Neuroanatomy, Pupillary Dilation Pathway


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Jacqueline Lykstad


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Updated:
12/9/2018 9:42:52 PM

Introduction

The pupillary dilation pathway is a sympathetically driven response beginning in the hypothalamus and ending with the contraction of the dilator pupillae muscle. It is for this reason that pupillary dilation may result from any physical or emotional stress that triggers the autonomic sympathetic nervous system which is mediated by the hypothalamus.

The pupillary dilation pathway is a three-neuron pathway; disruptions anywhere along the oculosympathetic pathway may cause Horner's syndrome, which is a classic triad of ptosis, miosis, and anhydrosis of the face due to loss of sympathetic innervation. It is essential to avoid damaging the superior cervical ganglion during cervical surgery, as such damage could prompt the development of Horner’s syndrome.

Although Horner’s syndrome is predominantly a clinical diagnosis, in more subtle cases, administration of topical cocaine to the eye for confirmation secondary to cocaine's sympathetically activating qualities is an option. One of cocaine's mechanisms of action is to block the reuptake of norepinephrine at the neuromuscular junction. Topical cocaine in a person without Horner's syndrome will cause pupillary dilatation. Topical cocaine in a person with Horner's syndrome will lead to minimal or no dilation at all.  In addition to Horner's syndrome, chronic opiate abuse can cause miosis.

Structure and Function

The pupillary dilation pathway is a sympathetically driven response to stimuli and is a three-neuron pathway.[1] The first-order neuron begins in the hypothalamus and descends through the midbrain to synapse onto the spinal cords ciliospinal center of Budge, found between C8 to T2. The second-order neuron, the preganglionic sympathetic neuron, exits the spinal cord through the ventral roots and ascends through the thorax, near the lung apex and subclavian vessels, onto the superior cervical ganglion.

The superior cervical ganglion is located opposite the second and third cervical vertebrae,[2] near the angle of the mandible and the bifurcation of the common carotid artery. The third-order neuron, postganglionic neurons travel along the periarterial carotid plexus, through the cavernous sinus. These axons then enter the orbit upon the short and long ciliary nerves (branches of V1, the ophthalmic division of CN V - the trigeminal nerve) to synapse on the dilator pupillae muscle, causing pupillary dilation.

Blood Supply and Lymphatics

Blood supply to the sympathetic chain and ganglia is primarily via the ascending pharyngeal artery, ascending cervical artery, thyrocervical trunk, and supreme intercostal arteries[3] The internal jugular vein supplies the venous drainage to this region. As the pathway ascends past the superior cervical ganglion, blood supply is from the internal carotid artery, followed by the ophthalmic artery. Additionally, as the pathway ascends, lymphatic drainage follows regional lymph nodes.

Surgical Considerations

Any disruption along the three neuron pathway can result in loss of pupillary dilation. Although rare, damage to the superior cervical ganglion can occur as a complication of anterior or posterior cervical spine surgery, or surgery involving the thoracic outlet or lung apex. This damage presents as an abnormally small pupil with the inability to dilate due to the disruption of the cervical sympathetic nerves, known as Horner’s syndrome.[1]. Horner’s syndrome is a classic triad of ipsilateral ptosis, miosis, and anhydrosis of the face due to disruption of the sympathetic pathway in the head and neck.

Although the diagnosis of Horner’s syndrome is predominantly clinical, in subtle cases, it can be confirmed by applying topical cocaine eye drops.[4] Cocaine is a stimulant that activates the sympathetic nervous system and acts by blocking the reuptake of norepinephrine, dopamine, and serotonin at the synaptic cleft. Since pupillary dilation is sympathetically driven, a classic sign of cocaine and other stimulant use is dilated pupils. If the pupillary dilation pathway has been disrupted, in this case via damage to the superior cervical ganglion, applying cocaine eye drops to the ipsilateral eye will not produce pupillary dilation. Therefore, in the presence of the triad mentioned above, if there is no pupillary dilation with the administration of cocaine eye drops, Horner’s syndrome can be confirmed.

Of note, apraclonidine eye drops are also an option in the place of cocaine eye drops.[5] Horner’s syndrome can also occur secondary to a variety of causes, located anywhere along the pupillary dilation pathway. These include dissection of the carotid artery,[6] brachial plexus injury, neck mass, cervicothoracic spinal lesion, and Pancoast tumors, among many others.

Clinical Significance

Clinically, monitoring pupil dilation is intrinsic to the management of opioid overdose. According to the CDC’s 2018 Annual Surveillance Report of Drug Related Risks and Outcomes, although opioid prescribing has continued to decrease through 2017, drug overdose deaths in the United States reached a record high in 2016 of 63,632.[7]. Of these fatalities, 66.4% involved opioids (42,249), the most common of which were synthetic opioids other than methadone (19,413), prescription opioids (17,087), and heroin (15,469). Amidst the opioid crisis, it is imperative to understand the treatment of opioid overdose. 

