Anatomy, Head and Neck, Parathyroid, Ectopic Glands


Article Author:
Bianca Georgakopoulos


Article Editor:
Yasir Al Khalili


Editors In Chief:
Rodrigo Kuljis
Oleg Chernyshev
Aninda Acharya


Managing Editors:
Avais Raja
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Khalid Alsayouri
Trevor Nezwek
Radia Jamil
Patrick Le
Anoosh Zafar Gondal
Saad Nazir
William Gossman
Hassam Zulfiqar
Hussain Sajjad
Steve Bhimji
Muhammad Hashmi
John Shell
Matthew Varacallo
Heba Mahdy
Ahmad Malik
Sarosh Vaqar
Mark Pellegrini
James Hughes
Beata Beatty
Beenish Sohail
Nazia Sadiq
Hajira Basit
Phillip Hynes


Updated:
4/20/2019 8:22:37 PM

Introduction

Hyperparathyroidism is a condition mainly due to adenomas of the parathyroid that are overactive. Most cases of hyperparathyroidism go unnoticed because they are clinically silent. When symptomatic, the patient usually requires a referral to an otolaryngologist that will decide if surgery or medical intervention would better benefit the patient. If surgery is the option chosen, the patient will undergo imaging and a parathyroidectomy. Imaging is used to locate the parathyroid glands since these structures are notorious for being ectopically placed along a median line. If the clinical signs of hyperparathyroidism continue post-operatively, these serve as clues to the head and neck surgeon that there may be remaining tissue in the parathyroid, a parathyroid ectopically placed, or supernumerary parathyroids. Positive labs for continued primary hyperparathyroidism include hypercalcemia and high levels of PTH.[1] Symptoms of retained parathyroid tissue mirror symptoms of hypercalcemia: renal stones, osteoporosis, confusion, constipation, and weakness.[2]

Structure and Function

The parathyroid glands are typically located posterior to the thyroid glands, but anterior relative to the rest of the neck. These glands primarily function as the regulators of calcium homeostasis. If there is normal anatomy, the inferior parathyroid glands are located at the lower poles of the thyroid gland, while the superior parathyroid glands are present near the upper poles.[3] Typically, a person has four parathyroid glands, but the number of glands can vary from one, up to as high as twelve glands in total. [1] The parathyroid glands are activated via G-protein coupled receptors (GPCRs) that are sensitive to surrounding parathyroid hormone. These GPCRs exist on bone and kidney cells.[4] The parathyroid hormone itself functions by increasing renal tubular calcium reabsorption, enhancing net bone resorption, as well as stimulation net intestinal calcium absorption by increasing Vitamin D because of activation of 1-alpha-hydroxylase in the proximal convoluted tubule.[5] Intermittent binding of PTH to its GPCR leads to bone formation, while constant binding leads to bone degradation.[4] Intermittent PTH activates osteoblast differentiation which enhances bone formation, resulting in net bone gain; continuous PTH leads to greater osteoclastogenesis.[6] PTH regulation is by ionized calcium, extracellular phosphate, and vitamin D. In contrast to other regulatory systems, the parathyroids are not under the direct influence of other glands and organs. Usually, in primary hyperparathyroidism, calcium levels remain elevated, while phosphate and Vitamin D levels are low (attempting to initiate negative feedback).[5]

Embryology

The upper parathyroid glands descend from the fourth pharyngeal pouch within the thyroid, while the lower parathyroid glands travel with the thymus in the third pharyngeal pouch.[3] Due to the line of migration from the mandibular angle to the mediastinum, the ectopic glands can be located anywhere along this median line.[7]

Blood Supply and Lymphatics

Inferior parathyroid adenomas are hypervascular and receive most of their blood supply from inferior thyroidal artery branches, while superior parathyroid adenomas receive their blood supply from the superior or inferior thyroidal artery branches. The ectopic parathyroid glands located in the mediastinum receive their vascular supply from the internal thoracic artery, specifically the thymic branch.[8]

Nerves

Recurrent laryngeal nerve injuries are the most feared complication of parathyroid and thyroid operations due to the subsequent rise in postoperative morbidity. Some other symptoms of recurrent laryngeal nerve injury include vocal cord paresis or palsy, dyspnea, and deglutition.[9]

Muscles

In some rare cases, ectopic parathyroid adenomas are present in the sternohyoid muscles.[10]

Physiologic Variants

Another identified cause of primary hyperparathyroidism is an autosomal dominant condition known as multiple endocrine neoplasia type 1 (MEN1). The usual treatment of MEN1 in the context of primary hyperparathyroidism is surgical removal, but this is complicated when the parathyroid gland is ectopic. Ectopic parathyroid glands are more common in MEN1 patients than sporadically hyper-parathyroid patients.[11]

Surgical Considerations

The upper parathyroid glands are found above the inferior thyroid artery, at the cervical level of the cricoid cartilage, and posterolaterally to the recurrent laryngeal nerve.[1] The upper parathyroid glands have to travel a shorter distance when compared to the lower parathyroid glands, so the upper parathyroid glands are generally not ectopic.[3] Regardless of this, there are many ectopic locations for the superior parathyroid glands, and they consist of the tracheoesophageal groove, posteromedial to the thyroid in the paraesophageal area, within the carotid sheath, within the thyroid gland itself, and in the mediastinum (anywhere from superficial to deep).[1] Typically, the inferior parathyroid glands are located below the inferior thyroid artery and anteromedially to the recurrent laryngeal nerve. Some usual ectopic locations for the inferior parathyroid glands include: within the thymus, the perithymic fac, the thyrothymic ligament, as well as within the carotid sheath, the thyroid glands themselves, and the anterior mediastinal glands.[1] The most common ectopic locations for the parathyroid are within the mediastinum, the thymus, and the thyroid gland. The rarest locations for ectopic parathyroid glands include within the vagus nerve or pharynx, and behind the esophagus.[10]

