Psoriasis, Guttate


Article Author:
Dahlia Saleh


Article Editor:
Laura Tanner


Editors In Chief:
Ahmad Al Aboud
Jayakar Thomas
Pramod Nigam


Managing Editors:
Orawan Chaigasame
Carrie Smith
Abdul Waheed
Frank Smeeks
Kristina Soman-Faulkner
Benjamin Eovaldi
Radia Jamil
Sobhan Daneshfar
Pritesh Sheth
Hassam Zulfiqar
Steve Bhimji
John Shell
Matthew Varacallo
Ahmad Malik
Mark Pellegrini
James Hughes
Beata Beatty
Hajira Basit
Phillip Hynes
Kavin Sugumar


Updated:
10/27/2018 12:31:36 PM

Introduction

Psoriasis is a chronic, inflammatory disorder that presents as well-defined, scaly, erythematous plaques, and occasionally, sterile pustules. Several clinical variants of psoriasis exist including plaque psoriasis, guttate psoriasis, and pustular variants. Psoriasis frequently involves the joints, leading to psoriatic arthritis. Nail involvement is found in 10-80% of patients with psoriasis. Psoriasis displays a spectrum of clinical manifestations, and several variants may be present at one time in the same patient.

Guttate psoriasis is a distinct variant of psoriasis that is classically triggered by streptococcal infection (pharyngitis or perianal) and is more common in children and adolescents than adults. Patients present with several, small “drop-like” lesions that respond well to topical and phototherapies.

Etiology

Risk factors for developing guttate psoriasis include recent streptococcal infection (oropharynx or perianal) or upper respiratory infection. Infections typically occur 1 to 3 weeks before the onset of guttate lesions. Guttate psoriasis lesions have also been described following TNF-alpha therapy.

Epidemiology

Approximately 2% of the world population is afflicted with psoriasis; in the United States and Canada, the prevalence is as high as 4%. In general, psoriasis has a bimodal peak of onset. Onset can peak at 20 to 30 years of age and 50 to 60 years of age. Guttate psoriasis accounts for less than 30% of all total cases of psoriasis. It occurs equally in both genders and is more common in children and adolescents than adults over the age of 30.

Pathophysiology

The interplay between genetic and environmental factors are implicated in the pathogenesis of psoriasis. Psoriasis is primarily a disorder of T cells, namely CD*+ T cells in the epidermis and a mixture of CD4+ and CD8+ cells in the dermis. Th1 cytokines (interferon-gamma [IFN-] and interleukin [IL-]2), IL-1, I-6, and tumor necrosis factor-alpha (TNF-alpha) are upregulated, and Th2 cytokines (IL-10) are downregulated. Much of the success of biologic therapy is owed to the role of IL-23 in the pathogenesis of psoriasis. Dendritic cells release IL-23, which promotes Th17 stimulation, causing IL-17 and IL-22 release leading to dermal inflammation and keratinocyte replication. An understanding of this complex interplay between interleukins has allowed targeted biologic therapy for psoriasis.

The most important gene implicated in the pathogenesis of psoriasis is the PSORS1 gene on chromosome 6p, containing the HLA-Cw6 allele.  The HLA-Cw6 allele is strongly linked to both early onset plaque psoriasis and guttate psoriasis. HLA B-13 and HLA B-17 are also strongly associated with guttate psoriasis (and erythrodermic) psoriasis.

Histopathology

Psoriasis is the model of the psoriasiform reaction pattern, defined as epidermal hyperplasia with elongation of the rete ridges. In addition to hyperplasia of the epidermis, there is an elongation of the dermal papillae, dilated superficial blood vessels, hypergranulosis, and parakeratosis.

Remnants of neutrophils in the stratum corneum are referred to as microabscesses of Munro. A discrete collection of neutrophils  (spongiform pustule of Kogoj) can also be found in the upper stratum spinosum.

History and Physical

Eliciting a thorough history can be valuable in the diagnosis of guttate psoriasis. Assessing the presence of risk factors can aid in diagnosing guttate psoriasis. Guttate psoriasis classically follows a preceding streptococcal infection, typically pharyngitis or perianal streptococcus.  The patient should be questioned regarding recent use of TNF- alpha inhibitors, as they have been implicated in guttate psoriasis.

On physical exam, guttate psoriasis manifests as numerous, small scattered papules and plaques. These are often referred to as “drop-like” and typically manifest as 2 to 6 mm papules. These lesions exhibit an isomorphic response or the Koebner phenomenon. The Koebner phenomenon refers to the appearance of lesions in areas of trauma (e.g., excoriations, sunburn, lesions of other eruptions such as Varicella or pityrosporum folliculitis), as wound healing triggers hyperproliferative changes in the skin. Although psoriasis is the prototype of koebnerization, this response can also be seen in pityriasis rubra pilaris, lichen planus, verruca plana (flat warts), lichen nitidus, vitiligo, lichen sclerosus, elastosis perforans serpiginosa, systemic lupus erythematosus, and other dermatological conditions.

