Cutaneous Larva Migrans


Article Author:
Luke Maxfield


Article Editor:
Jonathan Crane


Editors In Chief:
Venkat Minnaganti
John Brusch
Janak Koirala


Managing Editors:
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Frank Smeeks
Kristina Soman-Faulkner
Benjamin Eovaldi
Radia Jamil
Sobhan Daneshfar
Saad Nazir
William Gossman
Pritesh Sheth
Hassam Zulfiqar
Steve Bhimji
John Shell
Matthew Varacallo
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Hajira Basit
Phillip Hynes


Updated:
3/23/2019 12:04:48 AM

Introduction

Cutaneous larva migrans (CLM), also having been termed for the clinical sign of creeping eruption, is an infectious syndrome caused by multiple types of hookworms. This is most commonly transmitted by animal feces depositing eggs in the soil, with larvae entering humans through direct contact with skin. Cutaneous larva migrans is distinguished from the cutaneous manifestation of Strongyloides stercoralis infection termed larva currens. The latter demonstrating fast movement through the skin. Other non-larval cutaneous migrations including loiasis, scabies, or larva with dermal penetration are also excluded from CLM.[1]

  • This disease is classically seen in warmer climates including the southeast United States. Latin America, Southeast Asia, and Africa.
  • Symptomatology includes a progressive migrating serpiginous rash commonly with pruritus. While the disease can affect any exposed area, the most common location is the feet.
  • The natural progression of the disease is self-limited as the organisms are unable to produce a collagenase to penetrate the basement membrane and reach the gastrointestinal (GI) tract to reproduce. When treatment is given topical thiabendazole, oral albendazole, or ivermectin are the drugs of choice.
  • Complications often arise from secondary bacterial superinfection or complications from inappropriate empiric therapy.[1][2][3]

Etiology

CLM is a clinical manifestation demonstrated by creeping migration of larva through the skin. Organisms include animal vector nematode hookworms Ancylostoma braziliense, Ancylostoma caninum, and Uncinarai stenocephala. Human hookworms Ancylostoma duodenale and Necator americanus also can cause disease.[4]

Epidemiology

Organisms responsible for the disease are most commonly found in tropical climates such as the southeastern United States, Latin America, the Caribbean, Southeast Asia, and Africa. Prevalence of disease is often highest during wet seasons. Tourists traveling to endemic areas who are affected have been tended to be younger.[1],[3]

Pathophysiology

Adult hookworms live in intestines of dogs and cats. Eggs are shed in feces and after deposition into the soil hatch within one day. Over the course of the proceeding week, these develop into infective larvae. Worms respond to physical vibration and increased temperature and move in a snake like fashion. Upon contacting a host organism penetrate the corneal layer by secreting a hyaluronidase. Despite burrowing through the superficial cutaneous layers, they are unable to penetrate the basal membrane to enter lymphatics are therefore are unable to complete their lifecycle. Hookworms subsequently die without reproducing, and disease is self-limited.[1],[2],[4]

Histopathology

Biopsy of affected areas show the larvae in the epidermis or below surrounded by eosinophilic infiltrate. Spongiotic dermatitis with vesicles containing neutrophils and eosinophils may also be present.[2],[5]

History and Physical

Patient history often involves travel to endemic areas and a history of walking barefoot. The most common initial finding is a small reddish papule that progresses to a serpiginous pruritic rash with a slow rate of progression from less than 1 to 2 cm per day. The initial presentation may vary depending on species. Disease from A. braziliense manifests within 1 hour, while papular lesions may take days to appear when U. stenocephala is the organism that infects a person. Vesiculobullous disease may occur as well, and papulopustular inflammation of the follicles has been documented, although this is not common.[2][6][7]

Evaluation

Diagnosis is usually made clinically based on the history of recent travel to endemic areas in combination with a classic serpiginous rash. The rash is very pruritic, raised, and has a slower rate of millimeters up to 2 cm per day. This distinguishes it from other migrating infections. Blood tests are not necessary for diagnosis. Not only is eosinophilia found in less than 40% of patients with CLM, but it is also not specific. Non-invasive optical coherence tomography has been used to establish diagnosis although this is not often used. Skin biopsy is occasionally performed and may reveal the nematode larvae within a circular canal. A biopsy is not sensitive, and while secondary changes and infiltrate assist in diagnosis, it is not necessary to confirm this clinical diagnosis.[2][5],

Treatment / Management

The disease is self-limited; however, if the infection is local, topical thiabendazole 10% solution or 15% ointment may be tried first. The cream is applied 2 to 3 times daily for 5 to 10 days. Small studies have shown improvement of pruritus may occur as early as 48 hours after beginning treatment, and cure rates as high as 98% within 10 days have been achieved. The largest advantage of topical therapy is lack of systemic absorption and side effects, but use is limited by multiple applications daily, and utility is less valuable with multiple lesions.

Local disease has historically been treated with cryotherapy. However, freezing the leading edge of the skin with either liquid nitrogen, solid carbon dioxide, or ethylene chloride spray has been shown to be largely ineffective and should be avoided.

For multiple lesions or severe infestation albendazole and ivermectin are first-line systemic therapies. Oral albendazole, 400 mg daily for 3 to 5 days, is very effective with cure rates nearing 100%. Some studies show that a 7-day course of albendazole may decrease the rates of recurrent disease. Oral ivermectin is also effective, and its advantage is a patient only has to take a one-time dose of 12 mg by mouth. Cure rates near 100% with ivermectin administration.

