2017 Jun 20     [PubMed]
Sass H,Cayé-Thomasen P, Contemporary Molecular Biology of Sporadic Vestibular Schwannomas: A Systematic Review and Clinical Implications. The journal of international advanced otology. 2018 Aug     [PubMed]
Lees KA,Tombers NM,Link MJ,Driscoll CL,Neff BA,Van Gompel JJ,Lane JI,Lohse CM,Carlson ML, Natural History of Sporadic Vestibular Schwannoma: A Volumetric Study of Tumor Growth. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2018 Sep     [PubMed]
Sweeney AD,Carlson ML,Shepard NT,McCracken DJ,Vivas EX,Neff BA,Olson JJ, Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Otologic and Audiologic Screening for Patients With Vestibular Schwannomas. Neurosurgery. 2018 Feb 1     [PubMed]
Lin KF,Stewart CR,Steig PE,Brennan CW,Gutin PH,Selesnick SH, Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications. Journal of neurological surgery. Part B, Skull base. 2018 Dec     [PubMed]
Peng KA,Chen BS,Lorenz MB,Lekovic GP,Schwartz MS,Slattery WH,Wilkinson EP, Revision Surgery for Vestibular Schwannomas. Journal of neurological surgery. Part B, Skull base. 2018 Dec     [PubMed]
Chiluwal AK,Rothman A,Svrakic M,Dehdashti AR, Surgical outcome in smaller symptomatic vestibular schwannomas. Is there a role for surgery? Acta neurochirurgica. 2018 Nov     [PubMed]

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