Clinical Significance

Today, the majority of ectopic parathyroid glands are relatively silent without clinical manifestations. Because of this, surgery is not usually a recommendation unless the patient has symptoms. Guidelines for surgery include adjusted calcium over 0.25 mmol/L above the reference range, urine calcium greater than 10 mmol/ 24 hours, more than 30% reduction in creatinine clearance, less than -2.5 bone density T-score, and being less than 50 years old. Active ectopic parathyroid gland complications include namely hypercalcemia, which results in an increased fracture rate (more commonly in females), kidney stone disease, hypertension, cardiac valve calcification, and neurological symptoms (such as weakness, anxiety, and depression). For those patients that do not meet surgery guidelines, medications can be used and include hormone replacement therapy (specifically in post-menopausal women to decrease fracture rates) and calcimimetics that inhibit the release of PTH by binding to calcium receptors and dominating the negative feedback loop.[2]

Other Issues

Usual imaging for parathyroid glands includes ultrasound and CT. Ectopic parathyroid glands are not readily visible with ultrasound, so technetium-sestamibi CT scanning may be a diagnostic option which has high sensitivity and specificity for parathyroid adenomas. [2] After removal, parathyroid glands are taken to pathology to determine malignancy status. Because the regulation of calcium is vital, many times, surgeons will autoimplant a parathyroid gland within the forearm of a patient. By doing this, the gland's functionality remains the same with a lower incidence of malignancy and hyperparathyroidism because of close monitoring by the physician and patient.[10]

Ectopic parathyroid management requires close collaboration with an interdisciplinary team that includes the family physician, specialists, nursing staff, and pharmacists; this interprofessional team approach best leads to optimal patient management and clinical results. [Level V]


  • Image 9907 Not availableImage 9907 Not available
    Image courtesy S Bhimji MD
Attributed To: Image courtesy S Bhimji MD

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Anatomy, Head and Neck, Parathyroid, Ectopic Glands - Questions

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A 50-year-old female patient presents with confusion and kidney stones. Upon further physical exam, the clinician notices a scar on her anterior neck. What is the typical line of migration of the structure of structures in question?



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A 55-year-old female patient with a past medical history of myasthenia gravis presents with shortness of breath secondary to a thymoma. Upon further questioning, the patient has severe osteoporosis and has a history of constipation. During the operation of the thymoma, the healthcare provider notes another anomaly that may be the cause of his constipation and osteoporosis. Which of the following vascular structures are responsible?



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A 42-year-old female presents for a pre-operative consult for hypercalcemia. After the Technetium scan, it is discovered that an adenoma is located within a muscle. Which of the following functions will be impaired if the muscle is injured?



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Anatomy, Head and Neck, Parathyroid, Ectopic Glands - References

References

Caron NR,Sturgeon C,Clark OH, Persistent and recurrent hyperparathyroidism. Current treatment options in oncology. 2004 Aug;     [PubMed]
Taterra D,Wong LM,Vikse J,Sanna B,Pękala P,Walocha J,Cirocchi R,Tomaszewski K,Henry BM, The prevalence and anatomy of parathyroid glands: a meta-analysis with implications for parathyroid surgery. Langenbeck's archives of surgery. 2019 Feb;     [PubMed]
Patrinos A,Zarokosta M,Piperos T,Chrysikos D,Kakaviatos D,Theodoropoulos P,Kalles V,Tsiaoussis J,Noussios G,Mariolis-Sapsako T, An anatomic aberration and a surgical challenge: Mediastinal parathyroid adenoma anterior the pericardium. A case report. International journal of surgery case reports. 2019 Mar 21;     [PubMed]
Culhane KJ,Belina ME,Sims JN,Cai Y,Liu Y,Wang PSP,Yan ECY, Parathyroid Hormone Senses Extracellular Calcium To Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor. ACS chemical biology. 2018 Aug 17;     [PubMed]
Choi H,Magyar CE,Nervina JM,Tetradis S, Different duration of parathyroid hormone exposure distinctively regulates primary response genes Nurr1 and RANKL in osteoblasts. PloS one. 2018;     [PubMed]
Schappacher-Tilp G,Cherif A,Fuertinger DH,Bushinsky D,Kotanko P, A mathematical model of parathyroid gland biology. Physiological reports. 2019 Apr;     [PubMed]
Fraser WD, Hyperparathyroidism. Lancet (London, England). 2009 Jul 11;     [PubMed]
Lane MJ,Desser TS,Weigel RJ,Jeffrey RB Jr, Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas. AJR. American journal of roentgenology. 1998 Sep;     [PubMed]
Miura D, Ectopic parathyroid tumor in the sternohyoid muscles: supernumerary gland in a patient with MEN type 1. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2005 Aug;     [PubMed]
Joliat GR,Guarnero V,Demartines N,Schweizer V,Matter M, Recurrent laryngeal nerve injury after thyroid and parathyroid surgery: Incidence and postoperative evolution assessment. Medicine. 2017 Apr;     [PubMed]
Park HL,Yoo IR,Kim SH,Lee S, Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT. Annals of surgical treatment and research. 2016 Dec;     [PubMed]

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