Mebendazole is another anti-helminthic agent; however, it has poor bioavailability, absorption, and subsequently poor efficacy and should not be used as a first line medication. Also ineffective include topical steroids, oral steroids, and antibiotics. While systemic corticosteroids may reduce itching, the side-effect profile limits usefulness.

In addition to pharmacologic therapy, banning dogs from beaches may decrease deposition of larvae into the soil. Notably, towels do not consistently protect against transmission but wearing protective footwear can be effective.[3][4][6][7][8]

Differential Diagnosis

While the creeping eruption and clinical signs lead to diagnosis in most cases, other organisms may be confused for this infective processes. Scabies, loiasis, myiasis, schistosomiasis, tinea corporis, and contact dermatitis may have some overlapping features. These are all easily differentiated by lack of serpentine migration. The most similar disease is the migrating lesion of Strongyloides stercoralis, termed larva currens. This progressing serpiginous infection is differentiated by its rate of progression with intermittent movement and rates of several centimeters by the hour. Additionally, the pattern is haphazard, and disease more often occurs on the perianal skin, thighs, or the trunk. A human trematode, Fasciola gigantica causes a disease called fascioliasis and is also in the differential. Non-infectious linear or serpiginous dermatoses include jellyfish stings, lichenoid eruptions, and phytophotodermatitis, which again are non-migratory. Creeping ingrown hair may present but is rare. [2][4][6]

Prognosis

Disease is often self-limited, and resolution without treatment is the rule rather than the exception. However, migration may continue for months, and during this time, pruritus may be severe, often interfering with sleep. Treatment, topical or systemic results in cure rates near  100%, and although recurrence can occur, it is also well prevented and responsive to systemic therapy.[3][6][7]

Complications

Complications include secondary infection most commonly with Staphylococcus aureus and Streptococcal species. Secondary impetiginization occurs in up to 8% of cases. If the infection is prolonged post-streptococcal glomerulonephritis has been reported. Although it is well accepted that larvae cannot penetrate the basement membrane of skin, visceral disease has been rarely reported. Larvae has been identified in sputum, found in viscera of a human host, and also found in skeletal musculature. Host response to infection has rarely occurred as erythema multiforme. [9]

Enhancing Healthcare Team Outcomes

The healthcare team, including clinicians, pharmacists, and nurses should work together to help educate the public on strategies to avoid this disease in endemic areas as well as the importance of following treatment guidelines. [Level V]


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Cutaneous Larva Migrans - Questions

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A Canadian female returns from a cruise to the Caribbean where she enjoyed multiple excursions on the beach. She presents with a winding, serpiginous, erythematous rash on her foot. She does not remember any bites, stepping on anything unusual, and her only complaint is itching. She thinks that it has gotten larger or moved since she first noticed it. What is the most likely organism?



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A 17-year-old male returns from Africa for which he was building well with his local church. After his return, he presented for a mildly pruritic red raised migrating rash. He is astutely diagnosed with cutaneous larva migrans. Which is the most appropriate initial treatment option?



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A 17-year-old male diagnosed with cutaneous larva migrans has been observed for the last month. The patient states the itching is bearable, not interfering with sleep, but he has noticed that the lesion has a new honey-colored crust that that has developed over the last week. He also states similar lesions have appeared at other sites. He denies any fever or constitutional symptoms. What is the most likely complication?



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During a trip to a remote tropical region, you notice a serpentine migrating rash on the lower leg of a young woman. You are uncertain what the organism is but you remember that the rate can help distinguish between hookworms associated with cutaneous larva migrans and other organisms. What is the classic rate that is distinguishing for cutaneous larva migrans?



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A patient presents to your dermatology office from his primary care provider's office with suspected cutaneous larva migrans. The patient had a punch biopsy to prove it is a hookworm infection but the hookworm is not present in the specimen. What secondary findings could be seen under microscopy to help confirm this diagnosis?



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Cutaneous Larva Migrans - References

References

Epidemiological and clinical characteristics of hookworm-related cutaneous larva migrans., Heukelbach J,Feldmeier H,, The Lancet. Infectious diseases, 2008 May     [PubMed]
Parasitic infestations., Jacobson CC,Abel EA,, Journal of the American Academy of Dermatology, 2007 Jun     [PubMed]
Management of imported cutaneous larva migrans: A case series and mini-review., Kincaid L,Klowak M,Klowak S,Boggild AK,, Travel medicine and infectious disease, 2015 Sep-Oct     [PubMed]
Hookworm-related cutaneous larva migrans., Hochedez P,Caumes E,, Journal of travel medicine, 2007 Sep-Oct     [PubMed]
Imaging of cutaneous larva migrans by optical coherence tomography., Morsy H,Mogensen M,Thomsen J,Thrane L,Andersen PE,Jemec GB,, Travel medicine and infectious disease, 2007 Jul     [PubMed]
Mini review: Hookworm-related cutaneous larva migrans., Feldmeier H,Schuster A,, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012 Jun     [PubMed]
Follicular cutaneous larva migrans: a report of three cases and review of the literature., Veraldi S,Persico MC,Francia C,Nazzaro G,Gianotti R,, International journal of dermatology, 2013 Mar     [PubMed]
Treatment of cutaneous larva migrans., Caumes E,, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000 May     [PubMed]
Pyoderma, group A streptococci and parasitic skin diseases -- a dangerous relationship., Feldmeier H,Singh Chhatwal G,Guerra H,, Tropical medicine & international health : TM & IH, 2005 Aug     [PubMed]

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