In addition to Koebner phenomenon, all variants of psoriasis share certain characteristics that are reflected on histology, for example, erythema (elongated and dilated capillaries on histology), thickness (acanthosis with cellular infiltrates on histology), and silver scale (reflects abnormal keratinization). All lesions of psoriasis exhibit Auspitz sign, or pinpoint bleeding when the surface of a psoriatic lesion is removed. This reflects elongated vessels in the dermal papillae, together with thinning of the epidermis.

Evaluation

A diagnosis of guttate psoriasis can usually be made on history and clinical grounds alone. Skin biopsy is typically not necessary; however, lesions should demonstrate the histopathological findings discussed above. An elevated antistreptolysin O, anti-DNase B or streptozyme titer can indicate a recent streptococcal infection, further guiding the diagnosis towards guttate psoriasis.

Treatment / Management

For mild psoriasis, topical corticosteroids are first-line treatment. Topical steroids are available in several forms including ointments, creams, lotions, gels, foams, sprays, and shampoos. Ointment formulations are the most efficacious mainly secondary to their lipophilic properties. Corticosteroids are contraindicated in cases of bacterial, viral, and mycotic infections, atrophy of the skin, pregnancy, and lactation. Second-line therapy for mild psoriasis is anthralin (dithranol) as monotherapy or in combination with topical corticosteroids. Other topical steroids include vitamin D analogs (calcipotriene), topical retinoids (tazarotene), topical calcineurin inhibitors, and salicylic acid.

For moderate to severe psoriasis, phototherapy is first-line treatment as monotherapy or in combination. This includes phototherapy with broadband or narrowband ultraviolet B (UVB) and photochemotherapy with ultraviolet A (UVA) following psoralen ingestion or application (PUVA). Broadband UVB is the best phototherapy option for guttate psoriasis, in contrast to plaque psoriasis, which is better treated by narrowband UVB. Excimer laser (308 nm) can be used for localized psoriatic plaques.

Currently, there are several biologic treatment options indicated for plaque psoriasis. However, they have not been well-studied for guttate psoriasis. At this time, targeted biologic therapy is best reserved for the 40% of guttate lesions that progress to plaque type.

Differential Diagnosis

The differential diagnoses of guttate psoriasis include tinea corporis, secondary syphilis, nummular eczema, and pityriasis rosea. Guttate psoriasis can be distinguished from these entities by history and physical exam, although further studies such as potassium hydroxide (KOH) scrapings and serologies may be helpful in ruling out the other disorders in the differential diagnoses.

Prognosis

Forty percent of patients with guttate psoriasis convert to plaque psoriasis.


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Psoriasis, Guttate - Questions

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Guttate psoriasis is associated with:



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Which of the many forms of psoriasis is most likely to be preceded by a streptococcal infection?



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A 6-year-old male has a 10-day history of a rash and sore throat. The patient has had no fevers or upper respiratory symptoms. The patient has erythema of the posterior pharynx and 1- to 10-millimeter erythematous plaques over the trunk in a random pattern. What test is most important?



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A 6-year-old male has a 10-day history of a rash and sore throat. The patient has had no fevers or upper respiratory symptoms. The patient has erythema of the posterior pharynx and 1- to 10-millimeter erythematous plaques over the trunk in a random pattern. A rapid strep screen is positive, and the patient is treated with antibiotics. What should the parents be told about the rash?

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Psoriasis, Guttate - References

References

Maruani A,Samimi M,Stembridge N,Abdel Hay R,Tavernier E,Hughes C,Le Cleach L, Non-antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis. The Cochrane database of systematic reviews. 2019 Apr 8;     [PubMed]
Chimenti MS,Caso F,Alivernini S,De Martino E,Costa L,Tolusso B,Triggianese P,Conigliaro P,Gremese E,Scarpa R,Perricone R, Amplifying the concept of psoriatic arthritis: The role of autoimmunity in systemic psoriatic disease. Autoimmunity reviews. 2019 Apr 5;     [PubMed]
Dupire G,Droitcourt C,Hughes C,Le Cleach L, Antistreptococcal interventions for guttate and chronic plaque psoriasis. The Cochrane database of systematic reviews. 2019 Mar 5;     [PubMed]
Brandon A,Mufti A,Gary Sibbald R, Diagnosis and Management of Cutaneous Psoriasis: A Review. Advances in skin     [PubMed]
Gürel G,Sabah-Özcan S, Evaluation of Toll-like receptor expression profile in patients with psoriasis vulgaris. Gene. 2019 Mar 29;     [PubMed]
Sarzi-Puttini P,Ceribelli A,Marotto D,Batticciotto A,Atzeni F, Systemic rheumatic diseases: From biological agents to small molecules. Autoimmunity reviews. 2019 Apr 5;     [PubMed]

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