Opioids are parasympathomimetics that act predominantly on mu receptors to produce feelings of euphoria, analgesia, and sedation. In toxic doses, opioids cause depressed mental status, respiratory depression (<12/min), decreased tidal volume, and pupillary constriction, or miosis. Due to respiratory depression, initial management should focus on airway and breathing, with preparation to mechanically ventilate if it becomes necessary. This is closely followed by the administration of naloxone, ideally via the intravenous route, which is a short-acting pure opioid antagonist.

Naloxone has a duration of approximately two hours, and repeat administration may be necessary if respiratory depression and coma return, especially if a long-acting opioid was taken. Since naloxone reverses pupillary constriction, administration via injection can continue until pupillary dilation takes place. Similarly, the size of the patient’s pupils can be monitored to assess whether a subsequent dose is indicated, although monitoring of pupils should be performed in conjunction with observation for the return of respiratory depression. Of note, Naloxone is available OTC in many states, and expanded access to naloxone is essential for reducing opioid overdose morbidity and mortalit.y[8]

Another common clinical scenario associated with pupillary dilation is an uncal brain herniation, a complication of high intracranial pressure in which a portion of the temporal lobe herniates over the tentorium and places pressure on the midbrain. However, the associated pupillary dilation is not from activation of the pupillary dilation pathway. Instead, it is from compression of the oculomotor nerve which causes altered parasympathetic input to the ipsilateral eye.[9] Since pupillary constriction occurs parasympathetically, parasympathetic paralysis results in loss of pupillary constriction and hence, pupillary dilation.

Additionally, pupillary dilation as an adaptation to low levels of light is due to the pupillary light reflex, in which varying intensities of light fall on the retinal ganglion cells and cause pupillary constriction or dilation. This is a separate pathway from the pupillary dilation pathway. 


  • Image 4773 Not availableImage 4773 Not available
    Contributed by Wikimedia Commons, Henry Vandyke Carter - Henry Gray (1918) (Public Domain)
Attributed To: Contributed by Wikimedia Commons, Henry Vandyke Carter - Henry Gray (1918) (Public Domain)

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Neuroanatomy, Pupillary Dilation Pathway - Questions

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When the drug atropine is placed in the eye, the pupil remains temporarily dilated. Which of the following nerve pathways has been anesthetized?



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A 44-year-old patient undergoes a successful head and neck surgery. However, when she awakens, the provider notices anisocoria of the left eye compared to the right, drooping of the left eyelid, and flushing of the left side of the patient's face. Surgical damage to which of the following structures could explain her current presentation?



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Which of the following is not involved in the pupillary dilation pathway?



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Which landmark is best used to locate the superior cervical ganglion?



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Neuroanatomy, Pupillary Dilation Pathway - References

References

Tubbs RS,Salter G,Wellons JC 3rd,Oakes WJ, Blood supply of the human cervical sympathetic chain and ganglia. European journal of morphology. 2002 Dec     [PubMed]
Khan Z,Bollu PC, Horner Syndrome null. 2018 Jan     [PubMed]
Martin GC,Aymard PA,Denier C,Seghir C,Abitbol M,Boddaert N,Bremond-Gignac D,Robert MP, Usefulness of cocaine drops in investigating infant anisocoria. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 2017 Nov     [PubMed]
Cooper-Knock J,Pepper I,Hodgson T,Sharrack B, Early diagnosis of Horner syndrome using topical apraclonidine. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2011 Sep     [PubMed]
Garberi C,Ravizza R,Colombo R,Borromeo F,Rossetti C,Cisini S,Motta M,Birkhoff JM, Unusual case of traumatic carotid artery dissection occurred during a work-related activity. A case report. La Medicina del lavoro. 2018 Oct 30     [PubMed]
Moberg K, The role of managed care professionals and pharmacists in combating opioid abuse. The American journal of managed care. 2018 May     [PubMed]
Eggleston W,Podolak C,Sullivan RW,Pacelli L,Keenan M,Wojcik S, A randomized usability assessment of simulated naloxone administration by community members. Addiction (Abingdon, England). 2018 Dec     [PubMed]
Ritter AM,Muizelaar JP,Barnes T,Choi S,Fatouros P,Ward J,Bullock MR, Brain stem blood flow, pupillary response, and outcome in patients with severe head injuries. Neurosurgery. 1999 May     [PubMed]
Mitsuoka K,Kikutani T,Sato I, Morphological relationship between the superior cervical ganglion and cervical nerves in Japanese cadaver donors. Brain and behavior. 2017 Feb     [PubMed]

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